Mutagenetix > Incidental Mutation

Incidental Mutation 'R0554:Ugt1a10'

67005

Institutional Source

Beutler Lab

Gene Symbol

Ugt1a10

Ensembl Gene

ENSMUSG00000090165

Gene Name

UDP glycosyltransferase 1 family, polypeptide A10

Synonyms

A13

MMRRC Submission

038746-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.147) question?

Stock #

R0554 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

88055388-88219004 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 88056095 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Glutamic Acid to Glycine at position 205 (E205G)

Ref Sequence

ENSEMBL: ENSMUSP00000108767 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000113142] [ENSMUST00000138182] [ENSMUST00000173325]

AlphaFold

no structure available at present

Predicted Effect

probably damaging
Transcript: ENSMUST00000113142
AA Change: E205G

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)

SMART Domains

Protein: ENSMUSP00000108767
Gene: ENSMUSG00000090165
AA Change: E205G

Domain	Start	End	E-Value	Type
signal peptide	1	25	N/A	INTRINSIC
Pfam:UDPGT	26	521	7.3e-231	PFAM
Pfam:Glyco_tran_28_C	360	449	1.3e-9	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000138182

SMART Domains

Protein: ENSMUSP00000119985
Gene: ENSMUSG00000090165

Domain	Start	End	E-Value	Type
signal peptide	1	25	N/A	INTRINSIC
Pfam:UDPGT	26	62	7e-11	PFAM
Pfam:UDPGT	58	207	1.9e-90	PFAM
Pfam:Glyco_tran_28_C	137	207	4.8e-9	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000173165

Predicted Effect

probably benign
Transcript: ENSMUST00000173325

SMART Domains

Protein: ENSMUSP00000134443
Gene: ENSMUSG00000090165

Domain	Start	End	E-Value	Type
signal peptide	1	25	N/A	INTRINSIC
Pfam:UDPGT	26	61	3.4e-10	PFAM
Pfam:UDPGT	59	210	8.9e-92	PFAM

