Incidental Mutation 'R8709:Cwf19l2'
ID 669444
Institutional Source Beutler Lab
Gene Symbol Cwf19l2
Ensembl Gene ENSMUSG00000025898
Gene Name CWF19 like cell cycle control factor 2
Synonyms 3230401L03Rik
MMRRC Submission 068563-MU
Accession Numbers
Essential gene? Probably essential (E-score: 0.934) question?
Stock # R8709 (G1)
Quality Score 225.009
Status Validated
Chromosome 9
Chromosomal Location 3403592-3479236 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to A at 3430723 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamine to Lysine at position 352 (Q352K)
Ref Sequence ENSEMBL: ENSMUSP00000027027 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000027027]
AlphaFold Q8BG79
Predicted Effect probably benign
Transcript: ENSMUST00000027027
AA Change: Q352K

PolyPhen 2 Score 0.262 (Sensitivity: 0.91; Specificity: 0.88)
SMART Domains Protein: ENSMUSP00000027027
Gene: ENSMUSG00000025898
AA Change: Q352K

DomainStartEndE-ValueType
low complexity region 64 114 N/A INTRINSIC
coiled coil region 165 196 N/A INTRINSIC
low complexity region 403 418 N/A INTRINSIC
coiled coil region 496 524 N/A INTRINSIC
Pfam:CwfJ_C_1 655 779 1.8e-40 PFAM
Pfam:CwfJ_C_2 788 882 4.6e-34 PFAM
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 99.1%
Validation Efficiency 96% (55/57)
Allele List at MGI
Other mutations in this stock
Total: 55 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
3100002H09Rik A G 4: 124,504,316 (GRCm39) S79P unknown Het
Aadacl4fm2 C G 4: 144,281,863 (GRCm39) A310P probably damaging Het
Adamts20 T A 15: 94,238,947 (GRCm39) D757V probably damaging Het
Adamts9 C T 6: 92,784,144 (GRCm39) G1570D probably damaging Het
Adamtsl3 A G 7: 82,077,642 (GRCm39) Y109C possibly damaging Het
Agl G A 3: 116,566,121 (GRCm39) R335C Het
Ankfy1 C A 11: 72,646,532 (GRCm39) T805K possibly damaging Het
Cast A T 13: 74,892,780 (GRCm39) V96E probably damaging Het
Cdh17 G T 4: 11,795,685 (GRCm39) E422* probably null Het
Cox4i1 T A 8: 121,396,110 (GRCm39) L21H possibly damaging Het
Cwc22 T C 2: 77,726,694 (GRCm39) E795G probably benign Het
Cyp2d9 T C 15: 82,339,276 (GRCm39) V226A probably benign Het
Dnah12 A G 14: 26,414,757 (GRCm39) I53V probably benign Het
Dnah7a T C 1: 53,674,476 (GRCm39) I434V probably benign Het
Dock8 C T 19: 25,055,448 (GRCm39) Q137* probably null Het
Eif4b T G 15: 102,002,116 (GRCm39) V515G unknown Het
Far2 T A 6: 148,067,133 (GRCm39) N339K probably benign Het
Gpr22 T C 12: 31,759,829 (GRCm39) T98A probably damaging Het
Hamp2 A G 7: 30,621,974 (GRCm39) C72R probably damaging Het
Hmgn1 G A 16: 95,928,540 (GRCm39) P16S possibly damaging Het
Hspd1 A G 1: 55,120,922 (GRCm39) S256P probably benign Het
Iqcn T C 8: 71,162,372 (GRCm39) C522R possibly damaging Het
Iqgap2 T C 13: 95,796,713 (GRCm39) H1147R probably damaging Het
Itgb1 T A 8: 129,439,887 (GRCm39) probably benign Het
Klhl29 A T 12: 5,140,681 (GRCm39) W654R probably damaging Het
Krtap22-2 T A 16: 88,807,514 (GRCm39) Y28F unknown Het
Lcp2 T A 11: 34,004,354 (GRCm39) probably benign Het
Muc5ac T G 7: 141,370,663 (GRCm39) L3225R possibly damaging Het
Myom3 A G 4: 135,523,607 (GRCm39) E908G possibly damaging Het
Nup54 A G 5: 92,570,267 (GRCm39) probably benign Het
