Mutagenetix > Incidental Mutations

Incidental Mutation 'R0280:Gm973'

66492

Institutional Source

Beutler Lab

Gene Symbol

Gm973

Ensembl Gene

ENSMUSG00000047361

Gene Name

predicted gene 973

Synonyms

LOC381260

MMRRC Submission

038502-MU

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.082) question?

Stock #

R0280 (G1)

Quality Score

214

Status

Validated

Chromosome

Chromosomal Location

59516264-59636417 bp(+) (GRCm38)

Type of Mutation

frame shift

DNA Base Change (assembly)

GCC to GC at 59544680 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000141102 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000114243] [ENSMUST00000186434]

AlphaFold

E9Q295

Predicted Effect

probably null
Transcript: ENSMUST00000114243

SMART Domains

Protein: ENSMUSP00000109881
Gene: ENSMUSG00000047361

Domain	Start	End	E-Value	Type
low complexity region	364	375	N/A	INTRINSIC
Pfam:DUF4670	583	1045	7.3e-160	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000185291

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000186310

Predicted Effect

probably null
Transcript: ENSMUST00000186434

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000189864

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000191318

Meta Mutation Damage Score

0.9755

Coding Region Coverage

1x: 99.2%
3x: 98.6%
10x: 96.9%
20x: 94.6%

Validation Efficiency

96% (55/57)

Allele List at MGI

Other mutations in this stock

Total: 52 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700061G19Rik	T	A	17: 56,885,169	Y577*	probably null	Het
Adam18	C	T	8: 24,674,054	G38R	probably benign	Het
Ankrd16	T	G	2: 11,781,501	V187G	probably damaging	Het
AU019823	T	C	9: 50,609,379	T123A	probably damaging	Het
Ccdc110	A	T	8: 45,943,450	N793Y	probably benign	Het
Ccdc170	T	C	10: 4,558,663	I629T	possibly damaging	Het
Clcn6	A	G	4: 148,008,715	L836P	probably damaging	Het
Colgalt2	G	T	1: 152,508,561	A551S	possibly damaging	Het
Crocc	T	C	4: 141,028,426	E1097G	probably damaging	Het
Csmd1	A	T	8: 16,271,602	V494E	probably damaging	Het
Drg1	A	T	11: 3,256,537		probably null	Het
Dscam	T	C	16: 97,039,006	K134E	possibly damaging	Het
Dyrk1b	T	C	7: 28,184,312	Y198H	probably damaging	Het
Esr1	A	G	10: 4,856,951	D289G	probably benign	Het
Esr1	G	T	10: 4,939,289	V396F	probably damaging	Het
Evi5l	T	C	8: 4,193,133	V339A	probably damaging	Het
Fat4	A	T	3: 38,890,816	Q1286L	probably benign	Het
Frem1	T	C	4: 82,969,444	H1118R	probably damaging	Het
Fuk	A	T	8: 110,894,748	V188D	probably damaging	Het
Fut9	C	T	4: 25,619,852	D321N	probably benign	Het
Gaa	T	G	11: 119,284,547	V917G	probably damaging	Het
Kidins220	A	G	12: 25,010,141	T767A	probably damaging	Het
Kif7	A	G	7: 79,698,823	S1257P	probably benign	Het
Ltn1	A	G	16: 87,397,838	L1391P	probably damaging	Het
Mast3	A	G	8: 70,783,795	Y681H	probably damaging	Het
Mast3	A	G	8: 70,787,920	V291A	possibly damaging	Het
Metrn	C	T	17: 25,795,135	R239H	probably benign	Het
Mphosph10	C	A	7: 64,376,703	K666N	possibly damaging	Het
Mtbp	C	T	15: 55,586,461	T433I	probably benign	Het
Mtmr2	A	G	9: 13,799,249	K365E	probably damaging	Het
Nanog	A	G	6: 122,713,398	D229G	probably damaging	Het
Npepps	T	C	11: 97,241,014	N338S	possibly damaging	Het
Nphp4	T	A	4: 152,551,936		probably benign	Het
Olfr1279	T	C	2: 111,307,072	F289S	possibly damaging	Het
Plcl2	A	G	17: 50,607,034	E357G	probably damaging	Het
Polb	A	T	8: 22,640,392	Y173N	probably damaging	Het
R3hdm1	T	A	1: 128,162,775	S74T	probably benign	Het
Raet1d	T	A	10: 22,370,883	C37S	probably damaging	Het
Reln	G	A	5: 22,227,513		probably benign	Het
Rps6kc1	T	C	1: 190,809,000	S369G	probably damaging	Het
Sgf29	A	G	7: 126,671,571	E108G	probably benign	Het
Sh3tc1	A	G	5: 35,706,017	L942P	probably damaging	Het
Slc22a27	A	T	19: 7,896,822	L188*	probably null	Het
Slc9a3	T	A	13: 74,159,424	I445N	probably damaging	Het
Sufu	A	T	19: 46,450,673		probably benign	Het
Tomm40	G	A	7: 19,713,751	T118I	probably damaging	Het
Ttc25	A	T	11: 100,550,265	K107N	probably damaging	Het
Ttn	C	T	2: 76,740,479	R26690H	probably damaging	Het
Vmn2r16	A	G	5: 109,340,139	I293V	possibly damaging	Het
Vmn2r68	T	A	7: 85,233,249		probably benign	Het
Vmn2r68	C	G	7: 85,233,258		probably null	Het
Vsig8	A	G	1: 172,561,538	D119G	probably benign	Het

