Incidental Mutation 'R8767:Vmn2r5'
ID |
667908 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Vmn2r5
|
Ensembl Gene |
ENSMUSG00000068999 |
Gene Name |
vomeronasal 2, receptor 5 |
Synonyms |
EG667060 |
MMRRC Submission |
068601-MU
|
Accession Numbers |
|
Essential gene? |
Probably non essential
(E-score: 0.145)
|
Stock # |
R8767 (G1)
|
Quality Score |
152.008 |
Status
|
Not validated
|
Chromosome |
3 |
Chromosomal Location |
64398242-64417156 bp(-) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
G to A
at 64415103 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Arginine to Cysteine
at position 86
(R86C)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000135592
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000170270]
[ENSMUST00000177184]
|
AlphaFold |
K7N788 |
Predicted Effect |
probably benign
Transcript: ENSMUST00000170270
|
SMART Domains |
Protein: ENSMUSP00000131925 Gene: ENSMUSG00000068999
Domain | Start | End | E-Value | Type |
Pfam:ANF_receptor
|
1 |
416 |
9.9e-78 |
PFAM |
Pfam:NCD3G
|
458 |
511 |
8.5e-18 |
PFAM |
Pfam:7tm_3
|
542 |
779 |
2.3e-74 |
PFAM |
|
Predicted Effect |
possibly damaging
Transcript: ENSMUST00000177184
AA Change: R86C
PolyPhen 2
Score 0.785 (Sensitivity: 0.85; Specificity: 0.93)
|
SMART Domains |
Protein: ENSMUSP00000135592 Gene: ENSMUSG00000068999 AA Change: R86C
Domain | Start | End | E-Value | Type |
signal peptide
|
1 |
22 |
N/A |
INTRINSIC |
Pfam:ANF_receptor
|
86 |
503 |
1.8e-80 |
PFAM |
Pfam:NCD3G
|
545 |
598 |
1e-14 |
PFAM |
Pfam:7tm_3
|
631 |
865 |
1.4e-45 |
PFAM |
|
Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.7%
- 20x: 99.1%
|
Validation Efficiency |
100% (36/36) |
Allele List at MGI |
|
Other mutations in this stock |
Total: 36 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
Ankrd31 |
A |
G |
13: 96,969,224 (GRCm39) |
T954A |
probably damaging |
Het |
Arhgap24 |
A |
T |
5: 103,039,740 (GRCm39) |
M319L |
probably benign |
Het |
Aste1 |
A |
G |
9: 105,274,098 (GRCm39) |
N113D |
possibly damaging |
Het |
Ccnh |
C |
T |
13: 85,356,959 (GRCm39) |
Q275* |
probably null |
Het |
Cfi |
G |
A |
3: 129,644,497 (GRCm39) |
|
probably null |
Het |
Cntn1 |
G |
A |
15: 92,132,347 (GRCm39) |
V148M |
probably damaging |
Het |
Crybg3 |
T |
A |
16: 59,376,500 (GRCm39) |
M1585L |
probably benign |
Het |
D630036H23Rik |
A |
G |
12: 36,431,441 (GRCm39) |
S186P |
unknown |
Het |
Dnhd1 |
T |
C |
7: 105,301,330 (GRCm39) |
L229P |
probably damaging |
Het |
Dtymk |
A |
T |
1: 93,728,635 (GRCm39) |
|
probably benign |
Het |
Eif4g3 |
T |
A |
4: 137,930,779 (GRCm39) |
I1511K |
probably damaging |
Het |
Entrep3 |
T |
G |
3: 89,091,725 (GRCm39) |
|
probably benign |
Het |
Fastkd2 |
A |
G |
1: 63,775,080 (GRCm39) |
D342G |
probably benign |
Het |
Hcar1 |
A |
G |
5: 124,017,113 (GRCm39) |
F193L |
probably damaging |
Het |
Hivep2 |
T |
G |
10: 14,004,992 (GRCm39) |
L530R |
probably damaging |
Het |
Ilrun |
T |
C |
17: 27,987,043 (GRCm39) |
T228A |
probably benign |
Het |
Krtap5-2 |
TCCACAGGAACTACAGCCTCCCTTGCAGCCCCCACAGGAACCACAGCCCCCACAGGAACTACA |
TCCACAGGAACTACA |
7: 141,728,845 (GRCm39) |
|
probably benign |
Het |
Lats2 |
G |
