Mutagenetix > Incidental Mutation

Incidental Mutation 'R8699:Vmn1r170'

668929

Institutional Source

Beutler Lab

Gene Symbol

Vmn1r170

Ensembl Gene

ENSMUSG00000094187

Gene Name

vomeronasal 1 receptor 170

Synonyms

Gm5999

MMRRC Submission

068553-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.057) question?

Stock #

R8699 (G1)

Quality Score

225.009

Status

Not validated

Chromosome

Chromosomal Location

23305600-23306514 bp(+) (GRCm39)

Type of Mutation

nonsense

DNA Base Change (assembly)

C to T at 23306080 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Glutamine to Stop codon at position 161 (Q161*)

Ref Sequence

ENSEMBL: ENSMUSP00000127655 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000170166]

AlphaFold

K7N6W9

Predicted Effect

probably null
Transcript: ENSMUST00000170166
AA Change: Q161*

SMART Domains

Protein: ENSMUSP00000127655
Gene: ENSMUSG00000094187
AA Change: Q161*

Domain	Start	End	E-Value	Type
Pfam:TAS2R	8	296	1.8e-13	PFAM
Pfam:7tm_1	30	287	3.6e-6	PFAM
Pfam:V1R	42	295	1.4e-20	PFAM

Coding Region Coverage

1x: 100.0%
3x: 100.0%
10x: 99.7%
20x: 99.1%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 79 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4933430I17Rik	T	C	4: 62,450,515 (GRCm39)	W30R	probably damaging	Het
Abca3	A	G	17: 24,627,199 (GRCm39)	D1555G	probably benign	Het
Anapc1	T	C	2: 128,483,373 (GRCm39)	T1241A	probably damaging	Het
Ano5	G	A	7: 51,243,519 (GRCm39)	V881I	probably benign	Het
Appl1	G	A	14: 26,662,212 (GRCm39)	S490L	probably benign	Het
Asxl3	A	G	18: 22,567,664 (GRCm39)	T81A	probably benign	Het
Bclaf1	T	C	10: 20,209,184 (GRCm39)	S754P	possibly damaging	Het
Bicra	G	T	7: 15,723,113 (GRCm39)	Q135K	probably benign	Het
Cad	T	C	5: 31,233,605 (GRCm39)	V1951A	possibly damaging	Het
Cadm3	T	A	1: 173,168,683 (GRCm39)	Y295F	probably damaging	Het
Ccnt1	A	G	15: 98,462,995 (GRCm39)	I59T	probably damaging	Het
Ccr6	C	T	17: 8,475,398 (GRCm39)	T201M	probably benign	Het
Cd5	A	G	19: 10,702,556 (GRCm39)	F209S	possibly damaging	Het
Cep126	A	C	9: 8,087,362 (GRCm39)	D1017E	probably damaging	Het
Cfap298	T	C	16: 90,727,945 (GRCm39)	K82E	probably benign	Het
Cntnap4	A	T	8: 113,484,228 (GRCm39)	D427V	probably damaging	Het
Col4a4	T	A	1: 82,433,455 (GRCm39)	N1496I	unknown	Het
Crybg3	A	G	16: 59,375,291 (GRCm39)	Y274H	probably damaging	Het
Cubn	C	A	2: 13,388,770 (GRCm39)	S1479I	probably damaging	Het
Diras2	A	T	13: 52,662,143 (GRCm39)	C55S	probably damaging	Het
Dleu7	G	A	14: 62,530,279 (GRCm39)	R41C	probably benign	Het
Dync2i1	T	C	12: 116,171,321 (GRCm39)	T972A	probably benign	Het
Efcab3	A	G	11: 104,672,072 (GRCm39)	T1464A	probably benign	Het
Exo5	A	G	4: 120,779,193 (GRCm39)	I224T	probably damaging	Het
Fcho1	T	C	8: 72,162,277 (GRCm39)	I774V	possibly damaging	Het
Gclm	T	G	3: 122,059,972 (GRCm39)	S251A	possibly damaging	Het
Gm13889	T	C	2: 93,787,327 (GRCm39)	Q49R	unknown	Het
Gm35315	T	A	5: 110,228,392 (GRCm39)	H18L	probably benign	Het
Gm9949	G	A	18: 62,317,043 (GRCm39)	G65R	unknown	Het
