Incidental Mutation 'R0310:Vmn2r114'
ID 66442
Institutional Source Beutler Lab
Gene Symbol Vmn2r114
Ensembl Gene ENSMUSG00000091945
Gene Name vomeronasal 2, receptor 114
Synonyms EG666002
MMRRC Submission 038520-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.131) question?
Stock # R0310 (G1)
Quality Score 118
Status Validated
Chromosome 17
Chromosomal Location 23509908-23531287 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 23509917 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Histidine to Glutamine at position 854 (H854Q)
Ref Sequence ENSEMBL: ENSMUSP00000127505 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000168033]
AlphaFold E9Q281
Predicted Effect probably benign
Transcript: ENSMUST00000168033
AA Change: H854Q

PolyPhen 2 Score 0.227 (Sensitivity: 0.91; Specificity: 0.88)
SMART Domains Protein: ENSMUSP00000127505
Gene: ENSMUSG00000091945
AA Change: H854Q

DomainStartEndE-ValueType
signal peptide 1 18 N/A INTRINSIC
Pfam:ANF_receptor 154 470 1.5e-24 PFAM
Pfam:NCD3G 511 564 1.5e-18 PFAM
Pfam:7tm_3 597 832 1.4e-55 PFAM
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 98.6%
  • 3x: 97.3%
  • 10x: 93.3%
  • 20x: 82.5%
Validation Efficiency 99% (113/114)
Allele List at MGI
Other mutations in this stock
Total: 109 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930550C14Rik A C 9: 53,336,971 (GRCm39) T92P probably damaging Het
Abca13 T C 11: 9,243,810 (GRCm39) V1891A probably benign Het
Abcc1 T A 16: 14,228,791 (GRCm39) I346N probably damaging Het
Afdn G T 17: 14,105,770 (GRCm39) probably null Het
Ahrr G A 13: 74,431,143 (GRCm39) probably benign Het
Akap13 A G 7: 75,264,678 (GRCm39) D507G probably damaging Het
Akap8 A T 17: 32,535,234 (GRCm39) M260K possibly damaging Het
Akr1b8 T C 6: 34,342,194 (GRCm39) V265A probably benign Het
Alpk3 C G 7: 80,728,358 (GRCm39) P496R possibly damaging Het
Ankrd13b A G 11: 77,363,571 (GRCm39) V249A possibly damaging Het
Arid4a T C 12: 71,122,604 (GRCm39) V995A probably benign Het
Ascc3 G T 10: 50,625,022 (GRCm39) V1637L probably benign Het
Atad2 G A 15: 57,977,653 (GRCm39) A499V probably damaging Het
Barhl2 G T 5: 106,605,253 (GRCm39) A152E possibly damaging Het
Bbs12 T A 3: 37,375,194 (GRCm39) D547E probably damaging Het
Btaf1 A G 19: 36,981,934 (GRCm39) M1655V probably damaging Het
Ccdc50 T A 16: 27,225,408 (GRCm39) H40Q probably damaging Het
Ccr9 A T 9: 123,603,617 (GRCm39) probably benign Het
Cdh15 A G 8: 123,592,175 (GRCm39) D654G probably damaging Het
Cebpz T C 17: 79,233,553 (GRCm39) D758G probably damaging Het
Cgn C T 3: 94,672,960 (GRCm39) R906K possibly damaging Het
Chil3 T A 3: 106,067,839 (GRCm39) M109L possibly damaging Het
Cntnap4 A T 8: 113,569,148 (GRCm39) probably null Het
Cyp4f18 C T 8: 72,754,856 (GRCm39) probably benign Het
Daam2 A G 17: 49,770,952 (GRCm39) probably null Het
Ddost T A 4: 138,037,922 (GRCm39) H220Q probably benign Het
