Incidental Mutation 'R8694:Or8h10'
ID 668545
Institutional Source Beutler Lab
Gene Symbol Or8h10
Ensembl Gene ENSMUSG00000070875
Gene Name olfactory receptor family 8 subfamily H member 10
Synonyms Olfr1100, GA_x6K02T2Q125-48465387-48464422, MOR206-4
MMRRC Submission 068548-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.101) question?
Stock # R8694 (G1)
Quality Score 225.009
Status Validated
Chromosome 2
Chromosomal Location 86808173-86809138 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 86808591 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Proline to Leucine at position 183 (P183L)
Ref Sequence ENSEMBL: ENSMUSP00000151088 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000094913] [ENSMUST00000117211]
AlphaFold Q8VFM1
Predicted Effect probably damaging
Transcript: ENSMUST00000094913
AA Change: P183L

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
SMART Domains Protein: ENSMUSP00000092517
Gene: ENSMUSG00000070875
AA Change: P183L

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 1.7e-51 PFAM
Pfam:7tm_1 41 314 2.3e-19 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000117211
AA Change: P183L

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.8%
  • 20x: 99.3%
Validation Efficiency 98% (51/52)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 53 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adar T C 3: 89,642,950 (GRCm39) L277P probably damaging Het
Adgrb3 C A 1: 25,865,472 (GRCm39) D124Y probably damaging Het
Afdn T C 17: 14,108,641 (GRCm39) V1403A probably benign Het
Afg3l1 T C 8: 124,227,973 (GRCm39) V586A probably damaging Het
Ajm1 A G 2: 25,469,831 (GRCm39) S27P possibly damaging Het
Aloxe3 A G 11: 69,033,677 (GRCm39) D597G probably damaging Het
Asb15 T C 6: 24,570,666 (GRCm39) V548A probably benign Het
Atp6v1a C T 16: 43,921,991 (GRCm39) R388Q probably damaging Het
Btbd8 A G 5: 107,658,635 (GRCm39) D1735G probably benign Het
C130074G19Rik G A 1: 184,615,184 (GRCm39) T2M probably damaging Het
Ccdc187 T C 2: 26,165,505 (GRCm39) T884A probably benign Het
Cdk5rap1 G A 2: 154,195,148 (GRCm39) R356* probably null Het
Cebpz A T 17: 79,234,334 (GRCm39) H725Q probably damaging Het
Celsr2 T C 3: 108,314,176 (GRCm39) D1283G probably damaging Het
Cldn11 G T 3: 31,217,239 (GRCm39) V136F probably damaging Het
Cpxm2 T C 7: 131,681,783 (GRCm39) N249D probably benign Het
Ctsz T C 2: 174,280,072 (GRCm39) N67D probably benign Het
Drd3 A C 16: 43,643,075 (GRCm39) H405P probably damaging Het
F2rl2 T C 13: 95,837,339 (GRCm39) V128A probably benign Het
Fh1 C T 1: 175,448,126 (GRCm39) P43S probably benign Het
Fndc7 C T 3: 108,779,622 (GRCm39) W307* probably null Het
Gmip G T 8: 70,270,485 (GRCm39) V732L probably benign Het
Heatr4 A G 12: 84,027,038 (GRCm39) F73S probably damaging Het
Iqcf4 T C 9: 106,448,111 (GRCm39) probably benign Het
Itln1 T A 1: 171,359,279 (GRCm39) Q67L probably damaging Het
Jak1 A G 4: 101,013,704 (GRCm39) V1008A probably damaging Het
Kcnh1 A T 1: 191,921,031 (GRCm39) probably benign Het
Kcnu1 T G 8: 26,342,101 (GRCm39) probably benign Het
Kif1b A G 4: 149,305,024 (GRCm39) S967P probably damaging Het
Klra17 A G 6: 129,851,780 (GRCm39) S31P probably benign Het
Kmt2d C T 15: 98,742,615 (GRCm39) E4182K unknown Het
Lama5 T C 2: 179,822,677 (GRCm39) D2825G probably damaging Het
Lmtk2 T C 5: 144,108,566 (GRCm39) V336A probably damaging Het
Mad1l1 A G 5: 140,074,438 (GRCm39) I584T probably benign Het
Magea1 T A X: 153,871,787 (GRCm39) N313I possibly damaging Het
