Mutagenetix > Incidental Mutation

Incidental Mutation 'Z1192:Ank2'

667414

Institutional Source

Beutler Lab

Gene Symbol

Ank2

Ensembl Gene

ENSMUSG00000032826

Gene Name

ankyrin 2, brain

Synonyms

Gm4392, Ank-2, ankyrin B, Ankyrin-B, Ankyrin-2

Accession Numbers

Essential gene?

Essential (E-score: 1.000) question?

Stock #

Z1192 ()

Quality Score

87.0076

Status

Not validated

Chromosome

Chromosomal Location

126715261-127292999 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 126749601 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Phenylalanine to Serine at position 476 (F476S)

Ref Sequence

ENSEMBL: ENSMUSP00000043765 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000044443] [ENSMUST00000182064] [ENSMUST00000182078] [ENSMUST00000182711] [ENSMUST00000182959]

AlphaFold

no structure available at present

Predicted Effect

probably damaging
Transcript: ENSMUST00000044443
AA Change: F476S

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)

SMART Domains

Protein: ENSMUSP00000043765
Gene: ENSMUSG00000032826
AA Change: F476S

Domain	Start	End	E-Value	Type
low complexity region	9	22	N/A	INTRINSIC
low complexity region	57	69	N/A	INTRINSIC
ZU5	128	232	4.13e-61	SMART
Pfam:ZU5	289	374	2.8e-8	PFAM
low complexity region	587	597	N/A	INTRINSIC
DEATH	603	697	1.52e-27	SMART
low complexity region	732	748	N/A	INTRINSIC
low complexity region	860	873	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000182025

Predicted Effect

SMART Domains

Protein: ENSMUSP00000138620
Gene: ENSMUSG00000032826
AA Change: F1347S

Domain	Start	End	E-Value	Type
ANK	9	38	1e1	SMART
ANK	42	71	8.9e-7	SMART
ANK	75	104	4.4e-9	SMART
ANK	108	137	2.8e-9	SMART
ANK	141	169	5.3e-1	SMART
ANK	170	199	7.3e-1	SMART
ANK	211	240	1.1e-7	SMART
ANK	244	273	4.4e-9	SMART
ANK	277	306	9.3e-8	SMART
ANK	310	339	2.1e-8	SMART
ANK	343	372	1.3e-7	SMART
ANK	376	405	6.2e-9	SMART
ANK	409	438	1.1e-7	SMART
ANK	442	471	2.9e-8	SMART
ANK	475	504	1.1e-5	SMART
ANK	508	537	6.5e-6	SMART
ANK	541	570	2.3e-7	SMART
ANK	574	603	2.4e-7	SMART
ANK	607	636	3.2e-9	SMART
ANK	640	669	5.5e-5	SMART
ANK	673	702	1.9e-8	SMART
ANK	706	735	3.3e-9	SMART
low complexity region	755	775	N/A	INTRINSIC
low complexity region	793	806	N/A	INTRINSIC
low complexity region	841	853	N/A	INTRINSIC
ZU5	912	1016	2e-63	SMART
low complexity region	1371	1381	N/A	INTRINSIC
low complexity region	1448	1463	N/A	INTRINSIC
low complexity region	1490	1503	N/A	INTRINSIC

Predicted Effect

unknown
Transcript: ENSMUST00000182078
AA Change: F1260S

SMART Domains

Protein: ENSMUSP00000138753
Gene: ENSMUSG00000032826
AA Change: F1260S

Domain	Start	End	E-Value	Type
low complexity region	7	18	N/A	INTRINSIC
low complexity region	114	125	N/A	INTRINSIC
low complexity region	191	209	N/A	INTRINSIC
low complexity region	304	312	N/A	INTRINSIC
low complexity region	478	493	N/A	INTRINSIC
low complexity region	527	544	N/A	INTRINSIC
DEATH	591	685	1e-29	SMART
low complexity region	720	736	N/A	INTRINSIC
low complexity region	848	861	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000182711

SMART Domains

Protein: ENSMUSP00000138781
Gene: ENSMUSG00000032826

Domain	Start	End	E-Value	Type
ANK	26	55	1e1	SMART
ANK	59	88	8.9e-7	SMART
ANK	92	121	4.4e-9	SMART
ANK	125	154	2.8e-9	SMART
ANK	158	186	5.3e-1	SMART
ANK	187	216	7.3e-1	SMART
ANK	228	257	1.1e-7	SMART
ANK	261	290	4.4e-9	SMART
ANK	294	323	9.3e-8	SMART
ANK	327	356	2.1e-8	SMART
ANK	360	389	1.3e-7	SMART
ANK	393	422	6.2e-9	SMART
ANK	426	455	1.1e-7	SMART
ANK	459	488	2.9e-8	SMART
ANK	492	521	1.1e-5	SMART
ANK	525	554	6.5e-6	SMART
ANK	558	587	2.3e-7	SMART
ANK	591	620	5.3e-7	SMART
ANK	624	653	2.4e-7	SMART
ANK	657	686	3.2e-9	SMART
ANK	690	719	5.5e-5	SMART
ANK	723	752	1.9e-8	SMART
ANK	756	785	3.3e-9	SMART
low complexity region	805	825	N/A	INTRINSIC
low complexity region	843	856	N/A	INTRINSIC
ZU5	961	1098	1.1e-50	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000182959

SMART Domains

Protein: ENSMUSP00000138251
Gene: ENSMUSG00000032826

Domain	Start	End	E-Value	Type
ANK	9	38	1.63e3	SMART
ANK	42	71	1.4e-4	SMART
ANK	75	104	6.76e-7	SMART
ANK	108	137	4.46e-7	SMART
ANK	141	169	8.36e1	SMART
ANK	170	199	1.17e2	SMART
ANK	211	240	1.76e-5	SMART
ANK	244	273	6.76e-7	SMART
ANK	277	306	1.43e-5	SMART
ANK	310	339	3.33e-6	SMART
ANK	343	372	2.02e-5	SMART
ANK	376	405	9.55e-7	SMART
ANK	409	438	1.76e-5	SMART
ANK	442	471	4.71e-6	SMART
ANK	475	504	1.7e-3	SMART
ANK	508	537	1.05e-3	SMART
ANK	541	570	3.51e-5	SMART
ANK	574	603	8.65e-5	SMART
ANK	607	636	3.76e-5	SMART
ANK	640	669	5.12e-7	SMART
ANK	673	702	8.39e-3	SMART
ANK	706	735	2.9e-6	SMART
ANK	739	768	5.12e-7	SMART
low complexity region	788	808	N/A	INTRINSIC
low complexity region	826	839	N/A	INTRINSIC
low complexity region	874	886	N/A	INTRINSIC
Pfam:ZU5	945	1028	1.5e-30	PFAM
Pfam:ZU5	1021	1082	4.4e-21	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000183075

