Mutagenetix > Incidental Mutation

Incidental Mutation 'R8712:Vmn2r101'

669680

Institutional Source

Beutler Lab

Gene Symbol

Vmn2r101

Ensembl Gene

ENSMUSG00000094892

Gene Name

vomeronasal 2, receptor 101

Synonyms

EG627576

MMRRC Submission

068566-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.124) question?

Stock #

R8712 (G1)

Quality Score

225.009

Status

Validated

Chromosome

Chromosomal Location

19797493-19832579 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 19811397 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Leucine to Isoleucine at position 494 (L494I)

Ref Sequence

ENSEMBL: ENSMUSP00000131583 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000171914]

AlphaFold

E9PZS9

Predicted Effect

probably benign
Transcript: ENSMUST00000171914
AA Change: L494I

PolyPhen 2 Score 0.236 (Sensitivity: 0.91; Specificity: 0.88)

SMART Domains

Protein: ENSMUSP00000131583
Gene: ENSMUSG00000094892
AA Change: L494I

Domain	Start	End	E-Value	Type
signal peptide	1	19	N/A	INTRINSIC
Pfam:ANF_receptor	82	466	1.6e-36	PFAM
Pfam:NCD3G	509	562	6.4e-22	PFAM
Pfam:7tm_3	595	830	1.4e-51	PFAM

Coding Region Coverage

1x: 100.0%
3x: 100.0%
10x: 99.8%
20x: 99.2%

Validation Efficiency

100% (75/75)

