Incidental Mutation 'R8555:Trim5'
| ID |
668206 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Trim5
|
| Ensembl Gene |
ENSMUSG00000060441 |
| Gene Name |
tripartite motif-containing 5 |
| Synonyms |
|
| MMRRC Submission |
068518-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.065)
|
| Stock # |
R8555 (G1)
|
| Quality Score |
72.0078 |
|
Status
|
Validated
|
| Chromosome |
7 |
| Chromosomal Location |
103912593-103937301 bp(-) (GRCm39) |
| Type of Mutation |
splice site (293 bp from exon) |
| DNA Base Change (assembly) |
T to C
at 103927330 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000095781
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000051795]
[ENSMUST00000098179]
|
| AlphaFold |
E9PV98 |
| Predicted Effect |
probably null
Transcript: ENSMUST00000051795
|
| SMART Domains |
Protein: ENSMUSP00000050084
Gene: ENSMUSG00000060441
| Domain | Start | End | E-Value | Type |
|---|
|
RING
|
15 |
58 |
3.64e-7 |
SMART |
|
BBOX
|
91 |
132 |
4.83e-12 |
SMART |
|
coiled coil region
|
172 |
232 |
N/A |
INTRINSIC |
|
Pfam:SPRY
|
349 |
485 |
9.2e-22 |
PFAM |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000098179
|
| SMART Domains |
Protein: ENSMUSP00000095781
Gene: ENSMUSG00000060441
| Domain | Start | End | E-Value | Type |
|---|
|
RING
|
15 |
58 |
3.64e-7 |
SMART |
|
BBOX
|
91 |
132 |
4.83e-12 |
SMART |
|
Pfam:SPRY
|
351 |
493 |
1.6e-13 |
PFAM |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 100.0%
- 10x: 99.8%
- 20x: 99.2%
|
| Validation Efficiency |
100% (35/35) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 35 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 4933405O20Rik |
C |
T |
7: 50,250,010 (GRCm39) |
A348V |
possibly damaging |
Het |
| Alk |
A |
T |
17: 72,228,869 (GRCm39) |
V732E |
probably damaging |
Het |
| Ccdc88a |
T |
C |
11: 29,380,169 (GRCm39) |
S182P |
probably benign |
Het |
| Cyp2c70 |
T |
C |
19: 40,172,345 (GRCm39) |
D99G |
probably benign |
Het |
| Dnah8 |
G |
T |
17: 30,940,084 (GRCm39) |
E1677* |
probably null |
Het |
| Dop1b |
A |
G |
16: 93,568,698 (GRCm39) |
T797A |
probably damaging |
Het |
| Fam181b |
A |
T |
7: 92,729,296 (GRCm39) |
D23V |
probably damaging |
Het |
| Fbxo4 |
A |
T |
15: 3,995,273 (GRCm39) |
V357D |
probably damaging |
Het |
| Gm4924 |
T |
C |
10: 82,213,224 (GRCm39) |
|
probably benign |
Het |
| Grhl2 |
A |
G |
15: 37,233,507 (GRCm39) |
|
probably benign |
Het |
| Magee2 |
A |
T |
X: 103,900,087 (GRCm39) |
L188H |
probably damaging |
Het |
| Matn2 |
A |
G |
15: 34,423,951 (GRCm39) |
K603R |
probably benign |
Het |
| Mfsd6l |
G |
A |
11: 68,447,898 (GRCm39) |
V250I |
probably benign |
Het |
| Mroh9 |
T |
C |
1: 162,899,595 (GRCm39) |
|
probably null |
Het |
| Ntsr1 |
A |
G |
2: 180,180,470 (GRCm39) |
I259V |
probably benign |
Het |
| Ogfr |
GGCCAGAGGACCCCAAAAGCCAGGTGGAGCCAGAGGACCCCAAAAGCCAGGTGGAGCCAGAGGACCCCAAAAGCCAGGTGGAGCCAGAGGACCCCAAAAGCCAGGTGGGGCCAGAGGACCCCCAAAGCCAGGTGG |
GGCCAGAGGACCCCAAAAGCCAGGTGGAGCCAGAGGACCCCAAAAGCCAGGTGGGGCCAGAGGACCCCCAAAGCCAGGTGG |
2: 180,237,059 (GRCm39) |
|
probably benign |
Het |
| Or14j3 |
A |
G |
17: 37,900,540 (GRCm39) |
S235P |
possibly damaging |
Het |
| Or6d14 |
G |
T |
6: 116,534,289 (GRCm39) |
R301L |
probably damaging |
Het |
| Pax2 |
T |
C |
19: 44,750,128 (GRCm39) |
Y72H |
probably damaging |
Het |
| Pcdh10 |
A |
T |
3: 45,334,030 (GRCm39) |
I115F |
probably benign |
Het |
| Pkp4 |
A |
T |
2: 59,138,379 (GRCm39) |
R210* |
probably null |
Het |
| Rftn1 |
G |
T |
17: 50,354,408 (GRCm39) |
A318D |
probably damaging |
Het |
| Rpa2 |
A |
G |
4: 132,499,481 (GRCm39) |
|
probably null |
Het |
| Sec31a |
T |
C |
5: 100,540,273 (GRCm39) |
N471S |
probably benign |
Het |
| Serpinb9g |
A |
T |
13: 33,676,796 (GRCm39) |
T193S |
probably benign |
Het |
| Sh3pxd2b |
C |
T |
11: 32,361,469 (GRCm39) |
T227M |
probably benign |
Het |
| Speg |
A |
G |
1: 75,378,908 (GRCm39) |
|
probably null |
Het |
| Suz12 |
T |
C |
11: 79,922,817 (GRCm39) |
I653T |
probably damaging |
Het |
| Thsd7b |
C |
A |
1: 129,523,191 (GRCm39) |
T75K |
probably damaging |
Het |
| Trav5-1 |
A |
C |
14: 52,860,276 (GRCm39) |
Q27P |
probably damaging |
Het |
| Vmn1r174 |
A |
T |
7: 23,453,970 (GRCm39) |
Y212F |
