Incidental Mutation 'R8696:Myo10'
| ID |
668734 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Myo10
|
| Ensembl Gene |
ENSMUSG00000022272 |
| Gene Name |
myosin X |
| Synonyms |
myosin-X, D15Ertd600e |
| MMRRC Submission |
068550-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R8696 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
15 |
| Chromosomal Location |
25622636-25813759 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
C to G
at 25799572 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Histidine to Glutamine
at position 1378
(H1378Q)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000106087
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000022882]
[ENSMUST00000110457]
|
| AlphaFold |
F8VQB6 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000022882
AA Change: H632Q
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000022882
Gene: ENSMUSG00000022272
AA Change: H632Q
| Domain | Start | End | E-Value | Type |
|---|
|
IQ
|
1 |
17 |
7.83e1 |
SMART |
|
IQ
|
18 |
40 |
1.06e0 |
SMART |
|
IQ
|
41 |
63 |
7.07e-2 |
SMART |
|
PDB:2LW9|B
|
136 |
171 |
7e-13 |
PDB |
|
low complexity region
|
172 |
186 |
N/A |
INTRINSIC |
|
low complexity region
|
213 |
235 |
N/A |
INTRINSIC |
|
low complexity region
|
344 |
356 |
N/A |
INTRINSIC |
|
low complexity region
|
401 |
419 |
N/A |
INTRINSIC |
|
PH
|
471 |
570 |
1.39e-21 |
SMART |
|
SCOP:d1faoa_
|
588 |
639 |
3e-6 |
SMART |
|
PH
|
651 |
757 |
6.76e-11 |
SMART |
|
MyTH4
|
805 |
953 |
4.12e-37 |
SMART |
|
B41
|
954 |
1216 |
1.72e-44 |
SMART |
|
Blast:B41
|
1218 |
1303 |
3e-45 |
BLAST |
|
low complexity region
|
1304 |
1316 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000110457
AA Change: H1378Q
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000106087
Gene: ENSMUSG00000022272
AA Change: H1378Q
| Domain | Start | End | E-Value | Type |
|---|
|
MYSc
|
57 |
740 |
N/A |
SMART |
|
IQ
|
741 |
763 |
1.27e-3 |
SMART |
|
IQ
|
764 |
786 |
1.06e0 |
SMART |
|
IQ
|
787 |
809 |
7.07e-2 |
SMART |
|
Pfam:MYO10_CC
|
881 |
932 |
4.2e-22 |
PFAM |
|
low complexity region
|
959 |
981 |
N/A |
INTRINSIC |
|
low complexity region
|
1090 |
1102 |
N/A |
INTRINSIC |
|
low complexity region
|
1147 |
1165 |
N/A |
INTRINSIC |
|
PH
|
1217 |
1316 |
1.39e-21 |
SMART |
|
PH
|
1397 |
1503 |
6.76e-11 |
SMART |
|
MyTH4
|
1551 |
1699 |
4.12e-37 |
SMART |
|
B41
|
1700 |
1962 |
1.72e-44 |
SMART |
|
low complexity region
|
2050 |
2062 |
N/A |
INTRINSIC |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 100.0%
- 10x: 99.8%
- 20x: 99.3%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the myosin superfamily. The protein represents an unconventional myosin; it should not be confused with the conventional non-muscle myosin-10 (MYH10). Unconventional myosins contain the basic domains of conventional myosins and are further distinguished from class members by their tail domains. This gene functions as an actin-based molecular motor and plays a role in integration of F-actin and microtubule cytoskeletons during meiosis. [provided by RefSeq, Dec 2011]
PHENOTYPE: Homozygous null mutations are semi-lethal with over half of homozygous embryos exhibiting exencephaly. Surviving mutants show decreased body weight, white spotting, syndactyly, persistence of hyaloid vascular system and other eye defects. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 80 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Adcy8 |
T |
C |
15: 64,687,235 (GRCm39) |
N423S |
probably benign |
Het |
