Incidental Mutation 'R8771:Or5p76'
ID 664412
Institutional Source Beutler Lab
Gene Symbol Or5p76
Ensembl Gene ENSMUSG00000058014
Gene Name olfactory receptor family 5 subfamily P member 76
Synonyms Olfr502, MOR204-8, GA_x6K02T2PBJ9-10853935-10852991
MMRRC Submission 068602-MU
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.303) question?
Stock # R8771 (G1)
Quality Score 225.009
Status Validated
Chromosome 7
Chromosomal Location 108122211-108123155 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 108122632 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Asparagine to Isoleucine at position 175 (N175I)
Ref Sequence ENSEMBL: ENSMUSP00000151167 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000078933] [ENSMUST00000216919]
AlphaFold Q8VG09
Predicted Effect possibly damaging
Transcript: ENSMUST00000078933
AA Change: N175I

PolyPhen 2 Score 0.624 (Sensitivity: 0.87; Specificity: 0.91)
SMART Domains Protein: ENSMUSP00000077963
Gene: ENSMUSG00000058014
AA Change: N175I

DomainStartEndE-ValueType
Pfam:7tm_4 34 311 4.8e-55 PFAM
Pfam:7tm_1 44 293 7.7e-24 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000216919
AA Change: N175I

PolyPhen 2 Score 0.624 (Sensitivity: 0.87; Specificity: 0.91)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.5%
  • 20x: 98.3%
Validation Efficiency 100% (47/47)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 48 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca4 T C 3: 121,880,320 (GRCm39) I451T probably damaging Het
Acin1 T C 14: 54,880,496 (GRCm39) K1236E unknown Het
AI661453 T C 17: 47,777,683 (GRCm39) S470P unknown Het
Ano5 C A 7: 51,216,095 (GRCm39) N357K probably damaging Het
Ano5 C T 7: 51,220,047 (GRCm39) Q396* probably null Het
Baz1b T A 5: 135,273,151 (GRCm39) M1425K probably benign Het
Cdh22 A T 2: 164,988,689 (GRCm39) V222E possibly damaging Het
Celsr1 A T 15: 85,788,175 (GRCm39) S2692R probably benign Het
Ces5a A G 8: 94,255,249 (GRCm39) I144T possibly damaging Het
D5Ertd579e T A 5: 36,761,940 (GRCm39) N1309I probably damaging Het
Dnmt3b C T 2: 153,504,734 (GRCm39) T112M possibly damaging Het
Eif4g3 C T 4: 137,907,848 (GRCm39) Q1283* probably null Het
Etnppl T A 3: 130,414,024 (GRCm39) M41K probably damaging Het
Hhatl G A 9: 121,617,776 (GRCm39) T271I possibly damaging Het
Igkv5-37 A G 6: 69,940,423 (GRCm39) S74P probably damaging Het
Krt87 A G 15: 101,385,779 (GRCm39) V272A probably benign Het
Lgr6 A T 1: 134,933,429 (GRCm39) L262* probably null Het
Lrriq3 G A 3: 154,899,270 (GRCm39) V590I probably damaging Het
Mfsd13a T C 19: 46,360,668 (GRCm39) V382A probably damaging Het
Minar2 T C 18: 59,200,052 (GRCm39) probably benign Het
Mrc2 A G 11: 105,240,596 (GRCm39) T1429A probably benign Het
Mroh5 A T 15: 73,693,203 (GRCm39) M79K possibly damaging Het
Myo1c A G 11: 75,556,709 (GRCm39) K553R probably benign Het
Nbeal1 A G 1: 60,300,743 (GRCm39) T1488A probably benign Het
Or4c12 T C 2: 89,773,565 (GRCm39) K298R probably benign Het
Or5aq6 T C 2: 86,923,294 (GRCm39) Y149C probably benign Het
