|Institutional Source||Beutler Lab|
|Gene Name||zinc finger protein 606|
|Essential gene?||Probably non essential (E-score: 0.073)|
|Stock #||R8701 (G1)|
|Chromosomal Location||12478293-12496235 bp(+) (GRCm38)|
|Type of Mutation||missense|
|DNA Base Change (assembly)||T to A at 12481098 bp (GRCm38)|
|Amino Acid Change||Aspartic acid to Glutamic Acid at position 84 (D84E)|
|Ref Sequence||ENSEMBL: ENSMUSP00000147558 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000098822] [ENSMUST00000123589] [ENSMUST00000151933] [ENSMUST00000209403]|
AA Change: D84E
|Coding Region Coverage||
|MGI Phenotype||FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a zinc finger protein containing a Kruppel-associated box (KRAB) domain at its N-terminus, followed by contiguous C2H2 zinc finger motifs. The encoded protein is a nuclear protein that can act as a transcriptional repressor of growth factor-mediated signaling pathways in a reporter gene assay. This protein has been shown to interact with the SRY-box 9 gene product, and suppresses its transcriptional activity by inhibiting its DNA binding activity. Reduced expression of this gene promotes chondrocyte differentiation. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2016]|
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Zfp606||
(F):5'- ATAGGGTACATGATGAACTTCTGC -3'
(R):5'- AGCTGATGACAGAGATGTGTC -3'
(F):5'- CATGATGAACTTCTGCTAGGAAG -3'
(R):5'- TCTCAGCTCTGTGGAGAGGC -3'