Dennd2a C T 6: 39,441,135 (GRCm39) probably benign Het
Depdc1b G A 13: 108,510,375 (GRCm39) V296I possibly damaging Het
Dnaaf4 A T 9: 72,879,618 (GRCm39) D386V probably damaging Het
Dnah5 A T 15: 28,299,256 (GRCm39) R1539S probably benign Het
Dusp22 T C 13: 30,889,641 (GRCm39) I74T probably damaging Het
Epc1 A G 18: 6,440,202 (GRCm39) probably benign Het
Epha7 A G 4: 28,961,301 (GRCm39) I845V probably benign Het
Fanci C T 7: 79,057,165 (GRCm39) probably benign Het
Fbn1 T A 2: 125,205,564 (GRCm39) E1104V probably damaging Het
Fbxo8 T A 8: 57,043,132 (GRCm39) F205L probably damaging Het
Fcgbpl1 G T 7: 27,841,699 (GRCm39) V545L probably benign Het
Fetub T C 16: 22,748,506 (GRCm39) probably benign Het
Frs3 T C 17: 48,014,747 (GRCm39) V480A probably benign Het
Gne C A 4: 44,060,157 (GRCm39) E79* probably null Het
Hrc T A 7: 44,985,921 (GRCm39) H357Q probably benign Het
Idh1 T C 1: 65,201,079 (GRCm39) M291V probably damaging Het
Il22b T A 10: 118,129,090 (GRCm39) H133L probably benign Het
Ino80b T C 6: 83,101,072 (GRCm39) E165G probably damaging Het
Inppl1 A T 7: 101,477,706 (GRCm39) probably benign Het
Ints15 G T 5: 143,293,643 (GRCm39) T278K probably benign Het
Ip6k2 T C 9: 108,676,432 (GRCm39) probably benign Het
Itga11 A T 9: 62,667,628 (GRCm39) I654F probably damaging Het
Jag2 G T 12: 112,876,997 (GRCm39) probably benign Het
Katna1 G T 10: 7,619,513 (GRCm39) probably benign Het
Kcnh4 G T 11: 100,636,995 (GRCm39) S707Y probably benign Het
Kcnn2 T G 18: 45,693,585 (GRCm39) L387R probably damaging Het
Khnyn A G 14: 56,125,425 (GRCm39) T503A probably damaging Het
Lama5 G T 2: 179,823,359 (GRCm39) probably benign Het
Lmbr1l A T 15: 98,806,654 (GRCm39) probably benign Het
Mast4 A T 13: 102,890,669 (GRCm39) S870T possibly damaging Het
Med1 A G 11: 98,058,400 (GRCm39) Y266H probably benign Het
Med13 A T 11: 86,236,829 (GRCm39) N109K probably benign Het
Mgam T C 6: 40,737,969 (GRCm39) probably benign Het
Mmp8 A G 9: 7,561,455 (GRCm39) Q153R probably benign Het
Mpeg1 C A 19: 12,439,055 (GRCm39) T171N probably benign Het
Mtus2 T C 5: 148,043,829 (GRCm39) S806P probably benign Het
Naip2 T A 13: 100,285,350 (GRCm39) E1226V probably damaging Het
Naip6 A G 13: 100,444,721 (GRCm39) F246L possibly damaging Het
Nav3 T C 10: 109,602,989 (GRCm39) I1187V possibly damaging Het
Nbeal1 T C 1: 60,344,529 (GRCm39) probably benign Het
Nbeal2 C A 9: 110,467,231 (GRCm39) V653L probably damaging Het
Ndufa9 G T 6: 126,804,495 (GRCm39) probably benign Het
Nlrp5 G T 7: 23,129,582 (GRCm39) C883F probably damaging Het
Nr0b2 C A 4: 133,283,303 (GRCm39) probably null Het
Or1m1 T A 9: 18,666,629 (GRCm39) M101L possibly damaging Het
Or6c209 T A 10: 129,483,600 (GRCm39) V201E probably damaging Het
Or6c69c G A 10: 129,910,692 (GRCm39) V138I probably benign Het
Or8b101 T A 9: 38,020,782 (GRCm39) S267T possibly damaging Het
Pkhd1 A T 1: 20,620,046 (GRCm39) probably null Het