Coding Region Coverage

1x: 99.2%
3x: 98.5%
10x: 96.7%
20x: 93.9%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 99 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700018F24Rik	T	A	5: 145,045,371	Y255*	probably null	Het
1810024B03Rik	A	G	2: 127,187,276	M1T	probably null	Het
4930503L19Rik	T	C	18: 70,467,380	D386G	probably damaging	Het
Ace2	T	A	X: 164,175,951	N601K	probably benign	Het
Adam4	A	C	12: 81,421,424	I141R	probably damaging	Het
Adcy10	G	A	1: 165,513,130	G235S	probably benign	Het
Adcy5	G	A	16: 35,294,017	V997I	probably benign	Het
Aff2	T	G	X: 69,864,074	W1221G	possibly damaging	Het
Ankrd44	T	C	1: 54,763,758	N194D	probably benign	Het
Apba2	T	G	7: 64,745,780	L668R	probably damaging	Het
Asph	T	C	4: 9,604,581	D152G	probably damaging	Het
Bcl3	C	G	7: 19,820,066	V126L	probably benign	Het
Cd163	A	G	6: 124,312,660	T446A	probably benign	Het
Cd209g	C	T	8: 4,134,995		probably benign	Het
Cdadc1	A	T	14: 59,586,452	V197E	probably damaging	Het
CN725425	T	C	15: 91,260,763	C610R	possibly damaging	Het
Col6a2	A	G	10: 76,611,161		probably null	Het
Coro7	A	G	16: 4,632,257	L576P	possibly damaging	Het
Dgkb	T	A	12: 38,216,031	V503E	probably benign	Het
Dhx57	A	T	17: 80,260,236	L806*	probably null	Het
Dlec1	T	C	9: 119,115,002	V373A	probably benign	Het
Dnah11	G	T	12: 117,931,178	R3645S	probably benign	Het
Dnhd1	T	C	7: 105,694,395	S1649P	probably benign	Het
Draxin	T	G	4: 148,107,963	K297N	probably damaging	Het
Epha7	T	C	4: 28,951,401	S841P	probably damaging	Het
Esp8	T	G	17: 40,530,275	D142E	unknown	Het
F5	T	G	1: 164,179,449	V274G	probably damaging	Het
Fancc	T	C	13: 63,317,469	S475G	probably benign	Het
Fmo3	T	C	1: 162,954,332	N484S	probably benign	Het
Focad	T	C	4: 88,348,889	Y1046H	unknown	Het
Furin	C	T	7: 80,391,284	G602D	probably damaging	Het
Fut8	A	T	12: 77,364,970	I69L	probably benign	Het
Gm10436	T	C	12: 88,177,558	T162A	probably benign	Het
Gm4951	G	A	18: 60,245,417	R8H	probably benign	Het
Gnai3	A	G	3: 108,123,612	I78T	probably benign	Het
Gpr182	T	C	10: 127,751,071	I4V	probably benign	Het
Gpr63	T	C	4: 25,007,447	M57T	probably benign	Het
Grm1	T	A	10: 10,719,923	T654S	probably benign	Het
Gtf2h4	T	C	17: 35,668,639	T371A	probably benign	Het
Helq	T	C	5: 100,790,200	N460S	probably benign	Het
Hmcn1	T	C	1: 150,719,117	N1867S	probably benign	Het
Hsh2d	G	A	8: 72,200,460	D229N	probably benign	Het
Inpp5j	A	G	11: 3,499,644	Y713H	probably damaging	Het
Ints6	A	T	14: 62,704,751	V511D	possibly damaging	Het
Itga4	A	G	2: 79,279,117	Y220C	probably damaging	Het
Itgav	T	G	2: 83,794,270	S735A	possibly damaging	Het
Kctd16	A	G	18: 40,258,439	I27V	probably benign	Het
Klhl6	T	C	16: 19,953,593	E334G	probably damaging	Het
Lrmp	G	A	6: 145,165,287	A237T	probably benign	Het
Ltbp1	T	A	17: 75,225,279	L116H	probably damaging	Het
Magohb	T	A	6: 131,285,697	H98L	probably benign	Het
Mgat2	A	G	12: 69,185,392	T247A	probably benign	Het
Mtif2	G	A	11: 29,533,398		probably null	Het
Myrfl	T	C	10: 116,828,973	E384G	probably damaging	Het
Nfam1	G	T	15: 83,033,209	R8S	probably benign	Het
Numa1	T	C	7: 101,995,524	S236P	possibly damaging	Het
Olfr1022	T	C	2: 85,869,519	F309S	probably benign	Het
Olfr310	A	T	7: 86,269,657	I44N	probably damaging	Het
Olfr317	T	C	11: 58,733,039	N42S	probably damaging	Het
Olfr777	T	C	10: 129,268,499	T275A	probably benign	Het
Orc4	C	T	2: 48,905,421	S431N	probably benign	Het
Pax2	T	C	19: 44,761,861	V129A	probably damaging	Het
Pcdhb15	A	G	18: 37,474,519	D268G	probably damaging	Het
Pdcd1	G	A	1: 94,039,382	R264C	probably damaging	Het
Pi15	T	A	1: 17,621,648	M187K	probably benign	Het
Plag1	C	T	4: 3,904,546	C215Y	probably damaging	Het
Plagl1	A	G	10: 13,127,182	T65A	probably benign	Het
Prss48	T	A	3: 86,000,921	Q18L	probably benign	Het
Prune2	T	A	19: 17,125,218	C2580*	probably null	Het
Rab40b	T	A	11: 121,359,606	Q74L	probably damaging	Het
Raf1	A	G	6: 115,623,530	I376T	probably benign	Het
Rbm46	A	T	3: 82,865,268	F186I	probably damaging	Het
Reps1	C	T	10: 18,123,119	T720M	possibly damaging	Het
Rgs22	A	G	15: 36,054,709	M649T	probably benign	Het
Rhot1	C	T	11: 80,243,438	R47*	probably null	Het
Rhox2f	A	G	X: 37,571,471	Y8C	possibly damaging	Het
Rnf17	A	G	14: 56,522,550	Y1604C	probably damaging	Het
Rnf40	T	C	7: 127,602,584	C943R	probably damaging	Het
Ropn1l	A	T	15: 31,451,149	M63K	probably benign	Het
Sbf2	C	A	7: 110,428,287	V501F	probably damaging	Het
Sh3bp1	T	A	15: 78,907,267	M354K	probably damaging	Het
Sipa1l3	T	C	7: 29,388,030	H590R	possibly damaging	Het
Slco6d1	T	A	1: 98,466,697	C369S	probably benign	Het
Sulf1	T	C	1: 12,805,194	Y143H	probably damaging	Het
Tiam2	A	T	17: 3,438,681	R755*	probably null	Het
Trim12c	C	A	7: 104,344,962	L228F	probably damaging	Het
Ttc23l	G	T	15: 10,530,657	Q290K	probably benign	Het
Uba3	T	C	6: 97,191,260		probably null	Het
Ugt3a2	T	A	15: 9,351,120	S72T	probably benign	Het
Upk3bl	C	T	5: 136,059,794	T113I	probably damaging	Het
Uspl1	T	A	5: 149,187,834	D20E	probably damaging	Het
Vmn2r19	G	A	6: 123,336,143	G724E	probably damaging	Het
Vmn2r63	T	A	7: 42,933,705	K29*	probably null	Het
Vwf	C	T	6: 125,642,781	A1474V	probably benign	Het
Xpc	C	T	6: 91,491,226	A860T	probably benign	Het
Zfp462	A	G	4: 55,013,689	H737R	probably damaging	Het
Zfp536	T	C	7: 37,480,819	D787G	probably damaging	Het
Zfp692	A	G	11: 58,314,227	H434R	probably damaging	Het
Zp1	C	A	19: 10,920,562	C5F	probably benign	Het

