Mutagenetix > Incidental Mutation

Incidental Mutation 'R0534:Wdr59'

66939

Institutional Source

Beutler Lab

Gene Symbol

Wdr59

Ensembl Gene

ENSMUSG00000031959

Gene Name

WD repeat domain 59

Synonyms

5430401O09Rik

MMRRC Submission

038726-MU

Accession Numbers

Essential gene?

Essential (E-score: 1.000) question?

Stock #

R0534 (G1)

Quality Score

217

Status

Validated

Chromosome

Chromosomal Location

111448797-111522092 bp(-) (GRCm38)

Type of Mutation

small deletion (1 aa in frame mutation)

DNA Base Change (assembly)

GGGTGGTG to GGGTG at 111480540 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000148397 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000034437] [ENSMUST00000038193] [ENSMUST00000211981]

AlphaFold

no structure available at present

Predicted Effect

probably benign
Transcript: ENSMUST00000034437

SMART Domains

Protein: ENSMUSP00000034437
Gene: ENSMUSG00000031959

Domain	Start	End	E-Value	Type
WD40	41	91	1.37e2	SMART
WD40	94	134	9.52e-6	SMART
WD40	138	176	4.46e-1	SMART
WD40	180	220	2.59e-7	SMART
WD40	271	315	8.59e-1	SMART
RWD	393	494	4.13e-14	SMART
low complexity region	620	632	N/A	INTRINSIC
low complexity region	802	813	N/A	INTRINSIC
Blast:RING	941	980	3e-10	BLAST

Predicted Effect

probably benign
Transcript: ENSMUST00000038193

SMART Domains

Protein: ENSMUSP00000043671
Gene: ENSMUSG00000031959

Domain	Start	End	E-Value	Type
WD40	41	91	1.37e2	SMART
WD40	94	134	9.52e-6	SMART
WD40	138	176	4.46e-1	SMART
WD40	180	220	2.59e-7	SMART
WD40	271	315	8.59e-1	SMART
RWD	393	494	4.13e-14	SMART
low complexity region	803	814	N/A	INTRINSIC
Pfam:Zn_ribbon_17	937	992	2e-14	PFAM
Pfam:zinc_ribbon_16	949	990	1.6e-10	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000211981

Coding Region Coverage

1x: 99.2%
3x: 98.6%
10x: 97.0%
20x: 94.8%

Validation Efficiency

96% (47/49)

Allele List at MGI

Other mutations in this stock

Total: 48 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4933416C03Rik	T	C	10: 116,112,802	E273G	possibly damaging	Het
4933425L06Rik	C	A	13: 105,082,254	S32*	probably null	Het
Cand2	A	G	6: 115,787,236	M324V	probably damaging	Het
Cap1	C	T	4: 122,862,719	V340M	probably benign	Het
Ccdc110	T	C	8: 45,935,138	V44A	possibly damaging	Het
Cps1	A	G	1: 67,143,900	D139G	probably benign	Het
Cwc27	T	A	13: 104,631,616	E457V	unknown	Het
Cxxc1	C	T	18: 74,218,891	P280S	probably benign	Het
Dopey2	T	A	16: 93,762,505	L595Q	probably benign	Het
Dscam	G	T	16: 96,652,172	S1292R	possibly damaging	Het
E2f4	C	A	8: 105,304,219	F353L	probably damaging	Het
Ep300	A	G	15: 81,600,896		probably benign	Het
Fads1	C	T	19: 10,183,065	P5L	probably benign	Het
Fign	T	A	2: 63,980,791	H45L	probably damaging	Het
Flcn	T	A	11: 59,794,199		probably benign	Het
Gm5141	A	T	13: 62,774,594	F254I	probably damaging	Het
Gpbp1l1	T	A	4: 116,591,268	N402K	probably damaging	Het
Gpr37	A	T	6: 25,669,824	C340*	probably null	Het
Gtf3c2	A	T	5: 31,158,132		probably benign	Het
Hcfc2	T	A	10: 82,738,408	F139I	probably damaging	Het
Hectd4	T	C	5: 121,348,476	L3178P	possibly damaging	Het
Hrc	AGAGGAGGAGGAAGAGGAGGAGGA	AGAGGAGGAGGAGGAAGAGGAGGAGGA	7: 45,337,235		probably benign	Het
Igf2bp1	A	G	11: 95,966,796		probably benign	Het
Igsf9b	T	G	9: 27,333,062		probably null	Het
Il23r	G	A	6: 67,426,588	A443V	probably benign	Het
Kcnv1	A	G	15: 45,109,249	F413L	probably damaging	Het
Lipe	C	A	7: 25,388,186	A150S	possibly damaging	Het
Lrrcc1	T	C	3: 14,557,273	S557P	probably damaging	Het
Mrpl54	C	A	10: 81,266,853	W13L	probably damaging	Het
Myrf	G	C	19: 10,218,162	T428S	probably benign	Het
Npy1r	C	A	8: 66,705,018	Q327K	probably damaging	Het
Olfr64	C	T	7: 103,893,231	R168H	probably benign	Het
Osbpl10	C	T	9: 115,167,178	L139F	probably damaging	Het
P2rx6	A	C	16: 17,567,904	T199P	probably damaging	Het
Phyhip	A	T	14: 70,461,759	M1L	possibly damaging	Het
Pkd1l3	C	G	8: 109,623,649	D375E	possibly damaging	Het
Psmc1	T	A	12: 100,120,130	I342N	possibly damaging	Het
Reln	A	T	5: 21,947,408	D2353E	probably damaging	Het
Rmdn3	T	C	2: 119,146,370	E294G	probably benign	Het
Scnn1g	A	G	7: 121,767,424	M615V	probably benign	Het
Shcbp1l	T	A	1: 153,428,568	D124E	possibly damaging	Het
Sipa1l1	T	C	12: 82,425,280	S1345P	possibly damaging	Het
Soga3	T	A	10: 29,180,956		probably benign	Het
St5	A	T	7: 109,541,428	V197D	probably damaging	Het
Timp4	A	G	6: 115,249,841	Y114H	probably damaging	Het
Tlr9	T	A	9: 106,224,887	L459Q	probably benign	Het
Tmem104	C	A	11: 115,200,828	T59K	probably damaging	Het
Zfp622	A	T	15: 25,984,568	I7F	possibly damaging	Het

