Incidental Mutation 'R8719:Sin3b'
ID 670016
Institutional Source Beutler Lab
Gene Symbol Sin3b
Ensembl Gene ENSMUSG00000031622
Gene Name transcriptional regulator, SIN3B (yeast)
Synonyms 2810430C10Rik
MMRRC Submission 068614-MU
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # R8719 (G1)
Quality Score 225.009
Status Validated
Chromosome 8
Chromosomal Location 73449913-73484829 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to T at 73450139 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glycine to Tryptophan at position 19 (G19W)
Ref Sequence ENSEMBL: ENSMUSP00000148599 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000004494] [ENSMUST00000109950] [ENSMUST00000212095] [ENSMUST00000212096]
AlphaFold Q62141
Predicted Effect probably benign
Transcript: ENSMUST00000004494
SMART Domains Protein: ENSMUSP00000004494
Gene: ENSMUSG00000031622

DomainStartEndE-ValueType
low complexity region 5 26 N/A INTRINSIC
Pfam:PAH 53 97 2.5e-19 PFAM
Pfam:PAH 173 227 4.4e-20 PFAM
Pfam:PAH 313 357 1.6e-8 PFAM
HDAC_interact 384 484 2.75e-58 SMART
low complexity region 667 688 N/A INTRINSIC
Pfam:Sin3a_C 712 1011 7.2e-81 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000109950
SMART Domains Protein: ENSMUSP00000105576
Gene: ENSMUSG00000031622

DomainStartEndE-ValueType
low complexity region 5 26 N/A INTRINSIC
Pfam:PAH 53 97 3.4e-20 PFAM
Pfam:PAH 173 227 5.6e-21 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000212095
Predicted Effect unknown
Transcript: ENSMUST00000212096
AA Change: G19W
Meta Mutation Damage Score 0.0852 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.7%
  • 20x: 99.2%
Validation Efficiency 100% (61/61)
MGI Phenotype PHENOTYPE: Homozygous null mice fail to survive past P1 and exhibit pallor, fetal growth retardation, impaired terminal differentiation of erythrocytes and granulocytes, a pale liver and reduced ossification of the long bones in the hindlimb. Mutant MEFs show impaired G0 arrest upon serum deprivation. [provided by MGI curators]
Allele List at MGI

All alleles(8) : Targeted, knock-out(1) Targeted, other(4) Gene trapped(3)