Gpr153	C	T	4: 152,363,558 (GRCm39)		probably benign	Het
Gria4	C	A	9: 4,424,347 (GRCm39)	K839N	probably damaging	Het
Gria4	T	G	9: 4,424,351 (GRCm39)	Y838S	probably damaging	Het
Hrh3	A	G	2: 179,743,149 (GRCm39)	W160R	probably damaging	Het
Htr4	G	A	18: 62,570,763 (GRCm39)	A273T	probably damaging	Het
Lig3	G	T	11: 82,685,376 (GRCm39)	C599F	probably damaging	Het
Lrp1b	A	T	2: 41,172,207 (GRCm39)	V1594E		Het
Map3k10	A	T	7: 27,367,780 (GRCm39)	V286D	probably damaging	Het
Map4k4	T	A	1: 40,015,910 (GRCm39)	V117E	unknown	Het
Mdga1	C	T	17: 30,061,348 (GRCm39)	V548M	possibly damaging	Het
Mms22l	A	T	4: 24,507,363 (GRCm39)	L248F	possibly damaging	Het
Ncaph	T	C	2: 126,963,096 (GRCm39)	D379G	possibly damaging	Het
Neb	A	G	2: 52,037,246 (GRCm39)	V7064A	probably benign	Het
Neb	G	A	2: 52,102,563 (GRCm39)	T4570M	probably benign	Het
Npy5r	G	T	8: 67,134,274 (GRCm39)	T173K	probably damaging	Het
Or52a33	A	T	7: 103,288,822 (GRCm39)	I175N	probably damaging	Het
Or5b94	A	G	19: 12,652,246 (GRCm39)	M226V	probably benign	Het
Or5b97	A	T	19: 12,878,828 (GRCm39)	F105L	possibly damaging	Het
Or5g25	A	T	2: 85,478,330 (GRCm39)	C112S	possibly damaging	Het
Or8u10	A	T	2: 85,915,518 (GRCm39)	I201N	probably damaging	Het
Oxsm	A	G	14: 16,242,631 (GRCm38)	I46T	possibly damaging	Het
Pcdha1	A	T	18: 37,064,076 (GRCm39)	I247F	probably benign	Het
Pcdhgb6	A	T	18: 37,875,975 (GRCm39)	I228L	probably benign	Het
Peg10	T	TCCA	6: 4,756,451 (GRCm39)		probably benign	Het
Ppp1r9a	A	G	6: 5,115,474 (GRCm39)	S866G	probably benign	Het
Ppp6r3	T	A	19: 3,546,587 (GRCm39)	S304C	probably damaging	Het
Pramel11	A	T	4: 143,623,762 (GRCm39)	N137K	probably benign	Het
Ptprd	A	T	4: 75,959,629 (GRCm39)	F279I	probably benign	Het
Repin1	G	T	6: 48,574,279 (GRCm39)	E403*	probably null	Het
Rest	G	A	5: 77,429,389 (GRCm39)	G603R	probably benign	Het
Rgs17	A	T	10: 5,868,194 (GRCm39)	L9M	probably benign	Het
Rtp1	A	G	16: 23,250,133 (GRCm39)	Y166C	probably damaging	Het
Sec24b	C	A	3: 129,798,653 (GRCm39)	R572I	probably damaging	Het
Setd1a	G	T	7: 127,385,774 (GRCm39)	R827L	possibly damaging	Het
Sh3tc1	T	C	5: 35,859,235 (GRCm39)	Y1091C	probably damaging	Het
Sorbs1	G	C	19: 40,365,244 (GRCm39)	R180G	probably benign	Het
Stat4	T	A	1: 52,111,096 (GRCm39)	M181K	probably benign	Het
Stk16	A	G	1: 75,188,682 (GRCm39)	E67G	probably benign	Het
Supv3l1	A	G	10: 62,268,234 (GRCm39)	V537A	possibly damaging	Het
Tmc8	A	G	11: 117,674,361 (GRCm39)	E101G	possibly damaging	Het
Tmem106a	A	T	11: 101,473,120 (GRCm39)		probably benign	Het
Tpr	T	A	1: 150,293,772 (GRCm39)	I922N	probably damaging	Het
Uaca	G	T	9: 60,778,347 (GRCm39)	L911F	probably damaging	Het
Ubn1	A	T	16: 4,881,567 (GRCm39)	I200L	possibly damaging	Het
Ush2a	A	G	1: 188,643,574 (GRCm39)	D4312G	probably damaging	Het
Virma	A	T	4: 11,528,678 (GRCm39)	Y1255F	probably benign	Het
Vmn1r175	G	T	7: 23,508,234 (GRCm39)	A131D	probably benign	Het
Vmn1r52	T	A	6: 90,155,742 (GRCm39)	N15K	probably benign	Het
Wdr46	T	A	17: 34,167,826 (GRCm39)	I513N	probably damaging	Het
Zfp788	A	G	7: 41,297,840 (GRCm39)	N159D	probably benign	Het