| Adgrl4 |
T |
C |
3: 151,248,344 (GRCm39) |
L672P |
probably damaging |
Het |
| Akr1b10 |
C |
T |
6: 34,369,067 (GRCm39) |
T182I |
possibly damaging |
Het |
| Ankrd33 |
A |
G |
15: 101,014,864 (GRCm39) |
I84V |
probably benign |
Het |
| Arhgap32 |
A |
G |
9: 32,159,799 (GRCm39) |
Y272C |
possibly damaging |
Het |
| Arid4a |
T |
C |
12: 71,110,090 (GRCm39) |
S144P |
probably damaging |
Het |
| Bicd1 |
A |
G |
6: 149,415,285 (GRCm39) |
D666G |
probably damaging |
Het |
| Blk |
A |
T |
14: 63,618,149 (GRCm39) |
|
probably benign |
Het |
| Btbd2 |
C |
T |
10: 80,480,515 (GRCm39) |
R366Q |
possibly damaging |
Het |
| Cacna1i |
T |
C |
15: 80,266,175 (GRCm39) |
V1554A |
probably damaging |
Het |
| Camsap3 |
T |
C |
8: 3,653,614 (GRCm39) |
L428P |
probably damaging |
Het |
| Ccdc30 |
T |
G |
4: 119,234,505 (GRCm39) |
Y69S |
possibly damaging |
Het |
| Ccdc7a |
T |
A |
8: 129,715,244 (GRCm39) |
E280V |
probably damaging |
Het |
| Cdk11b |
T |
C |
4: 155,732,779 (GRCm39) |
V539A |
unknown |
Het |
| Ceacam3 |
A |
T |
7: 16,893,937 (GRCm39) |
N483Y |
|
Het |
| Cenpf |
C |
T |
1: 189,390,194 (GRCm39) |
A1213T |
probably benign |
Het |
| Chrna6 |
G |
T |
8: 27,897,195 (GRCm39) |
Y227* |
probably null |
Het |
| Cntnap5c |
A |
T |
17: 58,601,294 (GRCm39) |
D814V |
probably damaging |
Het |
| Csl |
A |
T |
10: 99,594,826 (GRCm39) |
Y80N |
probably damaging |
Het |
| Ctsm |
A |
G |
13: 61,685,521 (GRCm39) |
L297P |
probably damaging |
Het |
| Cyp4a31 |
G |
A |
4: 115,422,225 (GRCm39) |
E70K |
probably benign |
Het |
| Dhx8 |
T |
C |
11: 101,623,958 (GRCm39) |
V31A |
unknown |
Het |
| Dis3l2 |
G |
T |
1: 86,719,162 (GRCm39) |
G131* |
probably null |
Het |
| Dkk1 |
G |
A |
19: 30,526,688 (GRCm39) |
A31V |
probably damaging |
Het |
| Dlx3 |
C |
T |
11: 95,012,596 (GRCm39) |
R130* |
probably null |
Het |
| Dnajc24 |
T |
C |
2: 105,832,315 (GRCm39) |
M23V |
probably benign |
Het |
| Dnmbp |
T |
A |
19: 43,862,662 (GRCm39) |
N76I |
probably damaging |
Het |
| Ezh1 |
T |
C |
11: 101,100,305 (GRCm39) |
N226S |
probably benign |
Het |
| Fabp9 |
C |
T |
3: 10,259,047 (GRCm39) |
V120M |
possibly damaging |
Het |
| Fcrlb |
A |
G |
1: 170,739,648 (GRCm39) |
C85R |
probably damaging |
Het |
| Gnai2 |
A |
C |
9: 107,496,968 (GRCm39) |
L131R |
|
Het |
| Gprin1 |
A |
G |
13: 54,885,764 (GRCm39) |
W837R |
probably damaging |
Het |
| Grm3 |
C |
T |
5: 9,562,311 (GRCm39) |
C513Y |
probably damaging |
Het |
| H60c |
T |
A |
10: 3,210,265 (GRCm39) |
I95F |
possibly damaging |
Het |
| Hecw1 |
A |
G |
13: 14,531,743 (GRCm39) |
V177A |
possibly damaging |
Het |
| Herc6 |
T |
A |
6: 57,624,134 (GRCm39) |
C635S |
probably benign |
Het |
| Itga4 |
A |
T |
2: 79,112,125 (GRCm39) |
M347L |
probably benign |
Het |
| Kif20b |
A |
G |
19: 34,914,752 (GRCm39) |
H436R |
probably benign |
Het |
| Klrg2 |
G |
T |
6: 38,613,430 (GRCm39) |
P191Q |
possibly damaging |
Het |
| Krt5 |
A |
G |
15: 101,618,742 (GRCm39) |
Y340H |
probably damaging |
Het |
| Map9 |
T |
A |
3: 82,270,668 (GRCm39) |
H77Q |
possibly damaging |
Het |
| Mfsd13a |
A |
G |
19: 46,356,557 (GRCm39) |
T221A |
probably benign |
Het |
| Nkx6-1 |
T |
C |
5: 101,807,513 (GRCm39) |
T290A |
possibly damaging |
Het |
| Nlgn3 |
T |
C |
X: 100,352,390 (GRCm39) |
V179A |
probably damaging |
Het |
| Notch1 |
T |
A |
2: 26,368,004 (GRCm39) |
|
probably benign |
Het |
| Nr1d2 |
A |
T |
14: 18,216,661 (GRCm38) |
M169K |
probably damaging |
Het |
| Or10ak8 |
C |
T |
4: 118,774,635 (GRCm39) |
V10I |
probably benign |
Het |
| Or11g1 |
