Incidental Mutation 'R8693:Trappc3l'
ID 668511
Institutional Source Beutler Lab
Gene Symbol Trappc3l
Ensembl Gene ENSMUSG00000071340
Gene Name trafficking protein particle complex 3 like
Synonyms ENSMUSG00000071340, Bet3l
MMRRC Submission 068547-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.154) question?
Stock # R8693 (G1)
Quality Score 225.009
Status Not validated
Chromosome 10
Chromosomal Location 33913593-33985811 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 33974917 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Cysteine to Tyrosine at position 133 (C133Y)
Ref Sequence ENSEMBL: ENSMUSP00000093432 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000069125] [ENSMUST00000095758]
AlphaFold Q4KL14
Predicted Effect probably benign
Transcript: ENSMUST00000069125
SMART Domains Protein: ENSMUSP00000064462
Gene: ENSMUSG00000049872

DomainStartEndE-ValueType
Pfam:Ca_hom_mod 1 251 2.7e-90 PFAM
low complexity region 290 299 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000095758
AA Change: C133Y

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000093432
Gene: ENSMUSG00000071340
AA Change: C133Y

DomainStartEndE-ValueType
Pfam:TRAPP 19 167 2.5e-36 PFAM
low complexity region 169 181 N/A INTRINSIC
Predicted Effect
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.6%
  • 20x: 98.8%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 60 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcc2 T C 19: 43,810,474 (GRCm39) S924P probably benign Het
Acacb A G 5: 114,364,844 (GRCm39) H1508R probably damaging Het
Adam34 T C 8: 44,104,641 (GRCm39) M335V probably benign Het
Akap8 A T 17: 32,529,625 (GRCm39) N438K probably damaging Het
Alpi C A 1: 87,026,405 (GRCm39) G529C unknown Het
Arhgap30 T C 1: 171,225,094 (GRCm39) V50A probably damaging Het
Armh1 T C 4: 117,088,960 (GRCm39) E145G probably damaging Het
Ccdc177 A G 12: 80,804,582 (GRCm39) L564P unknown Het
Cdk12 C T 11: 98,141,133 (GRCm39) P1458L unknown Het
Chek1 A G 9: 36,625,140 (GRCm39) F314L probably benign Het
Cndp1 T C 18: 84,646,938 (GRCm39) D250G probably damaging Het
Cnot3 T C 7: 3,656,522 (GRCm39) V239A probably benign Het
Cplane1 T C 15: 8,258,492 (GRCm39) M2246T probably benign Het
Crhr2 A G 6: 55,079,779 (GRCm39) F187S possibly damaging Het
Dchs2 T A 3: 83,192,631 (GRCm39) V1692D probably damaging Het
Dctd T A 8: 48,565,046 (GRCm39) I57N probably damaging Het
Dennd5b A T 6: 148,911,272 (GRCm39) L977* probably null Het
Dhrs13 G C 11: 77,923,492 (GRCm39) R70P possibly damaging Het
Dysf T C 6: 84,088,952 (GRCm39) S865P probably damaging Het
Eif2ak3 A T 6: 70,858,535 (GRCm39) I275F possibly damaging Het
Eif2ak4 T A 2: 118,262,718 (GRCm39) I757N probably damaging Het
Exog A G 9: 119,276,108 (GRCm39) Q110R possibly damaging Het
Fbxl4 T C 4: 22,403,704 (GRCm39) C426R probably benign Het
Fndc11 A C 2: 180,863,864 (GRCm39) H223P probably damaging Het