Other mutations in Gm973

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01359:Gm973	APN	1	59630279	missense	probably benign	0.00
IGL01732:Gm973	APN	1	59630237	missense	probably benign	0.24
IGL02124:Gm973	APN	1	59582473	nonsense	probably null
IGL02251:Gm973	APN	1	59582423	missense	probably benign	0.18
IGL02818:Gm973	APN	1	59541475	critical splice donor site	probably null
IGL03385:Gm973	APN	1	59582470	missense	probably benign	0.14
R0105:Gm973	UTSW	1	59582474	missense	probably null	0.60
R0105:Gm973	UTSW	1	59582474	missense	probably null	0.60
R0490:Gm973	UTSW	1	59558234	splice site	probably benign
R0491:Gm973	UTSW	1	59558234	splice site	probably benign
R0508:Gm973	UTSW	1	59582490	splice site	probably benign
R0636:Gm973	UTSW	1	59551144	missense	probably benign	0.13
R0709:Gm973	UTSW	1	59558234	splice site	probably benign
R0900:Gm973	UTSW	1	59566668	missense	probably benign	0.00
R1758:Gm973	UTSW	1	59634010	missense	unknown
R1816:Gm973	UTSW	1	59582399	missense	probably damaging	0.99
R1975:Gm973	UTSW	1	59562771	missense	possibly damaging	0.50
R2166:Gm973	UTSW	1	59526739	missense	possibly damaging	0.61
R3052:Gm973	UTSW	1	59633140	splice site	probably benign
R3899:Gm973	UTSW	1	59625140	missense	probably benign	0.00
R4181:Gm973	UTSW	1	59551240	missense	possibly damaging	0.93
R4302:Gm973	UTSW	1	59551240	missense	possibly damaging	0.93
R4623:Gm973	UTSW	1	59556276	missense	probably damaging	1.00
R4642:Gm973	UTSW	1	59558114	missense	probably damaging	1.00
R4716:Gm973	UTSW	1	59552554	nonsense	probably null
R4920:Gm973	UTSW	1	59627566	missense	probably benign
R4951:Gm973	UTSW	1	59541474	critical splice donor site	probably null
R5214:Gm973	UTSW	1	59526721	missense	probably damaging	1.00
R5225:Gm973	UTSW	1	59562700	missense	probably benign	0.01
R5472:Gm973	UTSW	1	59628287	splice site	probably null
R5554:Gm973	UTSW	1	59526972	missense	probably benign	0.09
R5709:Gm973	UTSW	1	59552555	missense	possibly damaging	0.73
R5886:Gm973	UTSW	1	59558250	intron	probably benign
R6044:Gm973	UTSW	1	59628234	missense	probably benign
R6046:Gm973	UTSW	1	59632350	missense	unknown
R6818:Gm973	UTSW	1	59630169	missense	probably damaging	0.99
R6920:Gm973	UTSW	1	59552461	missense	possibly damaging	0.76
R6999:Gm973	UTSW	1	59634092	missense	unknown
R7214:Gm973	UTSW	1	59562729	nonsense	probably null
R7418:Gm973	UTSW	1	59526813	missense	probably damaging	1.00
R7780:Gm973	UTSW	1	59558130	missense	probably damaging	1.00
R8834:Gm973	UTSW	1	59524661	missense
R9083:Gm973	UTSW	1	59636158	missense
R9206:Gm973	UTSW	1	59552426	missense	possibly damaging	0.86
R9297:Gm973	UTSW	1	59544670	missense	probably damaging	1.00
Z1176:Gm973	UTSW	1	59524602	start gained	probably benign
Z1177:Gm973	UTSW	1	59541330	missense	probably damaging	0.99

Predicted Primers

Posted On

2013-08-19