Mutagenetix > Incidental Mutation

Incidental Mutation 'R0533:Vmn2r71'

66954

Institutional Source

Beutler Lab

Gene Symbol

Vmn2r71

Ensembl Gene

ENSMUSG00000091205

Gene Name

vomeronasal 2, receptor 71

Synonyms

EG233445

MMRRC Submission

038725-MU

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.066) question?

Stock #

R0533 (G1)

Quality Score

217

Status

Validated

Chromosome

Chromosomal Location

85574614-85624547 bp(+) (GRCm38)

Type of Mutation

frame shift

DNA Base Change (assembly)

GT to GTT at 85619218 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000132337 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000172338]

AlphaFold

L7N2D8

Predicted Effect

probably null
Transcript: ENSMUST00000172338

SMART Domains

Protein: ENSMUSP00000132337
Gene: ENSMUSG00000091205

Domain	Start	End	E-Value	Type
signal peptide	1	18	N/A	INTRINSIC
Pfam:ANF_receptor	77	468	2.1e-31	PFAM
Pfam:NCD3G	511	563	8.7e-20	PFAM
Pfam:7tm_3	593	831	2e-55	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000208273

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000208545

Coding Region Coverage

1x: 99.1%
3x: 98.2%
10x: 96.0%
20x: 91.5%

Validation Efficiency

100% (57/57)

Allele List at MGI

Other mutations in this stock

Total: 56 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Aadat	T	G	8: 60,531,763		probably benign	Het
Abcb1b	A	T	5: 8,864,113		probably null	Het
Adcy10	A	G	1: 165,564,023	N1283S	probably benign	Het
Adgrb1	T	A	15: 74,541,559	W531R	probably damaging	Het
Ago4	A	G	4: 126,516,860	V246A	probably benign	Het
Arid5b	A	T	10: 68,186,033	D242E	probably damaging	Het
Arpp21	A	G	9: 112,126,505	V522A	probably benign	Het
Atg4b	T	A	1: 93,784,910		probably benign	Het
Capn12	T	C	7: 28,887,683	F359S	possibly damaging	Het
Ccdc88c	A	T	12: 100,954,282	I360N	probably damaging	Het
Clic3	A	G	2: 25,458,138	Y99C	probably damaging	Het
Cux1	T	C	5: 136,307,859	E925G	probably damaging	Het
Dnah10	G	A	5: 124,775,250		probably null	Het
Dnah17	A	G	11: 118,110,537	V860A	possibly damaging	Het
Etv5	C	T	16: 22,436,075		probably benign	Het
Fam83a	T	A	15: 58,009,811	N345K	probably benign	Het
G3bp1	T	C	11: 55,498,626	F383L	probably damaging	Het
Gm13089	G	T	4: 143,698,020	C284*	probably null	Het
Gpm6a	A	G	8: 55,055,374		probably null	Het
Grid1	T	A	14: 35,309,385	Y312N	possibly damaging	Het
Gstm4	T	C	3: 108,043,525	N51S	probably benign	Het
Hid1	A	T	11: 115,348,809	I765N	probably damaging	Het
Hmmr	A	G	11: 40,709,989	V518A	unknown	Het
Itgb6	A	G	2: 60,669,197	V84A	probably benign	Het
Kbtbd4	A	G	2: 90,907,604	K233E	probably benign	Het
Kif15	A	T	9: 123,009,433		probably benign	Het
Klre1	T	C	6: 129,583,193	S143P	probably damaging	Het
Krt81	T	C	15: 101,461,389	D216G	probably benign	Het
Mctp2	G	T	7: 72,080,822	H868Q	probably benign	Het
Morc2b	G	C	17: 33,135,932	Y955*	probably null	Het
Myog	A	C	1: 134,290,473	N140H	possibly damaging	Het
Myrf	G	C	19: 10,218,162	T428S	probably benign	Het
Naip2	A	C	13: 100,161,782	I582S	probably benign	Het
Neil3	A	T	8: 53,638,775		probably null	Het
Nrg1	T	C	8: 31,831,245		probably null	Het
Olfr681	G	A	7: 105,122,350	V298I	probably benign	Het
Olfr689	A	T	7: 105,314,372	M123L	probably benign	Het
Olfr99	A	T	17: 37,280,291	L43*	probably null	Het
Pramef25	A	T	4: 143,950,720	D96E	possibly damaging	Het
Ptger2	T	A	14: 44,988,982	N6K	possibly damaging	Het
Ryr1	T	A	7: 29,078,780	E2097V	probably damaging	Het
Sel1l	A	T	12: 91,820,094	F397Y	probably damaging	Het
Skint5	A	G	4: 113,827,867	V551A	unknown	Het
Slc39a12	A	G	2: 14,400,331	T245A	probably benign	Het
Syne1	C	T	10: 5,358,438	V706I	probably benign	Het
Tbc1d8	G	T	1: 39,372,774	Q994K	possibly damaging	Het
Tnrc6b	C	T	15: 80,876,653	T187I	probably benign	Het
Ttll6	G	A	11: 96,154,756	A600T	probably benign	Het
Ust	T	C	10: 8,248,080		probably benign	Het
Vstm2a	C	T	11: 16,263,041	A142V	probably damaging	Het
Wfs1	T	A	5: 36,973,722		probably benign	Het
Wrap73	G	A	4: 154,151,649	G145D	probably damaging	Het
Wrap73	G	A	4: 154,156,154	V368M	possibly damaging	Het
Xrra1	T	A	7: 99,875,145		probably null	Het
Zfhx2	C	T	14: 55,064,090	V2146I	probably benign	Het
Zfp335	A	T	2: 164,907,922	L185*	probably null	Het