Or1p1 T A 11: 74,180,054 (GRCm39) I194N possibly damaging Het
Or4a74 C T 2: 89,440,366 (GRCm39) V27I probably benign Het
Or51af1 T C 7: 103,141,519 (GRCm39) T189A probably benign Het
Or5ae1 T A 7: 84,565,671 (GRCm39) I228N probably damaging Het
Pak4 A C 7: 28,261,969 (GRCm39) D453E probably benign Het
Pkd1l1 T C 11: 8,805,567 (GRCm39) T2120A Het
Pkhd1l1 T A 15: 44,381,570 (GRCm39) S1099T probably benign Het
Pld2 C T 11: 70,444,275 (GRCm39) R524W probably damaging Het
Polr1a T A 6: 71,951,832 (GRCm39) D1466E probably benign Het
Pxdn C T 12: 30,056,601 (GRCm39) L1271F probably damaging Het
Rp1l1 A C 14: 64,269,295 (GRCm39) D1627A probably damaging Het
Sephs1 T C 2: 4,889,402 (GRCm39) V60A probably benign Het
Sipa1 C T 19: 5,710,980 (GRCm39) R10Q probably damaging Het
Sp4 T C 12: 118,263,189 (GRCm39) T286A possibly damaging Het
Spag5 T A 11: 78,192,738 (GRCm39) S23R probably benign Het
Spag9 T A 11: 93,958,916 (GRCm39) N313K probably benign Het
Stag1 T A 9: 100,772,975 (GRCm39) probably benign Het
Stkld1 T A 2: 26,835,817 (GRCm39) H217Q probably benign Het
Stxbp2 T A 8: 3,683,914 (GRCm39) F104I possibly damaging Het
Tcf12 A G 9: 71,765,787 (GRCm39) V575A possibly damaging Het
Tcf12 A T 9: 71,830,069 (GRCm39) S131T probably benign Het
Tg T A 15: 66,553,786 (GRCm39) S400R probably benign Het
Tomm40 T C 7: 19,444,703 (GRCm39) T200A possibly damaging Het
Trio T C 15: 27,919,323 (GRCm39) E71G unknown Het
Zfp292 A T 4: 34,805,982 (GRCm39) V2359E probably damaging Het
Other mutations in Cwf19l2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00227:Cwf19l2 APN 9 3,409,990 (GRCm39) missense probably benign 0.01
IGL00573:Cwf19l2 APN 9 3,450,161 (GRCm39) splice site probably benign
IGL00757:Cwf19l2 APN 9 3,460,054 (GRCm39) missense probably damaging 1.00
IGL00803:Cwf19l2 APN 9 3,430,810 (GRCm39) missense probably benign 0.41
IGL01916:Cwf19l2 APN 9 3,477,869 (GRCm39) missense possibly damaging 0.82
IGL02315:Cwf19l2 APN 9 3,410,030 (GRCm39) missense probably damaging 1.00
IGL02419:Cwf19l2 APN 9 3,418,777 (GRCm39) critical splice donor site probably null
IGL02427:Cwf19l2 APN 9 3,456,817 (GRCm39) missense probably benign 0.00
IGL03026:Cwf19l2 APN 9 3,428,777 (GRCm39) missense probably benign 0.28
IGL03028:Cwf19l2 APN 9 3,430,622 (GRCm39) missense probably benign 0.26
IGL03199:Cwf19l2 APN 9 3,477,830 (GRCm39) missense probably damaging 1.00
R0015:Cwf19l2 UTSW 9 3,454,666 (GRCm39) missense probably benign 0.00
R0015:Cwf19l2 UTSW 9 3,454,666 (GRCm39) missense probably benign 0.00
R0532:Cwf19l2 UTSW 9 3,431,057 (GRCm39) missense probably benign 0.38
R0724:Cwf19l2 UTSW 9 3,421,377 (GRCm39) critical splice donor site probably null
R0924:Cwf19l2 UTSW 9 3,441,047 (GRCm39) splice site probably benign
R0947:Cwf19l2 UTSW 9 3,421,286 (GRCm39) missense probably benign 0.16
R1210:Cwf19l2 UTSW 9 3,430,810 (GRCm39) missense probably benign 0.00
R1393:Cwf19l2 UTSW 9 3,456,818 (GRCm39) missense probably benign 0.01
R1541:Cwf19l2 UTSW 9 3,456,760 (GRCm39) missense probably damaging 1.00
R1594:Cwf19l2 UTSW 9 3,430,973 (GRCm39) missense probably benign
R1870:Cwf19l2 UTSW 9 3,458,802 (GRCm39) missense possibly damaging 0.56
R1950:Cwf19l2 UTSW 9 3,418,674 (GRCm39) missense probably benign