A |
G |
14: 50,651,420 (GRCm39) |
M140V |
possibly damaging |
Het |
| Or13c7c |
A |
G |
4: 43,836,193 (GRCm39) |
V99A |
probably benign |
Het |
| Or6c69b |
A |
T |
10: 129,626,562 (GRCm39) |
F299I |
possibly damaging |
Het |
| Or8b41 |
A |
G |
9: 38,054,433 (GRCm39) |
M1V |
probably null |
Het |
| Pdia6 |
T |
A |
12: 17,329,662 (GRCm39) |
I266K |
probably damaging |
Het |
| Phactr4 |
T |
C |
4: 132,091,105 (GRCm39) |
|
probably null |
Het |
| Polr1b |
T |
A |
2: 128,967,571 (GRCm39) |
L988Q |
probably damaging |
Het |
| Por |
A |
T |
5: 135,763,112 (GRCm39) |
M541L |
probably benign |
Het |
| Ppid |
T |
C |
3: 79,498,689 (GRCm39) |
|
probably benign |
Het |
| Prp2 |
A |
T |
6: 132,577,322 (GRCm39) |
Q203L |
unknown |
Het |
| Psme4 |
T |
G |
11: 30,759,896 (GRCm39) |
F340V |
probably damaging |
Het |
| Ptges2 |
T |
C |
2: 32,290,077 (GRCm39) |
S164P |
probably damaging |
Het |
| Rab18 |
G |
A |
18: 6,788,635 (GRCm39) |
G201S |
probably damaging |
Het |
| Rbm19 |
A |
G |
5: 120,265,132 (GRCm39) |
E391G |
probably damaging |
Het |
| Rcbtb2 |
T |
G |
14: 73,404,305 (GRCm39) |
V259G |
probably damaging |
Het |
| Rpn1 |
C |
A |
6: 88,080,359 (GRCm39) |
Q553K |
possibly damaging |
Het |
| Sash1 |
A |
G |
10: 8,609,459 (GRCm39) |
S697P |
probably damaging |
Het |
| Sdad1 |
T |
G |
5: 92,437,645 (GRCm39) |
H603P |
probably damaging |
Het |
| Serpini1 |
T |
C |
3: 75,520,544 (GRCm39) |
L47P |
probably damaging |
Het |
| Sorbs2 |
T |
A |
8: 46,248,686 (GRCm39) |
S646T |
possibly damaging |
Het |
| Spdye4a |
T |
A |
5: 143,210,754 (GRCm39) |
E105D |
probably benign |
Het |
| Srsf12 |
G |
A |
4: 33,231,181 (GRCm39) |
C230Y |
possibly damaging |
Het |
| Stard9 |
A |
T |
2: 120,531,595 (GRCm39) |
R2617S |
probably benign |
Het |
| Tas2r118 |
G |
T |
6: 23,969,344 (GRCm39) |
T239K |
probably damaging |
Het |
| Tlr1 |
A |
G |
5: 65,084,094 (GRCm39) |
L161P |
probably benign |
Het |
| Ttc21a |
T |
G |
9: 119,772,977 (GRCm39) |
V218G |
possibly damaging |
Het |
| Ttc6 |
T |
C |
12: 57,784,492 (GRCm39) |
S1854P |
probably benign |
Het |
| Unc93a |
A |
G |
17: 13,341,852 (GRCm39) |
L93P |
probably damaging |
Het |
| Vcan |
A |
T |
13: 89,839,217 (GRCm39) |
I2109N |
probably benign |
Het |
| Vmn1r225 |
A |
T |
17: 20,723,419 (GRCm39) |
S287C |
probably damaging |
Het |
| Vmn1r43 |
A |
G |
6: 89,847,321 (GRCm39) |
F55S |
probably damaging |
Het |
| Zfp772 |
T |
C |
7: 7,208,518 (GRCm39) |
T109A |
possibly damaging |
Het |
| Zfp87 |
A |
G |
13: 74,520,599 (GRCm39) |
Y160H |
probably damaging |
Het |
|
| Other mutations in Myo10 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00557:Myo10
|
APN |
15 |
25,776,466 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01068:Myo10
|
APN |
15 |
25,739,395 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
IGL01352:Myo10
|
APN |
15 |
25,701,783 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01388:Myo10
|
APN |
15 |
25,736,703 (GRCm39) |
missense |
possibly damaging |
0.55 |
|
IGL01460:Myo10
|
APN |
15 |
25,714,194 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01553:Myo10
|
APN |
15 |
25,776,415 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01732:Myo10
|
APN |
15 |
25,732,149 (GRCm39) |
missense |
probably benign |
0.10 |
|
IGL01992:Myo10
|
APN |
15 |
25,799,634 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
IGL02000:Myo10
|
APN |
15 |
25,808,152 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02045:Myo10
|
APN |
15 |
25,726,574 (GRCm39) |
missense |
probably benign |