A |
14: 57,931,781 (GRCm39) |
T879M |
probably damaging |
Het |
Lin54 |
G |
A |
5: 100,600,884 (GRCm39) |
T503I |
probably benign |
Het |
Mmp16 |
T |
G |
4: 18,051,714 (GRCm39) |
|
probably benign |
Het |
Muc6 |
A |
G |
7: 141,229,549 (GRCm39) |
Y1186H |
probably damaging |
Het |
Nr3c1 |
A |
G |
18: 39,619,387 (GRCm39) |
F300S |
probably damaging |
Het |
Or2y1g |
A |
G |
11: 49,171,227 (GRCm39) |
N84S |
possibly damaging |
Het |
Or7g21 |
A |
C |
9: 19,032,922 (GRCm39) |
I221L |
possibly damaging |
Het |
Pcdha4 |
T |
C |
18: 37,086,905 (GRCm39) |
S363P |
possibly damaging |
Het |
Ptdss1 |
C |
T |
13: 67,101,608 (GRCm39) |
A99V |
probably benign |
Het |
Ptprz1 |
T |
A |
6: 22,986,187 (GRCm39) |
L329Q |
probably damaging |
Het |
Rnf115 |
T |
C |
3: 96,695,907 (GRCm39) |
V231A |
probably damaging |
Het |
Sh3pxd2a |
A |
G |
19: 47,257,345 (GRCm39) |
Y486H |
probably damaging |
Het |
Shh |
T |
A |
5: 28,671,487 (GRCm39) |
N92I |
possibly damaging |
Het |
Slc13a4 |
T |
A |
6: 35,245,783 (GRCm39) |
I621F |
probably benign |
Het |
Srrm1 |
T |
C |
4: 135,059,532 (GRCm39) |
T438A |
unknown |
Het |
Synj1 |
A |
C |
16: 90,758,406 (GRCm39) |
F813V |
probably damaging |
Het |
Tnrc6a |
A |
G |
7: 122,783,133 (GRCm39) |
|
probably benign |
Het |
Trir |
T |
A |
8: 85,753,690 (GRCm39) |
F55I |
probably damaging |
Het |
Tsr1 |
A |
G |
11: 74,799,149 (GRCm39) |
T777A |
probably damaging |
Het |
|
Other mutations in Vmn2r5 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL00742:Vmn2r5
|
APN |
3 |
64,398,834 (GRCm39) |
missense |
possibly damaging |
0.67 |
IGL01139:Vmn2r5
|
APN |
3 |
64,398,826 (GRCm39) |
missense |
probably benign |
0.28 |
IGL03293:Vmn2r5
|
APN |
3 |
64,398,747 (GRCm39) |
missense |
probably benign |
0.01 |
PIT4581001:Vmn2r5
|
UTSW |
3 |
64,411,348 (GRCm39) |
nonsense |
probably null |
|
R0063:Vmn2r5
|
UTSW |
3 |
64,411,221 (GRCm39) |
missense |
probably benign |
0.01 |
R0142:Vmn2r5
|
UTSW |
3 |
64,400,009 (GRCm39) |
missense |
probably damaging |
1.00 |
R0193:Vmn2r5
|
UTSW |
3 |
64,398,951 (GRCm39) |
missense |
possibly damaging |
0.91 |
R0219:Vmn2r5
|
UTSW |
3 |
64,411,734 (GRCm39) |
missense |
probably damaging |
0.99 |
R0313:Vmn2r5
|
UTSW |
3 |
64,411,248 (GRCm39) |
missense |
probably benign |
|
R0620:Vmn2r5
|
UTSW |
3 |
64,411,235 (GRCm39) |
nonsense |
probably null |
|
R0726:Vmn2r5
|
UTSW |
3 |
64,411,186 (GRCm39) |
missense |
probably benign |
0.01 |
R1073:Vmn2r5
|
UTSW |
3 |
64,398,726 (GRCm39) |
nonsense |
probably null |
|
R1549:Vmn2r5
|
UTSW |
3 |
64,411,421 (GRCm39) |
missense |
probably damaging |
1.00 |
R1581:Vmn2r5
|
UTSW |
3 |
64,398,640 (GRCm39) |
missense |
probably damaging |
1.00 |
R1624:Vmn2r5
|
UTSW |
3 |
64,417,116 (GRCm39) |
missense |
probably benign |
0.19 |
R1973:Vmn2r5
|
UTSW |
3 |
64,411,642 (GRCm39) |
missense |
probably damaging |
1.00 |
R1974:Vmn2r5
|
UTSW |
3 |
64,411,642 (GRCm39) |
missense |
probably damaging |
1.00 |
R1975:Vmn2r5
|
UTSW |
3 |
64,411,642 (GRCm39) |
missense |
probably damaging |
1.00 |
R1977:Vmn2r5
|
UTSW |
3 |
64,411,642 (GRCm39) |
missense |
probably damaging |
1.00 |
R2189:Vmn2r5
|
UTSW |
3 |
64,417,014 (GRCm39) |