Pkhd1l1 A G 15: 44,386,134 (GRCm39) probably benign Het
Ppm1l A G 3: 69,456,794 (GRCm39) K237R probably benign Het
Ppp1r18 T C 17: 36,184,603 (GRCm39) probably benign Het
Ptpn3 A T 4: 57,204,958 (GRCm39) D734E probably benign Het
Pxdn T C 12: 30,065,528 (GRCm39) C1283R probably damaging Het
Rbm12 A G 2: 155,937,644 (GRCm39) probably benign Het
Rttn A T 18: 89,027,584 (GRCm39) probably benign Het
Sgsm1 G T 5: 113,411,571 (GRCm39) H431Q probably benign Het
Siah3 A G 14: 75,763,367 (GRCm39) N206S possibly damaging Het
Slc22a15 G T 3: 101,767,827 (GRCm39) D521E probably benign Het
Sprr2k A T 3: 92,340,770 (GRCm39) probably benign Het
Stab2 G A 10: 86,803,477 (GRCm39) probably benign Het
Sval3 T A 6: 41,945,120 (GRCm39) L16Q probably damaging Het
Sycp2 C G 2: 178,023,648 (GRCm39) S456T probably benign Het
Tk1 T C 11: 117,707,921 (GRCm39) probably benign Het
Tlk2 C A 11: 105,145,799 (GRCm39) A335E probably benign Het
Tmtc1 T C 6: 148,151,079 (GRCm39) K659E probably benign Het
Tnk2 C T 16: 32,499,408 (GRCm39) P907L probably benign Het
Trim14 C A 4: 46,522,043 (GRCm39) K211N probably damaging Het
Trim15 A C 17: 37,177,878 (GRCm39) L39R probably damaging Het
Tspan15 T A 10: 62,023,872 (GRCm39) T269S probably benign Het
Ttc7 T A 17: 87,669,292 (GRCm39) D646E probably benign Het
Ttll6 A T 11: 96,038,382 (GRCm39) Q410L probably benign Het
Unc79 A G 12: 103,027,666 (GRCm39) Q419R probably damaging Het
Vcam1 A T 3: 115,908,065 (GRCm39) Y666N possibly damaging Het
Vmn1r10 A T 6: 57,090,486 (GRCm39) Y26F probably damaging Het
Vmn1r80 A G 7: 11,927,775 (GRCm39) N295S probably benign Het
Vmn2r2 A T 3: 64,042,039 (GRCm39) D225E probably damaging Het
Vmn2r4 A T 3: 64,296,855 (GRCm39) Y643* probably null Het
Vmn2r52 T A 7: 9,893,393 (GRCm39) Y582F probably damaging Het
Vmn2r60 G T 7: 41,844,564 (GRCm39) L642F possibly damaging Het
Zbtb20 T C 16: 43,430,109 (GRCm39) S207P probably damaging Het
Zic2 CCCACCACCACCATCACCACCACCACC CCCACCATCACCACCACCACC 14: 122,713,776 (GRCm39) probably benign Het
Zkscan7 G T 9: 122,717,958 (GRCm39) E118* probably null Het
Other mutations in Vmn2r114
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00157:Vmn2r114 APN 17 23,510,639 (GRCm39) missense probably damaging 1.00
IGL00990:Vmn2r114 APN 17 23,510,212 (GRCm39) missense probably damaging 1.00
IGL00990:Vmn2r114 APN 17 23,509,957 (GRCm39) missense probably benign 0.23
IGL00990:Vmn2r114 APN 17 23,509,939 (GRCm39) missense probably benign
IGL01838:Vmn2r114 APN 17 23,515,956 (GRCm39) missense probably benign 0.44
IGL01990:Vmn2r114 APN 17 23,529,355 (GRCm39) missense probably benign 0.22
IGL01994:Vmn2r114 APN 17 23,529,451 (GRCm39) missense probably damaging 1.00
IGL02153:Vmn2r114 APN 17 23,510,782 (GRCm39) missense probably benign 0.01
IGL02453:Vmn2r114 APN 17 23,530,108 (GRCm39) missense probably benign 0.00
IGL02621:Vmn2r114 APN 17 23,529,494 (GRCm39) missense probably damaging 0.98