Meta Mutation Damage Score

0.7545

Coding Region Coverage

1x: 99.9%
3x: 99.8%
10x: 99.4%
20x: 98.4%

Validation Efficiency

MGI Phenotype

PHENOTYPE: Homozygous mutation of this gene results in death by postnatal day 8, although some animals survive to P20. Mutant animals display reduced body size, impaired balance and locomotion, brain structure dysmorphologies, abnormal lens, and optic nerve degeneration. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 392 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700086D15Rik	A	G	11: 65,044,114 (GRCm39)	W27R	unknown	Het
1700086D15Rik	A	G	11: 65,044,080 (GRCm39)	F38S	unknown	Het
1700086D15Rik	A	C	11: 65,043,809 (GRCm39)	V84G	unknown	Het
1700086D15Rik	T	A	11: 65,043,794 (GRCm39)	Q89L	unknown	Het
1700086D15Rik	A	G	11: 65,044,128 (GRCm39)	L22P	unknown	Het
1810065E05Rik	C	T	11: 58,313,027 (GRCm39)	L27F	probably benign	Het
1810065E05Rik	C	T	11: 58,316,625 (GRCm39)	L202F	probably benign	Het
1810065E05Rik	C	T	11: 58,313,060 (GRCm39)	L38F	possibly damaging	Het
2810021J22Rik	C	T	11: 58,771,361 (GRCm39)	A281V	probably benign	Het
4930438A08Rik	A	G	11: 58,184,844 (GRCm39)	T521A	unknown	Het
4933427D14Rik	G	A	11: 72,067,535 (GRCm39)	T585I	possibly damaging	Het
4933427D14Rik	T	G	11: 72,089,750 (GRCm39)	S45R	probably damaging	Het
4933427D14Rik	C	A	11: 72,089,360 (GRCm39)	A175S	probably benign	Het
4933427D14Rik	G	A	11: 72,089,308 (GRCm39)	P192L	probably benign	Het
4933427D14Rik	T	C	11: 72,086,595 (GRCm39)	Q272R	probably damaging	Het
4933427D14Rik	T	TCCCCAGC	11: 72,086,590 (GRCm39)		probably null	Het
4933427D14Rik	T	G	11: 72,086,580 (GRCm39)	K277T	probably damaging	Het
4933427D14Rik	A	G	11: 72,086,569 (GRCm39)	C281R	possibly damaging	Het
4933427D14Rik	AAAAGTAA	AAA	11: 72,086,538 (GRCm39)		probably null	Het
4933427D14Rik	G	T	11: 72,080,442 (GRCm39)	P408H	probably damaging	Het
Adgra3	G	A	5: 50,156,623 (GRCm39)	T369I	probably benign	Het
Akap10	T	A	11: 61,806,096 (GRCm39)	S211C	probably benign	Het
Alox8	C	T	11: 69,076,873 (GRCm39)	R536Q	probably benign	Het
Alox8	A	G	11: 69,088,322 (GRCm39)	V76A	probably benign	Het
Aloxe3	A	G	11: 69,019,501 (GRCm39)	Q138R	probably benign	Het
Aloxe3	C	T	11: 69,039,429 (GRCm39)	A667V	probably benign	Het
Arsk	G	T	13: 76,246,637 (GRCm39)		probably benign	Het
Aspa	G	T	11: 73,213,013 (GRCm39)	L110I	probably benign	Het
Atp6v1g3	A	G	1: 138,201,582 (GRCm39)	K27E	possibly damaging	Het
Aurkb	C	T	11: 68,938,692 (GRCm39)	R44W	probably damaging	Het
Aurkb	T	C	11: 68,938,696 (GRCm39)	F45S	probably benign	Het
B9d1	A	T	11: 61,396,029 (GRCm39)		probably benign	Het
BC034090	A	G	1: 155,117,245 (GRCm39)	I291T	probably benign	Het
Borcs6	G	A	11: 68,951,453 (GRCm39)	R277Q	possibly damaging	Het
Btbd3	ATCGGGGTCG	ATCG	2: 138,126,010 (GRCm39)		probably benign	Het
Btnl10	T	C	11: 58,810,138 (GRCm39)	V93A	probably benign	Het
Btnl10	C	T	11: 58,817,650 (GRCm39)	T250I	unknown	Het
Btnl10	A	AAGC	11: 58,814,757 (GRCm39)		probably benign	Het
Btnl10	AAG	AAGGAG	11: 58,814,754 (GRCm39)		probably benign	Het
Btnl10	AAAGA	AAAGAAGA	11: 58,814,753 (GRCm39)		probably benign	Het
Btnl9	C	T	11: 49,066,805 (GRCm39)	R272H	unknown	Het
Camsap3	G	T	8: 3,654,124 (GRCm39)	R598L	probably damaging	Het
Ccdc42	C	T	11: 68,478,017 (GRCm39)		probably benign	Het
Ccdc92b	A	G	11: 74,520,880 (GRCm39)	M61V	possibly damaging	Het
Chd3	C	A	11: 69,239,271 (GRCm39)	E1753D	probably benign	Het
Chd3	A	G	11: 69,252,277 (GRCm39)	W42R	probably benign	Het
Cluh	AGCCTG	AGCCTGGGCCTG	11: 74,560,351 (GRCm39)		probably benign	Het
Cluh	CGAGCCTGAGCCTGAGCC	CGAGCCTGAGCCTGAGCCTGAGCC	11: 74,560,343 (GRCm39)		probably benign	Het
Cnot9	T	A	1: 74,556,285 (GRCm39)	N27K	probably benign	Het
Cntrob	G	A	11: 69,198,882 (GRCm39)	P622L	probably benign	Het
Cntrob	C	T	11: 69,196,404 (GRCm39)	R677H	probably benign	Het
Cyb5d1	C	A	11: 69,286,098 (GRCm39)	A8S	probably benign	Het
Cyb5d1	A	G	11: 69,286,028 (GRCm39)	L31P	probably benign	Het
Dach1	G	A	14: 98,140,587 (GRCm39)	P524S	probably benign	Het
Dnah9	G	A	11: 66,038,207 (GRCm39)	H110Y	probably benign	Het
Dnah9	A	C	11: 65,976,000 (GRCm39)	S1350A	probably benign	Het
Dpysl4	A	G	7: 138,669,324 (GRCm39)	M1V	probably null	Het
Eif2b5	C	T	16: 20,317,671 (GRCm39)	A3V	unknown	Het
Elac2	T	C	11: 64,870,015 (GRCm39)	S27P	probably benign	Het
Epn2	C	A	11: 61,470,460 (GRCm39)		probably benign	Het
Fam114a2	G	A	11: 57,380,940 (GRCm39)	A438V	probably benign	Het
Fam114a2	C	T	11: 57,390,581 (GRCm39)	V318I	probably benign	Het
Fam114a2	T	C	11: 57,390,623 (GRCm39)	N304D	probably benign	Het
Fam114a2	C	T	11: 57,405,060 (GRCm39)	G14E	probably benign	Het
Fam114a2	A	G	11: 57,374,858 (GRCm39)	S494P	probably benign	Het
Fam83g	G	A	11: 61,594,020 (GRCm39)	R518Q	probably benign	Het
Fat2	T	G	11: 55,200,625 (GRCm39)	K816N	probably benign	Het
Fat2	TGTACCTCACCCCAGTACCT	TGTACCT	11: 55,199,796 (GRCm39)		probably null	Het
Fbxw10	G	C	11: 62,738,118 (GRCm39)	R4T	probably benign	Het
Fbxw10	G	A	11: 62,767,671 (GRCm39)	V836I	probably benign	Het
