Incidental Mutation 'R8775:Vmn2r16'
ID 664653
Institutional Source Beutler Lab
Gene Symbol Vmn2r16
Ensembl Gene ENSMUSG00000092080
Gene Name vomeronasal 2, receptor 16
Synonyms EG384220
MMRRC Submission 068719-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.154) question?
Stock # R8775 (G1)
Quality Score 225.009
Status Not validated
Chromosome 5
Chromosomal Location 109478247-109512347 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 109488231 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Methionine at position 368 (T368M)
Ref Sequence ENSEMBL: ENSMUSP00000127838 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000165180]
AlphaFold A0A3B2WCY4
Predicted Effect probably benign
Transcript: ENSMUST00000165180
AA Change: T368M

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
SMART Domains Protein: ENSMUSP00000127838
Gene: ENSMUSG00000092080
AA Change: T368M

DomainStartEndE-ValueType
signal peptide 1 24 N/A INTRINSIC
Pfam:ANF_receptor 76 425 2.3e-28 PFAM
Pfam:NCD3G 509 563 8.2e-19 PFAM
Pfam:7tm_3 596 831 3.5e-56 PFAM
Meta Mutation Damage Score 0.0846 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 99.2%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 41 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adck2 T C 6: 39,552,142 (GRCm39) probably null Het
Alpk3 A C 7: 80,727,598 (GRCm39) M243L probably benign Het
Anapc1 A T 2: 128,499,093 (GRCm39) Y860N possibly damaging Het
Asprv1 T C 6: 86,605,321 (GRCm39) S56P probably damaging Het
D130043K22Rik G T 13: 25,040,982 (GRCm39) E135* probably null Het
Dnmt3b A G 2: 153,511,711 (GRCm39) H293R possibly damaging Het
Dsg1a C T 18: 20,473,564 (GRCm39) S879L probably damaging Het
Fbxo24 C T 5: 137,611,213 (GRCm39) A526T possibly damaging Het
Fign A T 2: 63,810,891 (GRCm39) D126E probably benign Het
Gpr137 A G 19: 6,915,800 (GRCm39) F377L probably damaging Het
Gsdma2 A G 11: 98,540,009 (GRCm39) K44E probably damaging Het
Iigp1 A C 18: 60,523,596 (GRCm39) Y238S probably damaging Het
Itga8 C G 2: 12,187,495 (GRCm39) G728A probably damaging Het
Kcnip2 T C 19: 45,782,149 (GRCm39) N258S possibly damaging Het
Lcat A G 8: 106,669,023 (GRCm39) I84T possibly damaging Het
Mansc1 C T 6: 134,587,631 (GRCm39) R182H probably benign Het
Myh4 T C 11: 67,148,006 (GRCm39) M1685T probably benign Het
Myo10 T A 15: 25,800,145 (GRCm39) V1407E probably damaging Het
Ncam2 T A 16: 81,314,429 (GRCm39) N468K probably benign Het
Nckap1 A G 2: 80,375,410 (GRCm39) S297P probably benign Het
Nefm T C 14: 68,362,108 (GRCm39) Y52C probably damaging Het
Ntng2 A T 2: 29,117,976 (GRCm39) N157K possibly damaging Het
Oscp1 T C 4: 125,970,619 (GRCm39) V136A probably benign Het
Oser1 G A 2: 163,249,004 (GRCm39) T66I probably benign Het
Palld A G 8: 62,138,006 (GRCm39) L583P possibly damaging Het
Pex7 A G 10: 19,760,522 (GRCm39) probably null Het
Ppp2r3d A G 9: 101,004,204 (GRCm39) Y378H probably benign Het
Prss33 T A 17: 24,052,885 (GRCm39) N263I possibly damaging Het
Psg25 A C 7: 18,255,153 (GRCm39) C454W probably damaging Het
Ptpn21 T C 12: 98,649,001 (GRCm39) probably null Het
Sh3bp2 A T 5: 34,719,751 (GRCm39) S587C probably damaging Het
Sos2 A G 12: 69,664,006 (GRCm39) F493L probably benign Het