Frmd3 T A 4: 74,080,286 (GRCm39) S334R probably damaging Het
Galnt14 A T 17: 73,833,257 (GRCm39) I239N probably damaging Het
Gm5930 C T 14: 44,576,015 (GRCm39) M1I probably null Het
Igkv4-63 A G 6: 69,355,051 (GRCm39) S77P probably benign Het
Igkv5-48 G A 6: 69,703,779 (GRCm39) S42F probably damaging Het
Kalrn T A 16: 33,854,884 (GRCm39) Y1992F probably damaging Het
Kmt2a T C 9: 44,721,981 (GRCm39) Y3788C unknown Het
Lgals4 C T 7: 28,540,921 (GRCm39) R282C probably damaging Het
Lpo T C 11: 87,700,066 (GRCm39) N525S probably benign Het
Med1 T C 11: 98,046,599 (GRCm39) H1399R unknown Het
Mga T A 2: 119,794,407 (GRCm39) V2697E possibly damaging Het
Msto1 T C 3: 88,819,184 (GRCm39) T188A probably benign Het
Nrap T C 19: 56,310,384 (GRCm39) H1456R probably damaging Het
Or10d1 G T 9: 39,483,800 (GRCm39) P252T probably damaging Het
Pbld1 A T 10: 62,910,890 (GRCm39) K248* probably null Het
Pcdhb12 G A 18: 37,570,474 (GRCm39) R540H probably benign Het
Pcx G T 19: 4,652,039 (GRCm39) A96S probably damaging Het
Plcb1 A G 2: 135,094,696 (GRCm39) I174V probably benign Het
Psme3 T C 11: 101,211,422 (GRCm39) I193T probably damaging Het
Pygl A T 12: 70,244,180 (GRCm39) M587K probably benign Het
Rph3a A T 5: 121,100,501 (GRCm39) H132Q probably damaging Het
Scrib C A 15: 75,936,354 (GRCm39) D501Y probably damaging Het
Sdad1 C A 5: 92,452,857 (GRCm39) R127L probably benign Het
Setdb1 T C 3: 95,249,041 (GRCm39) T356A probably damaging Het
Sh3bgrl3 T C 4: 133,855,116 (GRCm39) D73G probably benign Het
Sipa1l1 G T 12: 82,216,517 (GRCm39) probably benign Het
Slc17a8 G A 10: 89,428,758 (GRCm39) A261V probably benign Het
Sox6 T A 7: 115,261,632 (GRCm39) I195F probably damaging Het
Syne1 T C 10: 5,090,928 (GRCm39) K809E possibly damaging Het
Tmem30c G A 16: 57,086,855 (GRCm39) T316M probably damaging Het
Tnfrsf19 T C 14: 61,208,451 (GRCm39) T357A probably benign Het
Top2a T A 11: 98,900,868 (GRCm39) T574S probably damaging Het
Unk C T 11: 115,938,640 (GRCm39) T81I probably damaging Het
Vamp1 G A 6: 125,217,388 (GRCm39) R144K unknown Het
Wnt9b T C 11: 103,624,487 (GRCm39) N101S probably damaging Het
Wwtr1 T A 3: 57,369,945 (GRCm39) D390V probably damaging Het
Other mutations in Trappc3l
AlleleSourceChrCoordTypePredicted EffectPPH Score
R0240:Trappc3l UTSW 10 33,974,928 (GRCm39) nonsense probably null
R0240:Trappc3l UTSW 10 33,974,928 (GRCm39) nonsense probably null
R4775:Trappc3l UTSW 10 33,974,807 (GRCm39) missense probably benign 0.00
R5654:Trappc3l UTSW 10 33,978,703 (GRCm39) missense unknown
R8707:Trappc3l UTSW 10 33,978,727 (GRCm39) missense unknown
R9036:Trappc3l UTSW 10 33,932,786 (GRCm39) unclassified probably benign
Predicted Primers PCR Primer
(F):5'- AGCTTCTGTTGAGACTAAGTGC -3'
(R):5'- CCCAGGATGAGGCTGAATTC -3'

Sequencing Primer
(F):5'- GACCTGCCACAATTCAAG -3'
(R):5'- TACAGCACAGACTTGGCCTTG -3'
Posted On 2021-04-30