Mutagenetix > Incidental Mutation

Incidental Mutation 'R8775-TAIL:Iigp1'

668048

Institutional Source

Beutler Lab

Gene Symbol

Iigp1

Ensembl Gene

ENSMUSG00000054072

Gene Name

interferon inducible GTPase 1

Synonyms

2900074L10Rik, Irga6

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.059) question?

Stock #

R8775-TAIL

Quality Score

225.009

Status

Not validated

Chromosome

Chromosomal Location

60509099-60525706 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to C at 60523596 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Tyrosine to Serine at position 238 (Y238S)

Ref Sequence

ENSEMBL: ENSMUSP00000063390 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000032473] [ENSMUST00000066912]

AlphaFold

Q9QZ85

Predicted Effect

probably damaging
Transcript: ENSMUST00000032473
AA Change: Y238S

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000032473
Gene: ENSMUSG00000054072
AA Change: Y238S

Domain	Start	End	E-Value	Type
Pfam:IIGP	35	409	5.5e-182	PFAM
Pfam:MMR_HSR1	71	210	1.4e-7	PFAM

Predicted Effect

probably damaging
Transcript: ENSMUST00000066912
AA Change: Y238S

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000063390
Gene: ENSMUSG00000054072
AA Change: Y238S

Domain	Start	End	E-Value	Type
Pfam:IIGP	35	409	7.9e-182	PFAM
Pfam:MMR_HSR1	71	212	8.2e-9	PFAM

Coding Region Coverage

1x: 100.0%
3x: 100.0%
10x: 99.8%
20x: 99.5%

Validation Efficiency

MGI Phenotype

PHENOTYPE: Targeted deletion of this gene results in partial loss of IFN-gamma-mediated Toxoplasma gondii growth restriction in primary mouse astrocytes. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 42 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adck2	T	C	6: 39,552,142 (GRCm39)		probably null	Het
Alpk3	A	C	7: 80,727,598 (GRCm39)	M243L	probably benign	Het
Anapc1	A	T	2: 128,499,093 (GRCm39)	Y860N	possibly damaging	Het
Asprv1	T	C	6: 86,605,321 (GRCm39)	S56P	probably damaging	Het
Blm	TCC	TCCACC	7: 80,162,679 (GRCm39)		probably benign	Het
D130043K22Rik	G	T	13: 25,040,982 (GRCm39)	E135*	probably null	Het
Dnmt3b	A	G	2: 153,511,711 (GRCm39)	H293R	possibly damaging	Het
Dsg1a	C	T	18: 20,473,564 (GRCm39)	S879L	probably damaging	Het
Fbxo24	C	T	5: 137,611,213 (GRCm39)	A526T	possibly damaging	Het
Fign	A	T	2: 63,810,891 (GRCm39)	D126E	probably benign	Het
Gpr137	A	G	19: 6,915,800 (GRCm39)	F377L	probably damaging	Het
Gsdma2	A	G	11: 98,540,009 (GRCm39)	K44E	probably damaging	Het
Itga8	C	G	2: 12,187,495 (GRCm39)	G728A	probably damaging	Het
Kcnip2	T	C	19: 45,782,149 (GRCm39)	N258S	possibly damaging	Het
Lcat	A	G	8: 106,669,023 (GRCm39)	I84T	possibly damaging	Het
Mansc1	C	T	6: 134,587,631 (GRCm39)	R182H	probably benign	Het
Myh4	T	C	11: 67,148,006 (GRCm39)	M1685T	probably benign	Het
Myo10	T	A	15: 25,800,145 (GRCm39)	V1407E	probably damaging	Het
Ncam2	T	A	16: 81,314,429 (GRCm39)	N468K	probably benign	Het
Nckap1	A	G	2: 80,375,410 (GRCm39)	S297P	probably benign	Het
Nefm	T	C	14: 68,362,108 (GRCm39)	Y52C	probably damaging	Het
Ntng2	A	T	2: 29,117,976 (GRCm39)	N157K	possibly damaging	Het
Oscp1	T	C	4: 125,970,619 (GRCm39)	V136A	probably benign	Het
Oser1	G	A	2: 163,249,004 (GRCm39)	T66I	probably benign	Het
Palld	A	G	8: 62,138,006 (GRCm39)	L583P	possibly damaging	Het
Pex7	A	G	10: 19,760,522 (GRCm39)		probably null	Het
Ppp2r3d	A	G	9: 101,004,204 (GRCm39)	Y378H	probably benign	Het
Prss33	T	A	17: 24,052,885 (GRCm39)	N263I	possibly damaging	Het
Psg25	A	C	7: 18,255,153 (GRCm39)	C454W	probably damaging	Het
Ptpn21	T	C	12: 98,649,001 (GRCm39)		probably null	Het
Sh3bp2	A	T	5: 34,719,751 (GRCm39)	S587C	probably damaging	Het
Sos2	A	G	12: 69,664,006 (GRCm39)	F493L	probably benign	Het
St8sia4	T	A	1: 95,519,472 (GRCm39)	T339S	possibly damaging	Het
Taok1	T	C	11: 77,470,632 (GRCm39)	K58E	probably benign	Het
Thsd1	A	G	8: 22,749,643 (GRCm39)	D838G	possibly damaging	Het
Tulp2	A	G	7: 45,164,914 (GRCm39)	T65A	probably benign	Het
Usp54	A	T	14: 20,638,466 (GRCm39)	S205T	probably benign	Het
Vmn2r16	C	T	5: 109,488,231 (GRCm39)	T368M	probably benign	Het
Vmn2r37	A	T	7: 9,218,991 (GRCm39)	Y464*	probably null	Het
Wdsub1	A	G	2: 59,693,014 (GRCm39)	M300T	probably damaging	Het
Xrcc5	C	T	1: 72,433,089 (GRCm39)	T716I	probably benign	Het
Zfp619	G	T	7: 39,184,639 (GRCm39)	C223F	possibly damaging	Het