0.03 |
|
IGL02307:Myo10
|
APN |
15 |
25,776,401 (GRCm39) |
splice site |
probably benign |
|
|
IGL02511:Myo10
|
APN |
15 |
25,723,975 (GRCm39) |
missense |
probably damaging |
0.97 |
|
IGL03240:Myo10
|
APN |
15 |
25,701,688 (GRCm39) |
missense |
probably damaging |
1.00 |
|
least
|
UTSW |
15 |
25,726,561 (GRCm39) |
nonsense |
probably null |
|
|
R0037:Myo10
|
UTSW |
15 |
25,666,618 (GRCm39) |
intron |
probably benign |
|
|
R0153:Myo10
|
UTSW |
15 |
25,781,324 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R0282:Myo10
|
UTSW |
15 |
25,793,253 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0360:Myo10
|
UTSW |
15 |
25,804,454 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0585:Myo10
|
UTSW |
15 |
25,736,541 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0617:Myo10
|
UTSW |
15 |
25,738,091 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0729:Myo10
|
UTSW |
15 |
25,722,243 (GRCm39) |
splice site |
probably benign |
|
|
R0771:Myo10
|
UTSW |
15 |
25,778,264 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0960:Myo10
|
UTSW |
15 |
25,801,275 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1562:Myo10
|
UTSW |
15 |
25,780,497 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R1651:Myo10
|
UTSW |
15 |
25,742,455 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1789:Myo10
|
UTSW |
15 |
25,726,611 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1816:Myo10
|
UTSW |
15 |
25,800,286 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1835:Myo10
|
UTSW |
15 |
25,805,673 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R1908:Myo10
|
UTSW |
15 |
25,801,308 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2082:Myo10
|
UTSW |
15 |
25,786,079 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2101:Myo10
|
UTSW |
15 |
25,722,345 (GRCm39) |
missense |
probably benign |
0.26 |
|
R2129:Myo10
|
UTSW |
15 |
25,781,885 (GRCm39) |
missense |
probably benign |
0.09 |
|
R2141:Myo10
|
UTSW |
15 |
25,714,194 (GRCm39) |
missense |
probably benign |
|
|
R2142:Myo10
|
UTSW |
15 |
25,714,194 (GRCm39) |
missense |
probably benign |
|
|
R2920:Myo10
|
UTSW |
15 |
25,801,226 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2938:Myo10
|
UTSW |
15 |
25,795,803 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R3723:Myo10
|
UTSW |
15 |
25,803,374 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3852:Myo10
|
UTSW |
15 |
25,779,712 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4162:Myo10
|
UTSW |
15 |
25,726,501 (GRCm39) |
splice site |
probably null |
|
|
R4163:Myo10
|
UTSW |
15 |
25,726,501 (GRCm39) |
splice site |
probably null |
|
|
R4164:Myo10
|
UTSW |
15 |
25,726,501 (GRCm39) |
splice site |
probably null |
|
|
R4177:Myo10
|
UTSW |
15 |
25,734,137 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R4409:Myo10
|
UTSW |
15 |
25,807,955 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4667:Myo10
|
UTSW |
15 |
25,793,239 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R4905:Myo10
|
UTSW |
15 |
25,800,298 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4933:Myo10
|
UTSW |
15 |
25,781,204 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R4968:Myo10
|
UTSW |
15 |
25,808,270 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5081:Myo10
|
UTSW |
15 |
25,786,026 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5123:Myo10
|
UTSW |
15 |
25,726,569 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R5310:Myo10
|
UTSW |
15 |
25,778,164 (GRCm39) |
splice site |
probably null |