Mapt T C 11: 104,189,440 (GRCm39) S153P probably benign Het
Myo1e T C 9: 70,291,172 (GRCm39) Y988H probably benign Het
Ndufc2 A T 7: 97,049,403 (GRCm39) N3I probably benign Het
Nos2 T A 11: 78,836,515 (GRCm39) V531D possibly damaging Het
Npbwr1 T A 1: 5,986,617 (GRCm39) Y299F probably damaging Het
Or4a39 A G 2: 89,237,378 (GRCm39) L15P probably damaging Het
Or4a70 A G 2: 89,324,171 (GRCm39) Y162H possibly damaging Het
Or52n20 G T 7: 104,320,296 (GRCm39) C129F probably damaging Het
Pp2d1 T C 17: 53,815,191 (GRCm39) Y511C probably benign Het
Psmb4 T C 3: 94,793,435 (GRCm39) N149D probably benign Het
Setbp1 T C 18: 78,901,516 (GRCm39) K717R probably damaging Het
Slc25a11 T C 11: 70,535,630 (GRCm39) M303V probably benign Het
Spesp1 A T 9: 62,180,242 (GRCm39) M222K probably benign Het
Tmem132d A G 5: 127,869,495 (GRCm39) M613T probably benign Het
Ugt2a2 A G 5: 87,612,029 (GRCm39) F294L probably damaging Het
Usp34 A G 11: 23,434,161 (GRCm39) T3246A Het
Zfp750 T A 11: 121,404,456 (GRCm39) I140F possibly damaging Het
Zscan4e A T 7: 11,041,574 (GRCm39) H127Q possibly damaging Het
Other mutations in Or8h10
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02387:Or8h10 APN 2 86,808,193 (GRCm39) nonsense probably null
R0102:Or8h10 UTSW 2 86,808,549 (GRCm39) missense possibly damaging 0.90
R0477:Or8h10 UTSW 2 86,808,567 (GRCm39) missense probably damaging 0.99
R0586:Or8h10 UTSW 2 86,809,126 (GRCm39) missense probably damaging 0.99
R0743:Or8h10 UTSW 2 86,808,843 (GRCm39) missense probably benign 0.12
R1163:Or8h10 UTSW 2 86,809,020 (GRCm39) missense probably damaging 1.00
R1640:Or8h10 UTSW 2 86,808,963 (GRCm39) missense probably damaging 1.00
R2865:Or8h10 UTSW 2 86,808,805 (GRCm39) missense possibly damaging 0.56
R4478:Or8h10 UTSW 2 86,808,562 (GRCm39) missense probably benign
R4548:Or8h10 UTSW 2 86,809,014 (GRCm39) missense probably damaging 0.98
R4618:Or8h10 UTSW 2 86,808,618 (GRCm39) missense possibly damaging 0.87
R4829:Or8h10 UTSW 2 86,808,918 (GRCm39) missense probably damaging 0.99
R4858:Or8h10 UTSW 2 86,808,693 (GRCm39) missense probably damaging 1.00
R5071:Or8h10 UTSW 2 86,808,666 (GRCm39) missense possibly damaging 0.88
R5072:Or8h10 UTSW 2 86,808,666 (GRCm39) missense possibly damaging 0.88
R5073:Or8h10 UTSW 2 86,808,666 (GRCm39) missense possibly damaging 0.88
R5074:Or8h10 UTSW 2 86,808,666 (GRCm39) missense possibly damaging 0.88
R5574:Or8h10 UTSW 2 86,808,867 (GRCm39) missense probably benign 0.00
R5735:Or8h10 UTSW 2 86,809,044 (GRCm39) missense probably benign 0.08
R5874:Or8h10 UTSW 2 86,808,786 (GRCm39) missense probably damaging 0.99
R6228:Or8h10 UTSW 2 86,809,035 (GRCm39) missense probably damaging 1.00
R6689:Or8h10 UTSW 2 86,808,498 (GRCm39) missense probably benign 0.36
R6979:Or8h10 UTSW 2 86,808,577 (GRCm39) missense probably damaging 1.00
R7006:Or8h10 UTSW 2 86,808,303 (GRCm39) missense probably damaging 0.99
R7274:Or8h10 UTSW 2 86,808,867 (GRCm39) missense probably benign 0.00
R7399:Or8h10 UTSW 2 86,808,501 (GRCm39) missense probably benign 0.19
R7560:Or8h10 UTSW 2 86,809,122 (GRCm39) missense probably benign 0.00
R7765:Or8h10 UTSW 2 86,808,538 (GRCm39) missense probably damaging 0.98
R8381:Or8h10 UTSW 2 86,808,373 (GRCm39) missense probably benign 0.36
R8390:Or8h10 UTSW 2 86,808,501 (GRCm39) missense probably benign 0.19
Predicted Primers PCR Primer
(F):5'- AAGTGGAGAAGGCTTTGTGC -3'
(R):5'- CTCTTGGCTGCTGCTGAATG -3'

Sequencing Primer
(F):5'- AAGGCTTTGTGCTTTCCTGAAG -3'
(R):5'- CAATGGCCTATGATAGATATGTGGC -3'
Posted On 2021-04-30