Other mutations in Iigp1

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00798:Iigp1	APN	18	60,524,073 (GRCm39)	missense	probably benign	0.01
IGL03323:Iigp1	APN	18	60,522,896 (GRCm39)	missense	probably benign	0.04
R0025:Iigp1	UTSW	18	60,523,859 (GRCm39)	missense	possibly damaging	0.53
R0410:Iigp1	UTSW	18	60,523,375 (GRCm39)	missense	probably benign	0.15
R0564:Iigp1	UTSW	18	60,523,523 (GRCm39)	missense	probably damaging	0.98
R0609:Iigp1	UTSW	18	60,522,896 (GRCm39)	missense	probably benign	0.04
R1549:Iigp1	UTSW	18	60,522,948 (GRCm39)	missense	probably benign
R2226:Iigp1	UTSW	18	60,522,960 (GRCm39)	missense	possibly damaging	0.55
R2264:Iigp1	UTSW	18	60,523,738 (GRCm39)	missense	probably benign	0.20
R3110:Iigp1	UTSW	18	60,523,983 (GRCm39)	missense	probably benign	0.01
R3112:Iigp1	UTSW	18	60,523,983 (GRCm39)	missense	probably benign	0.01
R4575:Iigp1	UTSW	18	60,523,218 (GRCm39)	missense	probably benign	0.02
R4795:Iigp1	UTSW	18	60,522,964 (GRCm39)	missense	probably benign	0.13
R5439:Iigp1	UTSW	18	60,523,329 (GRCm39)	missense	probably damaging	1.00
R6565:Iigp1	UTSW	18	60,523,839 (GRCm39)	missense	probably damaging	1.00
R8775:Iigp1	UTSW	18	60,523,596 (GRCm39)	missense	probably damaging	1.00
R9298:Iigp1	UTSW	18	60,523,063 (GRCm39)	missense	probably benign	0.00
R9520:Iigp1	UTSW	18	60,523,451 (GRCm39)	missense	probably benign

Predicted Primers

Posted On

2021-03-08