Incidental Mutation 'R8767:Vmn2r5'
ID 667908
Institutional Source Beutler Lab
Gene Symbol Vmn2r5
Ensembl Gene ENSMUSG00000068999
Gene Name vomeronasal 2, receptor 5
Synonyms EG667060
MMRRC Submission 068601-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.145) question?
Stock # R8767 (G1)
Quality Score 152.008
Status Not validated
Chromosome 3
Chromosomal Location 64398242-64417156 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 64415103 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Arginine to Cysteine at position 86 (R86C)
Ref Sequence ENSEMBL: ENSMUSP00000135592 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000170270] [ENSMUST00000177184]
AlphaFold K7N788
Predicted Effect probably benign
Transcript: ENSMUST00000170270
SMART Domains Protein: ENSMUSP00000131925
Gene: ENSMUSG00000068999

DomainStartEndE-ValueType
Pfam:ANF_receptor 1 416 9.9e-78 PFAM
Pfam:NCD3G 458 511 8.5e-18 PFAM
Pfam:7tm_3 542 779 2.3e-74 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000177184
AA Change: R86C

PolyPhen 2 Score 0.785 (Sensitivity: 0.85; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000135592
Gene: ENSMUSG00000068999
AA Change: R86C

DomainStartEndE-ValueType
signal peptide 1 22 N/A INTRINSIC
Pfam:ANF_receptor 86 503 1.8e-80 PFAM
Pfam:NCD3G 545 598 1e-14 PFAM
Pfam:7tm_3 631 865 1.4e-45 PFAM
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 99.1%
Validation Efficiency 100% (36/36)
Allele List at MGI
Other mutations in this stock
Total: 36 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ankrd31 A G 13: 96,969,224 (GRCm39) T954A probably damaging Het
Arhgap24 A T 5: 103,039,740 (GRCm39) M319L probably benign Het
Aste1 A G 9: 105,274,098 (GRCm39) N113D possibly damaging Het
Ccnh C T 13: 85,356,959 (GRCm39) Q275* probably null Het
Cfi G A 3: 129,644,497 (GRCm39) probably null Het
Cntn1 G A 15: 92,132,347 (GRCm39) V148M probably damaging Het
Crybg3 T A 16: 59,376,500 (GRCm39) M1585L probably benign Het
D630036H23Rik A G 12: 36,431,441 (GRCm39) S186P unknown Het
Dnhd1 T C 7: 105,301,330 (GRCm39) L229P probably damaging Het
Dtymk A T 1: 93,728,635 (GRCm39) probably benign Het
Eif4g3 T A 4: 137,930,779 (GRCm39) I1511K probably damaging Het
Entrep3 T G 3: 89,091,725 (GRCm39) probably benign Het
Fastkd2 A G 1: 63,775,080 (GRCm39) D342G probably benign Het
Hcar1 A G 5: 124,017,113 (GRCm39) F193L probably damaging Het
Hivep2 T G 10: 14,004,992 (GRCm39) L530R probably damaging Het
Ilrun T C 17: 27,987,043 (GRCm39) T228A probably benign Het
Krtap5-2 TCCACAGGAACTACAGCCTCCCTTGCAGCCCCCACAGGAACCACAGCCCCCACAGGAACTACA TCCACAGGAACTACA 7: 141,728,845 (GRCm39) probably benign Het
Lats2 G A 14: 57,931,781 (GRCm39) T879M probably damaging Het
Lin54 G A 5: 100,600,884 (GRCm39) T503I probably benign Het
Mmp16 T G 4: 18,051,714 (GRCm39) probably benign Het
Muc6 A G 7: 141,229,549 (GRCm39) Y1186H probably damaging Het
Nr3c1 A G 18: 39,619,387 (GRCm39) F300S probably damaging Het
Or2y1g A G 11: 49,171,227 (GRCm39) N84S possibly damaging Het
Or7g21 A C 9: 19,032,922 (GRCm39) I221L possibly damaging Het
Pcdha4 T C 18: 37,086,905 (GRCm39) S363P possibly damaging Het
Ptdss1 C T 13: 67,101,608 (GRCm39) A99V probably benign Het
Ptprz1 T A 6: 22,986,187 (GRCm39) L329Q probably damaging Het
Rnf115 T C 3: 96,695,907 (GRCm39) V231A probably damaging Het
Sh3pxd2a A G 19: 47,257,345 (GRCm39) Y486H probably damaging Het
Shh T A 5: 28,671,487 (GRCm39) N92I possibly damaging Het
Slc13a4 T A 6: 35,245,783 (GRCm39) I621F probably benign Het
Srrm1 T C 4: 135,059,532 (GRCm39) T438A unknown Het
Synj1 A C 16: 90,758,406 (GRCm39) F813V probably damaging Het
Tnrc6a A G 7: 122,783,133 (GRCm39) probably benign Het
Trir T A 8: 85,753,690 (GRCm39) F55I probably damaging Het
Tsr1 A G 11: 74,799,149 (GRCm39) T777A probably damaging Het
Other mutations in Vmn2r5
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00742:Vmn2r5 APN 3 64,398,834 (GRCm39) missense possibly damaging 0.67