IGL02938:Vmn2r114 APN 17 23,510,263 (GRCm39) missense probably benign 0.10
IGL03130:Vmn2r114 APN 17 23,515,970 (GRCm39) splice site probably benign
IGL03325:Vmn2r114 APN 17 23,510,652 (GRCm39) missense probably damaging 1.00
BB004:Vmn2r114 UTSW 17 23,510,619 (GRCm39) missense probably damaging 1.00
R0109:Vmn2r114 UTSW 17 23,529,549 (GRCm39) nonsense probably null
R0164:Vmn2r114 UTSW 17 23,528,800 (GRCm39) critical splice donor site probably null
R0583:Vmn2r114 UTSW 17 23,509,906 (GRCm39) makesense probably null
R0677:Vmn2r114 UTSW 17 23,529,568 (GRCm39) missense probably damaging 1.00
R1127:Vmn2r114 UTSW 17 23,509,906 (GRCm39) makesense probably null
R1147:Vmn2r114 UTSW 17 23,530,037 (GRCm39) missense probably benign 0.00
R1147:Vmn2r114 UTSW 17 23,530,037 (GRCm39) missense probably benign 0.00
R1157:Vmn2r114 UTSW 17 23,529,314 (GRCm39) missense possibly damaging 0.60
R1323:Vmn2r114 UTSW 17 23,509,906 (GRCm39) makesense probably null
R1347:Vmn2r114 UTSW 17 23,509,906 (GRCm39) makesense probably null
R1435:Vmn2r114 UTSW 17 23,509,906 (GRCm39) makesense probably null
R1437:Vmn2r114 UTSW 17 23,510,185 (GRCm39) missense probably damaging 1.00
R1585:Vmn2r114 UTSW 17 23,510,675 (GRCm39) missense probably damaging 0.98
R1641:Vmn2r114 UTSW 17 23,515,962 (GRCm39) missense probably benign 0.00
R1748:Vmn2r114 UTSW 17 23,527,035 (GRCm39) missense probably benign 0.17
R1954:Vmn2r114 UTSW 17 23,530,086 (GRCm39) missense probably benign 0.32
R2081:Vmn2r114 UTSW 17 23,510,083 (GRCm39) missense possibly damaging 0.91
R2103:Vmn2r114 UTSW 17 23,509,906 (GRCm39) makesense probably null
R2113:Vmn2r114 UTSW 17 23,509,906 (GRCm39) makesense probably null
R2134:Vmn2r114 UTSW 17 23,510,737 (GRCm39) missense probably damaging 1.00
R2149:Vmn2r114 UTSW 17 23,509,906 (GRCm39) makesense probably null
R2424:Vmn2r114 UTSW 17 23,515,842 (GRCm39) missense possibly damaging 0.90
R2847:Vmn2r114 UTSW 17 23,509,948 (GRCm39) missense probably benign 0.00
R2848:Vmn2r114 UTSW 17 23,509,948 (GRCm39) missense probably benign 0.00
R2893:Vmn2r114 UTSW 17 23,509,906 (GRCm39) makesense probably null
R3017:Vmn2r114 UTSW 17 23,509,906 (GRCm39) makesense probably null
R3018:Vmn2r114 UTSW 17 23,509,906 (GRCm39) makesense probably null
R3019:Vmn2r114 UTSW 17 23,509,906 (GRCm39) makesense probably null
R3020:Vmn2r114 UTSW 17 23,509,906 (GRCm39) makesense probably null
R3021:Vmn2r114 UTSW 17 23,509,906 (GRCm39) makesense probably null
R4628:Vmn2r114 UTSW 17 23,509,906 (GRCm39) makesense probably null
R4668:Vmn2r114 UTSW 17 23,529,447 (GRCm39) missense possibly damaging 0.83
R4840:Vmn2r114 UTSW 17 23,510,353 (GRCm39) missense probably damaging 0.97
R4841:Vmn2r114 UTSW 17 23,529,336 (GRCm39) missense probably benign 0.04
R4842:Vmn2r114 UTSW 17 23,529,336 (GRCm39) missense probably benign 0.04
R4856:Vmn2r114 UTSW 17 23,527,008 (GRCm39) missense probably benign 0.11
