Incidental Mutation 'R8691:Nynrin'
ID 668388
Institutional Source Beutler Lab
Gene Symbol Nynrin
Ensembl Gene ENSMUSG00000075592
Gene Name NYN domain and retroviral integrase containing
Synonyms
MMRRC Submission 068545-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R8691 (G1)
Quality Score 225.009
Status Validated
Chromosome 14
Chromosomal Location 56091572-56112193 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 56110106 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Arginine to Tryptophan at position 1738 (R1738W)
Ref Sequence ENSEMBL: ENSMUSP00000098098 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000100529] [ENSMUST00000168479]
AlphaFold Q5DTZ0
Predicted Effect probably damaging
Transcript: ENSMUST00000100529
AA Change: R1738W

PolyPhen 2 Score 0.995 (Sensitivity: 0.68; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000098098
Gene: ENSMUSG00000075592
AA Change: R1738W

DomainStartEndE-ValueType
low complexity region 581 606 N/A INTRINSIC
Pfam:RNase_Zc3h12a 739 890 1.6e-54 PFAM
low complexity region 938 952 N/A INTRINSIC
low complexity region 1212 1228 N/A INTRINSIC
low complexity region 1390 1397 N/A INTRINSIC
PDB:3S3O|B 1478 1706 6e-8 PDB
SCOP:d1cxqa_ 1552 1646 2e-12 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000168479
AA Change: R1738W

PolyPhen 2 Score 0.995 (Sensitivity: 0.68; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000129557
Gene: ENSMUSG00000075592
AA Change: R1738W

DomainStartEndE-ValueType
low complexity region 581 606 N/A INTRINSIC
Pfam:RNase_Zc3h12a 739 890 5.5e-54 PFAM
low complexity region 938 952 N/A INTRINSIC
low complexity region 1212 1228 N/A INTRINSIC
low complexity region 1390 1397 N/A INTRINSIC
PDB:3S3O|B 1478 1706 6e-8 PDB
SCOP:d1cxqa_ 1552 1646 2e-12 SMART
Meta Mutation Damage Score 0.6329 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.7%
  • 20x: 99.2%
Validation Efficiency 98% (54/55)
Allele List at MGI
Other mutations in this stock
Total: 57 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
3110082J24Rik G T 5: 30,310,287 (GRCm39) A24E unknown Het
Acap1 A G 11: 69,781,003 (GRCm39) L117P probably damaging Het
Actl6b G A 5: 137,565,585 (GRCm39) G394S probably damaging Het
Actr3b G T 5: 26,030,202 (GRCm39) V177F possibly damaging Het
Adamts6 A G 13: 104,450,839 (GRCm39) T341A probably benign Het
Agbl4 G T 4: 111,520,156 (GRCm39) V474F probably benign Het
Atosa A T 9: 74,917,335 (GRCm39) T652S probably benign Het
Bach1 T C 16: 87,516,517 (GRCm39) S353P probably benign Het
C1qtnf9 G A 14: 61,017,141 (GRCm39) D224N probably damaging Het
Camkmt A T 17: 85,421,260 (GRCm39) N121Y probably damaging Het
Card6 A T 15: 5,129,078 (GRCm39) Y773N possibly damaging Het
Cbfa2t2 C A 2: 154,342,403 (GRCm39) P40T possibly damaging Het
Colec10 A C 15: 54,298,420 (GRCm39) E60D probably benign Het
Cspg4 T C 9: 56,800,280 (GRCm39) V1647A probably benign Het
Cyp2d34 A G 15: 82,502,471 (GRCm39) F222L probably benign Het
Dennd1b A T 1: 138,969,774 (GRCm39) I97F possibly damaging Het
Deptor A C 15: 55,083,596 (GRCm39) D388A possibly damaging Het