Galnt10	G	A	11: 57,656,514 (GRCm39)	V233I	probably benign	Het
Gemin5	C	G	11: 58,013,115 (GRCm39)	S1446T	probably benign	Het
Gemin5	C	G	11: 58,037,345 (GRCm39)	E623D	probably benign	Het
Gemin5	C	G	11: 58,030,401 (GRCm39)	C808S	probably benign	Het
Gemin5	C	G	11: 58,030,336 (GRCm39)	A830P	probably benign	Het
Gemin5	T	C	11: 58,020,897 (GRCm39)	M1097V	probably benign	Het
Gemin5	T	C	11: 58,016,044 (GRCm39)	S1321G	probably benign	Het
Ggnbp2	C	T	11: 84,727,478 (GRCm39)	R481Q	probably benign	Het
Gjc2	ACCCTCCCT	ACCCTCCCTCCCT	11: 59,073,561 (GRCm39)		probably benign	Het
Gjc2	A	G	11: 59,067,318 (GRCm39)	V388A	unknown	Het
Glod4	A	G	11: 76,133,836 (GRCm39)	V6A	probably benign	Het
Glod4	C	A	11: 76,133,819 (GRCm39)		probably null	Het
Glod4	T	C	11: 76,134,431 (GRCm39)	K14E	probably benign	Het
Glod4	T	C	11: 76,134,430 (GRCm39)	K14R	probably benign	Het
Glp2r	C	A	11: 67,600,470 (GRCm39)	V460F	probably benign	Het
Glp2r	C	G	11: 67,600,472 (GRCm39)	G459A	probably benign	Het
Glp2r	A	G	11: 67,631,878 (GRCm39)	V283A	probably benign	Het
Glp2r	T	C	11: 67,631,885 (GRCm39)	I281V	probably benign	Het
Glp2r	C	A	11: 67,600,394 (GRCm39)	R485L	probably damaging	Het
Glp2r	C	A	11: 67,661,662 (GRCm39)	A13S	probably benign	Het
Glp2r	A	G	11: 67,635,773 (GRCm39)	V189A	probably benign	Het
Glp2r	T	C	11: 67,633,129 (GRCm39)	T235A	probably benign	Het
Gm12253	A	G	11: 58,325,658 (GRCm39)	E43G	probably benign	Het
Gm12253	A	C	11: 58,325,686 (GRCm39)	E52D	probably benign	Het
Gm12253	A	C	11: 58,326,237 (GRCm39)	E84A	probably benign	Het
Gm12253	G	A	11: 58,326,309 (GRCm39)	S108N	probably benign	Het
Gm12253	G	A	11: 58,331,835 (GRCm39)	A215T	possibly damaging	Het
Gm12253	G	C	11: 58,325,367 (GRCm39)	S13T	possibly damaging	Het
Gm12258	C	T	11: 58,749,262 (GRCm39)	R146W		Het
Gm12258	G	A	11: 58,749,764 (GRCm39)	R313H	unknown	Het
Gm12258	G	A	11: 58,749,776 (GRCm39)	G317E	unknown	Het
Gm12258	A	T	11: 58,749,833 (GRCm39)	E336V	unknown	Het
Gm12258	A	G	11: 58,750,013 (GRCm39)		probably benign	Het
Gm12258	T	A	11: 58,750,014 (GRCm39)		probably benign	Het
Gm12258	G	C	11: 58,750,690 (GRCm39)	G622R	unknown	Het
Gm12258	T	G	11: 58,749,126 (GRCm39)	S100R		Het
Gps2	C	T	11: 69,807,130 (GRCm39)	A60V	probably benign	Het
Gucy2e	C	G	11: 69,127,429 (GRCm39)	G15R	unknown	Het
Gucy2e	C	A	11: 69,114,431 (GRCm39)	A1033S	probably benign	Het
Haspin	A	G	11: 73,028,777 (GRCm39)	L104P	probably benign	Het
Haspin	T	C	11: 73,028,174 (GRCm39)	Q305R	probably benign	Het
Hes7	T	C	11: 69,013,782 (GRCm39)	S214P	probably benign	Het
Hic1	GGGAGG	GGG	11: 75,060,276 (GRCm39)		probably benign	Het
Hic1	G	A	11: 75,058,352 (GRCm39)	T179M	probably damaging	Het
Iba57	T	C	11: 59,052,381 (GRCm39)	T87A	unknown	Het
Iba57	CAGA	CAGAGA	11: 59,052,329 (GRCm39)		probably null	Het
Iba57	C	G	11: 59,053,865 (GRCm39)	G36R	unknown	Het
Iba57	T	C	11: 59,052,384 (GRCm39)	T86A	unknown	Het
Ifi207	G	A	1: 173,558,093 (GRCm39)	T215I	unknown	Het
Iftap	T	C	2: 101,440,950 (GRCm39)	K18E	probably benign	Het
Igtp	C	G	11: 58,097,791 (GRCm39)	L321V	possibly damaging	Het
Igtp	T	G	11: 58,097,169 (GRCm39)	D113E	probably damaging	Het
Igtp	C	G	11: 58,097,944 (GRCm39)	L372V	probably benign	Het
Ihh	G	C	1: 74,990,204 (GRCm39)	P57R	probably damaging	Het
Insrr	T	C	3: 87,709,886 (GRCm39)	C280R	probably damaging	Het
Irgm2	A	G	11: 58,110,389 (GRCm39)	N27D	probably benign	Het
Irgm2	T	A	11: 58,110,339 (GRCm39)	V10D	probably benign	Het
Irgm2	C	G	11: 58,111,389 (GRCm39)	T360S	probably benign	Het
Irgm2	G	T	11: 58,111,238 (GRCm39)	A310S	possibly damaging	Het
Irgm2	T	C	11: 58,110,738 (GRCm39)	I143T	probably benign	Het
Irgm2	T	C	11: 58,110,780 (GRCm39)	L157S	probably benign	Het
Irgm2	G	A	11: 58,110,833 (GRCm39)	V175I	probably benign	Het
Irgm2	G	A	11: 58,110,924 (GRCm39)	S205N	probably benign	Het
Irgm2	A	C	11: 58,110,951 (GRCm39)	H214P	probably benign	Het
Itgae	T	A	11: 72,994,713 (GRCm39)	L22M	possibly damaging	Het
Itgae	A	T	11: 72,994,786 (GRCm39)	Q46L	probably damaging	Het
Itgae	A	G	11: 73,006,466 (GRCm39)	H378R	probably benign	Het
Itgae	G	A	11: 73,008,913 (GRCm39)	V465I	probably benign	Het
Itgae	A	T	11: 73,012,757 (GRCm39)	K696N	probably benign	Het
Itgae	G	T	11: 73,012,783 (GRCm39)	G705V	probably benign	Het
Itgae	C	G	11: 73,024,953 (GRCm39)	S1028W	probably benign	Het
Kif1c	C	T	11: 70,614,940 (GRCm39)	P578L	probably benign	Het
Kmt2d	T	C	15: 98,749,625 (GRCm39)	N2656D	unknown	Het
Larp1	G	A	11: 57,933,166 (GRCm39)	V257I	probably benign	Het
Llgl1	ACCCCAGCCCTTCTGATTACTGCCCTCCCCAGC	ACCCCAGC	11: 60,603,923 (GRCm39)		probably null	Het
Lypd8	T	C	11: 58,273,601 (GRCm39)	Y27H	probably benign	Het
Lypd8	C	A	11: 58,275,475 (GRCm39)	A70E	possibly damaging	Het
Lypd8	G	A	11: 58,275,489 (GRCm39)	E75K	probably benign	Het
Lypd8	CAATCACCAACA	CAATCACCAACAGTTCCCTCGCCTCTGTTACCCCACAAATCACCAACA	11: 58,281,059 (GRCm39)		probably benign	Het
Lypd8	ATCACCAACA	ATCACCAACAGTTCCCTCGCCTCTGTTACCCCACAACTCACCAACA	11: 58,281,061 (GRCm39)		probably benign	Het