Allele List at MGI

Other mutations in this stock

Total: 76 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adamts1	A	T	16: 85,594,896 (GRCm39)	N617K	probably benign	Het
Adnp2	A	T	18: 80,174,185 (GRCm39)	C75S	probably damaging	Het
Agmo	T	C	12: 37,407,673 (GRCm39)	F186L	possibly damaging	Het
Ahnak2	T	C	12: 112,749,872 (GRCm39)	Y122C		Het
Ahnak2	T	C	12: 112,750,709 (GRCm39)	E71G		Het
Aldh5a1	A	G	13: 25,102,524 (GRCm39)	V313A	probably damaging	Het
Ankib1	C	A	5: 3,822,643 (GRCm39)	C21F	probably benign	Het
Aqr	A	G	2: 113,949,358 (GRCm39)	Y947H	probably damaging	Het
Atp1a2	T	A	1: 172,103,547 (GRCm39)	Y991F	probably benign	Het
Atp8b3	G	A	10: 80,365,923 (GRCm39)	T309M	possibly damaging	Het
Blzf1	T	A	1: 164,125,859 (GRCm39)	D259V	possibly damaging	Het
Cacng5	T	C	11: 107,772,510 (GRCm39)	I113V	probably benign	Het
Catsper3	T	C	13: 55,953,657 (GRCm39)	M269T	probably benign	Het
Ccdc142	A	C	6: 83,079,233 (GRCm39)	Y190S	probably damaging	Het
Ccdc159	C	A	9: 21,845,051 (GRCm39)	Q306K	probably benign	Het
Ccdc180	A	T	4: 45,920,842 (GRCm39)		probably null	Het
Cebpz	A	G	17: 79,229,081 (GRCm39)	F955S	possibly damaging	Het
Cftr	C	T	6: 18,274,696 (GRCm39)	T938I	probably damaging	Het
Col28a1	T	C	6: 8,013,133 (GRCm39)	K973R	probably benign	Het
Cyp2c29	T	C	19: 39,310,138 (GRCm39)		probably benign	Het
Ddx1	A	G	12: 13,293,859 (GRCm39)		probably benign	Het
Duox2	A	C	2: 122,119,826 (GRCm39)	Y867*	probably null	Het
Ereg	T	C	5: 91,237,013 (GRCm39)	Y111H	possibly damaging	Het
Esrrb	T	A	12: 86,565,724 (GRCm39)	L417Q	probably damaging	Het
Fbxw7	G	A	3: 84,859,684 (GRCm39)	R2H	unknown	Het
Galnt6	C	T	15: 100,592,501 (GRCm39)	V569I	probably benign	Het
Gm14226	G	A	2: 154,866,094 (GRCm39)	C17Y	unknown	Het
Gpr150	T	G	13: 76,204,642 (GRCm39)	D101A	probably damaging	Het
Grm1	A	T	10: 10,565,296 (GRCm39)	L1004Q	probably benign	Het
Gtf2a1l	T	A	17: 89,022,351 (GRCm39)	D447E	probably damaging	Het
Gtf2ird1	C	T	5: 134,444,064 (GRCm39)	V64M	probably damaging	Het
Ifi206	A	T	1: 173,308,074 (GRCm39)	W641R		Het
Ifi214	T	A	1: 173,355,486 (GRCm39)	E107D	possibly damaging	Het
Kif19a	T	C	11: 114,675,599 (GRCm39)	V357A	probably damaging	Het
Klhdc7b	T	A	15: 89,271,025 (GRCm39)	S636T	probably benign	Het
Klhl25	C	T	7: 75,515,420 (GRCm39)	R109C	probably damaging	Het
Ltbp2	T	C	12: 84,853,124 (GRCm39)	E835G	probably benign	Het
Marchf1	A	G	8: 66,921,000 (GRCm39)	K226E	probably damaging	Het
Mcpt1	T	C	14: 56,256,170 (GRCm39)		probably benign	Het
Myrf	C	A	19: 10,192,434 (GRCm39)	R639L	probably benign	Het
Naip5	T	C	13: 100,359,604 (GRCm39)	H544R	possibly damaging	Het
Nccrp1	T	C	7: 28,245,769 (GRCm39)	I132V	probably benign	Het
Nprl3	C	T	11: 32,187,334 (GRCm39)	V333I	possibly damaging	Het
Or13a25	C	T	7: 140,248,052 (GRCm39)	S277L	possibly damaging	Het
Or14n1-ps1	T	C	7: 86,092,923 (GRCm39)	S245P	probably damaging	Het
Or2o1	T	C	11: 49,051,297 (GRCm39)	M152T	probably benign	Het
Or2y1	T	A	11: 49,385,671 (GRCm39)	S104T	probably benign	Het
Or4b1d	A	T	2: 89,969,114 (GRCm39)	I123N	probably damaging	Het
Or4f62	A	T	2: 111,986,934 (GRCm39)	I213F	probably damaging	Het
Or52h1	T	C	7: 103,829,025 (GRCm39)	N197D	probably damaging	Het
Or56a41	C	A	7: 104,741,808 (GRCm39)	V73F	possibly damaging	Het
Or8c15	T	C	9: 38,121,099 (GRCm39)	V248A	probably benign	Het
Or8d6	T	C	9: 39,853,891 (GRCm39)	S112P	probably damaging	Het
Otx2	A	G	14: 48,896,521 (GRCm39)	M179T	probably damaging	Het
Pmfbp1	A	G	8: 110,265,309 (GRCm39)		probably benign	Het
Ppfia3	T	A	7: 45,011,129 (GRCm39)	T34S	probably benign	Het
Prkcsh	T	C	9: 21,924,375 (GRCm39)	Y502H	probably damaging	Het
Psd	T	C	19: 46,301,775 (GRCm39)	E937G	probably damaging	Het
Rbbp6	T	A	7: 122,600,976 (GRCm39)	I1661N	unknown	Het
Rhobtb1	T	A	10: 69,106,587 (GRCm39)	M446K	probably damaging	Het
Sall3	T	C	18: 81,017,236 (GRCm39)	I231V	probably benign	Het
Slc12a9	C	T	5: 137,325,916 (GRCm39)	V270I	probably damaging	Het
Slc6a15	A	G	10: 103,225,112 (GRCm39)	K67E	probably damaging	Het
Slc9c1	A	G	16: 45,380,646 (GRCm39)	D524G	probably benign	Het
Smpdl3a	A	G	10: 57,687,526 (GRCm39)	D418G	probably benign	Het
Sox6	T	C	7: 115,196,743 (GRCm39)	T296A	probably benign	Het
Ssu2	T	C	6: 112,361,399 (GRCm39)	E19G	probably damaging	Het
Tctn3	T	C	19: 40,600,170 (GRCm39)	N90S	probably damaging	Het
Tex24	A	G	8: 27,834,652 (GRCm39)	Q60R	possibly damaging	Het
Tlcd1	T	A	11: 78,070,470 (GRCm39)	*128R	probably null	Het
Tti1	A	C	2: 157,834,930 (GRCm39)	L1010R	probably damaging	Het
Ttn	A	G	2: 76,567,682 (GRCm39)	L27737P	probably damaging	Het
Ubqln5	T	A	7: 103,778,322 (GRCm39)	K167N	probably benign	Het
Unkl	A	G	17: 25,450,689 (GRCm39)	I492V	possibly damaging	Het
Vmn1r8	G	A	6: 57,013,665 (GRCm39)	V239I	probably benign	Het
Vmn2r54	G	T	7: 12,369,877 (GRCm39)	T62K	probably benign	Het

