Incidental Mutation 'R8696:Or11g1'
ID 668731
Institutional Source Beutler Lab
Gene Symbol Or11g1
Ensembl Gene ENSMUSG00000094692
Gene Name olfactory receptor family 11 subfamily G member 1
Synonyms GA_x6K02T2PMLR-6110726-6111661, Olfr738, MOR106-3
MMRRC Submission 068550-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.088) question?
Stock # R8696 (G1)
Quality Score 225.009
Status Not validated
Chromosome 14
Chromosomal Location 50651003-50651938 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 50651420 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Valine at position 140 (M140V)
Ref Sequence ENSEMBL: ENSMUSP00000150067 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000058972] [ENSMUST00000214320] [ENSMUST00000214853] [ENSMUST00000216949]
AlphaFold L7N1X7
Predicted Effect possibly damaging
Transcript: ENSMUST00000058972
AA Change: M140V

PolyPhen 2 Score 0.946 (Sensitivity: 0.80; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000059540
Gene: ENSMUSG00000094692
AA Change: M140V

DomainStartEndE-ValueType
Pfam:7tm_4 35 311 2.5e-50 PFAM
Pfam:7TM_GPCR_Srsx 39 309 1.3e-5 PFAM
Pfam:7tm_1 45 294 6.9e-22 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000214320
AA Change: M140V

PolyPhen 2 Score 0.946 (Sensitivity: 0.80; Specificity: 0.95)
Predicted Effect possibly damaging
Transcript: ENSMUST00000214853
AA Change: M140V

