Incidental Mutation 'R8776-TAIL:Or7g19'
ID 668070
Institutional Source Beutler Lab
Gene Symbol Or7g19
Ensembl Gene ENSMUSG00000095957
Gene Name olfactory receptor family 7 subfamily G member 19
Synonyms GA_x6K02T2PVTD-12687800-12688738, Olfr832, MOR153-1
Accession Numbers
Essential gene? Probably non essential (E-score: 0.227) question?
Stock # R8776-TAIL
Quality Score 225.009
Status Not validated
Chromosome 9
Chromosomal Location 18855946-18856884 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 18856286 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Asparagine at position 114 (I114N)
Ref Sequence ENSEMBL: ENSMUSP00000151834 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000060601] [ENSMUST00000218385]
AlphaFold Q7TRG9
Predicted Effect possibly damaging
Transcript: ENSMUST00000060601
AA Change: I114N

PolyPhen 2 Score 0.929 (Sensitivity: 0.81; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000056724
Gene: ENSMUSG00000095957
AA Change: I114N

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 4.1e-51 PFAM
Pfam:7TM_GPCR_Srsx 35 305 3.1e-6 PFAM
Pfam:7tm_1 41 290 1.4e-19 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000218385
AA Change: I114N

PolyPhen 2 Score 0.929 (Sensitivity: 0.81; Specificity: 0.94)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.8%
  • 20x: 99.3%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 38 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930568D16Rik A G 2: 35,245,002 (GRCm39) Y117H probably benign Het
a A G 2: 154,892,612 (GRCm39) D97G probably damaging Het
Cdca7l T C 12: 117,836,098 (GRCm39) S190P probably damaging Het
Chst9 T A 18: 15,586,086 (GRCm39) Y159F possibly damaging Het
Col26a1 G A 5: 136,911,708 (GRCm39) R52C probably damaging Het
Dchs2 A T 3: 83,263,701 (GRCm39) D3323V possibly damaging Het
Dqx1 T A 6: 83,035,619 (GRCm39) I44N probably damaging Het
Edc4 A G 8: 106,613,992 (GRCm39) D415G probably damaging Het
Enpp3 T A 10: 24,650,733 (GRCm39) D801V probably damaging Het
Fam13b G A 18: 34,584,446 (GRCm39) R573C probably damaging Het
Fgfr2 A T 7: 129,798,002 (GRCm39) I415N possibly damaging Het
Gm32742 T A 9: 51,067,230 (GRCm39) M366L probably benign Het
Gm49336 A T 14: 60,457,515 (GRCm39) S563T possibly damaging Het
Gm5475 T C 15: 100,324,892 (GRCm39) F107L unknown Het
Lamp3 T C 16: 19,474,252 (GRCm39) D374G probably damaging Het
Lin9 T C 1: 180,496,450 (GRCm39) probably null Het
Mef2d T C 3: 88,074,956 (GRCm39) S381P probably benign Het
Mfsd9 A G 1: 40,812,915 (GRCm39) *467Q probably null Het
Mpo A G 11: 87,693,538 (GRCm39) I639V possibly damaging Het
Mrgprh T C 17: 13,096,375 (GRCm39) I205T probably benign Het
Ncapd2 T C 6: 125,154,476 (GRCm39) D580G probably benign Het
Nkain4 T A 2: 180,585,920 (GRCm39) I48F probably damaging Het
Notch4 C A 17: 34,806,579 (GRCm39) R1839S probably damaging Het
Nr6a1 A G 2: 38,650,244 (GRCm39) Y129H probably damaging Het
Robo1 G T 16: 72,821,141 (GRCm39) E1294* probably null Het
Septin8 A G 11: 53,428,343 (GRCm39) K331R probably benign Het
Shmt2 A G 10: 127,356,785 (GRCm39) probably null Het
Skint6 A C 4: 112,661,885 (GRCm39) L1233R possibly damaging Het
Slc41a3 A T 6: 90,621,165 (GRCm39) T402S probably benign Het
Slc9a2 A G 1: 40,781,889 (GRCm39) T373A probably damaging Het
Spata31d1b T C 13: 59,863,283 (GRCm39) C144R probably benign Het
Syne1 A G 10: 5,181,783 (GRCm39) V4184A possibly damaging Het
Tenm4 G A 7: 96,544,239 (GRCm39) R2122H probably damaging Het
Tlnrd1 A T 7: 83,532,316 (GRCm39) D38E probably benign Het
Tnnc2 C T 2: 164,620,135 (GRCm39) A6T probably benign Het
Usp9y A G Y: 1,356,320 (GRCm39) V1127A probably benign Het
Ylpm1 T C 12: 85,077,195 (GRCm39) Y1307H probably damaging Het
Zfp266 T C 9: 20,411,509 (GRCm39) S223G probably benign Het
Other mutations in Or7g19
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL03018:Or7g19 APN 9 18,856,177 (GRCm39) missense probably damaging 0.98
IGL03172:Or7g19 APN 9 18,856,757 (GRCm39) missense probably benign 0.01
R0537:Or7g19 UTSW 9 18,856,444 (GRCm39) missense probably damaging 1.00
R1923:Or7g19 UTSW 9 18,856,781 (GRCm39) missense probably benign 0.21
R2226:Or7g19 UTSW 9 18,856,177 (GRCm39) missense probably damaging 0.98
R2234:Or7g19 UTSW 9 18,856,112 (GRCm39) missense probably damaging 1.00
R2402:Or7g19 UTSW 9 18,856,496 (GRCm39) missense probably damaging 0.98
R4060:Or7g19 UTSW 9 18,856,346 (GRCm39) missense probably benign 0.09
R4537:Or7g19 UTSW 9 18,856,526 (GRCm39) missense possibly damaging 0.85
R4715:Or7g19 UTSW 9 18,856,742 (GRCm39) missense probably benign 0.01
R5557:Or7g19 UTSW 9 18,856,466 (GRCm39) missense possibly damaging 0.94
R6001:Or7g19 UTSW 9 18,856,340 (GRCm39) missense probably damaging 1.00
R6172:Or7g19 UTSW 9 18,856,042 (GRCm39) missense probably benign 0.00
R6415:Or7g19 UTSW 9 18,856,415 (GRCm39) missense probably damaging 1.00
R6594:Or7g19 UTSW 9 18,856,127 (GRCm39) missense probably damaging 0.98
R6874:Or7g19 UTSW 9 18,856,777 (GRCm39) missense possibly damaging 0.95
R7801:Or7g19 UTSW 9 18,856,555 (GRCm39) missense probably damaging 0.97
R7818:Or7g19 UTSW 9 18,856,305 (GRCm39) nonsense probably null
R7880:Or7g19 UTSW 9 18,856,024 (GRCm39) missense probably benign 0.06
R7890:Or7g19 UTSW 9 18,856,799 (GRCm39) missense probably benign 0.10
R8352:Or7g19 UTSW 9 18,856,459 (GRCm39) missense possibly damaging 0.51
R8452:Or7g19 UTSW 9 18,856,459 (GRCm39) missense possibly damaging 0.51
R8776:Or7g19 UTSW 9 18,856,286 (GRCm39) missense possibly damaging 0.93
R8931:Or7g19 UTSW 9 18,855,920 (GRCm39) splice site probably benign
R9438:Or7g19 UTSW 9 18,856,326 (GRCm39) nonsense probably null
Z1088:Or7g19 UTSW 9 18,856,717 (GRCm39) missense possibly damaging 0.69
Predicted Primers
Posted On 2021-03-08