Other mutations in this stock
Total: 61 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acsl1 T C 8: 46,966,700 (GRCm39) I224T probably benign Het
Adamts20 C G 15: 94,241,903 (GRCm39) A702P probably damaging Het
Ahdc1 T A 4: 132,791,533 (GRCm39) Y925N possibly damaging Het
Anapc1 T C 2: 128,483,369 (GRCm39) E1242G probably damaging Het
Angptl2 A G 2: 33,133,914 (GRCm39) N412S possibly damaging Het
Aox3 T C 1: 58,158,696 (GRCm39) V89A probably damaging Het
Atxn1l A T 8: 110,459,861 (GRCm39) S134T possibly damaging Het
Brf1 C A 12: 112,943,304 (GRCm39) probably benign Het
Cab39l A T 14: 59,734,314 (GRCm39) H11L probably benign Het
Cabcoco1 A G 10: 68,272,671 (GRCm39) probably benign Het
Ccdc150 C A 1: 54,302,668 (GRCm39) P96Q probably benign Het
Chek2 T C 5: 111,014,908 (GRCm39) V459A probably damaging Het
Cntnap2 A T 6: 45,978,161 (GRCm39) D272V probably damaging Het
Cspp1 T C 1: 10,160,516 (GRCm39) S572P possibly damaging Het
Cysltr2 T C 14: 73,267,111 (GRCm39) T200A possibly damaging Het
Dglucy T C 12: 100,804,821 (GRCm39) L104P probably damaging Het
Dnah8 T A 17: 30,960,289 (GRCm39) M2222K probably damaging Het
Dync2h1 C A 9: 7,041,641 (GRCm39) V3334F probably benign Het
Ear2 A T 14: 44,340,734 (GRCm39) T131S possibly damaging Het
Eef1akmt2 A T 7: 132,452,340 (GRCm39) V92D probably damaging Het
Fam83c T A 2: 155,671,128 (GRCm39) Q769L probably benign Het
Fanca A T 8: 124,014,867 (GRCm39) C812S probably benign Het
Gm21663 T G 5: 26,146,162 (GRCm39) R50S probably damaging Het
Gm5591 T G 7: 38,221,614 (GRCm39) S152R probably benign Het
Gm6370 T G 5: 146,430,626 (GRCm39) D270E probably damaging Het
H2-T22 T C 17: 36,352,835 (GRCm39) I91V probably benign Het
Hdac5 T C 11: 102,097,963 (GRCm39) M61V probably benign Het
Hsd17b6 A G 10: 127,829,492 (GRCm39) S237P possibly damaging Het
Khk T A 5: 31,088,374 (GRCm39) F294I possibly damaging Het
Klc1 G A 12: 111,772,509 (GRCm39) probably benign Het
Lamb3 T C 1: 193,006,099 (GRCm39) W143R probably damaging Het
Lmo2 T C 2: 103,811,264 (GRCm39) I171T probably damaging Het
Meis1 A G 11: 18,835,587 (GRCm39) S344P probably benign Het
Nf1 C A 11: 79,281,119 (GRCm39) R125S possibly damaging Het
Nrcam A G 12: 44,586,325 (GRCm39) E105G probably benign Het
Nudt22 T C 19: 6,972,638 (GRCm39) D150G possibly damaging Het
Or14j8 T C 17: 38,263,895 (GRCm39) T7A probably damaging Het
Or5an1 A G 19: 12,260,792 (GRCm39) I127V probably benign Het
Or5b109 A G 19: 13,211,836 (GRCm39) Y74C probably damaging Het
Pclo A T 5: 14,763,778 (GRCm39) R799* probably null Het
Pelp1 T C 11: 70,292,789 (GRCm39) N175S probably damaging Het
Perm1 TGCCTCTGAGCCTGACACGGCTTTGTCTACACCCGCCTCTGAGCCTGACACGGCTTTGTCTACACCCGCCTCTGAGCCTGACACGGCTTTGTCTACACCCGCCTCT TGCCTCTGAGCCTGACACGGCTTTGTCTACACCCGCCTCTGAGCCTGACACGGCTTTGTCTACACCCGCCTCT 4: 156,302,525 (GRCm39) probably benign Het
Pik3r4 C A 9: 105,559,394 (GRCm39) S1162R probably benign Het
Pkd1l3 A T 8: 110,341,255 (GRCm39) N36I unknown Het
Pomk T A 8: 26,473,503 (GRCm39) Y150F possibly damaging Het
Rdh11 T A 12: 79,229,574 (GRCm39) H233L probably benign Het
Rln1 A T 19: 29,309,281 (GRCm39) M166K probably benign Het
Rnf40 T A 7: 127,191,834 (GRCm39) L356Q probably damaging Het
Slc6a15 A G 10: 103,240,176 (GRCm39) R300G probably damaging Het
Sncaip A T 18: 53,027,910 (GRCm39) K433M probably damaging Het
Tead2 A T 7: 44,882,316 (GRCm39) probably benign Het
Tespa1 A G 10: 130,184,108 (GRCm39) D63G probably benign Het
Tmem117 T C 15: 94,992,248 (GRCm39) F303L probably damaging Het
Tmem270 T G 5: 134,930,650 (GRCm39) T204P probably damaging Het
Trip12 A G 1: 84,722,790 (GRCm39) V1320A probably damaging Het
Ttc7b A G 12: 100,267,812 (GRCm39) L843P probably damaging Het
Ttn T C 2: 76,543,041 (GRCm39) Y33315C probably damaging Het
Ttn A G 2: 76,607,146 (GRCm39) V17959A possibly damaging Het
Vmn2r73 A G 7: 85,521,095 (GRCm39) V291A probably damaging Het
Ywhag T A 5: 135,939,998 (GRCm39) T199S probably benign Het
Zfp810 T C 9: 22,190,571 (GRCm39) T77A probably benign Het
Other mutations in Sin3b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00586:Sin3b APN 8 73,483,628 (GRCm39) missense probably benign 0.22