Other mutations in Vmn2r101

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01121:Vmn2r101	APN	17	19,809,936 (GRCm39)	missense	probably damaging	0.99
IGL02125:Vmn2r101	APN	17	19,809,963 (GRCm39)	missense	possibly damaging	0.95
IGL02300:Vmn2r101	APN	17	19,832,199 (GRCm39)	missense	probably damaging	1.00
IGL02682:Vmn2r101	APN	17	19,832,507 (GRCm39)	missense	possibly damaging	0.82
IGL02825:Vmn2r101	APN	17	19,810,132 (GRCm39)	missense	probably benign	0.00
IGL02862:Vmn2r101	APN	17	19,831,867 (GRCm39)	missense	probably damaging	1.00
IGL02943:Vmn2r101	APN	17	19,831,666 (GRCm39)	missense	probably damaging	0.99
R0371:Vmn2r101	UTSW	17	19,810,394 (GRCm39)	missense	probably benign	0.07
R0462:Vmn2r101	UTSW	17	19,810,431 (GRCm39)	missense	probably benign	0.04
R0492:Vmn2r101	UTSW	17	19,809,245 (GRCm39)	missense	probably damaging	1.00
R0654:Vmn2r101	UTSW	17	19,810,373 (GRCm39)	missense	probably benign	0.01
R1120:Vmn2r101	UTSW	17	19,797,723 (GRCm39)	splice site	probably benign
R1323:Vmn2r101	UTSW	17	19,832,313 (GRCm39)	missense	probably damaging	1.00
R1323:Vmn2r101	UTSW	17	19,832,313 (GRCm39)	missense	probably damaging	1.00
R1676:Vmn2r101	UTSW	17	19,832,184 (GRCm39)	missense	probably benign	0.00
R2023:Vmn2r101	UTSW	17	19,810,368 (GRCm39)	nonsense	probably null
R2149:Vmn2r101	UTSW	17	19,809,225 (GRCm39)	missense	probably benign	0.00
R2350:Vmn2r101	UTSW	17	19,810,045 (GRCm39)	missense	probably benign	0.01
R2760:Vmn2r101	UTSW	17	19,809,901 (GRCm39)	missense	probably benign	0.14
R3085:Vmn2r101	UTSW	17	19,809,077 (GRCm39)	splice site	probably null
R3086:Vmn2r101	UTSW	17	19,809,077 (GRCm39)	splice site	probably null
R3719:Vmn2r101	UTSW	17	19,809,811 (GRCm39)	missense	possibly damaging	0.50
R3771:Vmn2r101	UTSW	17	19,809,919 (GRCm39)	missense	probably benign
R3773:Vmn2r101	UTSW	17	19,809,919 (GRCm39)	missense	probably benign
R4225:Vmn2r101	UTSW	17	19,831,951 (GRCm39)	missense	probably damaging	1.00
R4248:Vmn2r101	UTSW	17	19,809,376 (GRCm39)	missense	probably damaging	1.00
R4290:Vmn2r101	UTSW	17	19,832,303 (GRCm39)	missense	probably damaging	1.00
R4291:Vmn2r101	UTSW	17	19,832,303 (GRCm39)	missense	probably damaging	1.00
R4293:Vmn2r101	UTSW	17	19,832,303 (GRCm39)	missense	probably damaging	1.00
R4307:Vmn2r101	UTSW	17	19,810,423 (GRCm39)	missense	probably damaging	1.00
R4721:Vmn2r101	UTSW	17	19,832,287 (GRCm39)	missense	probably damaging	0.99
R4829:Vmn2r101	UTSW	17	19,832,229 (GRCm39)	missense	probably benign	0.03
R5022:Vmn2r101	UTSW	17	19,831,649 (GRCm39)	critical splice acceptor site	probably null
R5110:Vmn2r101	UTSW	17	19,831,897 (GRCm39)	missense	possibly damaging	0.92
R5244:Vmn2r101	UTSW	17	19,831,788 (GRCm39)	missense	probably damaging	1.00