Dhx40 T C 11: 86,690,419 (GRCm39) K201E possibly damaging Het
Dnah6 G A 6: 73,145,850 (GRCm39) R854C probably damaging Het
Dock9 T C 14: 121,877,517 (GRCm39) I409V possibly damaging Het
Eif1ad16 T G 12: 87,985,278 (GRCm39) K88N probably damaging Het
Esp31 G T 17: 38,955,592 (GRCm39) L78F possibly damaging Het
Fam98c A T 7: 28,852,889 (GRCm39) V48E probably damaging Het
Fcgbpl1 A T 7: 27,853,264 (GRCm39) E1517V possibly damaging Het
Fgfr1 A T 8: 26,052,253 (GRCm39) D193V possibly damaging Het
Furin C T 7: 80,041,775 (GRCm39) probably benign Het
Gm17078 A T 14: 51,848,693 (GRCm39) F15I probably damaging Het
Grid2 G T 6: 63,480,321 (GRCm39) R45L probably damaging Het
Hecw2 A G 1: 53,904,223 (GRCm39) V1175A probably benign Het
Hspa1b T C 17: 35,176,072 (GRCm39) I638V possibly damaging Het
Ighv6-7 A G 12: 114,419,304 (GRCm39) V100A probably benign Het
Itch G T 2: 155,052,478 (GRCm39) E693* probably null Het
Ivl G A 3: 92,478,823 (GRCm39) S414L unknown Het
Kif5b T A 18: 6,225,787 (GRCm39) N160I probably benign Het
Klhl5 A G 5: 65,306,881 (GRCm39) probably benign Het
Lpin1 C T 12: 16,623,660 (GRCm39) probably benign Het
Malsu1 C A 6: 49,052,171 (GRCm39) H130Q probably benign Het
Naip2 A C 13: 100,297,676 (GRCm39) L787V probably damaging Het
Or11g27 A G 14: 50,770,910 (GRCm39) T14A probably benign Het
Or4e1 A T 14: 52,701,358 (GRCm39) I36N possibly damaging Het
Or51d1 C T 7: 102,347,777 (GRCm39) Q111* probably null Het
Or7e176 T A 9: 20,171,747 (GRCm39) S204T probably benign Het
Pclo A G 5: 14,571,706 (GRCm39) T364A unknown Het
Phlda2 A C 7: 143,056,206 (GRCm39) S8A probably benign Het
Pou3f1 G A 4: 124,551,549 (GRCm39) G17E unknown Het
Ppfibp2 A G 7: 107,346,785 (GRCm39) D899G probably damaging Het
Pskh1 T C 8: 106,639,833 (GRCm39) V171A probably damaging Het
Rictor A G 15: 6,816,513 (GRCm39) T1262A probably damaging Het
Rnf41 T C 10: 128,274,077 (GRCm39) V243A probably benign Het
Slc9c1 T A 16: 45,427,182 (GRCm39) N1162K probably benign Het
Spef2 A T 15: 9,602,005 (GRCm39) L1419* probably null Het
Tenm4 C T 7: 96,555,148 (GRCm39) P2618S probably benign Het
Tnc A G 4: 63,880,313 (GRCm39) C1954R probably damaging Het
Ttll11 T A 2: 35,674,161 (GRCm39) I622F probably damaging Het
Utp25 T C 1: 192,796,110 (GRCm39) E673G probably benign Het
Vmn2r104 A G 17: 20,262,110 (GRCm39) I340T probably damaging Het
Vmn2r110 G T 17: 20,803,404 (GRCm39) D390E probably benign Het
Other mutations in Nynrin
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01020:Nynrin APN 14 56,105,905 (GRCm39) missense probably benign 0.38
IGL01131:Nynrin APN 14 56,110,142 (GRCm39) missense probably damaging 1.00
IGL01357:Nynrin APN 14 56,107,874 (GRCm39) missense probably benign
IGL01537:Nynrin APN 14 56,109,502 (GRCm39) missense possibly damaging 0.87
IGL01583:Nynrin APN 14 56,107,968 (GRCm39) missense probably damaging 1.00
IGL01726:Nynrin APN 14 56,101,611 (GRCm39) missense probably benign
IGL02161:Nynrin APN 14 56,101,441 (GRCm39) missense probably damaging 1.00
IGL02167:Nynrin APN 14 56,100,792 (GRCm39) missense probably damaging 1.00
