Incidental Mutation 'R8715:Lgals4'
ID 669816
Institutional Source Beutler Lab
Gene Symbol Lgals4
Ensembl Gene ENSMUSG00000053964
Gene Name lectin, galactose binding, soluble 4
Synonyms galectin-4
MMRRC Submission 068613-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R8715 (G1)
Quality Score 225.009
Status Not validated
Chromosome 7
Chromosomal Location 28533559-28541128 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 28540921 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Arginine to Cysteine at position 282 (R282C)
Ref Sequence ENSEMBL: ENSMUSP00000066461 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000066723] [ENSMUST00000151547] [ENSMUST00000208971]
AlphaFold Q8K419
PDB Structure Crystal structure of the N-terminal domain of mouse galectin-4 [X-RAY DIFFRACTION]
N-terminal CRD1 domain of mouse Galectin-4 in complex with lactose [X-RAY DIFFRACTION]
Predicted Effect probably damaging
Transcript: ENSMUST00000066723
AA Change: R282C

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000066461
Gene: ENSMUSG00000053964
AA Change: R282C

DomainStartEndE-ValueType
GLECT 17 150 1.24e-59 SMART
Gal-bind_lectin 23 149 1.49e-59 SMART
low complexity region 151 162 N/A INTRINSIC
GLECT 196 326 1.49e-53 SMART
Gal-bind_lectin 202 326 2.02e-56 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000151547
SMART Domains Protein: ENSMUSP00000141005
Gene: ENSMUSG00000053964

DomainStartEndE-ValueType
Gal-bind_lectin 1 109 4e-45 SMART
GLECT 1 110 2.3e-38 SMART
low complexity region 111 122 N/A INTRINSIC
Predicted Effect possibly damaging
Transcript: ENSMUST00000208971
AA Change: R258C