possibly damaging |
Het |
| Vmn2r110 |
G |
A |
17: 20,804,618 (GRCm39) |
P101S |
probably damaging |
Het |
| Vmn2r17 |
A |
G |
5: 109,600,810 (GRCm39) |
T703A |
probably damaging |
Het |
| Vmn2r84 |
A |
G |
10: 130,230,100 (GRCm39) |
M4T |
probably benign |
Het |
| Zfp709 |
A |
G |
8: 72,643,476 (GRCm39) |
T302A |
probably benign |
Het |
|
| Other mutations in Trim5 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01702:Trim5
|
APN |
7 |
103,928,638 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02165:Trim5
|
APN |
7 |
103,928,566 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02576:Trim5
|
APN |
7 |
103,927,624 (GRCm39) |
missense |
probably damaging |
0.97 |
|
IGL02660:Trim5
|
APN |
7 |
103,915,425 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL02732:Trim5
|
APN |
7 |
103,927,672 (GRCm39) |
missense |
probably benign |
0.02 |
|
R0278:Trim5
|
UTSW |
7 |
103,928,882 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0373:Trim5
|
UTSW |
7 |
103,914,891 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0508:Trim5
|
UTSW |
7 |
103,914,811 (GRCm39) |
missense |
probably null |
0.98 |
|
R0840:Trim5
|
UTSW |
7 |
103,914,978 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0947:Trim5
|
UTSW |
7 |
103,914,958 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1432:Trim5
|
UTSW |
7 |
103,928,728 (GRCm39) |
missense |
probably benign |
|
|
R1432:Trim5
|
UTSW |
7 |
103,928,726 (GRCm39) |
missense |
probably benign |
0.04 |
|
R1770:Trim5
|
UTSW |
7 |
103,925,868 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1782:Trim5
|
UTSW |
7 |
103,915,023 (GRCm39) |
splice site |
probably null |
|
|
R1988:Trim5
|
UTSW |
7 |
103,914,828 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2140:Trim5
|
UTSW |
7 |
103,925,998 (GRCm39) |
nonsense |
probably null |
|
|
R3110:Trim5
|
UTSW |
7 |
103,928,845 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3112:Trim5
|
UTSW |
7 |
103,928,845 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3893:Trim5
|
UTSW |
7 |
103,926,042 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R3948:Trim5
|
UTSW |
7 |
103,915,727 (GRCm39) |
nonsense |
probably null |
|
|
R4114:Trim5
|
UTSW |
7 |
103,914,947 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4249:Trim5
|
UTSW |
7 |
103,926,022 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R4352:Trim5
|
UTSW |
7 |
103,926,015 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4595:Trim5
|
UTSW |
7 |
103,914,639 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5057:Trim5
|
UTSW |
7 |
103,914,630 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5583:Trim5
|
UTSW |
7 |
103,926,042 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R5861:Trim5
|
UTSW |
7 |
103,928,728 (GRCm39) |
missense |
probably benign |
|
|
R5861:Trim5
|
UTSW |
7 |
103,928,726 (GRCm39) |
missense |
probably benign |
0.04 |
|
R7027:Trim5
|
UTSW |
7 |
103,914,875 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7078:Trim5
|
UTSW |
7 |
103,927,681 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R7150:Trim5
|
UTSW |
7 |
103,926,017 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R7657:Trim5
|
UTSW |
7 |
103,925,884 (GRCm39) |
missense |
possibly damaging |
0.51 |
|
R7660:Trim5
|
UTSW |
7 |
103,928,569 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7737:Trim5
|
UTSW |
7 |
103,928,771 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7821:Trim5
|
UTSW |
7 |
103,927,633 (GRCm39) |
missense |
probably benign |
0.32 |
|
R7861:Trim5
|
UTSW |
7 |
103,915,675 (GRCm39) |
critical splice donor site |
probably null |
|
|
R8167:Trim5
|
UTSW |
7 |
103,927,630 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8220:Trim5
|
UTSW |
7 |
103,926,033 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R8296:Trim5
|
UTSW |
7 |
103,914,993 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1088:Trim5
|
UTSW |
7 |
103,915,432 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
| Predicted Primers |
PCR Primer
(F):5'- TACCTACCTCCCTATCTAGACCAGG -3'
(R):5'- GATGAGGCCAGGAAACCTTG -3'
Sequencing Primer
(F):5'- GTTTTACCTTGTAGCTATAGTTGACC -3'
(R):5'- TGAGGCCAGGAAACCTTGATACTC -3'
|
| Posted On |
2021-04-28 |
Incidental Mutation