Lypd8	ACA	ACAGTTCCCTCGCCTCTGTTACCCCACAAATCACCACCA	11: 58,281,068 (GRCm39)		probably benign	Het
Lypd8	CA	CAGTTCCCTCGCCTCTGTTACCCCACAAATCACCAAGA	11: 58,281,069 (GRCm39)		probably benign	Het
Lypd8l	T	G	11: 58,503,397 (GRCm39)	S44R	probably benign	Het
Lypd8l	G	A	11: 58,499,335 (GRCm39)	P161L	probably benign	Het
Lypd8l	A	G	11: 58,503,387 (GRCm39)	L47P	probably benign	Het
Maml3	A	T	3: 51,763,165 (GRCm39)	L600M	probably damaging	Het
Mapk7	TGGGGCAGGGGCAGGGGCAGG	TGGCGCTGGGGCAGGGGCAGGGGCAGGGGCAGG	11: 61,381,053 (GRCm39)		probably benign	Het
Mfap3	A	T	11: 57,418,866 (GRCm39)	I9F	possibly damaging	Het
Mfap3	G	A	11: 57,418,902 (GRCm39)	G21S	probably benign	Het
Mrm3	G	A	11: 76,134,903 (GRCm39)	R102K	probably benign	Het
Mrm3	C	T	11: 76,138,221 (GRCm39)	P203L	probably benign	Het
Mroh2a	G	T	1: 88,162,938 (GRCm39)	Q360H	probably benign	Het
Mrpl22	G	A	11: 58,062,521 (GRCm39)	A4T	unknown	Het
Mrpl55	A	G	11: 59,094,999 (GRCm39)		probably null	Het
Mrpl55	A	T	11: 59,095,415 (GRCm39)	L26F	probably benign	Het
Myh7	A	T	14: 55,220,748 (GRCm39)	V1017D	probably damaging	Het
Myocd	A	G	11: 65,075,418 (GRCm39)	S697P	probably benign	Het
Nlgn2	A	G	11: 69,719,220 (GRCm39)	V210A	possibly damaging	Het
Nlrp1a	T	C	11: 70,983,069 (GRCm39)	K1299R	probably benign	Het
Nlrp1a	C	T	11: 70,988,077 (GRCm39)	R1131Q	probably damaging	Het
Nlrp1a	T	C	11: 70,990,442 (GRCm39)	I1038V	probably benign	Het
Nlrp1a	T	C	11: 71,014,914 (GRCm39)	E112G	probably benign	Het
Nlrp1a	C	G	11: 71,033,355 (GRCm39)		probably null	Het
Nlrp1b	A	G	11: 71,072,625 (GRCm39)	I406T	probably benign	Het
Nlrp1b	C	A	11: 71,072,534 (GRCm39)	M436I	probably benign	Het
Nlrp1b	T	C	11: 71,073,503 (GRCm39)	I113M	probably benign	Het
Nlrp1b	T	A	11: 71,073,396 (GRCm39)	Q149L	probably benign	Het
Nlrp1b	A	T	11: 71,073,378 (GRCm39)	M155K	probably benign	Het
Nlrp1b	C	G	11: 71,073,370 (GRCm39)	E158Q	probably benign	Het
Nlrp1b	T	C	11: 71,073,280 (GRCm39)	T188A	probably benign	Het
Nlrp1b	A	T	11: 71,073,266 (GRCm39)	D192E	probably benign	Het
Nlrp1b	A	G	11: 71,073,148 (GRCm39)	Y232H	probably benign	Het
Nmur2	T	C	11: 55,931,104 (GRCm39)	I202M	probably benign	Het
Nrp1	C	A	8: 129,224,419 (GRCm39)	H727Q	probably damaging	Het
Nsun6	C	T	2: 15,042,918 (GRCm39)	R181H	probably damaging	Het
Obscn	T	C	11: 58,990,755 (GRCm39)	H1606R	probably benign	Het
Obscn	C	G	11: 58,994,167 (GRCm39)	A1572P	probably damaging	Het
Obscn	G	A	11: 58,994,364 (GRCm39)	A1506V	probably benign	Het
Obscn	T	C	11: 59,003,380 (GRCm39)	E1306G	probably benign	Het
Obscn	T	C	11: 59,013,563 (GRCm39)	M1095V	probably benign	Het
Obscn	C	T	11: 59,018,892 (GRCm39)	A949T	probably benign	Het
Obscn	C	T	11: 59,018,895 (GRCm39)	V973M	probably damaging	Het
Obscn	C	T	11: 59,021,449 (GRCm39)	R797H	probably damaging	Het
Obscn	C	T	11: 59,023,937 (GRCm39)	A578T	possibly damaging	Het
Obscn	G	A	11: 59,024,066 (GRCm39)	P535S	probably damaging	Het
Obscn	C	G	11: 59,024,072 (GRCm39)	A533P	probably benign	Het
Obscn	T	C	11: 59,026,505 (GRCm39)	I233V	probably benign	Het
Obscn	C	T	11: 58,940,306 (GRCm39)	D5354N		Het
Obscn	C	A	11: 58,940,614 (GRCm39)	R4593S	possibly damaging	Het
Obscn	T	C	11: 58,940,623 (GRCm39)	T5307A		Het
Obscn	G	A	11: 58,942,383 (GRCm39)	T4372M	probably benign	Het
Obscn	T	C	11: 58,943,439 (GRCm39)	M4237V	probably benign	Het
Obscn	C	T	11: 58,944,594 (GRCm39)	R4700Q	probably benign	Het
Obscn	T	C	11: 58,944,651 (GRCm39)	K4681R	probably benign	Het
Obscn	T	C	11: 58,945,044 (GRCm39)	E4658G	probably benign	Het
Obscn	C	T	11: 58,945,176 (GRCm39)	R4614Q	probably benign	Het
Obscn	T	C	11: 58,946,331 (GRCm39)	D4458G	probably damaging	Het
Obscn	C	T	11: 58,946,340 (GRCm39)	R4455K	probably benign	Het
Obscn	G	T	11: 58,946,936 (GRCm39)	A4066E	possibly damaging	Het
Obscn	A	G	11: 58,947,595 (GRCm39)	M4478T		Het
Obscn	C	T	11: 58,952,388 (GRCm39)	G3894R	probably benign	Het
Obscn	T	C	11: 58,954,402 (GRCm39)	K3727E	probably damaging	Het
Obscn	G	A	11: 58,957,973 (GRCm39)	R3576C	probably benign	Het
Obscn	C	T	11: 58,958,655 (GRCm39)	V3433I	probably benign	Het
Obscn	C	A	11: 58,960,757 (GRCm39)	A3185S	probably benign	Het
Obscn	C	T	11: 58,967,334 (GRCm39)	V2792I	possibly damaging	Het
Obscn	G	A	11: 58,969,984 (GRCm39)	R53C	probably damaging	Het
Obscn	C	G	11: 58,970,722 (GRCm39)	V2328L	probably benign	Het
Obscn	C	A	11: 58,972,698 (GRCm39)	G2116V	possibly damaging	Het
Obscn	C	T	11: 58,977,505 (GRCm39)	R1865H	probably benign	Het
Obscn	G	A	11: 58,891,715 (GRCm39)	A6939V	probably benign	Het
Obscn	C	G	11: 58,900,019 (GRCm39)	G938A	probably benign	Het
Obscn	G	C	11: 58,904,014 (GRCm39)	T7320S	probably benign	Het
Obscn	C	T	11: 58,921,934 (GRCm39)	R5954Q	probably damaging	Het
Obscn	G	C	11: 58,929,976 (GRCm39)	P5080A	probably benign	Het
Obscn	T	A	11: 58,929,990 (GRCm39)	Q5075L	probably damaging	Het
Obscn	T	C	11: 58,932,601 (GRCm39)	I4869V	probably benign	Het
Obscn	T	C	11: 58,933,776 (GRCm39)	T5363A	probably benign	Het
Obscn	G	A	11: 58,933,853 (GRCm39)	A5337V	probably benign	Het
Obscn	G	A	11: 58,933,878 (GRCm39)	R5329C	probably benign	Het
