Incidental Mutation 'R8776-TAIL:Or7g19'
ID |
668070 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Or7g19
|
Ensembl Gene |
ENSMUSG00000095957 |
Gene Name |
olfactory receptor family 7 subfamily G member 19 |
Synonyms |
GA_x6K02T2PVTD-12687800-12688738, Olfr832, MOR153-1 |
Accession Numbers |
|
Essential gene? |
Probably non essential
(E-score: 0.227)
|
Stock # |
R8776-TAIL
|
Quality Score |
225.009 |
Status
|
Not validated
|
Chromosome |
9 |
Chromosomal Location |
18855946-18856884 bp(+) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
T to A
at 18856286 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Isoleucine to Asparagine
at position 114
(I114N)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000151834
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000060601]
[ENSMUST00000218385]
|
AlphaFold |
Q7TRG9 |
Predicted Effect |
possibly damaging
Transcript: ENSMUST00000060601
AA Change: I114N
PolyPhen 2
Score 0.929 (Sensitivity: 0.81; Specificity: 0.94)
|
SMART Domains |
Protein: ENSMUSP00000056724 Gene: ENSMUSG00000095957 AA Change: I114N
Domain | Start | End | E-Value | Type |
Pfam:7tm_4
|
31 |
308 |
4.1e-51 |
PFAM |
Pfam:7TM_GPCR_Srsx
|
35 |
305 |
3.1e-6 |
PFAM |
Pfam:7tm_1
|
41 |
290 |
1.4e-19 |
PFAM |
|
Predicted Effect |
possibly damaging
Transcript: ENSMUST00000218385
AA Change: I114N
PolyPhen 2
Score 0.929 (Sensitivity: 0.81; Specificity: 0.94)
|
Coding Region Coverage |
- 1x: 100.0%
- 3x: 100.0%
- 10x: 99.8%
- 20x: 99.3%
|
Validation Efficiency |
|
MGI Phenotype |
FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
|
Allele List at MGI |
|
Other mutations in this stock |
Total: 38 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
4930568D16Rik |
A |
G |
2: 35,245,002 (GRCm39) |
Y117H |
probably benign |
Het |
a |
A |
G |
2: 154,892,612 (GRCm39) |
D97G |
probably damaging |
Het |
Cdca7l |
T |
C |
12: 117,836,098 (GRCm39) |
S190P |
probably damaging |
Het |
Chst9 |
T |
A |
18: 15,586,086 (GRCm39) |
Y159F |
possibly damaging |
Het |
Col26a1 |
G |
A |
5: 136,911,708 (GRCm39) |
R52C |
probably damaging |
Het |
Dchs2 |
A |
T |
3: 83,263,701 (GRCm39) |
D3323V |
possibly damaging |
Het |
Dqx1 |
T |
A |
6: 83,035,619 (GRCm39) |
I44N |
probably damaging |
Het |
Edc4 |
A |
G |
8: 106,613,992 (GRCm39) |
D415G |
probably damaging |
Het |
Enpp3 |
T |
A |
10: 24,650,733 (GRCm39) |
D801V |
probably damaging |
Het |
Fam13b |
G |
A |
18: 34,584,446 (GRCm39) |
R573C |
probably damaging |
Het |
Fgfr2 |
A |
T |
7: 129,798,002 (GRCm39) |
I415N |
possibly damaging |
Het |
Gm32742 |
T |
A |
9: 51,067,230 (GRCm39) |
M366L |
probably benign |
Het |
Gm49336 |
A |
T |
14: 60,457,515 (GRCm39) |
S563T |
possibly damaging |
Het |
Gm5475 |
T |
C |
15: 100,324,892 (GRCm39) |
F107L |
unknown |
Het |
Lamp3 |
T |
C |
16: 19,474,252 (GRCm39) |
D374G |
probably damaging |
Het |
Lin9 |
T |
C |
1: 180,496,450 (GRCm39) |
|
probably null |
Het |
Mef2d |
T |
C |
3: 88,074,956 (GRCm39) |
S381P |
probably benign |
Het |
Mfsd9 |
A |
G |
1: 40,812,915 (GRCm39) |
*467Q |
probably null |
Het |
Mpo |
A |
G |
11: 87,693,538 (GRCm39) |
I639V |
possibly damaging |
Het |
Mrgprh |
T |
C |
17: 13,096,375 (GRCm39) |
I205T |
probably benign |
Het |
Ncapd2 |
T |
C |
6: 125,154,476 (GRCm39) |
D580G |
probably benign |
Het |
Nkain4 |
T |
A |
2: 180,585,920 (GRCm39) |
I48F |
probably damaging |
Het |
Notch4 |
C |
A |
17: 34,806,579 (GRCm39) |
R1839S |
probably damaging |
Het |
Nr6a1 |
A |
G |
