|Institutional Source||Beutler Lab|
|Gene Name||G protein-coupled receptor 153|
|Is this an essential gene?||Non essential (E-score: 0.000)|
|Stock #||R8699 (G1)|
|Chromosomal Location||152274232-152285337 bp(+) (GRCm38)|
|Type of Mutation||start gained|
|DNA Base Change (assembly)||C to T at 152279101 bp (GRCm38)|
|Amino Acid Change|
|Ref Sequence||ENSEMBL: ENSMUSP00000101276 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000055754] [ENSMUST00000105650] [ENSMUST00000105651]|
|Coding Region Coverage||
|MGI Phenotype||FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes an integral membrane protein that belongs to the Class A rhodopsin superfamily of G protein coupled receptors. The encoded protein is expressed primarily in the central nervous system. A knockdown of the orthologous gene in rat is associated with a significant reduction in food intake and impaired decision making ability. Mutations in this gene are associated with schizophrenia, autism, and other neuropsychiatric disorders. The expression of this gene is activated by the glioma-associated oncogene homolog 1 transcription factor which, in turn, is activated by sonic hedgehog in normal and tumorigenic cells. [provided by RefSeq, Feb 2017]|
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Gpr153||
(F):5'- CTTAGGCCTTCAACCCAGTGAG -3'
(R):5'- AGCGTGCAAAGCAAGAACTC -3'
(F):5'- ACATCCTGTTGTAAGCCAGG -3'
(R):5'- GCAAGAACTCCAGCGGCTTC -3'