|
|
R6073:Myo10
|
UTSW |
15 |
25,736,728 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6117:Myo10
|
UTSW |
15 |
25,805,745 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6185:Myo10
|
UTSW |
15 |
25,726,596 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6749:Myo10
|
UTSW |
15 |
25,714,196 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6819:Myo10
|
UTSW |
15 |
25,781,496 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R6875:Myo10
|
UTSW |
15 |
25,805,745 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6908:Myo10
|
UTSW |
15 |
25,804,469 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6963:Myo10
|
UTSW |
15 |
25,734,149 (GRCm39) |
missense |
probably benign |
0.31 |
|
R7144:Myo10
|
UTSW |
15 |
25,724,011 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7266:Myo10
|
UTSW |
15 |
25,783,067 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7380:Myo10
|
UTSW |
15 |
25,779,706 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7460:Myo10
|
UTSW |
15 |
25,807,913 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7614:Myo10
|
UTSW |
15 |
25,701,709 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7618:Myo10
|
UTSW |
15 |
25,726,561 (GRCm39) |
nonsense |
probably null |
|
|
R7717:Myo10
|
UTSW |
15 |
25,732,056 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7811:Myo10
|
UTSW |
15 |
25,804,610 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7830:Myo10
|
UTSW |
15 |
25,738,057 (GRCm39) |
nonsense |
probably null |
|
|
R7862:Myo10
|
UTSW |
15 |
25,666,522 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8232:Myo10
|
UTSW |
15 |
25,804,400 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R8264:Myo10
|
UTSW |
15 |
25,800,195 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8377:Myo10
|
UTSW |
15 |
25,804,481 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R8385:Myo10
|
UTSW |
15 |
25,804,484 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8426:Myo10
|
UTSW |
15 |
25,799,576 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8439:Myo10
|
UTSW |
15 |
25,725,158 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8775:Myo10
|
UTSW |
15 |
25,800,145 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R8775-TAIL:Myo10
|
UTSW |
15 |
25,800,145 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R8970:Myo10
|
UTSW |
15 |
25,803,467 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R9024:Myo10
|
UTSW |
15 |
25,793,295 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R9196:Myo10
|
UTSW |
15 |
25,805,716 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R9224:Myo10
|
UTSW |
15 |
25,808,081 (GRCm39) |
missense |
probably benign |
0.33 |
|
R9308:Myo10
|
UTSW |
15 |
25,781,862 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9358:Myo10
|
UTSW |
15 |
25,781,520 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
R9606:Myo10
|
UTSW |
15 |
25,776,401 (GRCm39) |
frame shift |
probably null |
|
|
R9722:Myo10
|
UTSW |
15 |
25,801,227 (GRCm39) |
missense |
probably damaging |
1.00 |
|
RF013:Myo10
|
UTSW |
15 |
25,799,565 (GRCm39) |
missense |
probably damaging |
0.99 |
|
Z1177:Myo10
|
UTSW |
15 |
25,799,640 (GRCm39) |
critical splice donor site |
probably null |
|
|
Z1177:Myo10
|
UTSW |
15 |
25,781,487 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- AATAGCATTCCAGTGTCTCCGG -3'
(R):5'- CAAACTCCTCTGTCCAAATAACTTG -3'
Sequencing Primer
(F):5'- AGTGTCTCCGGGGAGCC -3'
(R):5'- CTGAAGGGATGGCTCTCACATACTG -3'
|
| Posted On |
2021-04-30 |
Incidental Mutation