Incidental Mutation 'R8697:Xcl1'
ID 668753
Institutional Source Beutler Lab
Gene Symbol Xcl1
Ensembl Gene ENSMUSG00000026573
Gene Name chemokine (C motif) ligand 1
Synonyms SCM-1, Lptn, LTN, ATAC, Scyc1, lymphotactin, SCM-1a
MMRRC Submission 068551-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R8697 (G1)
Quality Score 225.009
Status Validated
Chromosome 1
Chromosomal Location 164759216-164763094 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 164763008 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Isoleucine at position 18 (V18I)
Ref Sequence ENSEMBL: ENSMUSP00000027860 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000027860]
AlphaFold P47993
Predicted Effect unknown
Transcript: ENSMUST00000027860
AA Change: V18I
SMART Domains Protein: ENSMUSP00000027860
Gene: ENSMUSG00000026573
AA Change: V18I

DomainStartEndE-ValueType
signal peptide 1 21 N/A INTRINSIC
SCY 28 84 2.18e-19 SMART
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.8%
  • 20x: 99.4%
Validation Efficiency 98% (58/59)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This antimicrobial gene encodes a member of the chemokine superfamily. Chemokines function in inflammatory and immunological responses, inducing leukocyte migration and activation. The encoded protein is a member of the C-chemokine subfamily, retaining only two of four cysteines conserved in other chemokines, and is thought to be specifically chemotactic for T cells. This gene and a closely related family member are located on the long arm of chromosome 1. [provided by RefSeq, Sep 2014]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit decreased stimulated cytotoxic T cell cytolysis. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 58 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930558K02Rik C T 1: 161,795,565 (GRCm39) A8T probably benign Het
Acacb T C 5: 114,351,441 (GRCm39) V1130A probably damaging Het
Ackr1 A G 1: 173,159,775 (GRCm39) F248S probably damaging Het
Alx4 G A 2: 93,505,657 (GRCm39) R253Q probably damaging Het
Ap3b2 T C 7: 81,122,783 (GRCm39) I485V possibly damaging Het
Aqp7 T C 4: 41,045,305 (GRCm39) E25G probably damaging Het
Cacna1g T C 11: 94,307,524 (GRCm39) N1753D probably benign Het
Cacna2d1 T A 5: 16,570,865 (GRCm39) N1063K possibly damaging Het
Cad T C 5: 31,231,945 (GRCm39) V1801A probably benign Het
Ccdc171 T C 4: 83,600,577 (GRCm39) W868R probably damaging Het
Cecr2 T C 6: 120,710,779 (GRCm39) Y165H probably damaging Het
Clip4 G T 17: 72,163,270 (GRCm39) G614V possibly damaging Het
Ctnnal1 T A 4: 56,838,986 (GRCm39) M236L probably damaging Het
Ctps1 T C 4: 120,399,947 (GRCm39) D470G probably benign Het
Dmwd A C 7: 18,812,113 (GRCm39) Q189P probably damaging Het
Dnah17 A G 11: 117,976,985 (GRCm39) I1869T possibly damaging Het
Eepd1 A G 9: 25,497,998 (GRCm39) N361S probably benign Het
Ephb6 C T 6: 41,591,157 (GRCm39) H105Y probably damaging Het
Fkbp15 A T 4: 62,239,295 (GRCm39) Y603* probably null Het