PolyPhen 2 Score 0.946 (Sensitivity: 0.80; Specificity: 0.95)
Predicted Effect probably benign
Transcript: ENSMUST00000216949
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.8%
  • 20x: 99.3%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 80 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adcy8 T C 15: 64,687,235 (GRCm39) N423S probably benign Het
Adgrl4 T C 3: 151,248,344 (GRCm39) L672P probably damaging Het
Akr1b10 C T 6: 34,369,067 (GRCm39) T182I possibly damaging Het
Ankrd33 A G 15: 101,014,864 (GRCm39) I84V probably benign Het
Arhgap32 A G 9: 32,159,799 (GRCm39) Y272C possibly damaging Het
Arid4a T C 12: 71,110,090 (GRCm39) S144P probably damaging Het
Bicd1 A G 6: 149,415,285 (GRCm39) D666G probably damaging Het
Blk A T 14: 63,618,149 (GRCm39) probably benign Het
Btbd2 C T 10: 80,480,515 (GRCm39) R366Q possibly damaging Het
Cacna1i T C 15: 80,266,175 (GRCm39) V1554A probably damaging Het
Camsap3 T C 8: 3,653,614 (GRCm39) L428P probably damaging Het
Ccdc30 T G 4: 119,234,505 (GRCm39) Y69S possibly damaging Het
Ccdc7a T A 8: 129,715,244 (GRCm39) E280V probably damaging Het
Cdk11b T C 4: 155,732,779 (GRCm39) V539A unknown Het
Ceacam3 A T 7: 16,893,937 (GRCm39) N483Y Het
Cenpf C T 1: 189,390,194 (GRCm39) A1213T probably benign Het
Chrna6 G T 8: 27,897,195 (GRCm39) Y227* probably null Het
Cntnap5c A T 17: 58,601,294 (GRCm39) D814V probably damaging Het
Csl A T 10: 99,594,826 (GRCm39) Y80N probably damaging Het
Ctsm A G 13: 61,685,521 (GRCm39) L297P probably damaging Het
Cyp4a31 G A 4: 115,422,225 (GRCm39) E70K probably benign Het
Dhx8 T C 11: 101,623,958 (GRCm39) V31A unknown Het
Dis3l2 G T 1: 86,719,162 (GRCm39) G131* probably null Het
Dkk1 G A 19: 30,526,688 (GRCm39) A31V probably damaging Het
Dlx3 C T 11: 95,012,596 (GRCm39) R130* probably null Het
Dnajc24 T C 2: 105,832,315 (GRCm39) M23V probably benign Het
Dnmbp T A 19: 43,862,662 (GRCm39) N76I probably damaging Het
Ezh1 T C 11: 101,100,305 (GRCm39) N226S probably benign Het
Fabp9 C T 3: 10,259,047 (GRCm39) V120M possibly damaging Het
Fcrlb A G 1: 170,739,648 (GRCm39) C85R probably damaging Het
Gnai2 A C 9: 107,496,968 (GRCm39) L131R Het
Gprin1 A G 13: 54,885,764 (GRCm39) W837R probably damaging Het
Grm3 C T 5: 9,562,311 (GRCm39) C513Y probably damaging Het
H60c T A 10: 3,210,265 (GRCm39) I95F possibly damaging Het
Hecw1 A G 13: 14,531,743 (GRCm39) V177A possibly damaging Het
Herc6 T A 6: 57,624,134 (GRCm39) C635S probably benign Het
Itga4 A T 2: 79,112,125 (GRCm39) M347L probably benign Het
Kif20b A G 19: 34,914,752 (GRCm39) H436R probably benign Het
Klrg2 G T 6: 38,613,430 (GRCm39) P191Q possibly damaging Het
Krt5 A G 15: 101,618,742 (GRCm39) Y340H probably damaging Het
Map9 T A 3: 82,270,668 (GRCm39) H77Q possibly damaging Het
Mfsd13a A G 19: 46,356,557 (GRCm39) T221A probably benign Het
Myo10 C G 15: 25,799,572 (GRCm39) H1378Q probably damaging Het
Nkx6-1 T C 5: 101,807,513 (GRCm39) T290A possibly damaging Het
Nlgn3 T C X: 100,352,390 (GRCm39) V179A probably damaging Het
Notch1 T A 2: 26,368,004 (GRCm39) probably benign Het
Nr1d2 A T 14: 18,216,661 (GRCm38) M169K probably damaging Het
Or10ak8 C T 4: 118,774,635 (GRCm39) V10I probably benign Het
Or13c7c A G 4: 43,836,193 (GRCm39) V99A probably benign Het
Or6c69b A T 10: 129,626,562 (GRCm39) F299I possibly damaging Het
Or8b41 A G 9: 38,054,433 (GRCm39) M1V probably null Het
Pdia6 T A 12: 17,329,662 (GRCm39) I266K probably damaging Het
Phactr4 T C 4: 132,091,105 (GRCm39) probably null Het
Polr1b T A 2: 128,967,571 (GRCm39) L988Q probably damaging Het