missense |
probably benign |
0.27 |
R2484:Vmn2r5
|
UTSW |
3 |
64,411,392 (GRCm39) |
missense |
possibly damaging |
0.94 |
R4573:Vmn2r5
|
UTSW |
3 |
64,411,339 (GRCm39) |
missense |
probably damaging |
0.98 |
R5243:Vmn2r5
|
UTSW |
3 |
64,411,497 (GRCm39) |
missense |
probably damaging |
1.00 |
R5384:Vmn2r5
|
UTSW |
3 |
64,416,931 (GRCm39) |
missense |
probably benign |
0.02 |
R5385:Vmn2r5
|
UTSW |
3 |
64,416,931 (GRCm39) |
missense |
probably benign |
0.02 |
R5587:Vmn2r5
|
UTSW |
3 |
64,411,497 (GRCm39) |
missense |
probably damaging |
1.00 |
R5588:Vmn2r5
|
UTSW |
3 |
64,411,497 (GRCm39) |
missense |
probably damaging |
1.00 |
R5589:Vmn2r5
|
UTSW |
3 |
64,411,497 (GRCm39) |
missense |
probably damaging |
1.00 |
R5590:Vmn2r5
|
UTSW |
3 |
64,411,497 (GRCm39) |
missense |
probably damaging |
1.00 |
R5739:Vmn2r5
|
UTSW |
3 |
64,411,497 (GRCm39) |
missense |
probably damaging |
1.00 |
R6113:Vmn2r5
|
UTSW |
3 |
64,398,820 (GRCm39) |
missense |
probably benign |
0.03 |
R6739:Vmn2r5
|
UTSW |
3 |
64,398,637 (GRCm39) |
missense |
probably damaging |
0.97 |
R7106:Vmn2r5
|
UTSW |
3 |
64,399,104 (GRCm39) |
missense |
probably benign |
0.05 |
R7304:Vmn2r5
|
UTSW |
3 |
64,411,671 (GRCm39) |
missense |
probably damaging |
0.97 |
R7402:Vmn2r5
|
UTSW |
3 |
64,403,176 (GRCm39) |
missense |
probably benign |
0.05 |
R7477:Vmn2r5
|
UTSW |
3 |
64,399,060 (GRCm39) |
missense |
probably damaging |
1.00 |
R7571:Vmn2r5
|
UTSW |
3 |
64,411,825 (GRCm39) |
missense |
probably damaging |
1.00 |
R7678:Vmn2r5
|
UTSW |
3 |
64,416,943 (GRCm39) |
missense |
probably benign |
|
R7874:Vmn2r5
|
UTSW |
3 |
64,398,453 (GRCm39) |
missense |
probably damaging |
1.00 |
R8110:Vmn2r5
|
UTSW |
3 |
64,398,709 (GRCm39) |
missense |
probably benign |
0.00 |
R8223:Vmn2r5
|
UTSW |
3 |
64,398,726 (GRCm39) |
nonsense |
probably null |
|
R8896:Vmn2r5
|
UTSW |
3 |
64,411,203 (GRCm39) |
missense |
probably benign |
0.00 |
R8948:Vmn2r5
|
UTSW |
3 |
64,398,522 (GRCm39) |
missense |
probably damaging |
1.00 |
R8950:Vmn2r5
|
UTSW |
3 |
64,398,522 (GRCm39) |
missense |
probably damaging |
1.00 |
R8962:Vmn2r5
|
UTSW |
3 |
64,398,564 (GRCm39) |
missense |
probably damaging |
1.00 |
R9012:Vmn2r5
|
UTSW |
3 |
64,411,915 (GRCm39) |
missense |
probably damaging |
1.00 |
R9109:Vmn2r5
|
UTSW |
3 |
64,411,411 (GRCm39) |
missense |
possibly damaging |
0.58 |
R9126:Vmn2r5
|
UTSW |
3 |
64,399,159 (GRCm39) |
missense |
probably benign |
0.13 |
R9192:Vmn2r5
|
UTSW |
3 |
64,398,938 (GRCm39) |
nonsense |
probably null |
|
R9221:Vmn2r5
|
UTSW |
3 |
64,411,721 (GRCm39) |
nonsense |
probably null |
|
R9375:Vmn2r5
|
UTSW |
3 |
64,411,316 (GRCm39) |
missense |
probably damaging |
1.00 |
R9529:Vmn2r5
|
UTSW |
3 |
64,400,018 (GRCm39) |
missense |
probably benign |
0.06 |
Z1088:Vmn2r5
|
UTSW |
3 |
64,416,963 (GRCm39) |
missense |
probably benign |
0.02 |
Z1177:Vmn2r5
|
UTSW |
3 |
64,398,472 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Predicted Primers |
PCR Primer
(F):5'- ACGAGATATTTTCCCGTGCTG -3'
(R):5'- ACAGATAAAGGCTGGATATGACTAC -3'
Sequencing Primer
(F):5'- CCCGTGCTGTTTCTATAATTGG -3'
(R):5'- GGCTGGATATGACTACTATTTGAATC -3'
|
Posted On |
2021-03-08 |