PolyPhen 2 Score 0.662 (Sensitivity: 0.86; Specificity: 0.91)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.8%
  • 20x: 99.3%
Validation Efficiency 100% (50/50)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions. The expression of this gene is restricted to small intestine, colon, and rectum, and it is underexpressed in colorectal cancer. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 52 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcb1b A T 5: 8,862,750 (GRCm39) H144L probably benign Het
Adam25 A G 8: 41,207,099 (GRCm39) N122D probably benign Het
Armc10 T C 5: 21,858,516 (GRCm39) F187S possibly damaging Het
Atosb A G 4: 43,033,944 (GRCm39) V444A possibly damaging Het
Best3 T A 10: 116,828,971 (GRCm39) F84I probably damaging Het
Card11 A T 5: 140,871,315 (GRCm39) D729E probably benign Het
Ccdc60 A T 5: 116,328,153 (GRCm39) F104I probably benign Het
Ccdc88b T C 19: 6,833,213 (GRCm39) E278G probably damaging Het
Cd209d CAT C 8: 3,923,772 (GRCm39) probably null Het
Cdhr4 G A 9: 107,874,596 (GRCm39) V9M Het
Cfap46 T C 7: 139,185,560 (GRCm39) T41A Het
Cyp2c66 A G 19: 39,159,388 (GRCm39) T280A probably benign Het
Dis3l C T 9: 64,214,342 (GRCm39) D1049N probably benign Het
Dlc1 T A 8: 37,405,795 (GRCm39) probably benign Het
Faap100 T C 11: 120,265,299 (GRCm39) T526A probably benign Het
Gimap6 A T 6: 48,679,552 (GRCm39) D161E probably damaging Het
Gmpr T C 13: 45,696,102 (GRCm39) V282A possibly damaging Het
Gsap A G 5: 21,431,245 (GRCm39) I190V possibly damaging Het
Gucy2d C T 7: 98,093,319 (GRCm39) T232I probably benign Het
Lrp1 C A 10: 127,396,490 (GRCm39) S2358I possibly damaging Het
Lrrc74a A G 12: 86,805,239 (GRCm39) N354D probably damaging Het
Mdga2 T C 12: 66,915,526 (GRCm39) E112G probably damaging Het
Msh6 C T 17: 88,293,195 (GRCm39) T650I probably benign Het
Mst1 T C 9: 107,959,242 (GRCm39) V203A possibly damaging Het
Muc1 G A 3: 89,138,821 (GRCm39) V477M possibly damaging Het
Naa11 A G 5: 97,540,066 (GRCm39) Y31H probably damaging Het
Nphp1 G T 2: 127,605,729 (GRCm39) H365Q possibly damaging Het
Or1p4-ps1 T A 11: 74,207,986 (GRCm39) I45N probably damaging Het
Or2y17 A T 11: 49,232,154 (GRCm39) Y265F probably damaging Het
Or5m13 G A 2: 85,748,273 (GRCm39) M1I probably null Het
Osbpl9 A G 4: 108,959,773 (GRCm39) F15S probably benign Het
Pcdha12 A C 18: 37,153,523 (GRCm39) N81H probably damaging Het
Pde4d A G 13: 110,071,876 (GRCm39) Q290R probably benign Het
Pla1a A T 16: 38,230,000 (GRCm39) N237K probably damaging Het
Podnl1 T C 8: 84,855,956 (GRCm39) Y239H Het
Pou4f3 G T 18: 42,528,593 (GRCm39) D179Y possibly damaging Het
Ptch2 T C 4: 116,968,719 (GRCm39) V995A probably damaging Het
Ptprt C T 2: 161,372,463 (GRCm39) C1403Y probably damaging Het
Rab7 T C 6: 87,989,369 (GRCm39) S34G probably damaging Het
Rspry1 A G 8: 95,349,888 (GRCm39) E92G probably damaging Het
Sdccag8 T A 1: 176,773,803 (GRCm39) probably benign Het
Sdk2 G A 11: 113,671,728 (GRCm39) T2140M probably damaging Het
Serpina1e T C 12: 103,917,177 (GRCm39) N164S probably benign Het
Shisal1 A C 15: 84,301,346 (GRCm39) V99G probably damaging Het
Tdrkh T C 3: 94,331,968 (GRCm39) V131A probably damaging Het
Tm9sf3 T A 19: 41,244,724 (GRCm39) N51I probably damaging Het
Trav4-3 A G 14: 53,836,762 (GRCm39) N76D possibly damaging Het
Trhr2 T A 8: 123,085,619 (GRCm39) I122F probably damaging Het
Tyw1 G A 5: 130,298,065 (GRCm39) R202Q probably damaging Het
Vmn2r99 A T 17: 19,613,922 (GRCm39) probably benign Het
Zfp663 T C 2: 165,194,644 (GRCm39) E525G probably damaging Het
Zfp976 C T 7: 42,262,869 (GRCm39) E324K possibly damaging Het
Other mutations in Lgals4
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01583:Lgals4 APN 7 28,540,973 (GRCm39) missense probably damaging 0.98
IGL03069:Lgals4 APN 7 28,540,343 (GRCm39) missense probably benign 0.00
IGL03180:Lgals4 APN 7 28,537,053 (GRCm39) missense probably damaging 1.00
R0131:Lgals4 UTSW 7 28,533,657 (GRCm39) splice site probably null
R4181:Lgals4 UTSW 7 28,535,437 (GRCm39) missense possibly damaging 0.87
R4981:Lgals4 UTSW 7 28,540,701 (GRCm39) missense probably damaging 0.98
R6199:Lgals4 UTSW 7 28,535,317 (GRCm39) missense probably damaging 1.00
R6425:Lgals4 UTSW 7 28,533,885 (GRCm39) nonsense probably null
R6431:Lgals4 UTSW 7 28,540,117 (GRCm39)
R7335:Lgals4 UTSW 7 28,540,571 (GRCm39) missense probably benign 0.01
R7359:Lgals4 UTSW 7 28,540,724 (GRCm39) missense probably benign 0.30
R7522:Lgals4 UTSW 7 28,537,117 (GRCm39) missense possibly damaging 0.73
R7975:Lgals4 UTSW 7 28,540,346 (GRCm39) missense probably benign 0.00
R8318:Lgals4 UTSW 7 28,533,940 (GRCm39) missense probably benign
R8669:Lgals4 UTSW 7 28,540,921 (GRCm39) missense probably damaging 1.00
R8692:Lgals4 UTSW 7 28,540,921 (GRCm39) missense probably damaging 1.00
R8693:Lgals4 UTSW 7 28,540,921 (GRCm39) missense probably damaging 1.00
R8716:Lgals4 UTSW 7 28,540,921 (GRCm39) missense probably damaging 1.00
R8735:Lgals4 UTSW 7 28,540,921 (GRCm39) missense probably damaging 1.00
R8738:Lgals4 UTSW 7 28,540,921 (GRCm39) missense probably damaging 1.00
R8920:Lgals4 UTSW 7 28,540,289 (GRCm39) missense probably benign
Z1177:Lgals4 UTSW 7 28,540,922 (GRCm39) missense probably damaging 1.00
Z1186:Lgals4 UTSW 7 28,535,353 (GRCm39) missense probably benign
Predicted Primers
Posted On 2021-04-30