Other mutations in Vmn2r71

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00922:Vmn2r71	APN	7	85618693	missense	probably benign
IGL00960:Vmn2r71	APN	7	85624374	missense	probably damaging	1.00
IGL01372:Vmn2r71	APN	7	85620814	splice site	probably benign
IGL01690:Vmn2r71	APN	7	85615574	missense	probably damaging	1.00
IGL01909:Vmn2r71	APN	7	85620793	missense	probably benign	0.00
IGL01950:Vmn2r71	APN	7	85615619	missense	probably damaging	0.98
IGL02570:Vmn2r71	APN	7	85615540	missense	possibly damaging	0.95
IGL02650:Vmn2r71	APN	7	85624327	missense	probably damaging	1.00
IGL02901:Vmn2r71	APN	7	85619262	missense	probably benign	0.00
IGL03128:Vmn2r71	APN	7	85619587	missense	probably damaging	1.00
IGL03328:Vmn2r71	APN	7	85624291	missense	probably damaging	1.00
R0707:Vmn2r71	UTSW	7	85619432	missense	probably benign
R0841:Vmn2r71	UTSW	7	85618541	missense	possibly damaging	0.62
R0865:Vmn2r71	UTSW	7	85619308	missense	probably benign	0.01
R0883:Vmn2r71	UTSW	7	85623634	missense	probably benign	0.19
R0939:Vmn2r71	UTSW	7	85623681	missense	possibly damaging	0.70
R1597:Vmn2r71	UTSW	7	85624144	missense	possibly damaging	0.46
R1646:Vmn2r71	UTSW	7	85621268	missense	probably damaging	0.99
R1719:Vmn2r71	UTSW	7	85621227	missense	probably damaging	1.00
R1860:Vmn2r71	UTSW	7	85615574	missense	probably damaging	1.00
R2013:Vmn2r71	UTSW	7	85620637	missense	probably benign	0.38
R2014:Vmn2r71	UTSW	7	85620637	missense	probably benign	0.38
R2015:Vmn2r71	UTSW	7	85620637	missense	probably benign	0.38
R2050:Vmn2r71	UTSW	7	85624473	missense	probably damaging	1.00
R2084:Vmn2r71	UTSW	7	85618737	missense	probably benign	0.03
R2221:Vmn2r71	UTSW	7	85624093	missense	probably benign	0.40
R2223:Vmn2r71	UTSW	7	85624093	missense	probably benign	0.40
R2245:Vmn2r71	UTSW	7	85624180	missense	probably damaging	1.00
R3115:Vmn2r71	UTSW	7	85623658	missense	probably damaging	0.97
R3122:Vmn2r71	UTSW	7	85615620	nonsense	probably null
R3609:Vmn2r71	UTSW	7	85619662	missense	probably damaging	1.00
R4093:Vmn2r71	UTSW	7	85621234	missense	probably benign	0.00
R4305:Vmn2r71	UTSW	7	85624152	missense	probably damaging	1.00
R4306:Vmn2r71	UTSW	7	85624152	missense	probably damaging	1.00
R4334:Vmn2r71	UTSW	7	85619834	missense	probably benign	0.01
R4569:Vmn2r71	UTSW	7	85624194	missense	possibly damaging	0.66
R4622:Vmn2r71	UTSW	7	85620609	missense	probably benign	0.00
R4915:Vmn2r71	UTSW	7	85621268	missense	probably damaging	0.99
R4956:Vmn2r71	UTSW	7	85619228	missense	probably benign	0.19
R5005:Vmn2r71	UTSW	7	85624144	missense	probably damaging	1.00
R5045:Vmn2r71	UTSW	7	85624389	missense	probably benign	0.00
R5153:Vmn2r71	UTSW	7	85619222	missense	possibly damaging	0.94
R5236:Vmn2r71	UTSW	7	85623669	missense	probably damaging	1.00
R5373:Vmn2r71	UTSW	7	85618542	missense	possibly damaging	0.79
R5405:Vmn2r71	UTSW	7	85619414	missense	probably benign
R5831:Vmn2r71	UTSW	7	85623714	missense	probably benign	0.16
R6061:Vmn2r71	UTSW	7	85619274	missense	probably benign
R6518:Vmn2r71	UTSW	7	85621228	missense	probably damaging	1.00
R6751:Vmn2r71	UTSW	7	85619887	critical splice donor site	probably null
R6920:Vmn2r71	UTSW	7	85623900	missense	probably damaging	1.00
R7358:Vmn2r71	UTSW	7	85624260	missense	possibly damaging	0.81
R7453:Vmn2r71	UTSW	7	85624089	missense	probably benign	0.21
R7560:Vmn2r71	UTSW	7	85623907	missense	probably benign	0.06
R7871:Vmn2r71	UTSW	7	85623661	missense	possibly damaging	0.81
R8267:Vmn2r71	UTSW	7	85615496	missense	probably benign	0.02
R8377:Vmn2r71	UTSW	7	85615499	missense	probably benign
R9278:Vmn2r71	UTSW	7	85620580	missense	probably benign	0.19
R9319:Vmn2r71	UTSW	7	85624486	missense	probably damaging	1.00
R9329:Vmn2r71	UTSW	7	85618742	missense	probably benign	0.00
R9368:Vmn2r71	UTSW	7	85624234	missense	probably damaging	1.00
R9636:Vmn2r71	UTSW	7	85619180	missense	possibly damaging	0.80
R9756:Vmn2r71	UTSW	7	85619365	nonsense	probably null
X0025:Vmn2r71	UTSW	7	85618665	missense	probably benign
Z1186:Vmn2r71	UTSW	7	85623886	missense	probably damaging	1.00

Predicted Primers

Posted On

2013-08-19