R4886:Vmn2r114 UTSW 17 23,527,008 (GRCm39) missense probably benign 0.11
R4992:Vmn2r114 UTSW 17 23,510,765 (GRCm39) missense probably benign 0.03
R5182:Vmn2r114 UTSW 17 23,510,632 (GRCm39) missense probably damaging 0.96
R5223:Vmn2r114 UTSW 17 23,509,906 (GRCm39) makesense probably null
R5405:Vmn2r114 UTSW 17 23,509,906 (GRCm39) makesense probably null
R5449:Vmn2r114 UTSW 17 23,509,906 (GRCm39) makesense probably null
R5615:Vmn2r114 UTSW 17 23,509,906 (GRCm39) makesense probably null
R5834:Vmn2r114 UTSW 17 23,529,599 (GRCm39) missense possibly damaging 0.90
R6150:Vmn2r114 UTSW 17 23,510,269 (GRCm39) missense probably benign 0.03
R6277:Vmn2r114 UTSW 17 23,509,954 (GRCm39) missense possibly damaging 0.93
R6403:Vmn2r114 UTSW 17 23,528,939 (GRCm39) missense probably damaging 0.99
R6589:Vmn2r114 UTSW 17 23,510,642 (GRCm39) missense probably damaging 1.00
R6613:Vmn2r114 UTSW 17 23,529,220 (GRCm39) missense possibly damaging 0.82
R6747:Vmn2r114 UTSW 17 23,528,850 (GRCm39) missense probably benign 0.00
R6837:Vmn2r114 UTSW 17 23,529,176 (GRCm39) missense probably benign 0.10
R6911:Vmn2r114 UTSW 17 23,510,104 (GRCm39) missense probably damaging 0.98
R6950:Vmn2r114 UTSW 17 23,529,137 (GRCm39) missense probably benign 0.03
R7276:Vmn2r114 UTSW 17 23,509,934 (GRCm39) missense probably damaging 0.97
R7482:Vmn2r114 UTSW 17 23,510,468 (GRCm39) missense probably damaging 1.00
R7514:Vmn2r114 UTSW 17 23,527,035 (GRCm39) missense probably null 0.96
R7523:Vmn2r114 UTSW 17 23,529,611 (GRCm39) missense probably benign 0.01
R7563:Vmn2r114 UTSW 17 23,510,000 (GRCm39) missense probably benign 0.01
R7585:Vmn2r114 UTSW 17 23,510,239 (GRCm39) missense probably damaging 1.00
R7593:Vmn2r114 UTSW 17 23,510,817 (GRCm39) nonsense probably null
R7611:Vmn2r114 UTSW 17 23,515,944 (GRCm39) missense probably damaging 0.97
R7641:Vmn2r114 UTSW 17 23,527,177 (GRCm39) missense possibly damaging 0.53
R7651:Vmn2r114 UTSW 17 23,509,986 (GRCm39) nonsense probably null
R7970:Vmn2r114 UTSW 17 23,530,186 (GRCm39) missense probably benign 0.00
R8737:Vmn2r114 UTSW 17 23,529,142 (GRCm39) missense probably benign 0.36
R8802:Vmn2r114 UTSW 17 23,528,836 (GRCm39) missense possibly damaging 0.65
R8847:Vmn2r114 UTSW 17 23,528,986 (GRCm39) missense probably damaging 1.00
R8991:Vmn2r114 UTSW 17 23,529,286 (GRCm39) missense probably damaging 1.00
R9138:Vmn2r114 UTSW 17 23,510,578 (GRCm39) missense probably damaging 1.00
R9173:Vmn2r114 UTSW 17 23,510,527 (GRCm39) missense probably damaging 0.99
R9175:Vmn2r114 UTSW 17 23,527,212 (GRCm39) missense probably damaging 1.00
R9657:Vmn2r114 UTSW 17 23,510,690 (GRCm39) missense probably damaging 1.00
R9670:Vmn2r114 UTSW 17 23,531,098 (GRCm39) missense
X0065:Vmn2r114 UTSW 17 23,529,931 (GRCm39) missense probably benign 0.34
Z1088:Vmn2r114 UTSW 17 23,509,906 (GRCm39) makesense probably null
Predicted Primers
Posted On 2013-08-19