Obscn	T	C	11: 58,977,527 (GRCm39)	R1858G	probably benign	Het
Obscn	C	T	11: 58,990,735 (GRCm39)	A1613T	possibly damaging	Het
Obscn	G	A	11: 58,984,385 (GRCm39)	A1690V	probably benign	Het
Obscn	C	T	11: 58,984,335 (GRCm39)	A1707T	probably benign	Het
Obscn	G	T	11: 58,984,334 (GRCm39)	A1707D	possibly damaging	Het
Obscn	C	T	11: 58,984,239 (GRCm39)	V1739M	possibly damaging	Het
Obscn	A	G	11: 58,984,142 (GRCm39)	F1771S	probably benign	Het
Obscn	A	G	11: 58,977,565 (GRCm39)	V1845A	probably benign	Het
Or11l3	G	A	11: 58,516,075 (GRCm39)	S79F	probably benign	Het
Or11l3	A	C	11: 58,516,732 (GRCm39)	C46G	possibly damaging	Het
Or11l3	T	G	11: 58,516,619 (GRCm39)	K84N	probably benign	Het
Or11l3	G	A	11: 58,516,588 (GRCm39)	P95S	probably benign	Het
Or11l3	C	G	11: 58,516,130 (GRCm39)	G61R	probably benign	Het
Or2ab1	A	C	11: 58,488,344 (GRCm39)	I35L	probably benign	Het
Or2ab1	A	G	11: 58,488,776 (GRCm39)	S179G	probably benign	Het
Or2ab1	A	G	11: 58,488,491 (GRCm39)	S84G	possibly damaging	Het
Or2ab1	A	G	11: 58,488,356 (GRCm39)	I39V	probably benign	Het
Or2ak4	G	A	11: 58,648,793 (GRCm39)	A101T	probably benign	Het
Or2ak4	A	C	11: 58,649,186 (GRCm39)	K232Q	probably benign	Het
Or2ak4	A	C	11: 58,649,168 (GRCm39)	I226L	probably benign	Het
Or2ak4	G	A	11: 58,649,153 (GRCm39)	V221M	probably damaging	Het
Or2ak4	A	G	11: 58,648,931 (GRCm39)	S147G	probably benign	Het
Or2ak4	C	T	11: 58,648,895 (GRCm39)	L135F	probably benign	Het
Or2ak5	G	A	11: 58,611,922 (GRCm39)		probably benign	Het
Or2ak6	C	A	11: 58,593,222 (GRCm39)	Q232K	probably benign	Het
Or2ak6	C	T	11: 58,593,153 (GRCm39)	L209F	possibly damaging	Het
Or2ak6	A	C	11: 58,592,784 (GRCm39)	I86L	probably benign	Het
Or2ak7	G	A	11: 58,575,083 (GRCm39)	R128Q	probably benign	Het
Or2ak7	T	C	11: 58,574,815 (GRCm39)	F39L	probably benign	Het
Or2ak7	C	T	11: 58,575,289 (GRCm39)	H197Y	probably benign	Het
Or2ak7	G	T	11: 58,574,758 (GRCm39)	D20Y	probably benign	Het
Or2av9	C	T	11: 58,381,123 (GRCm39)	A153T	probably benign	Het
Or2av9	T	C	11: 58,381,314 (GRCm39)	Q89R	probably benign	Het
Or2av9	C	A	11: 58,380,574 (GRCm39)	E336*	probably null	Het
Or2t29	G	T	11: 58,434,272 (GRCm39)	S23Y	probably benign	Het
Or2t43	A	T	11: 58,457,521 (GRCm39)	S217T	probably benign	Het
Or2t43	C	T	11: 58,457,920 (GRCm39)	V84I	probably benign	Het
Or2t43	G	A	11: 58,457,388 (GRCm39)	A261V	probably benign	Het
Or2t44	A	G	11: 58,677,773 (GRCm39)	T238A	probably damaging	Het
Or2t46	T	C	11: 58,471,757 (GRCm39)	V29A	probably benign	Het
Or2t46	T	G	11: 58,472,122 (GRCm39)	L151V	probably benign	Het
Or2t46	G	C	11: 58,472,483 (GRCm39)	S271T	probably benign	Het
Or2t46	C	T	11: 58,471,750 (GRCm39)	H27Y	probably benign	Het
Or2t47	C	T	11: 58,442,801 (GRCm39)	S88N	probably benign	Het
Or2t47	C	T	11: 58,442,940 (GRCm39)	A42T	probably benign	Het
Or2t47	T	C	11: 58,442,387 (GRCm39)	K226R	probably benign	Het
Or2t49	GGTGGATTGGTATGTGGAT	GGTGGAT	11: 58,393,212 (GRCm39)		probably benign	Het
Or2t49	C	G	11: 58,393,287 (GRCm39)	V38L	probably benign	Het
Or2t49	C	T	11: 58,393,396 (GRCm39)	M1I	probably null	Het
Or2t49	GAGGTGGATTGGTA	GA	11: 58,393,210 (GRCm39)		probably benign	Het
Or2w3	T	G	11: 58,557,342 (GRCm39)	I319R	probably benign	Het
Or2w3b	G	A	11: 58,623,295 (GRCm39)	A232V	probably benign	Het
Or2w3b	T	C	11: 58,623,475 (GRCm39)	H172R	probably benign	Het
Or2w3b	C	A	11: 58,624,048 (GRCm39)		probably benign	Het
Or2w3b	T	G	11: 58,623,200 (GRCm39)	N264H	probably benign	Het
Or5af2	T	C	11: 58,708,122 (GRCm39)	V96A	probably benign	Het
Or5af2	A	G	11: 58,707,887 (GRCm39)	I18V	probably benign	Het
Or5af2	C	G	11: 58,708,644 (GRCm39)	P270R	probably benign	Het
Or5af2	T	C	11: 58,708,508 (GRCm39)	C225R	probably benign	Het
Or5af2	A	C	11: 58,708,220 (GRCm39)	I129L	probably benign	Het
Or6k2	C	A	1: 173,986,907 (GRCm39)	C189*	probably null	Het
Or9e1	G	T	11: 58,731,945 (GRCm39)	A2S	probably benign	Het
Or9e1	C	T	11: 58,732,032 (GRCm39)	L31F	probably benign	Het
Or9e1	G	A	11: 58,732,569 (GRCm39)	A210T	probably benign	Het
Or9e1	A	G	11: 58,732,615 (GRCm39)	H225R	probably benign	Het
Or9e1	G	C	11: 58,731,907 (GRCm39)		probably benign	Het
Otx1	C	A	11: 21,947,037 (GRCm39)	A91S	probably damaging	Het
Ovca2	T	C	11: 75,069,528 (GRCm39)	T32A	probably benign	Het
Pimreg	G	A	11: 71,935,979 (GRCm39)	R154H	probably damaging	Het
Pimreg	TCACA	TCA	11: 71,935,801 (GRCm39)		probably benign	Het
Pitpnm3	T	C	11: 71,954,955 (GRCm39)	K520E	probably benign	Het
Pitpnm3	C	T	11: 72,010,969 (GRCm39)	R21Q	probably benign	Het
Ppp1r12b	C	G	1: 134,883,262 (GRCm39)	V87L	probably benign	Het
Prpsap2	A	C	11: 61,647,078 (GRCm39)	V21G	possibly damaging	Het
Psrc1	C	A	3: 108,293,873 (GRCm39)	S230*	probably null	Het
Rabep1	C	CT	11: 70,830,910 (GRCm39)		probably null	Het
Rai1	A	G	11: 60,078,389 (GRCm39)	N818D	probably benign	Het
Rap1gap2	C	T	11: 74,487,721 (GRCm39)	E52K	probably benign	Het
Rc3h2	G	A	2: 37,299,568 (GRCm39)	A154V	possibly damaging	Het
Rc3h2	T	C	2: 37,289,612 (GRCm39)	H400R	possibly damaging	Het
Rnf112	A	G	11: 61,341,775 (GRCm39)	L343P	unknown	Het
