|Institutional Source||Beutler Lab|
|Gene Name||deleted in lung and esophageal cancer 1|
|Is this an essential gene?||Non essential (E-score: 0.000)|
|Stock #||R8481 (G1)|
|Chromosomal Location||119102478-119148246 bp(+) (GRCm38)|
|Type of Mutation||splice site|
|DNA Base Change (assembly)||G to A at 119143267 bp (GRCm38)|
|Amino Acid Change|
|Ref Sequence||ENSEMBL: ENSMUSP00000128874 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000010795] [ENSMUST00000140326] [ENSMUST00000165231]|
|AlphaFold||no structure available at present|
|Meta Mutation Damage Score||0.9756|
|Coding Region Coverage||
|Validation Efficiency||98% (45/46)|
|MGI Phenotype||FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The cytogenetic location of this gene is 3p21.3, and it is located in a region that is commonly deleted in a variety of malignancies. Down-regulation of this gene has been observed in several human cancers including lung, esophageal, renal tumors, and head and neck squamous cell carcinoma. In some cases, reduced expression of this gene in tumor cells is a result of aberrant promoter methylation. Several alternatively spliced transcripts have been observed that contain disrupted coding regions and likely encode nonfunctional proteins.[provided by RefSeq, Mar 2016]|
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Dlec1||
(F):5'- AGGCTACTGTGTTCCTTCCAGG -3'
(R):5'- TCTCTCAAAGAGGACAGGGG -3'
(F):5'- TCCAGGTCATCCCAGCTG -3'
(R):5'- GCAGGGGAGGGAGGTCC -3'