Incidental Mutation 'R8704:Gal3st3'
ID 669212
Institutional Source Beutler Lab
Gene Symbol Gal3st3
Ensembl Gene ENSMUSG00000047658
Gene Name galactose-3-O-sulfotransferase 3
Synonyms
MMRRC Submission 068558-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.106) question?
Stock # R8704 (G1)
Quality Score 225.009
Status Validated
Chromosome 19
Chromosomal Location 5348359-5358766 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 5352663 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Alanine at position 30 (V30A)
Ref Sequence ENSEMBL: ENSMUSP00000061517 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000061169]
AlphaFold P61315
Predicted Effect probably benign
Transcript: ENSMUST00000061169
AA Change: V30A

PolyPhen 2 Score 0.207 (Sensitivity: 0.92; Specificity: 0.88)
SMART Domains Protein: ENSMUSP00000061517
Gene: ENSMUSG00000047658
AA Change: V30A

DomainStartEndE-ValueType
Pfam:Gal-3-0_sulfotr 1 399 3.4e-205 PFAM
Pfam:Sulfotransfer_2 60 298 1.9e-7 PFAM
low complexity region 416 428 N/A INTRINSIC
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.9%
  • 20x: 99.5%
Validation Efficiency 98% (39/40)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the galactose-3-O-sulfotransferase protein family. The product of this gene catalyzes sulfonation by transferring a sulfate group to the 3' position of galactose in N-acetyllactosamine in both type 2 (Gal-beta-1-4GlcNAc-R) oligosaccharides and core-2-branched O-glycans, but not on type 1 or core-1-branched structures. This gene, which has also been referred to as GAL3ST2, is different from the GAL3ST2 gene located on chromosome 2 that encodes a related enzyme with distinct tissue distribution and substrate specificities, compared to galactose-3-O-sulfotransferase 3. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 39 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acap1 T C 11: 69,773,489 (GRCm39) Q628R possibly damaging Het
Agbl1 G T 7: 76,239,302 (GRCm39) probably benign Het
Brf2 A G 8: 27,618,499 (GRCm39) V35A possibly damaging Het
Chtf8 A C 8: 107,612,672 (GRCm39) M89R probably benign Het
Copa A G 1: 171,931,693 (GRCm39) I315V probably benign Het
Csmd2 G A 4: 128,091,147 (GRCm39) E229K Het
Etf1 T C 18: 35,039,139 (GRCm39) E376G probably damaging Het
Fat2 T A 11: 55,172,137 (GRCm39) I2859F probably damaging Het
Foxp1 C G 6: 98,993,507 (GRCm39) Q132H unknown Het
Gars1 C T 6: 55,040,215 (GRCm39) R381C probably damaging Het
Gjd3 C T 11: 98,873,445 (GRCm39) R133H probably damaging Het
Haspin T C 11: 73,028,828 (GRCm39) N87S probably benign Het
Hcrt A T 11: 100,652,752 (GRCm39) probably benign Het
Heatr6 T A 11: 83,668,104 (GRCm39) M866K probably benign Het
Igf1r T C 7: 67,819,802 (GRCm39) probably benign Het
Lgr5 A G 10: 115,288,610 (GRCm39) L678P probably benign Het
Lypd5 A G 7: 24,050,982 (GRCm39) H31R possibly damaging Het
Mib2 A G 4: 155,743,620 (GRCm39) M275T possibly damaging Het
Mmp19 G A 10: 128,634,703 (GRCm39) V440I probably benign Het
Nefm T C 14: 68,358,510 (GRCm39) E508G unknown Het
Nlrp4a A T 7: 26,156,563 (GRCm39) I763L probably benign Het
Or5p61 A T 7: 107,758,711 (GRCm39) V123D possibly damaging Het
Or9g4 T A 2: 85,504,562 (GRCm39) H311L Het
Pcdhb1 T A 18: 37,399,402 (GRCm39) V451D possibly damaging Het
Pfkfb2 T C 1: 130,625,780 (GRCm39) N467D probably benign Het
Ptprc G A 1: 138,043,362 (GRCm39) T63I probably benign Het
Rab9 C T X: 165,240,754 (GRCm39) D186N probably benign Het
Rhobtb2 G A 14: 70,031,373 (GRCm39) P584L probably damaging Het
Rhoc G C 3: 104,699,342 (GRCm39) A44P probably damaging Het
Sardh T C 2: 27,120,477 (GRCm39) E435G possibly damaging Het
Stfa1 A T 16: 36,105,536 (GRCm39) D89V probably damaging Het
Tec T C 5: 72,926,105 (GRCm39) K316E probably damaging Het
Tsen15 A T 1: 152,247,541 (GRCm39) Y150* probably null Het
Ugt1a5 T C 1: 88,094,087 (GRCm39) I105T probably benign Het
Usp25 A G 16: 76,856,178 (GRCm39) D257G probably benign Het
Vmn1r195 A G 13: 22,463,058 (GRCm39) Y176C possibly damaging Het
Wdr31 G A 4: 62,380,442 (GRCm39) A87V probably benign Het
Wwp2 A T 8: 108,212,228 (GRCm39) T177S probably benign Het
Zfp28 T C 7: 6,397,637 (GRCm39) C691R probably damaging Het
Other mutations in Gal3st3
AlleleSourceChrCoordTypePredicted EffectPPH Score
R1446:Gal3st3 UTSW 19 5,356,939 (GRCm39) missense probably damaging 1.00
R4199:Gal3st3 UTSW 19 5,357,808 (GRCm39) nonsense probably null
R7635:Gal3st3 UTSW 19 5,357,434 (GRCm39) missense probably damaging 1.00
R7990:Gal3st3 UTSW 19 5,352,617 (GRCm39) missense probably benign 0.37
R9072:Gal3st3 UTSW 19 5,352,605 (GRCm39) missense probably benign
R9299:Gal3st3 UTSW 19 5,356,868 (GRCm39) missense probably damaging 1.00
R9337:Gal3st3 UTSW 19 5,356,868 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TTCCTCTGGCCACTGCAAAC -3'
(R):5'- AGCAATTTACTCAGTCTTGCCC -3'

Sequencing Primer
(F):5'- CTGGCAGGTTTTTCAGGAACAC -3'
(R):5'- ACTCACTTTGTAGATCAGGCAGGC -3'
Posted On 2021-04-30