Rnf167	C	CACAGGGA	11: 70,541,646 (GRCm39)		probably null	Het
Rtn3	G	C	19: 7,460,342 (GRCm39)	P36R	unknown	Het
Rtn4rl1	C	T	11: 75,156,863 (GRCm39)	P432S	probably benign	Het
Slc41a1	A	G	1: 131,767,972 (GRCm39)	M179V	probably benign	Het
Slc6a4	A	G	11: 76,903,858 (GRCm39)	K152R	probably benign	Het
Slc6a4	G	A	11: 76,901,382 (GRCm39)	G39E	probably benign	Het
Smcr8	T	C	11: 60,669,932 (GRCm39)	V360A	probably benign	Het
Smcr8	C	A	11: 60,670,699 (GRCm39)	R616S	probably benign	Het
Smcr8	A	G	11: 60,668,806 (GRCm39)		probably benign	Het
Smg6	G	T	11: 75,047,092 (GRCm39)	A1262S	probably benign	Het
Spink12	G	A	18: 44,237,775 (GRCm39)	A18T	probably benign	Het
Spns3	G	A	11: 72,440,917 (GRCm39)	P40S	probably benign	Het
Spns3	T	C	11: 72,440,986 (GRCm39)	S17G	probably benign	Het
Spns3	T	C	11: 72,440,863 (GRCm39)	I58V	probably benign	Het
Srebf1	C	T	11: 60,097,061 (GRCm39)	V256M	probably benign	Het
Tekt1	T	C	11: 72,250,597 (GRCm39)	Q33R	probably benign	Het
Timm22	T	G	11: 76,297,943 (GRCm39)	V18G	probably benign	Het
Tmem102	G	C	11: 69,695,927 (GRCm39)	R45G	probably benign	Het
Tmem102	C	G	11: 69,695,902 (GRCm39)	G53A	possibly damaging	Het
Tmem11	A	G	11: 60,766,658 (GRCm39)		probably benign	Het
Tom1l2	C	T	11: 60,132,682 (GRCm39)	A414T	probably benign	Het
Top3a	C	T	11: 60,641,410 (GRCm39)	G425S	probably benign	Het
Trim16	A	AAGC	11: 62,711,521 (GRCm39)		probably benign	Het
Trim16	TGAAGA	TGAAGAAGA	11: 62,711,516 (GRCm39)		probably benign	Het
Trim16	G	C	11: 62,711,502 (GRCm39)	V58L	probably benign	Het
Trim16	C	T	11: 62,711,428 (GRCm39)	A33V	probably benign	Het
Trim16	C	A	11: 62,731,675 (GRCm39)	D515E	probably benign	Het
Trim16	T	C	11: 62,731,572 (GRCm39)	V481A	probably benign	Het
Trim16	G	A	11: 62,727,643 (GRCm39)	E322K	probably benign	Het
Trim17	G	A	11: 58,856,331 (GRCm39)	M129I	probably benign	Het
Trim17	A	G	11: 58,861,272 (GRCm39)	N259S	probably benign	Het
Trim58	C	A	11: 58,531,684 (GRCm39)	L131M	possibly damaging	Het
Trim58	A	G	11: 58,542,486 (GRCm39)	N482S	probably benign	Het
Trmt1l	A	G	1: 151,333,331 (GRCm39)	N642S	possibly damaging	Het
Trpv1	C	G	11: 73,131,427 (GRCm39)	P322A	possibly damaging	Het
Trpv1	C	A	11: 73,145,117 (GRCm39)	D734E	probably benign	Het
Trpv3	A	G	11: 73,174,502 (GRCm39)	T290A	probably benign	Het
Trpv3	G	A	11: 73,169,803 (GRCm39)	A125T	probably benign	Het
Trpv3	C	T	11: 73,160,513 (GRCm39)	A9V	probably benign	Het
Tvp23b	A	C	11: 62,772,769 (GRCm39)	N7H	possibly damaging	Het
Usp43	AGGGC	AGGGCAGGGGATGAACCTCGGGC	11: 67,746,545 (GRCm39)		probably benign	Het
Usp43	C	T	11: 67,747,332 (GRCm39)	G792S	probably benign	Het
Utrn	C	T	10: 12,545,491 (GRCm39)	R1718H	probably damaging	Het
Vamp2	C	T	11: 68,979,411 (GRCm39)		probably benign	Het
Vamp2	G	A	11: 68,980,889 (GRCm39)	G124R	possibly damaging	Het
Wdr4	C	T	17: 31,731,177 (GRCm39)	G61E	probably damaging	Het
Xaf1	GCT	GCTGGCCACCT	11: 72,199,847 (GRCm39)		probably null	Het
Xaf1	GGCT	GGCTGGCCAGCT	11: 72,199,846 (GRCm39)		probably null	Het
Xaf1	T	G	11: 72,199,792 (GRCm39)	C176W	unknown	Het
Xaf1	A	G	11: 72,199,476 (GRCm39)	E71G	probably benign	Het
Xaf1	C	A	11: 72,197,434 (GRCm39)	L137I	probably benign	Het
Xaf1	G	C	11: 72,197,429 (GRCm39)	C135S	probably damaging	Het
Xaf1	G	A	11: 72,197,426 (GRCm39)	R134H	probably benign	Het
Xaf1	T	C	11: 72,199,881 (GRCm39)	L206S	unknown	Het
Xaf1	G	C	11: 72,199,856 (GRCm39)	V198L	unknown	Het
Xaf1	T	TGGCCAGCA	11: 72,199,849 (GRCm39)		probably null	Het
Zfp286	G	A	11: 62,675,782 (GRCm39)	T60M	probably damaging	Het
Zfp286	A	G	11: 62,678,795 (GRCm39)	V44A	probably benign	Het
Zfp287	C	G	11: 62,606,175 (GRCm39)	C244S	probably benign	Het
Zfp287	G	A	11: 62,613,757 (GRCm39)	R225*	probably null	Het
Zfp287	C	T	11: 62,604,633 (GRCm39)	R758H	probably benign	Het
Zfp39	T	C	11: 58,781,274 (GRCm39)	D496G	possibly damaging	Het
Zfp39	G	C	11: 58,781,273 (GRCm39)	D496E	probably benign	Het
Zfp39	G	C	11: 58,781,130 (GRCm39)	T544R	possibly damaging	Het
Zfp39	A	C	11: 58,780,873 (GRCm39)	Y630D	probably benign	Het
Zfp39	G	C	11: 58,780,871 (GRCm39)	Y630*	probably null	Het
Zfp39	T	G	11: 58,791,409 (GRCm39)	S93R	probably benign	Het
Zfp39	G	T	11: 58,791,407 (GRCm39)	S93R	probably benign	Het
Zfp39	T	C	11: 58,782,142 (GRCm39)	K207E	probably benign	Het
Zfp39	T	C	11: 58,781,526 (GRCm39)	N412S	possibly damaging	Het
Zfp39	G	T	11: 58,781,597 (GRCm39)	N388K	probably benign	Het
Zfp39	A	G	11: 58,781,605 (GRCm39)	S386P	probably benign	Het
Zfp39	A	G	11: 58,781,724 (GRCm39)	V346A	probably benign	Het
Zfp39	T	A	11: 58,781,751 (GRCm39)	K337M	probably benign	Het
Zfp39	T	A	11: 58,781,967 (GRCm39)	H265L	probably damaging	Het
Zfp39	A	G	11: 58,782,123 (GRCm39)	I213T	probably benign	Het
Zfp672	G	T	11: 58,220,452 (GRCm39)	T49K	unknown	Het
Zfp692	G	T	11: 58,199,859 (GRCm39)	E149D	probably benign	Het
Zfp692	G	A	11: 58,200,844 (GRCm39)	V242I	probably benign	Het
Zfpm1	C	A	8: 123,060,612 (GRCm39)	L234M	probably damaging	Het
Zzef1	G	A	11: 72,780,008 (GRCm39)	R1927H	probably benign	Het