St8sia4 T A 1: 95,519,472 (GRCm39) T339S possibly damaging Het
Taok1 T C 11: 77,470,632 (GRCm39) K58E probably benign Het
Thsd1 A G 8: 22,749,643 (GRCm39) D838G possibly damaging Het
Tulp2 A G 7: 45,164,914 (GRCm39) T65A probably benign Het
Usp54 A T 14: 20,638,466 (GRCm39) S205T probably benign Het
Vmn2r37 A T 7: 9,218,991 (GRCm39) Y464* probably null Het
Wdsub1 A G 2: 59,693,014 (GRCm39) M300T probably damaging Het
Xrcc5 C T 1: 72,433,089 (GRCm39) T716I probably benign Het
Zfp619 G T 7: 39,184,639 (GRCm39) C223F possibly damaging Het
Other mutations in Vmn2r16
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01116:Vmn2r16 APN 5 109,488,294 (GRCm39) missense probably damaging 1.00
IGL01374:Vmn2r16 APN 5 109,478,283 (GRCm39) missense probably benign 0.00
IGL01391:Vmn2r16 APN 5 109,511,627 (GRCm39) missense possibly damaging 0.50
IGL01419:Vmn2r16 APN 5 109,510,267 (GRCm39) splice site probably benign
IGL01634:Vmn2r16 APN 5 109,488,177 (GRCm39) missense probably benign 0.00
IGL01845:Vmn2r16 APN 5 109,511,762 (GRCm39) missense probably damaging 1.00
IGL01875:Vmn2r16 APN 5 109,478,277 (GRCm39) missense probably benign 0.01
IGL01910:Vmn2r16 APN 5 109,487,951 (GRCm39) missense probably damaging 1.00
IGL02217:Vmn2r16 APN 5 109,487,676 (GRCm39) missense probably damaging 0.98
IGL02327:Vmn2r16 APN 5 109,487,987 (GRCm39) missense probably benign 0.01
IGL02491:Vmn2r16 APN 5 109,487,703 (GRCm39) nonsense probably null
IGL02531:Vmn2r16 APN 5 109,488,134 (GRCm39) missense probably damaging 0.99
IGL02680:Vmn2r16 APN 5 109,487,948 (GRCm39) missense probably benign 0.44
IGL02884:Vmn2r16 APN 5 109,508,757 (GRCm39) missense possibly damaging 0.94
IGL03084:Vmn2r16 APN 5 109,478,292 (GRCm39) missense probably damaging 0.99
IGL03096:Vmn2r16 APN 5 109,487,751 (GRCm39) missense probably damaging 0.99
IGL03355:Vmn2r16 APN 5 109,511,580 (GRCm39) missense possibly damaging 0.74
R0280:Vmn2r16 UTSW 5 109,488,005 (GRCm39) missense possibly damaging 0.88
R0594:Vmn2r16 UTSW 5 109,511,762 (GRCm39) missense probably damaging 1.00
R1016:Vmn2r16 UTSW 5 109,487,754 (GRCm39) missense probably damaging 1.00
R1109:Vmn2r16 UTSW 5 109,487,652 (GRCm39) missense probably damaging 0.98
R1248:Vmn2r16 UTSW 5 109,508,643 (GRCm39) missense probably benign 0.10
R1626:Vmn2r16 UTSW 5 109,511,443 (GRCm39) missense probably damaging 1.00
R1909:Vmn2r16 UTSW 5 109,511,853 (GRCm39) missense probably benign 0.01
R1929:Vmn2r16 UTSW 5 109,487,124 (GRCm39) missense possibly damaging 0.92
R1982:Vmn2r16 UTSW 5 109,511,890 (GRCm39) missense probably benign 0.01
R3038:Vmn2r16 UTSW 5 109,487,199 (GRCm39) missense probably damaging 1.00
R3437:Vmn2r16 UTSW 5 109,478,362 (GRCm39) missense probably damaging 0.99
R3734:Vmn2r16 UTSW 5 109,478,280 (GRCm39) missense probably benign 0.11
R3820:Vmn2r16 UTSW 5 109,510,143 (GRCm39) missense probably benign 0.36
R3873:Vmn2r16 UTSW 5 109,488,177 (GRCm39) missense probably benign 0.33
R4165:Vmn2r16 UTSW 5 109,478,427 (GRCm39) missense possibly damaging 0.80
R4373:Vmn2r16 UTSW 5 109,511,667 (GRCm39) missense probably damaging 1.00
R4575:Vmn2r16 UTSW 5 109,511,665 (GRCm39) missense possibly damaging 0.81
R4576:Vmn2r16 UTSW 5 109,511,665 (GRCm39) missense possibly damaging 0.81
R4578:Vmn2r16 UTSW 5 109,511,665 (GRCm39) missense possibly damaging 0.81
