Mutagenetix > Incidental Mutations

Incidental Mutation 'R8703:Fpr-rs4'

669170

Institutional Source

Beutler Lab

Gene Symbol

Fpr-rs4

Ensembl Gene

ENSMUSG00000048062

Gene Name

formyl peptide receptor, related sequence 4

Synonyms

MMRRC Submission

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.124) question?

Stock #

R8703 (G1)

Quality Score

225.009

Status

Validated

Chromosome

Chromosomal Location

18021733-18022704 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 18022070 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Asparagine at position 113 (I113N)

Ref Sequence

ENSEMBL: ENSMUSP00000093311 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000095651]

AlphaFold

A4FUQ5

Predicted Effect

probably damaging
Transcript: ENSMUST00000095651
AA Change: I113N

PolyPhen 2 Score 0.990 (Sensitivity: 0.72; Specificity: 0.97)

SMART Domains

Protein: ENSMUSP00000093311
Gene: ENSMUSG00000048062
AA Change: I113N

Domain	Start	End	E-Value	Type
Pfam:7tm_1	43	297	4.9e-35	PFAM

Coding Region Coverage

1x: 100.0%
3x: 100.0%
10x: 99.8%
20x: 99.3%

Validation Efficiency

100% (44/44)

Allele List at MGI

Other mutations in this stock

Total: 45 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adgrv1	G	A	13: 81,528,673	T2013I	probably damaging	Het
Ak9	A	T	10: 41,325,124	N137Y		Het
Apol10b	T	A	15: 77,588,697	E52D	probably damaging	Het
Calr3	A	T	8: 72,438,447	Y128N	probably damaging	Het
Dnah14	T	A	1: 181,666,011	L1669*	probably null	Het
Dppa3	A	T	6: 122,628,778	D97V	probably damaging	Het
Dync1li1	C	A	9: 114,723,261	P490T	probably damaging	Het
Eya4	A	G	10: 23,163,442	S85P	probably benign	Het
Fryl	T	C	5: 73,090,654	D1040G	probably damaging	Het
Fsip2	A	T	2: 82,991,527	D5868V	probably damaging	Het
Gpr75	A	C	11: 30,891,890	Q265P	probably damaging	Het
Iqcm	G	T	8: 75,888,643	G451C	probably damaging	Het
Lgr5	A	G	10: 115,452,705	L678P	probably benign	Het
Mcm9	G	A	10: 53,629,977	P67L	probably damaging	Het
Naalad2	A	C	9: 18,378,712	Y207D	probably damaging	Het
Nrap	C	T	19: 56,335,271	D1325N	probably damaging	Het
Nup133	A	G	8: 123,916,282		probably null	Het
Ogfr	GGCCAGAGGACCCCAAAAGCCAGGTGGAGCCAGAGGACCCCAAAAGCCAGGTGGAGCCAGAGGACCCCAAAAGCCAGGTGGAGCCAGAGGACCCCAAAAGCCAGGTGGGGCCAGAGGACCCCCAAAGCCAGGTGG	GGCCAGAGGACCCCAAAAGCCAGGTGGAGCCAGAGGACCCCAAAAGCCAGGTGGAGCCAGAGGACCCCAAAAGCCAGGTGGGGCCAGAGGACCCCCAAAGCCAGGTGG	2: 180,595,266		probably benign	Het
Olfr1066	C	A	2: 86,455,900	V124L	possibly damaging	Het
Olfr1272	T	A	2: 90,296,493	I123F	probably damaging	Het
Olfr1499	G	T	19: 13,814,741	P283H	probably damaging	Het
Per2	T	A	1: 91,424,045	N913I	possibly damaging	Het
Rab9	C	T	X: 166,457,758	D186N	probably benign	Het
Reps1	C	T	10: 18,093,242	R183C	probably damaging	Het
Rims1	A	T	1: 22,425,887	C134S		Het
Rpl10-ps3	A	G	9: 50,344,884	S20P	probably benign	Het
Sash1	C	A	10: 8,729,831	G932C	probably damaging	Het
Sema4d	T	C	13: 51,700,923	Q46R		Het
Sh3d19	A	G	3: 86,107,261	E453G	probably damaging	Het
Sirt6	A	G	10: 81,625,714		probably benign	Het
Sis	A	T	3: 72,960,324	F129L	probably damaging	Het
Skint5	T	A	4: 113,876,010	I399F	unknown	Het
Slc22a7	T	C	17: 46,434,025	D365G	probably damaging	Het
Slc6a12	A	G	6: 121,347,488	M38V	probably benign	Het
Slc9b2	C	A	3: 135,326,163	Y261*	probably null	Het
Spata21	A	G	4: 141,104,907	I460V	probably benign	Het
Tes	C	G	6: 17,099,789	P261R	probably damaging	Het
Tex15	T	C	8: 33,572,696	L718P	probably benign	Het
Tmem135	G	A	7: 89,158,962	A202V	probably benign	Het
Usp29	T	C	7: 6,961,322	F55L	probably benign	Het
Usp9y	A	G	Y: 1,356,317	L1128P	probably damaging	Het
Zdhhc5	T	C	2: 84,690,252	E527G	probably benign	Het
Zfand4	A	G	6: 116,273,643	I11M	probably damaging	Het
Zfp110	T	A	7: 12,848,961	I512K	probably benign	Het
Zfp638	T	A	6: 83,977,161	F1416Y	probably damaging	Het