Other mutations in Vmn1r170

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02005:Vmn1r170	APN	7	23,306,338 (GRCm39)	missense	probably damaging	1.00
IGL02150:Vmn1r170	APN	7	23,306,465 (GRCm39)	nonsense	probably null
IGL02216:Vmn1r170	APN	7	23,305,915 (GRCm39)	missense	probably damaging	1.00
IGL02749:Vmn1r170	APN	7	23,305,716 (GRCm39)	missense	probably benign	0.00
IGL02807:Vmn1r170	APN	7	23,305,760 (GRCm39)	missense	probably damaging	1.00
IGL02828:Vmn1r170	APN	7	23,305,943 (GRCm39)	missense	probably damaging	0.99
IGL02971:Vmn1r170	APN	7	23,305,759 (GRCm39)	missense	possibly damaging	0.81
IGL03073:Vmn1r170	APN	7	23,306,273 (GRCm39)	missense	probably damaging	1.00
IGL03151:Vmn1r170	APN	7	23,306,002 (GRCm39)	missense	probably benign	0.35
R0079:Vmn1r170	UTSW	7	23,305,735 (GRCm39)	missense	possibly damaging	0.95
R0266:Vmn1r170	UTSW	7	23,305,906 (GRCm39)	missense	probably benign	0.00
R0980:Vmn1r170	UTSW	7	23,305,759 (GRCm39)	missense	possibly damaging	0.81
R1345:Vmn1r170	UTSW	7	23,305,787 (GRCm39)	missense	probably benign	0.00
R1620:Vmn1r170	UTSW	7	23,305,754 (GRCm39)	missense	probably benign	0.30
R1713:Vmn1r170	UTSW	7	23,306,288 (GRCm39)	missense	probably benign	0.30
R1745:Vmn1r170	UTSW	7	23,305,759 (GRCm39)	missense	probably damaging	0.98
R1974:Vmn1r170	UTSW	7	23,305,906 (GRCm39)	missense	probably benign	0.00
R2163:Vmn1r170	UTSW	7	23,306,462 (GRCm39)	missense	probably damaging	1.00
R3812:Vmn1r170	UTSW	7	23,305,717 (GRCm39)	missense	probably damaging	1.00
R4583:Vmn1r170	UTSW	7	23,306,087 (GRCm39)	missense	probably benign	0.25
R5309:Vmn1r170	UTSW	7	23,305,880 (GRCm39)	missense	probably damaging	0.97
R5378:Vmn1r170	UTSW	7	23,305,963 (GRCm39)	missense	probably benign	0.00
R5379:Vmn1r170	UTSW	7	23,306,054 (GRCm39)	missense	possibly damaging	0.81
R5661:Vmn1r170	UTSW	7	23,306,231 (GRCm39)	missense	possibly damaging	0.82
R5673:Vmn1r170	UTSW	7	23,305,630 (GRCm39)	missense	possibly damaging	0.58
R6181:Vmn1r170	UTSW	7	23,305,692 (GRCm39)	missense	probably damaging	0.98
R6192:Vmn1r170	UTSW	7	23,305,934 (GRCm39)	missense	probably damaging	1.00
R7467:Vmn1r170	UTSW	7	23,306,320 (GRCm39)	missense	not run
R7667:Vmn1r170	UTSW	7	23,306,473 (GRCm39)	missense	probably damaging	1.00
R8458:Vmn1r170	UTSW	7	23,306,321 (GRCm39)	missense	possibly damaging	0.90
R8927:Vmn1r170	UTSW	7	23,305,814 (GRCm39)	missense	possibly damaging	0.82
R8928:Vmn1r170	UTSW	7	23,305,814 (GRCm39)	missense	possibly damaging	0.82
R9269:Vmn1r170	UTSW	7	23,306,263 (GRCm39)	missense	probably benign	0.02
R9569:Vmn1r170	UTSW	7	23,306,294 (GRCm39)	missense	probably benign	0.19
X0060:Vmn1r170	UTSW	7	23,306,368 (GRCm39)	missense	possibly damaging	0.50
Z1176:Vmn1r170	UTSW	7	23,305,835 (GRCm39)	missense	possibly damaging	0.89

Predicted Primers

PCR Primer
(F):5'- TACAAACATGTGCTCCACCTGC -3'
(R):5'- ACTCTCAGCATGAACTCTGAGC -3'

Sequencing Primer
(F):5'- CTCTCTGAGCACTTATCAGCTTG -3'
(R):5'- AGCATGAACTCTGAGCTTCTG -3'

Posted On

2021-04-30