R1996:Cwf19l2 UTSW 9 3,417,947 (GRCm39) missense probably benign 0.01
R2005:Cwf19l2 UTSW 9 3,430,720 (GRCm39) missense possibly damaging 0.92
R2246:Cwf19l2 UTSW 9 3,430,661 (GRCm39) missense probably benign 0.16
R2420:Cwf19l2 UTSW 9 3,411,341 (GRCm39) missense possibly damaging 0.80
R3051:Cwf19l2 UTSW 9 3,410,006 (GRCm39) missense probably benign 0.05
R3738:Cwf19l2 UTSW 9 3,456,803 (GRCm39) missense probably benign 0.01
R3915:Cwf19l2 UTSW 9 3,456,776 (GRCm39) missense probably damaging 1.00
R4034:Cwf19l2 UTSW 9 3,456,803 (GRCm39) missense probably benign 0.01
R4035:Cwf19l2 UTSW 9 3,456,803 (GRCm39) missense probably benign 0.01
R4323:Cwf19l2 UTSW 9 3,430,452 (GRCm39) missense probably damaging 0.99
R4328:Cwf19l2 UTSW 9 3,458,878 (GRCm39) missense probably damaging 1.00
R4329:Cwf19l2 UTSW 9 3,458,878 (GRCm39) missense probably damaging 1.00
R4692:Cwf19l2 UTSW 9 3,428,709 (GRCm39) missense probably damaging 1.00
R4775:Cwf19l2 UTSW 9 3,430,973 (GRCm39) missense probably benign
R4779:Cwf19l2 UTSW 9 3,410,035 (GRCm39) missense possibly damaging 0.95
R4822:Cwf19l2 UTSW 9 3,458,839 (GRCm39) missense probably damaging 1.00
R4833:Cwf19l2 UTSW 9 3,430,783 (GRCm39) missense probably benign 0.28
R5110:Cwf19l2 UTSW 9 3,450,012 (GRCm39) critical splice acceptor site probably null
R5120:Cwf19l2 UTSW 9 3,418,761 (GRCm39) nonsense probably null
R5164:Cwf19l2 UTSW 9 3,475,511 (GRCm39) missense probably damaging 1.00
R5440:Cwf19l2 UTSW 9 3,475,549 (GRCm39) missense probably damaging 1.00
R5567:Cwf19l2 UTSW 9 3,456,831 (GRCm39) missense probably damaging 1.00
R5594:Cwf19l2 UTSW 9 3,418,773 (GRCm39) missense probably benign 0.42
R5960:Cwf19l2 UTSW 9 3,411,404 (GRCm39) missense probably benign 0.43
R6222:Cwf19l2 UTSW 9 3,454,569 (GRCm39) nonsense probably null
R6259:Cwf19l2 UTSW 9 3,458,879 (GRCm39) missense probably damaging 1.00
R6688:Cwf19l2 UTSW 9 3,450,015 (GRCm39) missense probably benign 0.00
R6983:Cwf19l2 UTSW 9 3,477,817 (GRCm39) missense probably damaging 1.00
R7063:Cwf19l2 UTSW 9 3,430,532 (GRCm39) missense probably benign 0.03
R7506:Cwf19l2 UTSW 9 3,456,775 (GRCm39) missense probably damaging 1.00
R7733:Cwf19l2 UTSW 9 3,450,066 (GRCm39) missense probably benign 0.19
R7846:Cwf19l2 UTSW 9 3,477,889 (GRCm39) missense probably damaging 1.00
R7900:Cwf19l2 UTSW 9 3,460,107 (GRCm39) missense probably damaging 1.00
R8510:Cwf19l2 UTSW 9 3,454,732 (GRCm39) missense possibly damaging 0.89
R8900:Cwf19l2 UTSW 9 3,447,245 (GRCm39) missense probably benign 0.01
R9031:Cwf19l2 UTSW 9 3,417,942 (GRCm39) missense probably benign 0.00
R9373:Cwf19l2 UTSW 9 3,454,718 (GRCm39) missense probably damaging 0.99
R9701:Cwf19l2 UTSW 9 3,430,454 (GRCm39) missense probably damaging 1.00
T0722:Cwf19l2 UTSW 9 3,456,755 (GRCm39) missense probably benign 0.00
X0003:Cwf19l2 UTSW 9 3,456,755 (GRCm39) missense probably benign 0.00
X0020:Cwf19l2 UTSW 9 3,418,662 (GRCm39) missense probably damaging 1.00
Z1177:Cwf19l2 UTSW 9 3,428,782 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- ACGGTGGAGAAAGCCTACATATTC -3'
(R):5'- ATCGACTGCAGGATGCTGAAC -3'

Sequencing Primer
(F):5'- TTCAGATAGAGCACAGTGTAGTC -3'
(R):5'- GACTGCAGGATGCTGAACTTTCTTC -3'
Posted On 2021-04-30