Other mutations in Ank2

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01298:Ank2	APN	3	126,753,369 (GRCm39)	missense	possibly damaging	0.80
IGL01652:Ank2	APN	3	126,726,690 (GRCm39)	missense	probably benign	0.00
IGL01969:Ank2	APN	3	126,746,872 (GRCm39)	missense	possibly damaging	0.47
IGL02122:Ank2	APN	3	126,731,523 (GRCm39)	splice site	probably benign
IGL02537:Ank2	APN	3	126,749,565 (GRCm39)	missense	probably damaging	1.00
IGL02858:Ank2	APN	3	126,749,519 (GRCm39)	missense	probably damaging	1.00
IGL02981:Ank2	APN	3	126,728,211 (GRCm39)	missense	possibly damaging	0.58
IGL02981:Ank2	APN	3	126,749,519 (GRCm39)	missense	probably damaging	1.00
IGL03024:Ank2	APN	3	126,749,519 (GRCm39)	missense	probably damaging	1.00
IGL03074:Ank2	APN	3	126,749,519 (GRCm39)	missense	probably damaging	1.00
IGL03111:Ank2	APN	3	126,749,519 (GRCm39)	missense	probably damaging	1.00
IGL03129:Ank2	APN	3	126,749,519 (GRCm39)	missense	probably damaging	1.00
IGL03174:Ank2	APN	3	126,733,744 (GRCm39)	missense	probably damaging	0.98
IGL03177:Ank2	APN	3	126,749,519 (GRCm39)	missense	probably damaging	1.00
IGL03185:Ank2	APN	3	126,749,519 (GRCm39)	missense	probably damaging	1.00
IGL03188:Ank2	APN	3	126,749,519 (GRCm39)	missense	probably damaging	1.00
IGL03242:Ank2	APN	3	126,722,454 (GRCm39)	missense	possibly damaging	0.90
IGL03244:Ank2	APN	3	126,749,519 (GRCm39)	missense	probably damaging	1.00
IGL03248:Ank2	APN	3	126,749,519 (GRCm39)	missense	probably damaging	1.00
IGL03285:Ank2	APN	3	126,749,519 (GRCm39)	missense	probably damaging	1.00
IGL03304:Ank2	APN	3	126,749,519 (GRCm39)	missense	probably damaging	1.00
IGL03358:Ank2	APN	3	126,749,519 (GRCm39)	missense	probably damaging	1.00
IGL03380:Ank2	APN	3	126,749,519 (GRCm39)	missense	probably damaging	1.00
IGL03389:Ank2	APN	3	126,749,519 (GRCm39)	missense	probably damaging	1.00
IGL03400:Ank2	APN	3	126,749,519 (GRCm39)	missense	probably damaging	1.00
IGL03409:Ank2	APN	3	126,749,519 (GRCm39)	missense	probably damaging	1.00
ballast	UTSW	3	126,736,782 (GRCm39)	missense	unknown
Chain	UTSW	3	126,740,587 (GRCm39)	intron	probably benign
Deadman	UTSW	3	126,723,471 (GRCm39)	missense	probably benign	0.19
drag	UTSW	3	126,797,631 (GRCm39)	missense	probably damaging	1.00
mooring	UTSW	3	126,728,226 (GRCm39)	missense	possibly damaging	0.73
Treasure	UTSW	3	126,740,398 (GRCm39)	missense	unknown
Windlass	UTSW	3	126,739,798 (GRCm39)	missense	probably benign
R0033:Ank2	UTSW	3	126,898,397 (GRCm39)	splice site	probably benign
R0042:Ank2	UTSW	3	126,730,280 (GRCm39)	missense	probably damaging	0.99
R0042:Ank2	UTSW	3	126,730,280 (GRCm39)	missense	probably damaging	0.99
R0079:Ank2	UTSW	3	126,728,264 (GRCm39)	missense	probably benign	0.01
R0423:Ank2	UTSW	3	126,723,509 (GRCm39)	nonsense	probably null
R0699:Ank2	UTSW	3	126,723,478 (GRCm39)	missense	probably benign	0.00
R0724:Ank2	UTSW	3	126,755,986 (GRCm39)	missense	probably damaging	1.00
R0990:Ank2	UTSW	3	126,728,315 (GRCm39)	missense	possibly damaging	0.64
R1450:Ank2	UTSW	3	126,750,951 (GRCm39)	missense	possibly damaging	0.94
R1500:Ank2	UTSW	3	126,726,631 (GRCm39)	missense	probably benign
R1702:Ank2	UTSW	3	126,749,548 (GRCm39)	missense	probably benign	0.00
R1703:Ank2	UTSW	3	126,723,415 (GRCm39)	missense	probably damaging	1.00
R1710:Ank2	UTSW	3	126,726,709 (GRCm39)	nonsense	probably null
R1743:Ank2	UTSW	3	126,722,324 (GRCm39)	missense	probably damaging	0.99
R1775:Ank2	UTSW	3	126,728,196 (GRCm39)	missense	probably benign	0.00
R1852:Ank2	UTSW	3	126,791,500 (GRCm39)	critical splice donor site	probably null
R2198:Ank2	UTSW	3	126,728,226 (GRCm39)	missense	possibly damaging	0.73
R2892:Ank2	UTSW	3	127,041,892 (GRCm39)	splice site	probably null
R2893:Ank2	UTSW	3	127,041,892 (GRCm39)	splice site	probably null
R2894:Ank2	UTSW	3	127,041,892 (GRCm39)	splice site	probably null
R3148:Ank2	UTSW	3	126,726,724 (GRCm39)	missense	probably benign	0.00
R3776:Ank2	UTSW	3	126,735,911 (GRCm39)	intron	probably benign
R3784:Ank2	UTSW	3	126,746,842 (GRCm39)	missense	probably damaging	1.00
R3856:Ank2	UTSW	3	126,723,493 (GRCm39)	missense	probably benign	0.00
R3906:Ank2	UTSW	3	126,810,547 (GRCm39)	missense	probably damaging	1.00
R3907:Ank2	UTSW	3	126,810,547 (GRCm39)	missense	probably damaging	1.00
R3953:Ank2	UTSW	3	126,781,809 (GRCm39)	missense	probably damaging	1.00
R3963:Ank2	UTSW	3	126,728,245 (GRCm39)	missense	probably benign
R4367:Ank2	UTSW	3	126,739,798 (GRCm39)	missense	probably benign
R4414:Ank2	UTSW	3	127,019,411 (GRCm39)	critical splice donor site	probably null
R4432:Ank2	UTSW	3	126,741,455 (GRCm39)	intron	probably benign
R4433:Ank2	UTSW	3	126,741,455 (GRCm39)	intron	probably benign
R4579:Ank2	UTSW	3	126,752,612 (GRCm39)	missense	probably damaging	1.00
R4597:Ank2	UTSW	3	126,781,800 (GRCm39)	missense	probably damaging	1.00
R4603:Ank2	UTSW	3	126,825,665 (GRCm39)	missense	probably benign	0.00
R4729:Ank2	UTSW	3	126,770,545 (GRCm39)	nonsense	probably null
R4815:Ank2	UTSW	3	126,730,410 (GRCm39)	missense	probably benign
R4826:Ank2	UTSW	3	126,749,650 (GRCm39)	missense	probably benign	0.35
R4871:Ank2	UTSW	3	126,753,444 (GRCm39)	missense	probably damaging	1.00
R4880:Ank2	UTSW	3	126,840,475 (GRCm39)	splice site	probably null
R4915:Ank2	UTSW	3	126,736,320 (GRCm39)	intron	probably benign
R4935:Ank2	UTSW	3	126,749,713 (GRCm39)	missense	probably damaging	1.00
R4936:Ank2	UTSW	3	126,748,688 (GRCm39)	missense	possibly damaging	0.94
R4937:Ank2	UTSW	3	126,756,050 (GRCm39)	missense	probably damaging	1.00
R4946:Ank2	UTSW	3	126,735,589 (GRCm39)	intron	probably benign
R4963:Ank2	UTSW	3	126,825,745 (GRCm39)	missense	probably benign	0.01
R4989:Ank2	UTSW	3	126,757,094 (GRCm39)	missense	possibly damaging	0.94
R5023:Ank2	UTSW	3	126,735,520 (GRCm39)	intron	probably benign
R5060:Ank2	UTSW	3	126,739,570 (GRCm39)	intron	probably benign
R5078:Ank2	UTSW	3	126,736,002 (GRCm39)	intron	probably benign
R5086:Ank2	UTSW	3	126,740,997 (GRCm39)	intron	probably benign
R5134:Ank2	UTSW	3	126,757,094 (GRCm39)	missense	possibly damaging	0.94
R5148:Ank2	UTSW	3	126,819,285 (GRCm39)	splice site	probably null
R5175:Ank2	UTSW	3	126,797,673 (GRCm39)	missense	probably damaging	1.00
R5275:Ank2	UTSW	3	126,825,832 (GRCm39)	missense	probably damaging	1.00
R5295:Ank2	UTSW	3	126,825,832 (GRCm39)	missense	probably damaging	1.00
R5303:Ank2	UTSW	3	126,739,453 (GRCm39)	intron	probably benign
R5309:Ank2	UTSW	3	126,753,417 (GRCm39)	missense	probably damaging	0.99
R5312:Ank2	UTSW	3	126,753,417 (GRCm39)	missense	probably damaging	0.99
R5352:Ank2	UTSW	3	127,292,640 (GRCm39)	utr 5 prime	probably benign
R5355:Ank2	UTSW	3	126,737,698 (GRCm39)	intron	probably benign
R5386:Ank2	UTSW	3	126,775,582 (GRCm39)	missense	probably benign	0.01
R5396:Ank2	UTSW	3	126,746,875 (GRCm39)	missense	probably damaging	1.00
R5518:Ank2	UTSW	3	126,753,348 (GRCm39)	missense	probably damaging	0.98
R5534:Ank2	UTSW	3	126,740,947 (GRCm39)	intron	probably benign
R5554:Ank2	UTSW	3	126,792,622 (GRCm39)	missense	possibly damaging	0.78
R5582:Ank2	UTSW	3	126,739,954 (GRCm39)	intron	probably benign
R5747:Ank2	UTSW	3	126,735,400 (GRCm39)	intron	probably benign
R5794:Ank2	UTSW	3	126,723,669 (GRCm39)	missense	probably benign	0.00
R5831:Ank2	UTSW	3	127,132,808 (GRCm39)	start gained	probably benign
R5925:Ank2	UTSW	3	126,726,612 (GRCm39)	missense	probably benign	0.18
R5954:Ank2	UTSW	3	126,791,510 (GRCm39)	missense	probably benign	0.34
R5956:Ank2	UTSW	3	126,736,337 (GRCm39)	intron	probably benign
R5986:Ank2	UTSW	3	126,806,335 (GRCm39)	missense	possibly damaging	0.94