IGL02247:Nynrin APN 14 56,109,167 (GRCm39) nonsense probably null
IGL02302:Nynrin APN 14 56,105,962 (GRCm39) missense probably benign 0.43
IGL02524:Nynrin APN 14 56,108,931 (GRCm39) missense possibly damaging 0.73
IGL02600:Nynrin APN 14 56,101,449 (GRCm39) missense probably benign 0.38
IGL02639:Nynrin APN 14 56,108,112 (GRCm39) missense probably damaging 1.00
IGL02654:Nynrin APN 14 56,100,716 (GRCm39) missense possibly damaging 0.95
IGL02659:Nynrin APN 14 56,103,554 (GRCm39) unclassified probably benign
IGL02736:Nynrin APN 14 56,108,366 (GRCm39) missense probably damaging 1.00
IGL02949:Nynrin APN 14 56,109,837 (GRCm39) missense probably damaging 0.99
PIT4458001:Nynrin UTSW 14 56,101,425 (GRCm39) missense probably benign 0.39
R0017:Nynrin UTSW 14 56,109,852 (GRCm39) missense probably damaging 1.00
R0078:Nynrin UTSW 14 56,100,789 (GRCm39) missense probably damaging 1.00
R0211:Nynrin UTSW 14 56,109,255 (GRCm39) missense probably benign 0.08
R0211:Nynrin UTSW 14 56,109,255 (GRCm39) missense probably benign 0.08
R0413:Nynrin UTSW 14 56,109,648 (GRCm39) missense possibly damaging 0.90
R0609:Nynrin UTSW 14 56,110,218 (GRCm39) missense probably damaging 1.00
R0626:Nynrin UTSW 14 56,105,492 (GRCm39) missense probably damaging 1.00
R1205:Nynrin UTSW 14 56,091,646 (GRCm39) intron probably benign
R1222:Nynrin UTSW 14 56,100,998 (GRCm39) missense probably benign 0.02
R1385:Nynrin UTSW 14 56,102,356 (GRCm39) missense probably benign 0.00
R1820:Nynrin UTSW 14 56,107,835 (GRCm39) missense possibly damaging 0.95
R1829:Nynrin UTSW 14 56,110,404 (GRCm39) missense possibly damaging 0.50
R1874:Nynrin UTSW 14 56,100,950 (GRCm39) missense probably benign 0.04
R1927:Nynrin UTSW 14 56,101,049 (GRCm39) missense probably benign 0.00
R2233:Nynrin UTSW 14 56,109,524 (GRCm39) missense possibly damaging 0.83
R3018:Nynrin UTSW 14 56,100,867 (GRCm39) missense probably benign 0.00
R3154:Nynrin UTSW 14 56,101,044 (GRCm39) missense possibly damaging 0.46
R3853:Nynrin UTSW 14 56,101,562 (GRCm39) missense probably benign 0.24
R4648:Nynrin UTSW 14 56,110,351 (GRCm39) nonsense probably null
R4722:Nynrin UTSW 14 56,091,852 (GRCm39) missense probably damaging 0.97
R4735:Nynrin UTSW 14 56,107,625 (GRCm39) missense probably benign 0.03
R4736:Nynrin UTSW 14 56,101,454 (GRCm39) missense probably damaging 1.00
R4780:Nynrin UTSW 14 56,100,720 (GRCm39) missense probably damaging 1.00
R4804:Nynrin UTSW 14 56,102,326 (GRCm39) missense probably benign
R4816:Nynrin UTSW 14 56,109,458 (GRCm39) missense probably damaging 1.00
R5307:Nynrin UTSW 14 56,101,263 (GRCm39) missense probably damaging 1.00
R5372:Nynrin UTSW 14 56,105,948 (GRCm39) missense probably benign 0.01
R5432:Nynrin UTSW 14 56,101,923 (GRCm39) missense possibly damaging 0.80
R5800:Nynrin UTSW 14 56,108,088 (GRCm39) missense probably damaging 1.00
R5825:Nynrin UTSW 14 56,101,683 (GRCm39) missense probably benign 0.00
R6149:Nynrin UTSW 14 56,091,780 (GRCm39) missense possibly damaging 0.83
R6244:Nynrin UTSW 14 56,105,485 (GRCm39) missense probably damaging 1.00