R4637:Vmn2r16 UTSW 5 109,478,280 (GRCm39) missense probably benign 0.00
R4696:Vmn2r16 UTSW 5 109,487,168 (GRCm39) missense probably benign 0.01
R5026:Vmn2r16 UTSW 5 109,508,722 (GRCm39) nonsense probably null
R5180:Vmn2r16 UTSW 5 109,478,391 (GRCm39) missense probably benign 0.01
R5433:Vmn2r16 UTSW 5 109,511,708 (GRCm39) missense probably damaging 1.00
R5955:Vmn2r16 UTSW 5 109,511,613 (GRCm39) missense possibly damaging 0.78
R5958:Vmn2r16 UTSW 5 109,510,153 (GRCm39) missense possibly damaging 0.81
R6353:Vmn2r16 UTSW 5 109,488,119 (GRCm39) missense probably benign 0.33
R6389:Vmn2r16 UTSW 5 109,478,344 (GRCm39) missense probably benign 0.19
R6819:Vmn2r16 UTSW 5 109,488,412 (GRCm39) missense probably benign 0.04
R6994:Vmn2r16 UTSW 5 109,487,969 (GRCm39) missense probably damaging 1.00
R7061:Vmn2r16 UTSW 5 109,511,620 (GRCm39) missense probably damaging 0.99
R7063:Vmn2r16 UTSW 5 109,511,650 (GRCm39) missense probably damaging 1.00
R7220:Vmn2r16 UTSW 5 109,508,772 (GRCm39) missense probably damaging 0.97
R7268:Vmn2r16 UTSW 5 109,488,331 (GRCm39) nonsense probably null
R7420:Vmn2r16 UTSW 5 109,511,736 (GRCm39) missense probably damaging 0.96
R7591:Vmn2r16 UTSW 5 109,510,223 (GRCm39) missense probably damaging 0.99
R7644:Vmn2r16 UTSW 5 109,487,837 (GRCm39) missense probably damaging 1.00
R7939:Vmn2r16 UTSW 5 109,487,705 (GRCm39) missense possibly damaging 0.79
R7977:Vmn2r16 UTSW 5 109,488,015 (GRCm39) missense probably damaging 1.00
R7987:Vmn2r16 UTSW 5 109,488,015 (GRCm39) missense probably damaging 1.00
R8023:Vmn2r16 UTSW 5 109,488,272 (GRCm39) nonsense probably null
R8427:Vmn2r16 UTSW 5 109,488,138 (GRCm39) missense probably benign 0.03
R8436:Vmn2r16 UTSW 5 109,511,649 (GRCm39) missense probably damaging 1.00
R8475:Vmn2r16 UTSW 5 109,487,073 (GRCm39) missense probably benign 0.01
R8554:Vmn2r16 UTSW 5 109,511,997 (GRCm39) missense probably benign 0.13
R8771:Vmn2r16 UTSW 5 109,488,231 (GRCm39) missense probably benign 0.00
R8774:Vmn2r16 UTSW 5 109,488,231 (GRCm39) missense probably benign 0.00
R8774-TAIL:Vmn2r16 UTSW 5 109,488,231 (GRCm39) missense probably benign 0.00
R8775-TAIL:Vmn2r16 UTSW 5 109,488,231 (GRCm39) missense probably benign 0.00
R8777:Vmn2r16 UTSW 5 109,488,231 (GRCm39) missense probably benign 0.00
R8777-TAIL:Vmn2r16 UTSW 5 109,488,231 (GRCm39) missense probably benign 0.00
R8825:Vmn2r16 UTSW 5 109,487,019 (GRCm39) missense probably benign 0.41
R8865:Vmn2r16 UTSW 5 109,487,910 (GRCm39) missense probably benign 0.33
R8900:Vmn2r16 UTSW 5 109,511,619 (GRCm39) missense probably benign 0.04
R9365:Vmn2r16 UTSW 5 109,488,064 (GRCm39) missense probably damaging 0.99
R9683:Vmn2r16 UTSW 5 109,511,677 (GRCm39) missense probably damaging 1.00
X0027:Vmn2r16 UTSW 5 109,487,175 (GRCm39) missense probably damaging 1.00
Z1088:Vmn2r16 UTSW 5 109,511,779 (GRCm39) frame shift probably null
Z1088:Vmn2r16 UTSW 5 109,488,381 (GRCm39) missense probably benign 0.03
Z1177:Vmn2r16 UTSW 5 109,487,864 (GRCm39) missense possibly damaging 0.79
Predicted Primers PCR Primer
(F):5'- CACAACCTCACAATGGGATGTC -3'
(R):5'- ACAGTCACTGAATACTCCTTTGAG -3'

Sequencing Primer
(F):5'- CCTCACAATGGGATGTCATCAC -3'
(R):5'- AGTTTTGGCATTTTCTGAGACTCTAC -3'
Posted On 2021-03-08