Or5m10b T G 2: 85,699,712 (GRCm39) Y259D probably damaging Het
Prl7a1 A T 13: 27,819,811 (GRCm39) W148R probably damaging Het
Ptpn2 G T 18: 67,805,659 (GRCm39) T402K probably benign Het
Ptprf A G 4: 118,068,987 (GRCm39) M1665T possibly damaging Het
Raet1e G T 10: 22,057,041 (GRCm39) V122F probably damaging Het
Serpina3m A G 12: 104,357,841 (GRCm39) E255G probably damaging Het
Sorcs2 T C 5: 36,188,624 (GRCm39) Y828C probably damaging Het
Sprr1a T A 3: 92,391,989 (GRCm39) H4L probably benign Het
Sptssa A G 12: 54,703,211 (GRCm39) Y20H probably damaging Het
Synpo2l A G 14: 20,710,491 (GRCm39) S939P probably damaging Het
Tdrd7 T C 4: 46,010,800 (GRCm39) V568A probably damaging Het
Tmem132c C T 5: 127,437,192 (GRCm39) P227L probably benign Het
Tmtc3 A G 10: 100,286,180 (GRCm39) S548P possibly damaging Het
Trip12 A T 1: 84,721,018 (GRCm39) probably benign Het
Ttll6 A G 11: 96,042,762 (GRCm39) Y436C probably damaging Het
Unc80 A G 1: 66,685,554 (GRCm39) D2226G possibly damaging Het
Vmn1r142 T C 7: 21,862,737 (GRCm39) M242V probably benign Het
Vmn2r12 T G 5: 109,239,952 (GRCm39) T204P possibly damaging Het
Vmn2r16 C T 5: 109,488,231 (GRCm39) T368M probably benign Het
Vmn2r61 C A 7: 41,916,194 (GRCm39) A269D probably damaging Het
Zfp148 A G 16: 33,317,656 (GRCm39) D776G possibly damaging Het
Zfp775 A T 6: 48,596,906 (GRCm39) Q260L probably benign Het
Other mutations in Or5p76
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02260:Or5p76 APN 7 108,122,492 (GRCm39) missense probably benign 0.00
R0007:Or5p76 UTSW 7 108,122,420 (GRCm39) missense probably damaging 1.00
R0650:Or5p76 UTSW 7 108,122,289 (GRCm39) missense probably damaging 1.00
R1448:Or5p76 UTSW 7 108,122,525 (GRCm39) missense probably benign
R1469:Or5p76 UTSW 7 108,122,411 (GRCm39) missense probably benign 0.14
R1469:Or5p76 UTSW 7 108,122,411 (GRCm39) missense probably benign 0.14
R1701:Or5p76 UTSW 7 108,122,731 (GRCm39) missense probably benign 0.01
R3736:Or5p76 UTSW 7 108,122,626 (GRCm39) missense possibly damaging 0.79
R5030:Or5p76 UTSW 7 108,122,384 (GRCm39) missense possibly damaging 0.66
R5315:Or5p76 UTSW 7 108,123,097 (GRCm39) missense probably damaging 1.00
R6052:Or5p76 UTSW 7 108,122,945 (GRCm39) missense probably benign 0.34
R6548:Or5p76 UTSW 7 108,122,423 (GRCm39) missense probably benign 0.00
R6866:Or5p76 UTSW 7 108,122,377 (GRCm39) missense probably damaging 0.96
R6946:Or5p76 UTSW 7 108,122,528 (GRCm39) missense probably benign 0.02
R7582:Or5p76 UTSW 7 108,123,058 (GRCm39) missense probably benign 0.00
R8824:Or5p76 UTSW 7 108,122,350 (GRCm39) missense probably benign 0.28
R8854:Or5p76 UTSW 7 108,122,936 (GRCm39) missense probably benign 0.00
R9398:Or5p76 UTSW 7 108,123,035 (GRCm39) missense probably damaging 0.98
Z1088:Or5p76 UTSW 7 108,122,605 (GRCm39) missense probably damaging 0.99
Predicted Primers PCR Primer
(F):5'- TGCAGGTAGAGAAAGCCTTC -3'
(R):5'- ACAGTTGAATGTTTCCTTCTGGC -3'

Sequencing Primer
(F):5'- CAGGTAGAGAAAGCCTTCTGTCG -3'
(R):5'- CTGGCTGCCATGGCTTATGAC -3'
Posted On 2021-03-08