Incidental Mutation 'IGL00585:Gm136'
ID6695
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Gm136
Ensembl Gene ENSMUSG00000071015
Gene Namepredicted gene 136
SynonymsLOC214568
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.063) question?
Stock #IGL00585
Quality Score
Status
Chromosome4
Chromosomal Location34743784-34756263 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to A at 34752322 bp
ZygosityHeterozygous
Amino Acid Change Glutamic Acid to Valine at position 69 (E69V)
Ref Sequence ENSEMBL: ENSMUSP00000092748 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000095129]
Predicted Effect probably damaging
Transcript: ENSMUST00000095129
AA Change: E69V

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000092748
Gene: ENSMUSG00000071015
AA Change: E69V

DomainStartEndE-ValueType
low complexity region 72 83 N/A INTRINSIC
coiled coil region 119 189 N/A INTRINSIC
coiled coil region 223 251 N/A INTRINSIC
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 44 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca17 T A 17: 24,300,320 I664F probably damaging Het
Abcg4 A T 9: 44,281,623 M142K probably benign Het
Afdn A G 17: 13,884,628 T1198A probably damaging Het
Angptl2 T C 2: 33,246,227 S475P probably damaging Het
Ap3s2 T C 7: 79,916,076 E34G probably benign Het
C1qtnf9 T C 14: 60,779,993 F324S probably damaging Het
Cacng7 A G 7: 3,366,031 Y170C probably damaging Het
Ceacam18 G A 7: 43,637,011 V103M possibly damaging Het
Chrnb1 G A 11: 69,793,916 P144S probably damaging Het
Chuk T C 19: 44,078,312 H652R probably damaging Het
Ckap5 C T 2: 91,619,825 L1948F probably damaging Het
Clstn1 A T 4: 149,638,312 H469L probably benign Het
Csf2rb2 C T 15: 78,284,847 G594S possibly damaging Het
Ctsq A T 13: 61,037,127 D248E probably benign Het
Ep400 A T 5: 110,755,905 I276K possibly damaging Het
Gbf1 G A 19: 46,284,249 probably null Het
Gldn T A 9: 54,338,464 I433N probably damaging Het
Gm28177 T C 1: 52,082,579 probably null Het
Gtf2h2 A G 13: 100,480,998 probably benign Het
Ints12 T C 3: 133,100,809 probably null Het
Ltbp4 T C 7: 27,326,733 D615G probably damaging Het
Mgme1 C T 2: 144,271,989 P4S probably benign Het
Nae1 A G 8: 104,526,278 probably null Het
Nup133 G A 8: 123,909,994 A956V probably damaging Het
Oacyl T A 18: 65,749,640 M529K possibly damaging Het
Osbpl1a T A 18: 12,757,626 E519V possibly damaging Het
Pacs1 A T 19: 5,153,698 V333E probably damaging Het
Pik3c3 T G 18: 30,303,078 probably benign Het
Polh C T 17: 46,172,243 probably benign Het
Ppp6r3 A G 19: 3,490,826 C431R probably damaging Het
Pprc1 T C 19: 46,062,648 S206P possibly damaging Het
Rab20 A G 8: 11,454,212 Y163H probably benign Het
Sde2 T A 1: 180,855,818 C46S possibly damaging Het
Serpinb1c T C 13: 32,883,975 K213E probably damaging Het
Spata20 T G 11: 94,479,117 L784F probably damaging Het
Tnnt1 A C 7: 4,507,550 M224R possibly damaging Het
Trank1 T C 9: 111,349,290 F349L possibly damaging Het
Ttf1 T C 2: 29,073,883 probably benign Het
Usp54 T A 14: 20,573,837 S651C probably damaging Het
Vps45 A G 3: 96,000,066 *571R probably null Het
Yod1 G A 1: 130,719,133 G249E probably damaging Het
Ythdc2 A G 18: 44,864,361 Y340C probably damaging Het
Zfp366 G A 13: 99,246,572 probably benign Het
Zfp648 T A 1: 154,204,189 D31E possibly damaging Het
Other mutations in Gm136
AlleleSourceChrCoordTypePredicted EffectPPH Score
R0104:Gm136 UTSW 4 34746593 missense possibly damaging 0.65
R0108:Gm136 UTSW 4 34746593 missense possibly damaging 0.65
R1221:Gm136 UTSW 4 34744127 missense possibly damaging 0.71
R1635:Gm136 UTSW 4 34750919 critical splice donor site probably null
R1674:Gm136 UTSW 4 34746662 splice site probably benign
R1971:Gm136 UTSW 4 34755986 missense probably benign 0.00
R2496:Gm136 UTSW 4 34746541 missense probably damaging 1.00
R4441:Gm136 UTSW 4 34755911 missense probably benign 0.35
R4901:Gm136 UTSW 4 34746580 nonsense probably null
R5300:Gm136 UTSW 4 34750930 missense probably damaging 0.98
R6609:Gm136 UTSW 4 34746526 missense probably benign
R6709:Gm136 UTSW 4 34755884 missense probably damaging 1.00
R6824:Gm136 UTSW 4 34746591 missense probably benign 0.15
R7098:Gm136 UTSW 4 34746628 missense probably benign 0.08
R7689:Gm136 UTSW 4 34743875 missense probably null 0.00
R8249:Gm136 UTSW 4 34750955 missense probably benign
Posted On2012-04-20