2: 38,650,244 (GRCm39) |
Y129H |
probably damaging |
Het |
Robo1 |
G |
T |
16: 72,821,141 (GRCm39) |
E1294* |
probably null |
Het |
Septin8 |
A |
G |
11: 53,428,343 (GRCm39) |
K331R |
probably benign |
Het |
Shmt2 |
A |
G |
10: 127,356,785 (GRCm39) |
|
probably null |
Het |
Skint6 |
A |
C |
4: 112,661,885 (GRCm39) |
L1233R |
possibly damaging |
Het |
Slc41a3 |
A |
T |
6: 90,621,165 (GRCm39) |
T402S |
probably benign |
Het |
Slc9a2 |
A |
G |
1: 40,781,889 (GRCm39) |
T373A |
probably damaging |
Het |
Spata31d1b |
T |
C |
13: 59,863,283 (GRCm39) |
C144R |
probably benign |
Het |
Syne1 |
A |
G |
10: 5,181,783 (GRCm39) |
V4184A |
possibly damaging |
Het |
Tenm4 |
G |
A |
7: 96,544,239 (GRCm39) |
R2122H |
probably damaging |
Het |
Tlnrd1 |
A |
T |
7: 83,532,316 (GRCm39) |
D38E |
probably benign |
Het |
Tnnc2 |
C |
T |
2: 164,620,135 (GRCm39) |
A6T |
probably benign |
Het |
Usp9y |
A |
G |
Y: 1,356,320 (GRCm39) |
V1127A |
probably benign |
Het |
Ylpm1 |
T |
C |
12: 85,077,195 (GRCm39) |
Y1307H |
probably damaging |
Het |
Zfp266 |
T |
C |
9: 20,411,509 (GRCm39) |
S223G |
probably benign |
Het |
|
Other mutations in Or7g19 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL03018:Or7g19
|
APN |
9 |
18,856,177 (GRCm39) |
missense |
probably damaging |
0.98 |
IGL03172:Or7g19
|
APN |
9 |
18,856,757 (GRCm39) |
missense |
probably benign |
0.01 |
R0537:Or7g19
|
UTSW |
9 |
18,856,444 (GRCm39) |
missense |
probably damaging |
1.00 |
R1923:Or7g19
|
UTSW |
9 |
18,856,781 (GRCm39) |
missense |
probably benign |
0.21 |
R2226:Or7g19
|
UTSW |
9 |
18,856,177 (GRCm39) |
missense |
probably damaging |
0.98 |
R2234:Or7g19
|
UTSW |
9 |
18,856,112 (GRCm39) |
missense |
probably damaging |
1.00 |
R2402:Or7g19
|
UTSW |
9 |
18,856,496 (GRCm39) |
missense |
probably damaging |
0.98 |
R4060:Or7g19
|
UTSW |
9 |
18,856,346 (GRCm39) |
missense |
probably benign |
0.09 |
R4537:Or7g19
|
UTSW |
9 |
18,856,526 (GRCm39) |
missense |
possibly damaging |
0.85 |
R4715:Or7g19
|
UTSW |
9 |
18,856,742 (GRCm39) |
missense |
probably benign |
0.01 |
R5557:Or7g19
|
UTSW |
9 |
18,856,466 (GRCm39) |
missense |
possibly damaging |
0.94 |
R6001:Or7g19
|
UTSW |
9 |
18,856,340 (GRCm39) |
missense |
probably damaging |
1.00 |
R6172:Or7g19
|
UTSW |
9 |
18,856,042 (GRCm39) |
missense |
probably benign |
0.00 |
R6415:Or7g19
|
UTSW |
9 |
18,856,415 (GRCm39) |
missense |
probably damaging |
1.00 |
R6594:Or7g19
|
UTSW |
9 |
18,856,127 (GRCm39) |
missense |
probably damaging |
0.98 |
R6874:Or7g19
|
UTSW |
9 |
18,856,777 (GRCm39) |
missense |
possibly damaging |
0.95 |
R7801:Or7g19
|
UTSW |
9 |
18,856,555 (GRCm39) |
missense |
probably damaging |
0.97 |
R7818:Or7g19
|
UTSW |
9 |
18,856,305 (GRCm39) |
nonsense |
probably null |
|
R7880:Or7g19
|
UTSW |
9 |
18,856,024 (GRCm39) |
missense |
probably benign |
0.06 |
R7890:Or7g19
|
UTSW |
9 |
18,856,799 (GRCm39) |
missense |
probably benign |
0.10 |
R8352:Or7g19
|
UTSW |
9 |
18,856,459 (GRCm39) |
missense |
possibly damaging |
0.51 |
R8452:Or7g19
|
UTSW |
9 |
18,856,459 (GRCm39) |
missense |
possibly damaging |
0.51 |
R8776:Or7g19
|
UTSW |
9 |
18,856,286 (GRCm39) |
missense |
possibly damaging |
0.93 |
R8931:Or7g19
|
UTSW |
9 |
18,855,920 (GRCm39) |
splice site |
probably benign |
|
R9438:Or7g19
|
UTSW |
9 |
18,856,326 (GRCm39) |
nonsense |
probably null |
|
Z1088:Or7g19
|
UTSW |
9 |
18,856,717 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
Predicted Primers |
|
Posted On |
2021-03-08 |