Other mutations in Fpr-rs4

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00539:Fpr-rs4	APN	17	18021926	missense	probably damaging	1.00
IGL01064:Fpr-rs4	APN	17	18022517	missense	probably damaging	1.00
IGL01626:Fpr-rs4	APN	17	18022231	missense	probably damaging	0.97
IGL02544:Fpr-rs4	APN	17	18022211	missense	probably benign
IGL02837:Fpr-rs4	UTSW	17	18022251	missense	probably benign	0.00
R0179:Fpr-rs4	UTSW	17	18022027	nonsense	probably null
R0383:Fpr-rs4	UTSW	17	18022097	missense	probably damaging	1.00
R0686:Fpr-rs4	UTSW	17	18022351	missense	probably benign	0.05
R1551:Fpr-rs4	UTSW	17	18022327	missense	possibly damaging	0.89
R1956:Fpr-rs4	UTSW	17	18022256	missense	probably damaging	0.97
R2040:Fpr-rs4	UTSW	17	18022334	frame shift	probably null
R2041:Fpr-rs4	UTSW	17	18022334	frame shift	probably null
R2043:Fpr-rs4	UTSW	17	18022334	frame shift	probably null
R2045:Fpr-rs4	UTSW	17	18022334	frame shift	probably null
R2048:Fpr-rs4	UTSW	17	18022334	frame shift	probably null
R2092:Fpr-rs4	UTSW	17	18022334	frame shift	probably null
R2093:Fpr-rs4	UTSW	17	18022334	frame shift	probably null
R2136:Fpr-rs4	UTSW	17	18022334	frame shift	probably null
R3624:Fpr-rs4	UTSW	17	18022334	frame shift	probably null
R4684:Fpr-rs4	UTSW	17	18022184	missense	probably damaging	1.00
R6076:Fpr-rs4	UTSW	17	18022055	missense	probably damaging	1.00
R6247:Fpr-rs4	UTSW	17	18022486	missense	probably benign	0.00
R6639:Fpr-rs4	UTSW	17	18022132	nonsense	probably null
R6757:Fpr-rs4	UTSW	17	18022132	nonsense	probably null
R9007:Fpr-rs4	UTSW	17	18022154	missense	probably damaging	1.00
R9318:Fpr-rs4	UTSW	17	18021955	missense	probably benign
R9357:Fpr-rs4	UTSW	17	18021949	missense	probably damaging	0.97
R9435:Fpr-rs4	UTSW	17	18022129	missense	probably benign	0.00
Z1088:Fpr-rs4	UTSW	17	18021919	missense	possibly damaging	0.85
Z1088:Fpr-rs4	UTSW	17	18022694	missense	probably benign	0.16

Predicted Primers

PCR Primer
(F):5'- CACACTGTGACCACTGTCTC -3'
(R):5'- CTGCTCTTCAGAGGTTGCAACC -3'

Sequencing Primer
(F):5'- GACCACTGTCTCTTATCTGAACTTGG -3'
(R):5'- GGTTGCAACCCAGGATTCAAATTTAG -3'

Posted On

2021-04-30