Incidental Mutation 'R8703:Apol10b'
ID 669169
Institutional Source Beutler Lab
Gene Symbol Apol10b
Ensembl Gene ENSMUSG00000050014
Gene Name apolipoprotein L 10B
Synonyms 9130218O11Rik
MMRRC Submission 068557-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R8703 (G1)
Quality Score 225.009
Status Validated
Chromosome 15
Chromosomal Location 77468019-77480325 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 77472897 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamic Acid to Aspartic acid at position 52 (E52D)
Ref Sequence ENSEMBL: ENSMUSP00000086890 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000089465]
AlphaFold G3X9K7
Predicted Effect probably damaging
Transcript: ENSMUST00000089465
AA Change: E52D

PolyPhen 2 Score 0.996 (Sensitivity: 0.55; Specificity: 0.98)
SMART Domains Protein: ENSMUSP00000086890
Gene: ENSMUSG00000050014
AA Change: E52D

DomainStartEndE-ValueType
Pfam:ApoL 28 328 2.8e-88 PFAM
Meta Mutation Damage Score 0.2598 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.8%
  • 20x: 99.3%
Validation Efficiency 100% (44/44)
Allele List at MGI
Other mutations in this stock
Total: 45 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adgrv1 G A 13: 81,676,792 (GRCm39) T2013I probably damaging Het
Ak9 A T 10: 41,201,120 (GRCm39) N137Y Het
Calr3 A T 8: 73,192,291 (GRCm39) Y128N probably damaging Het
Dnah14 T A 1: 181,493,576 (GRCm39) L1669* probably null Het
Dppa3 A T 6: 122,605,737 (GRCm39) D97V probably damaging Het
Dync1li1 C A 9: 114,552,329 (GRCm39) P490T probably damaging Het
Eya4 A G 10: 23,039,340 (GRCm39) S85P probably benign Het
Fpr-rs4 T A 17: 18,242,332 (GRCm39) I113N probably damaging Het
Fryl T C 5: 73,247,997 (GRCm39) D1040G probably damaging Het
Fsip2 A T 2: 82,821,871 (GRCm39) D5868V probably damaging Het
Gpr75 A C 11: 30,841,890 (GRCm39) Q265P probably damaging Het
Iqcm G T 8: 76,615,271 (GRCm39) G451C probably damaging Het
Lgr5 A G 10: 115,288,610 (GRCm39) L678P probably benign Het
Mcm9 G A 10: 53,506,073 (GRCm39) P67L probably damaging Het
Naalad2 A C 9: 18,290,008 (GRCm39) Y207D probably damaging Het
Nrap C T 19: 56,323,703 (GRCm39) D1325N probably damaging Het
Nup133 A G 8: 124,643,021 (GRCm39) probably null Het
Ogfr GGCCAGAGGACCCCAAAAGCCAGGTGGAGCCAGAGGACCCCAAAAGCCAGGTGGAGCCAGAGGACCCCAAAAGCCAGGTGGAGCCAGAGGACCCCAAAAGCCAGGTGGGGCCAGAGGACCCCCAAAGCCAGGTGG GGCCAGAGGACCCCAAAAGCCAGGTGGAGCCAGAGGACCCCAAAAGCCAGGTGGAGCCAGAGGACCCCAAAAGCCAGGTGGGGCCAGAGGACCCCCAAAGCCAGGTGG 2: 180,237,059 (GRCm39) probably benign Het
Or4b1b T A 2: 90,126,837 (GRCm39) I123F probably damaging Het
Or8k28 C A 2: 86,286,244 (GRCm39) V124L possibly damaging Het
Or9i14 G T 19: 13,792,105 (GRCm39) P283H probably damaging Het
Per2 T A 1: 91,351,767 (GRCm39) N913I possibly damaging Het
Rab9 C T X: 165,240,754 (GRCm39) D186N probably benign Het
Reps1 C T 10: 17,968,990 (GRCm39) R183C probably damaging Het