IGL01139:Vmn2r5 APN 3 64,398,826 (GRCm39) missense probably benign 0.28
IGL03293:Vmn2r5 APN 3 64,398,747 (GRCm39) missense probably benign 0.01
PIT4581001:Vmn2r5 UTSW 3 64,411,348 (GRCm39) nonsense probably null
R0063:Vmn2r5 UTSW 3 64,411,221 (GRCm39) missense probably benign 0.01
R0142:Vmn2r5 UTSW 3 64,400,009 (GRCm39) missense probably damaging 1.00
R0193:Vmn2r5 UTSW 3 64,398,951 (GRCm39) missense possibly damaging 0.91
R0219:Vmn2r5 UTSW 3 64,411,734 (GRCm39) missense probably damaging 0.99
R0313:Vmn2r5 UTSW 3 64,411,248 (GRCm39) missense probably benign
R0620:Vmn2r5 UTSW 3 64,411,235 (GRCm39) nonsense probably null
R0726:Vmn2r5 UTSW 3 64,411,186 (GRCm39) missense probably benign 0.01
R1073:Vmn2r5 UTSW 3 64,398,726 (GRCm39) nonsense probably null
R1549:Vmn2r5 UTSW 3 64,411,421 (GRCm39) missense probably damaging 1.00
R1581:Vmn2r5 UTSW 3 64,398,640 (GRCm39) missense probably damaging 1.00
R1624:Vmn2r5 UTSW 3 64,417,116 (GRCm39) missense probably benign 0.19
R1973:Vmn2r5 UTSW 3 64,411,642 (GRCm39) missense probably damaging 1.00
R1974:Vmn2r5 UTSW 3 64,411,642 (GRCm39) missense probably damaging 1.00
R1975:Vmn2r5 UTSW 3 64,411,642 (GRCm39) missense probably damaging 1.00
R1977:Vmn2r5 UTSW 3 64,411,642 (GRCm39) missense probably damaging 1.00
R2189:Vmn2r5 UTSW 3 64,417,014 (GRCm39) missense probably benign 0.27
R2484:Vmn2r5 UTSW 3 64,411,392 (GRCm39) missense possibly damaging 0.94
R4573:Vmn2r5 UTSW 3 64,411,339 (GRCm39) missense probably damaging 0.98
R5243:Vmn2r5 UTSW 3 64,411,497 (GRCm39) missense probably damaging 1.00
R5384:Vmn2r5 UTSW 3 64,416,931 (GRCm39) missense probably benign 0.02
R5385:Vmn2r5 UTSW 3 64,416,931 (GRCm39) missense probably benign 0.02
R5587:Vmn2r5 UTSW 3 64,411,497 (GRCm39) missense probably damaging 1.00
R5588:Vmn2r5 UTSW 3 64,411,497 (GRCm39) missense probably damaging 1.00
R5589:Vmn2r5 UTSW 3 64,411,497 (GRCm39) missense probably damaging 1.00
R5590:Vmn2r5 UTSW 3 64,411,497 (GRCm39) missense probably damaging 1.00
R5739:Vmn2r5 UTSW 3 64,411,497 (GRCm39) missense probably damaging 1.00
R6113:Vmn2r5 UTSW 3 64,398,820 (GRCm39) missense probably benign 0.03
R6739:Vmn2r5 UTSW 3 64,398,637 (GRCm39) missense probably damaging 0.97
R7106:Vmn2r5 UTSW 3 64,399,104 (GRCm39) missense probably benign 0.05
R7304:Vmn2r5 UTSW 3 64,411,671 (GRCm39) missense probably damaging 0.97
R7402:Vmn2r5 UTSW 3 64,403,176 (GRCm39) missense probably benign 0.05
R7477:Vmn2r5 UTSW 3 64,399,060 (GRCm39) missense probably damaging 1.00
R7571:Vmn2r5 UTSW 3 64,411,825 (GRCm39) missense probably damaging 1.00
R7678:Vmn2r5 UTSW 3 64,416,943 (GRCm39) missense probably benign
R7874:Vmn2r5 UTSW 3 64,398,453 (GRCm39) missense probably damaging 1.00
R8110:Vmn2r5 UTSW 3 64,398,709 (GRCm39) missense probably benign 0.00
R8223:Vmn2r5 UTSW 3 64,398,726 (GRCm39) nonsense probably null
R8896:Vmn2r5 UTSW 3 64,411,203 (GRCm39) missense probably benign 0.00
R8948:Vmn2r5 UTSW 3 64,398,522 (GRCm39) missense probably damaging 1.00
R8950:Vmn2r5 UTSW 3 64,398,522 (GRCm39) missense probably damaging 1.00
R8962:Vmn2r5 UTSW 3 64,398,564 (GRCm39) missense probably damaging 1.00
R9012:Vmn2r5 UTSW 3 64,411,915 (GRCm39) missense probably damaging 1.00
R9109:Vmn2r5 UTSW 3 64,411,411 (GRCm39) missense possibly damaging 0.58
R9126:Vmn2r5 UTSW 3 64,399,159 (GRCm39) missense probably benign 0.13
R9192:Vmn2r5 UTSW 3 64,398,938 (GRCm39) nonsense probably null
R9221:Vmn2r5 UTSW 3 64,411,721 (GRCm39) nonsense probably null
R9375:Vmn2r5 UTSW 3 64,411,316 (GRCm39) missense probably damaging 1.00
R9529:Vmn2r5 UTSW 3 64,400,018 (GRCm39) missense probably benign 0.06
Z1088:Vmn2r5 UTSW 3 64,416,963 (GRCm39) missense probably benign 0.02
Z1177:Vmn2r5 UTSW 3 64,398,472 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- ACGAGATATTTTCCCGTGCTG -3'
(R):5'- ACAGATAAAGGCTGGATATGACTAC -3'

Sequencing Primer
(F):5'- CCCGTGCTGTTTCTATAATTGG -3'
(R):5'- GGCTGGATATGACTACTATTTGAATC -3'
Posted On 2021-03-08