Flt3 T C 5: 147,294,811 (GRCm39) Y420C possibly damaging Het
Frem2 T A 3: 53,433,249 (GRCm39) T2692S probably damaging Het
Gna12 T A 5: 140,771,200 (GRCm39) R157S probably benign Het
Gsdmc A T 15: 63,651,883 (GRCm39) S243T probably benign Het
Hectd1 A G 12: 51,819,320 (GRCm39) probably benign Het
Hoxd11 G A 2: 74,513,013 (GRCm39) G93R unknown Het
Hydin A G 8: 111,259,515 (GRCm39) I2496V probably benign Het
Igsf10 A G 3: 59,226,308 (GRCm39) I2455T probably benign Het
Ilvbl A T 10: 78,419,196 (GRCm39) R482* probably null Het
Itpr1 A G 6: 108,500,327 (GRCm39) Y2640C probably damaging Het
Kif20a C G 18: 34,761,584 (GRCm39) Q326E probably benign Het
Lamp1 A T 8: 13,224,448 (GRCm39) M371L possibly damaging Het
Lcn6 A G 2: 25,567,166 (GRCm39) N56D probably benign Het
Map3k10 A G 7: 27,362,784 (GRCm39) V434A probably benign Het
Mdga1 T C 17: 30,065,615 (GRCm39) N331S probably damaging Het
Mndal C A 1: 173,700,558 (GRCm39) E138* probably null Het
Morc3 T C 16: 93,667,908 (GRCm39) V762A probably benign Het
Ngef A T 1: 87,417,459 (GRCm39) F279Y probably damaging Het
Or10ac1 A G 6: 42,515,629 (GRCm39) V109A probably damaging Het
Or5m13b A T 2: 85,754,200 (GRCm39) K196I possibly damaging Het
Padi4 GGAGCTCCTGA GGA 4: 140,485,230 (GRCm39) probably null Het
Pcdhb4 G A 18: 37,441,832 (GRCm39) V381M probably benign Het
Ppm1d T C 11: 85,227,986 (GRCm39) Y301H possibly damaging Het
Rasgrf1 A G 9: 89,877,055 (GRCm39) T807A probably benign Het
Repin1 G T 6: 48,574,279 (GRCm39) E403* probably null Het
Sipa1l2 T C 8: 126,208,855 (GRCm39) K518E probably damaging Het
Skic3 A G 13: 76,328,274 (GRCm39) S1441G probably damaging Het
Slc52a3 A G 2: 151,846,396 (GRCm39) D119G probably damaging Het
Srsf4 C T 4: 131,628,042 (GRCm39) H379Y unknown Het
Ssr1 G T 13: 38,167,425 (GRCm39) S246* probably null Het
Tars2 C T 3: 95,653,374 (GRCm39) E509K possibly damaging Het
Tepsin G T 11: 119,988,354 (GRCm39) Y34* probably null Het
Tmtc2 A G 10: 105,205,831 (GRCm39) I488T probably damaging Het
Trgc2 A T 13: 19,491,514 (GRCm39) M69K Het
Ttn A G 2: 76,575,120 (GRCm39) W25258R probably damaging Het
Utp14b T C 1: 78,644,244 (GRCm39) M714T probably benign Het
Vwa3b T A 1: 37,115,461 (GRCm39) H308Q probably benign Het
Washc2 A G 6: 116,206,220 (GRCm39) D480G probably benign Het
Zcchc2 C A 1: 105,958,494 (GRCm39) N988K probably damaging Het
Other mutations in Xcl1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01910:Xcl1 APN 1 164,759,458 (GRCm39) missense probably damaging 1.00
IGL03295:Xcl1 APN 1 164,763,004 (GRCm39) missense unknown
R7742:Xcl1 UTSW 1 164,763,041 (GRCm39) missense unknown
R8532:Xcl1 UTSW 1 164,759,515 (GRCm39) missense probably damaging 1.00
R8671:Xcl1 UTSW 1 164,759,419 (GRCm39) missense probably benign 0.01
R8843:Xcl1 UTSW 1 164,763,079 (GRCm39) start gained probably benign
Predicted Primers PCR Primer
(F):5'- CAGCTCACAGTGTTGAGATATATAGAC -3'
(R):5'- TGCAAAGACTTTCCGTGATTC -3'

Sequencing Primer
(F):5'- AGGCTTACCTGGAGAAAG -3'
(R):5'- AAGACTTTCCGTGATTCCACAC -3'
Posted On 2021-04-30