R5397:Vmn2r101	UTSW	17	19,809,104 (GRCm39)	missense	probably damaging	1.00
R5875:Vmn2r101	UTSW	17	19,809,092 (GRCm39)	missense	probably damaging	0.99
R5944:Vmn2r101	UTSW	17	19,809,769 (GRCm39)	missense	probably benign	0.00
R6216:Vmn2r101	UTSW	17	19,811,267 (GRCm39)	missense	probably benign	0.00
R6334:Vmn2r101	UTSW	17	19,810,112 (GRCm39)	missense	possibly damaging	0.83
R6512:Vmn2r101	UTSW	17	19,809,146 (GRCm39)	missense	probably damaging	1.00
R6607:Vmn2r101	UTSW	17	19,832,296 (GRCm39)	missense	probably damaging	1.00
R6965:Vmn2r101	UTSW	17	19,811,284 (GRCm39)	missense	probably benign	0.00
R7101:Vmn2r101	UTSW	17	19,809,350 (GRCm39)	missense	probably null	0.14
R7183:Vmn2r101	UTSW	17	19,832,440 (GRCm39)	missense	probably damaging	1.00
R7344:Vmn2r101	UTSW	17	19,832,059 (GRCm39)	missense	probably benign	0.38
R7375:Vmn2r101	UTSW	17	19,831,652 (GRCm39)	missense	probably damaging	1.00
R7574:Vmn2r101	UTSW	17	19,831,899 (GRCm39)	missense	possibly damaging	0.91
R7575:Vmn2r101	UTSW	17	19,831,654 (GRCm39)	missense	probably benign	0.01
R7592:Vmn2r101	UTSW	17	19,811,443 (GRCm39)	splice site	probably null
R7626:Vmn2r101	UTSW	17	19,832,192 (GRCm39)	nonsense	probably null
R7715:Vmn2r101	UTSW	17	19,832,177 (GRCm39)	missense	probably damaging	1.00
R7730:Vmn2r101	UTSW	17	19,831,950 (GRCm39)	missense	possibly damaging	0.81
R8078:Vmn2r101	UTSW	17	19,810,507 (GRCm39)	missense	probably benign	0.07
R8228:Vmn2r101	UTSW	17	19,811,284 (GRCm39)	missense	probably benign	0.00
R8283:Vmn2r101	UTSW	17	19,832,253 (GRCm39)	missense	probably damaging	1.00
R8765:Vmn2r101	UTSW	17	19,809,245 (GRCm39)	missense	probably damaging	1.00
R9091:Vmn2r101	UTSW	17	19,810,244 (GRCm39)	missense	probably benign
R9092:Vmn2r101	UTSW	17	19,809,807 (GRCm39)	missense	probably benign	0.07
R9113:Vmn2r101	UTSW	17	19,811,288 (GRCm39)	missense	possibly damaging	0.56
R9158:Vmn2r101	UTSW	17	19,809,161 (GRCm39)	missense	probably benign	0.00
R9168:Vmn2r101	UTSW	17	19,809,138 (GRCm39)	missense	probably damaging	1.00
R9235:Vmn2r101	UTSW	17	19,810,238 (GRCm39)	missense	probably damaging	0.99
R9270:Vmn2r101	UTSW	17	19,810,244 (GRCm39)	missense	probably benign
R9290:Vmn2r101	UTSW	17	19,811,395 (GRCm39)	missense	probably benign	0.05
R9296:Vmn2r101	UTSW	17	19,810,047 (GRCm39)	missense	probably damaging	0.98
R9602:Vmn2r101	UTSW	17	19,831,780 (GRCm39)	nonsense	probably null
R9706:Vmn2r101	UTSW	17	19,809,925 (GRCm39)	missense	probably damaging	1.00
Z1088:Vmn2r101	UTSW	17	19,809,237 (GRCm39)	missense	possibly damaging	0.78

Predicted Primers

PCR Primer
(F):5'- AGTCAGTGGTCATTGATTGCTTAC -3'
(R):5'- TTACTGGCCTGTCTATATATGTACC -3'

Sequencing Primer
(F):5'- CAGTGGTCATTGATTGCTTACTTAAG -3'
(R):5'- TGGCCTGTCTATATATGTACCAATAC -3'

Posted On

2021-04-30