Other mutations in Wdr59

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00737:Wdr59	APN	8	111458736	missense	probably damaging	0.98
IGL01330:Wdr59	APN	8	111481933	missense	possibly damaging	0.87
IGL01413:Wdr59	APN	8	111501074	missense	probably benign	0.23
IGL02306:Wdr59	APN	8	111492733	missense	probably damaging	1.00
IGL03027:Wdr59	APN	8	111462192	missense	probably damaging	1.00
IGL03057:Wdr59	APN	8	111476118	missense	probably damaging	1.00
IGL03204:Wdr59	APN	8	111485370	missense	probably benign	0.05
electron	UTSW	8	111458638	missense	probably benign	0.00
photon	UTSW	8	111460813	missense	probably benign	0.00
R0056:Wdr59	UTSW	8	111480607	splice site	probably benign
R0096:Wdr59	UTSW	8	111504373	missense	probably damaging	1.00
R0096:Wdr59	UTSW	8	111504373	missense	probably damaging	1.00
R0440:Wdr59	UTSW	8	111480540	small deletion	probably benign
R0452:Wdr59	UTSW	8	111521972	missense	possibly damaging	0.87
R0472:Wdr59	UTSW	8	111486997	critical splice acceptor site	probably null
R0501:Wdr59	UTSW	8	111458947	missense	possibly damaging	0.90
R0526:Wdr59	UTSW	8	111480540	small deletion	probably benign
R0601:Wdr59	UTSW	8	111480540	small deletion	probably benign
R1144:Wdr59	UTSW	8	111486944	missense	probably benign	0.09
R1415:Wdr59	UTSW	8	111498596	missense	probably damaging	1.00
R1571:Wdr59	UTSW	8	111451050	missense	probably damaging	0.98
R1661:Wdr59	UTSW	8	111479362	missense	probably damaging	1.00
R1665:Wdr59	UTSW	8	111479362	missense	probably damaging	1.00
R1839:Wdr59	UTSW	8	111485340	missense	probably benign
R1856:Wdr59	UTSW	8	111476181	missense	probably damaging	1.00
R1872:Wdr59	UTSW	8	111459017	missense	probably damaging	1.00
R1921:Wdr59	UTSW	8	111486950	nonsense	probably null
R1965:Wdr59	UTSW	8	111451077	missense	probably damaging	1.00
R1966:Wdr59	UTSW	8	111450903	missense	possibly damaging	0.92
R1977:Wdr59	UTSW	8	111458638	missense	probably benign	0.00
R2019:Wdr59	UTSW	8	111466793	missense	probably damaging	1.00
R4245:Wdr59	UTSW	8	111490364	missense	possibly damaging	0.63
R4471:Wdr59	UTSW	8	111466787	critical splice donor site	probably null
R4820:Wdr59	UTSW	8	111480814	missense	probably benign	0.19
R5198:Wdr59	UTSW	8	111481988	missense	probably benign	0.00
R5540:Wdr59	UTSW	8	111485184	missense	possibly damaging	0.84
R5571:Wdr59	UTSW	8	111465831	missense	probably damaging	1.00
R6166:Wdr59	UTSW	8	111472661	missense	probably damaging	1.00
R6732:Wdr59	UTSW	8	111501052	missense	probably damaging	1.00
R6767:Wdr59	UTSW	8	111476101	missense	probably damaging	1.00
R6823:Wdr59	UTSW	8	111459040	missense	possibly damaging	0.95
R6841:Wdr59	UTSW	8	111496880	missense	probably damaging	1.00
R6888:Wdr59	UTSW	8	111451043	missense	probably benign	0.00
R6974:Wdr59	UTSW	8	111460788	missense	possibly damaging	0.86
R6982:Wdr59	UTSW	8	111460813	missense	probably benign	0.00
R7066:Wdr59	UTSW	8	111465845	missense	probably benign	0.07
R7154:Wdr59	UTSW	8	111458735	missense
R7176:Wdr59	UTSW	8	111492756	missense
R7286:Wdr59	UTSW	8	111465862	missense
R7332:Wdr59	UTSW	8	111494354	missense
R7537:Wdr59	UTSW	8	111490369	missense
R7614:Wdr59	UTSW	8	111492762	missense
R7758:Wdr59	UTSW	8	111480485	missense
R7800:Wdr59	UTSW	8	111521938	missense
R7861:Wdr59	UTSW	8	111494280	missense
R8137:Wdr59	UTSW	8	111485379	missense
R8726:Wdr59	UTSW	8	111496834	missense
R8942:Wdr59	UTSW	8	111485176	missense	probably benign
R9318:Wdr59	UTSW	8	111451068	missense
X0026:Wdr59	UTSW	8	111479340	missense	possibly damaging	0.95

Predicted Primers

Posted On

2013-08-19