Other mutations in Ugt1a10

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01126:Ugt1a10	APN	1	88055987	missense	possibly damaging	0.72
IGL02219:Ugt1a10	APN	1	88056058	missense	probably benign	0.00
IGL02511:Ugt1a10	APN	1	88055863	missense	probably damaging	1.00
IGL02990:Ugt1a10	APN	1	88055879	missense	probably damaging	1.00
PIT4142001:Ugt1a10	UTSW	1	88216158	small deletion	probably benign
R0201:Ugt1a10	UTSW	1	88215123	missense	probably damaging	1.00
R0201:Ugt1a10	UTSW	1	88218249	missense	probably damaging	1.00
R0522:Ugt1a10	UTSW	1	88218249	missense	probably damaging	1.00
R0525:Ugt1a10	UTSW	1	88218249	missense	probably damaging	1.00
R0748:Ugt1a10	UTSW	1	88215123	missense	probably damaging	1.00
R0811:Ugt1a10	UTSW	1	88056182	missense	probably benign	0.33
R0812:Ugt1a10	UTSW	1	88056182	missense	probably benign	0.33
R1129:Ugt1a10	UTSW	1	88055609	missense	probably benign
R1207:Ugt1a10	UTSW	1	88216254	missense	probably damaging	1.00
R1432:Ugt1a10	UTSW	1	88216260	missense	probably damaging	1.00
R1457:Ugt1a10	UTSW	1	88055711	missense	probably damaging	1.00
R1469:Ugt1a10	UTSW	1	88216254	missense	probably damaging	1.00
R1972:Ugt1a10	UTSW	1	88056047	missense	probably damaging	1.00
R1973:Ugt1a10	UTSW	1	88056047	missense	probably damaging	1.00
R2039:Ugt1a10	UTSW	1	88055981	missense	probably benign	0.32
R2307:Ugt1a10	UTSW	1	88055947	missense	probably benign	0.01
R3952:Ugt1a10	UTSW	1	88216140	missense	probably damaging	1.00
R3973:Ugt1a10	UTSW	1	88216140	missense	probably damaging	1.00
R4232:Ugt1a10	UTSW	1	88056210	missense	probably benign	0.39
R4392:Ugt1a10	UTSW	1	88215123	missense	probably damaging	1.00
R4393:Ugt1a10	UTSW	1	88215123	missense	probably damaging	1.00
R4402:Ugt1a10	UTSW	1	88215123	missense	probably damaging	1.00
R4417:Ugt1a10	UTSW	1	88055995	missense	probably benign
R4474:Ugt1a10	UTSW	1	88215928	intron	probably benign
R4476:Ugt1a10	UTSW	1	88215928	intron	probably benign
R4515:Ugt1a10	UTSW	1	88056197	missense	probably damaging	1.00
R4579:Ugt1a10	UTSW	1	88056116	missense	probably benign
R4582:Ugt1a10	UTSW	1	88055741	missense	possibly damaging	0.90
R4609:Ugt1a10	UTSW	1	88055482	start codon destroyed	possibly damaging	0.92
R4627:Ugt1a10	UTSW	1	88218390	missense	probably damaging	1.00
R4790:Ugt1a10	UTSW	1	88056287	missense	probably damaging	0.98
R4799:Ugt1a10	UTSW	1	88215928	intron	probably benign
R4910:Ugt1a10	UTSW	1	88215123	missense	probably damaging	1.00
R4915:Ugt1a10	UTSW	1	88055924	missense	probably damaging	1.00
R5110:Ugt1a10	UTSW	1	88056252	splice site	probably null
R5168:Ugt1a10	UTSW	1	88055809	missense	probably benign	0.01
R5329:Ugt1a10	UTSW	1	88216254	missense	probably damaging	1.00
R5373:Ugt1a10	UTSW	1	88055910	missense	probably damaging	0.98
R5374:Ugt1a10	UTSW	1	88055910	missense	probably damaging	0.98
R5615:Ugt1a10	UTSW	1	88216158	small deletion	probably benign
R6498:Ugt1a10	UTSW	1	88216140	missense	probably damaging	1.00
R6727:Ugt1a10	UTSW	1	88056257	splice site	probably null
R6809:Ugt1a10	UTSW	1	88055925	missense	probably damaging	0.98
R6924:Ugt1a10	UTSW	1	88055657	missense	probably damaging	0.99
R6967:Ugt1a10	UTSW	1	88215123	missense	probably damaging	1.00
R7913:Ugt1a10	UTSW	1	88055755	missense	probably benign	0.00
R9165:Ugt1a10	UTSW	1	88055787	missense	probably benign	0.00
R9264:Ugt1a10	UTSW	1	88055671	missense	possibly damaging	0.62
R9475:Ugt1a10	UTSW	1	88216260	missense	probably damaging	1.00
S24628:Ugt1a10	UTSW	1	88216158	small deletion	probably benign
X0013:Ugt1a10	UTSW	1	88216254	missense	probably damaging	1.00
Z1088:Ugt1a10	UTSW	1	88055842	missense	probably benign	0.20
Z1190:Ugt1a10	UTSW	1	88216158	small deletion	probably benign

Predicted Primers

Posted On

2013-08-20