R5992:Ank2	UTSW	3	126,753,300 (GRCm39)	critical splice donor site	probably null
R6020:Ank2	UTSW	3	126,740,470 (GRCm39)	intron	probably benign
R6027:Ank2	UTSW	3	126,791,528 (GRCm39)	missense	possibly damaging	0.92
R6049:Ank2	UTSW	3	126,736,669 (GRCm39)	missense	possibly damaging	0.95
R6060:Ank2	UTSW	3	126,749,601 (GRCm39)	missense	probably damaging	1.00
R6114:Ank2	UTSW	3	126,804,700 (GRCm39)	missense	probably damaging	1.00
R6124:Ank2	UTSW	3	127,041,800 (GRCm39)	missense	probably benign	0.31
R6156:Ank2	UTSW	3	126,737,886 (GRCm39)	missense	probably damaging	1.00
R6173:Ank2	UTSW	3	126,846,395 (GRCm39)	missense	probably damaging	1.00
R6176:Ank2	UTSW	3	126,739,120 (GRCm39)	missense	probably benign	0.05
R6184:Ank2	UTSW	3	126,756,047 (GRCm39)	missense	probably damaging	1.00
R6199:Ank2	UTSW	3	126,797,655 (GRCm39)	missense	probably damaging	1.00
R6241:Ank2	UTSW	3	126,846,397 (GRCm39)	missense	probably damaging	1.00
R6254:Ank2	UTSW	3	126,735,453 (GRCm39)	intron	probably benign
R6259:Ank2	UTSW	3	126,810,635 (GRCm39)	missense	probably benign	0.28
R6260:Ank2	UTSW	3	126,737,206 (GRCm39)	missense	probably benign
R6321:Ank2	UTSW	3	126,740,587 (GRCm39)	intron	probably benign
R6393:Ank2	UTSW	3	126,723,406 (GRCm39)	missense	probably damaging	1.00
R6406:Ank2	UTSW	3	126,825,874 (GRCm39)	missense	probably damaging	1.00
R6544:Ank2	UTSW	3	126,726,871 (GRCm39)	missense	probably damaging	0.99
R6583:Ank2	UTSW	3	126,810,613 (GRCm39)	missense	probably damaging	1.00
R6739:Ank2	UTSW	3	126,873,643 (GRCm39)	missense	probably damaging	1.00
R6754:Ank2	UTSW	3	126,890,488 (GRCm39)	intron	probably benign
R6786:Ank2	UTSW	3	126,752,581 (GRCm39)	missense	probably damaging	0.99
R6798:Ank2	UTSW	3	126,737,913 (GRCm39)	intron	probably benign
R6882:Ank2	UTSW	3	126,739,406 (GRCm39)	intron	probably benign
R6940:Ank2	UTSW	3	126,735,621 (GRCm39)	intron	probably benign
R6949:Ank2	UTSW	3	126,804,533 (GRCm39)	missense	probably benign	0.00
R7001:Ank2	UTSW	3	126,871,230 (GRCm39)	missense	probably damaging	1.00
R7033:Ank2	UTSW	3	126,738,499 (GRCm39)	nonsense	probably null
R7036:Ank2	UTSW	3	126,740,041 (GRCm39)	intron	probably benign
R7045:Ank2	UTSW	3	126,806,393 (GRCm39)	missense	probably damaging	1.00
R7048:Ank2	UTSW	3	126,819,267 (GRCm39)	missense	probably benign	0.03
R7054:Ank2	UTSW	3	126,736,952 (GRCm39)	intron	probably benign
R7069:Ank2	UTSW	3	126,739,947 (GRCm39)	intron	probably benign
R7091:Ank2	UTSW	3	126,817,000 (GRCm39)	missense	probably damaging	0.98
R7107:Ank2	UTSW	3	126,797,631 (GRCm39)	missense	probably damaging	1.00
R7175:Ank2	UTSW	3	126,740,590 (GRCm39)	missense	unknown
R7191:Ank2	UTSW	3	126,740,041 (GRCm39)	missense	unknown
R7272:Ank2	UTSW	3	126,736,782 (GRCm39)	missense	unknown
R7381:Ank2	UTSW	3	126,730,277 (GRCm39)	missense	possibly damaging	0.46
R7394:Ank2	UTSW	3	126,730,302 (GRCm39)	missense	possibly damaging	0.77
R7462:Ank2	UTSW	3	126,736,683 (GRCm39)	missense	unknown
R7490:Ank2	UTSW	3	126,752,538 (GRCm39)	missense	probably damaging	0.99
R7514:Ank2	UTSW	3	126,819,252 (GRCm39)	missense	probably benign	0.06
R7534:Ank2	UTSW	3	126,727,982 (GRCm39)	splice site	probably null
R7540:Ank2	UTSW	3	126,781,808 (GRCm39)	missense	possibly damaging	0.94
R7547:Ank2	UTSW	3	126,738,852 (GRCm39)	missense	unknown
R7579:Ank2	UTSW	3	126,740,047 (GRCm39)	missense	unknown
R7584:Ank2	UTSW	3	126,739,777 (GRCm39)	nonsense	probably null
R7625:Ank2	UTSW	3	126,846,449 (GRCm39)	missense	probably damaging	1.00
R7698:Ank2	UTSW	3	126,825,860 (GRCm39)	missense	probably benign	0.35
R7716:Ank2	UTSW	3	126,736,815 (GRCm39)	missense	unknown
R7718:Ank2	UTSW	3	126,758,662 (GRCm39)	missense	possibly damaging	0.88
R7722:Ank2	UTSW	3	126,822,951 (GRCm39)	missense	probably benign	0.01
R7738:Ank2	UTSW	3	126,741,271 (GRCm39)	missense
R7977:Ank2	UTSW	3	126,739,356 (GRCm39)	missense	unknown
R7987:Ank2	UTSW	3	126,739,356 (GRCm39)	missense	unknown
R8007:Ank2	UTSW	3	126,730,096 (GRCm39)	intron	probably benign
R8150:Ank2	UTSW	3	126,741,162 (GRCm39)	missense
R8161:Ank2	UTSW	3	126,825,778 (GRCm39)	missense
R8196:Ank2	UTSW	3	126,723,532 (GRCm39)	missense	probably damaging	0.99
R8248:Ank2	UTSW	3	126,731,434 (GRCm39)	missense	possibly damaging	0.78
R8255:Ank2	UTSW	3	126,740,398 (GRCm39)	missense	unknown
R8279:Ank2	UTSW	3	126,726,820 (GRCm39)	missense	probably benign	0.04
R8300:Ank2	UTSW	3	126,804,555 (GRCm39)	missense
R8716:Ank2	UTSW	3	126,736,488 (GRCm39)	nonsense	probably null
R8724:Ank2	UTSW	3	126,737,405 (GRCm39)	missense	unknown
R8765:Ank2	UTSW	3	126,850,731 (GRCm39)	missense	possibly damaging	0.94
R8779:Ank2	UTSW	3	126,758,751 (GRCm39)	missense	probably damaging	0.99
R8783:Ank2	UTSW	3	126,846,455 (GRCm39)	missense	probably damaging	1.00
R8785:Ank2	UTSW	3	126,791,570 (GRCm39)	missense	probably damaging	1.00
R8826:Ank2	UTSW	3	126,740,951 (GRCm39)	missense	unknown
R8872:Ank2	UTSW	3	126,791,525 (GRCm39)	missense	possibly damaging	0.88
R8903:Ank2	UTSW	3	126,840,431 (GRCm39)	missense	probably damaging	1.00
R8906:Ank2	UTSW	3	126,726,720 (GRCm39)	missense	probably benign	0.00
R8918:Ank2	UTSW	3	126,737,380 (GRCm39)	missense	unknown
R8947:Ank2	UTSW	3	126,736,396 (GRCm39)	intron	probably benign
R8977:Ank2	UTSW	3	126,738,575 (GRCm39)	missense	unknown
R8990:Ank2	UTSW	3	126,841,829 (GRCm39)	critical splice donor site	probably null
R8994:Ank2	UTSW	3	126,723,471 (GRCm39)	missense	probably benign	0.19
R9009:Ank2	UTSW	3	126,728,025 (GRCm39)	unclassified	probably benign
R9123:Ank2	UTSW	3	126,733,744 (GRCm39)	missense	probably damaging	1.00
R9125:Ank2	UTSW	3	126,733,744 (GRCm39)	missense	probably damaging	1.00
R9130:Ank2	UTSW	3	126,810,565 (GRCm39)	missense
R9175:Ank2	UTSW	3	126,722,402 (GRCm39)	missense	possibly damaging	0.52
R9220:Ank2	UTSW	3	126,737,086 (GRCm39)	missense	unknown
R9225:Ank2	UTSW	3	126,736,111 (GRCm39)	missense	unknown
R9286:Ank2	UTSW	3	126,846,381 (GRCm39)	missense	probably damaging	0.99
R9325:Ank2	UTSW	3	126,775,504 (GRCm39)	missense	probably damaging	0.98
R9367:Ank2	UTSW	3	126,738,678 (GRCm39)	missense	unknown
R9385:Ank2	UTSW	3	126,753,366 (GRCm39)	missense	probably benign	0.00
R9391:Ank2	UTSW	3	126,731,394 (GRCm39)	missense	probably damaging	0.99
R9422:Ank2	UTSW	3	126,890,505 (GRCm39)	missense	unknown
R9536:Ank2	UTSW	3	126,736,031 (GRCm39)	missense	unknown
R9647:Ank2	UTSW	3	126,792,623 (GRCm39)	missense	possibly damaging	0.93
R9650:Ank2	UTSW	3	126,735,829 (GRCm39)	missense	unknown
R9666:Ank2	UTSW	3	126,726,838 (GRCm39)	nonsense	probably null
R9686:Ank2	UTSW	3	126,740,550 (GRCm39)	missense	unknown
R9730:Ank2	UTSW	3	127,019,493 (GRCm39)	missense
R9738:Ank2	UTSW	3	126,737,121 (GRCm39)	missense	unknown
R9743:Ank2	UTSW	3	126,733,794 (GRCm39)	missense	possibly damaging	0.81
R9747:Ank2	UTSW	3	126,752,667 (GRCm39)	missense	probably damaging	1.00
R9800:Ank2	UTSW	3	126,740,149 (GRCm39)	missense	unknown
R9803:Ank2	UTSW	3	126,752,726 (GRCm39)	missense	possibly damaging	0.64
RF020:Ank2	UTSW	3	126,739,125 (GRCm39)	missense	unknown
Z1088:Ank2	UTSW	3	126,823,158 (GRCm39)	missense	possibly damaging	0.45
Z1177:Ank2	UTSW	3	126,738,006 (GRCm39)	missense	unknown
Z1187:Ank2	UTSW	3	126,749,601 (GRCm39)	missense	probably damaging	1.00
Z1190:Ank2	UTSW	3	126,749,601 (GRCm39)	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- GGCCTTCAACTGATAGAAACATAGAC -3'
(R):5'- TCTGTTTTCAAGTTGCACACTG -3'

Sequencing Primer
(F):5'- GAAACATAGACTGGTCTTCCTTTTGC -3'
(R):5'- CAAGTTGCACACTGTAAACTTTAGG -3'

Posted On

2021-03-08