R6350:Nynrin UTSW 14 56,105,533 (GRCm39) missense probably benign 0.19
R6379:Nynrin UTSW 14 56,107,848 (GRCm39) missense probably damaging 1.00
R6437:Nynrin UTSW 14 56,109,227 (GRCm39) missense probably benign 0.00
R6501:Nynrin UTSW 14 56,100,989 (GRCm39) missense probably benign
R6702:Nynrin UTSW 14 56,101,935 (GRCm39) missense possibly damaging 0.80
R6703:Nynrin UTSW 14 56,101,935 (GRCm39) missense possibly damaging 0.80
R6907:Nynrin UTSW 14 56,101,335 (GRCm39) missense probably benign 0.20
R6908:Nynrin UTSW 14 56,101,335 (GRCm39) missense probably benign 0.20
R6928:Nynrin UTSW 14 56,101,335 (GRCm39) missense probably benign 0.20
R6934:Nynrin UTSW 14 56,101,335 (GRCm39) missense probably benign 0.20
R6935:Nynrin UTSW 14 56,101,335 (GRCm39) missense probably benign 0.20
R7197:Nynrin UTSW 14 56,109,380 (GRCm39) missense probably benign 0.00
R7204:Nynrin UTSW 14 56,110,190 (GRCm39) missense probably damaging 1.00
R7272:Nynrin UTSW 14 56,107,872 (GRCm39) missense probably damaging 1.00
R7335:Nynrin UTSW 14 56,101,371 (GRCm39) missense probably benign
R7361:Nynrin UTSW 14 56,107,857 (GRCm39) missense possibly damaging 0.71
R7368:Nynrin UTSW 14 56,107,968 (GRCm39) missense probably damaging 1.00
R7443:Nynrin UTSW 14 56,108,873 (GRCm39) missense probably benign 0.18
R7584:Nynrin UTSW 14 56,109,041 (GRCm39) missense probably damaging 1.00
R7677:Nynrin UTSW 14 56,107,693 (GRCm39) missense probably benign
R7723:Nynrin UTSW 14 56,109,502 (GRCm39) missense possibly damaging 0.87
R7776:Nynrin UTSW 14 56,103,420 (GRCm39) missense probably damaging 1.00
R7787:Nynrin UTSW 14 56,107,980 (GRCm39) missense probably benign
R7842:Nynrin UTSW 14 56,102,553 (GRCm39) missense probably damaging 1.00
R7852:Nynrin UTSW 14 56,108,886 (GRCm39) missense probably damaging 0.96
R8040:Nynrin UTSW 14 56,108,982 (GRCm39) missense probably benign 0.01
R8159:Nynrin UTSW 14 56,102,517 (GRCm39) missense probably benign
R8159:Nynrin UTSW 14 56,100,587 (GRCm39) missense probably damaging 0.99
R8258:Nynrin UTSW 14 56,100,815 (GRCm39) missense possibly damaging 0.95
R8259:Nynrin UTSW 14 56,100,815 (GRCm39) missense possibly damaging 0.95
R8343:Nynrin UTSW 14 56,101,248 (GRCm39) missense probably benign
R8504:Nynrin UTSW 14 56,107,703 (GRCm39) missense probably benign 0.01
R8671:Nynrin UTSW 14 56,107,899 (GRCm39) missense possibly damaging 0.52
R8777:Nynrin UTSW 14 56,109,120 (GRCm39) missense probably benign
R8777-TAIL:Nynrin UTSW 14 56,109,120 (GRCm39) missense probably benign
R9041:Nynrin UTSW 14 56,108,753 (GRCm39) missense possibly damaging 0.83
R9346:Nynrin UTSW 14 56,100,495 (GRCm39) missense probably benign 0.01
R9366:Nynrin UTSW 14 56,100,587 (GRCm39) missense probably damaging 0.99
R9690:Nynrin UTSW 14 56,108,204 (GRCm39) missense probably benign 0.00
RF007:Nynrin UTSW 14 56,103,658 (GRCm39) splice site probably null
Predicted Primers PCR Primer
(F):5'- ATTCAAGAGGGCCCTGAAGG -3'
(R):5'- ACCGGTCCCCAATATAGAAAGG -3'

Sequencing Primer
(F):5'- GGCCCTGAAGGAGTTCATCTTTC -3'
(R):5'- GGACCCATCCATTTGGCACTG -3'
Posted On 2021-04-30