Rims1 A T 1: 22,496,137 (GRCm39) C134S Het
Rpl10-ps3 A G 9: 50,256,184 (GRCm39) S20P probably benign Het
Sash1 C A 10: 8,605,595 (GRCm39) G932C probably damaging Het
Sema4d T C 13: 51,854,959 (GRCm39) Q46R Het
Sh3d19 A G 3: 86,014,568 (GRCm39) E453G probably damaging Het
Sirt6 A G 10: 81,461,548 (GRCm39) probably benign Het
Sis A T 3: 72,867,657 (GRCm39) F129L probably damaging Het
Skint5 T A 4: 113,733,207 (GRCm39) I399F unknown Het
Slc22a7 T C 17: 46,744,951 (GRCm39) D365G probably damaging Het
Slc6a12 A G 6: 121,324,447 (GRCm39) M38V probably benign Het
Slc9b2 C A 3: 135,031,924 (GRCm39) Y261* probably null Het
Spata21 A G 4: 140,832,218 (GRCm39) I460V probably benign Het
Tes C G 6: 17,099,788 (GRCm39) P261R probably damaging Het
Tex15 T C 8: 34,062,724 (GRCm39) L718P probably benign Het
Tmem135 G A 7: 88,808,170 (GRCm39) A202V probably benign Het
Usp29 T C 7: 6,964,321 (GRCm39) F55L probably benign Het
Usp9y A G Y: 1,356,317 (GRCm39) L1128P probably damaging Het
Zdhhc5 T C 2: 84,520,596 (GRCm39) E527G probably benign Het
Zfand4 A G 6: 116,250,604 (GRCm39) I11M probably damaging Het
Zfp110 T A 7: 12,582,888 (GRCm39) I512K probably benign Het
Zfp638 T A 6: 83,954,143 (GRCm39) F1416Y probably damaging Het
Other mutations in Apol10b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01295:Apol10b APN 15 77,469,796 (GRCm39) missense probably damaging 1.00
IGL01654:Apol10b APN 15 77,472,996 (GRCm39) missense probably benign
IGL01905:Apol10b APN 15 77,469,559 (GRCm39) missense possibly damaging 0.92
IGL01969:Apol10b APN 15 77,472,885 (GRCm39) splice site probably null
IGL02305:Apol10b APN 15 77,469,630 (GRCm39) missense possibly damaging 0.55
R0361:Apol10b UTSW 15 77,469,586 (GRCm39) missense possibly damaging 0.82
R0395:Apol10b UTSW 15 77,469,840 (GRCm39) missense probably damaging 1.00
R0437:Apol10b UTSW 15 77,469,608 (GRCm39) missense probably benign 0.00
R0502:Apol10b UTSW 15 77,476,349 (GRCm39) splice site probably benign
R0688:Apol10b UTSW 15 77,469,419 (GRCm39) missense probably damaging 0.99
R1663:Apol10b UTSW 15 77,472,914 (GRCm39) missense probably damaging 1.00
R1763:Apol10b UTSW 15 77,469,215 (GRCm39) missense probably benign 0.14
R4884:Apol10b UTSW 15 77,473,006 (GRCm39) missense possibly damaging 0.93
R6177:Apol10b UTSW 15 77,469,987 (GRCm39) missense possibly damaging 0.50
R7062:Apol10b UTSW 15 77,469,473 (GRCm39) missense probably benign 0.00
R7480:Apol10b UTSW 15 77,472,988 (GRCm39) missense probably benign 0.02
R8511:Apol10b UTSW 15 77,469,211 (GRCm39) missense probably benign 0.43
R8511:Apol10b UTSW 15 77,469,210 (GRCm39) missense probably benign 0.03
Predicted Primers PCR Primer
(F):5'- AAACAACCTGAGGTGATTTCCAC -3'
(R):5'- CATATTAGCAGGTCTGATGAAGGTG -3'

Sequencing Primer
(F):5'- CCACAAGGAATAACATGTTGTAAAC -3'
(R):5'- TGGAGAGACAATTGAGGTTCATG -3'
Posted On 2021-04-30