IGL01107:Sin3b APN 8 73,457,733 (GRCm39) missense possibly damaging 0.74
IGL01114:Sin3b APN 8 73,471,133 (GRCm39) missense probably benign 0.06
IGL01603:Sin3b APN 8 73,476,692 (GRCm39) missense probably damaging 1.00
IGL01763:Sin3b APN 8 73,473,236 (GRCm39) missense probably damaging 1.00
IGL02078:Sin3b APN 8 73,480,208 (GRCm39) missense possibly damaging 0.49
IGL02572:Sin3b APN 8 73,471,109 (GRCm39) missense probably benign 0.15
IGL02732:Sin3b APN 8 73,460,081 (GRCm39) missense possibly damaging 0.72
IGL02831:Sin3b APN 8 73,471,190 (GRCm39) missense probably damaging 1.00
IGL03064:Sin3b APN 8 73,483,686 (GRCm39) unclassified probably benign
IGL03107:Sin3b APN 8 73,480,213 (GRCm39) missense probably damaging 0.99
IGL03142:Sin3b APN 8 73,471,196 (GRCm39) missense probably damaging 1.00
3-1:Sin3b UTSW 8 73,479,837 (GRCm39) missense possibly damaging 0.95
R0070:Sin3b UTSW 8 73,452,210 (GRCm39) missense probably damaging 1.00
R0070:Sin3b UTSW 8 73,452,210 (GRCm39) missense probably damaging 1.00
R0226:Sin3b UTSW 8 73,471,136 (GRCm39) missense probably benign 0.44
R0629:Sin3b UTSW 8 73,480,164 (GRCm39) splice site probably benign
R1486:Sin3b UTSW 8 73,477,141 (GRCm39) missense probably benign 0.00
R1524:Sin3b UTSW 8 73,479,915 (GRCm39) missense probably benign 0.05
R1653:Sin3b UTSW 8 73,468,147 (GRCm39) missense probably benign 0.30
R2144:Sin3b UTSW 8 73,457,893 (GRCm39) missense probably damaging 1.00
R2180:Sin3b UTSW 8 73,479,923 (GRCm39) nonsense probably null
R2271:Sin3b UTSW 8 73,460,047 (GRCm39) missense probably benign 0.11
R2353:Sin3b UTSW 8 73,450,780 (GRCm39) critical splice donor site probably null
R3945:Sin3b UTSW 8 73,460,067 (GRCm39) missense possibly damaging 0.88
R4412:Sin3b UTSW 8 73,466,407 (GRCm39) missense probably benign 0.16
R4564:Sin3b UTSW 8 73,480,209 (GRCm39) missense probably damaging 1.00
R4782:Sin3b UTSW 8 73,452,271 (GRCm39) missense probably benign 0.04
R4799:Sin3b UTSW 8 73,452,271 (GRCm39) missense probably benign 0.04
R4863:Sin3b UTSW 8 73,471,576 (GRCm39) missense possibly damaging 0.91
R5011:Sin3b UTSW 8 73,471,184 (GRCm39) missense probably benign 0.39
R5237:Sin3b UTSW 8 73,459,971 (GRCm39) critical splice acceptor site probably null
R5325:Sin3b UTSW 8 73,477,154 (GRCm39) missense probably damaging 1.00
R5725:Sin3b UTSW 8 73,452,320 (GRCm39) critical splice donor site probably null
R5927:Sin3b UTSW 8 73,476,506 (GRCm39) missense probably benign 0.00
R5945:Sin3b UTSW 8 73,457,793 (GRCm39) missense probably damaging 0.97
R6492:Sin3b UTSW 8 73,460,118 (GRCm39) critical splice donor site probably null
R7092:Sin3b UTSW 8 73,474,498 (GRCm39) critical splice donor site probably null
R7106:Sin3b UTSW 8 73,450,765 (GRCm39) missense possibly damaging 0.90
R7258:Sin3b UTSW 8 73,476,836 (GRCm39) missense probably benign 0.00
R7472:Sin3b UTSW 8 73,479,853 (GRCm39) missense probably damaging 1.00
R7475:Sin3b UTSW 8 73,476,500 (GRCm39) missense possibly damaging 0.47
R7491:Sin3b UTSW 8 73,473,069 (GRCm39) missense probably damaging 1.00
R7636:Sin3b UTSW 8 73,474,362 (GRCm39) nonsense probably null
R8063:Sin3b UTSW 8 73,452,169 (GRCm39) missense probably damaging 1.00
R8354:Sin3b UTSW 8 73,468,108 (GRCm39) missense probably benign
R8454:Sin3b UTSW 8 73,468,108 (GRCm39) missense probably benign
R8711:Sin3b UTSW 8 73,450,026 (GRCm39) missense probably damaging 0.97
R8807:Sin3b UTSW 8 73,476,708 (GRCm39) missense probably benign 0.00
R8857:Sin3b UTSW 8 73,483,523 (GRCm39) missense probably benign
R8924:Sin3b UTSW 8 73,473,131 (GRCm39) missense probably benign 0.05
R9035:Sin3b UTSW 8 73,450,092 (GRCm39) missense unknown
R9127:Sin3b UTSW 8 73,460,034 (GRCm39) missense possibly damaging 0.70
R9272:Sin3b UTSW 8 73,471,168 (GRCm39) missense probably benign 0.02
R9455:Sin3b UTSW 8 73,450,681 (GRCm39) missense possibly damaging 0.56
R9641:Sin3b UTSW 8 73,477,187 (GRCm39) missense probably damaging 1.00
X0017:Sin3b UTSW 8 73,457,793 (GRCm39) missense probably damaging 0.97
Predicted Primers PCR Primer
(F):5'- ACTTCCAACATGGCGCATG -3'
(R):5'- ACTAGGAGGATCGAAGGTTTTC -3'

Sequencing Primer
(F):5'- AACATGGCGCATGCAGGC -3'
(R):5'- AAGGTTTTCGGGGTGCACC -3'
Posted On 2021-04-30