Por A T 5: 135,763,112 (GRCm39) M541L probably benign Het
Ppid T C 3: 79,498,689 (GRCm39) probably benign Het
Prp2 A T 6: 132,577,322 (GRCm39) Q203L unknown Het
Psme4 T G 11: 30,759,896 (GRCm39) F340V probably damaging Het
Ptges2 T C 2: 32,290,077 (GRCm39) S164P probably damaging Het
Rab18 G A 18: 6,788,635 (GRCm39) G201S probably damaging Het
Rbm19 A G 5: 120,265,132 (GRCm39) E391G probably damaging Het
Rcbtb2 T G 14: 73,404,305 (GRCm39) V259G probably damaging Het
Rpn1 C A 6: 88,080,359 (GRCm39) Q553K possibly damaging Het
Sash1 A G 10: 8,609,459 (GRCm39) S697P probably damaging Het
Sdad1 T G 5: 92,437,645 (GRCm39) H603P probably damaging Het
Serpini1 T C 3: 75,520,544 (GRCm39) L47P probably damaging Het
Sorbs2 T A 8: 46,248,686 (GRCm39) S646T possibly damaging Het
Spdye4a T A 5: 143,210,754 (GRCm39) E105D probably benign Het
Srsf12 G A 4: 33,231,181 (GRCm39) C230Y possibly damaging Het
Stard9 A T 2: 120,531,595 (GRCm39) R2617S probably benign Het
Tas2r118 G T 6: 23,969,344 (GRCm39) T239K probably damaging Het
Tlr1 A G 5: 65,084,094 (GRCm39) L161P probably benign Het
Ttc21a T G 9: 119,772,977 (GRCm39) V218G possibly damaging Het
Ttc6 T C 12: 57,784,492 (GRCm39) S1854P probably benign Het
Unc93a A G 17: 13,341,852 (GRCm39) L93P probably damaging Het
Vcan A T 13: 89,839,217 (GRCm39) I2109N probably benign Het
Vmn1r225 A T 17: 20,723,419 (GRCm39) S287C probably damaging Het
Vmn1r43 A G 6: 89,847,321 (GRCm39) F55S probably damaging Het
Zfp772 T C 7: 7,208,518 (GRCm39) T109A possibly damaging Het
Zfp87 A G 13: 74,520,599 (GRCm39) Y160H probably damaging Het
Other mutations in Or11g1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01608:Or11g1 APN 14 50,651,910 (GRCm39) missense probably benign
IGL01935:Or11g1 APN 14 50,651,012 (GRCm39) missense probably benign
IGL02431:Or11g1 APN 14 50,651,226 (GRCm39) missense probably damaging 1.00
BB008:Or11g1 UTSW 14 50,651,786 (GRCm39) missense probably damaging 0.96
BB018:Or11g1 UTSW 14 50,651,786 (GRCm39) missense probably damaging 0.96
PIT4480001:Or11g1 UTSW 14 50,651,372 (GRCm39) missense probably benign 0.14
R0620:Or11g1 UTSW 14 50,651,154 (GRCm39) missense probably benign 0.20
R1445:Or11g1 UTSW 14 50,651,858 (GRCm39) missense probably damaging 1.00
R1831:Or11g1 UTSW 14 50,651,658 (GRCm39) splice site probably null
R1915:Or11g1 UTSW 14 50,651,798 (GRCm39) missense probably damaging 1.00
R4748:Or11g1 UTSW 14 50,651,333 (GRCm39) missense possibly damaging 0.77
R5301:Or11g1 UTSW 14 50,651,030 (GRCm39) missense probably benign 0.09
R5767:Or11g1 UTSW 14 50,651,235 (GRCm39) missense possibly damaging 0.55
R5831:Or11g1 UTSW 14 50,651,439 (GRCm39) splice site probably null
R6173:Or11g1 UTSW 14 50,651,654 (GRCm39) missense possibly damaging 0.70
R6176:Or11g1 UTSW 14 50,651,847 (GRCm39) missense probably damaging 1.00
R7356:Or11g1 UTSW 14 50,651,159 (GRCm39) missense probably damaging 1.00
R7678:Or11g1 UTSW 14 50,651,471 (GRCm39) missense probably damaging 0.98
R7931:Or11g1 UTSW 14 50,651,786 (GRCm39) missense probably damaging 0.96
R8508:Or11g1 UTSW 14 50,651,132 (GRCm39) missense probably benign 0.00
R9374:Or11g1 UTSW 14 50,651,625 (GRCm39) missense probably benign 0.38
R9470:Or11g1 UTSW 14 50,651,235 (GRCm39) missense possibly damaging 0.55
R9551:Or11g1 UTSW 14 50,651,625 (GRCm39) missense probably benign 0.38
Predicted Primers PCR Primer
(F):5'- AACATGTTGGCCAACTTCCTC -3'
(R):5'- CATTACTAGAGCATAAGACCCCATG -3'

Sequencing Primer
(F):5'- ACTTCCTCTCTGACACGAAGG -3'
(R):5'- GGGAACTTAAAGTAGAGCTAGTCATC -3'
Posted On 2021-04-30