Incidental Mutation 'R8779:Rexo1'
| ID |
670178 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Rexo1
|
| Ensembl Gene |
ENSMUSG00000047417 |
| Gene Name |
REX1, RNA exonuclease 1 |
| Synonyms |
Rex1, Tceb3bp1, 2610511M11Rik, 1700021P10Rik |
| MMRRC Submission |
068721-MU
|
| Accession Numbers |
|
| Essential gene? |
Possibly non essential
(E-score: 0.413)
|
| Stock # |
R8779 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
10 |
| Chromosomal Location |
80376756-80397394 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 80384292 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Serine to Proline
at position 656
(S656P)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000049705
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000057910]
[ENSMUST00000183160]
|
| AlphaFold |
Q7TT28 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000057910
AA Change: S656P
PolyPhen 2
Score 0.257 (Sensitivity: 0.91; Specificity: 0.88)
|
| SMART Domains |
Protein: ENSMUSP00000049705
Gene: ENSMUSG00000047417
AA Change: S656P
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
34 |
53 |
N/A |
INTRINSIC |
|
coiled coil region
|
83 |
113 |
N/A |
INTRINSIC |
|
low complexity region
|
180 |
188 |
N/A |
INTRINSIC |
|
low complexity region
|
365 |
381 |
N/A |
INTRINSIC |
|
low complexity region
|
383 |
396 |
N/A |
INTRINSIC |
|
low complexity region
|
440 |
453 |
N/A |
INTRINSIC |
|
low complexity region
|
468 |
479 |
N/A |
INTRINSIC |
|
low complexity region
|
507 |
525 |
N/A |
INTRINSIC |
|
low complexity region
|
533 |
551 |
N/A |
INTRINSIC |
|
low complexity region
|
561 |
583 |
N/A |
INTRINSIC |
|
low complexity region
|
667 |
682 |
N/A |
INTRINSIC |
|
Pfam:EloA-BP1
|
794 |
954 |
3.8e-72 |
PFAM |
|
EXOIII
|
1051 |
1210 |
2.36e-38 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000182260
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000183073
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000183160
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 100.0%
- 10x: 99.8%
- 20x: 99.3%
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 35 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Adap1 |
C |
A |
5: 139,259,173 (GRCm39) |
C338F |
probably damaging |
Het |
| Ahsa1 |
A |
G |
12: 87,319,973 (GRCm39) |
N256S |
probably benign |
Het |
| Ambra1 |
A |
G |
2: 91,747,719 (GRCm39) |
I1152V |
probably benign |
Het |
| Ank2 |
A |
T |
3: 126,758,751 (GRCm39) |
N149K |
probably damaging |
Het |
| Arid1b |
G |
A |
17: 5,391,809 (GRCm39) |
D1727N |
probably benign |
Het |
| Cntn5 |
A |
T |
9: 10,171,920 (GRCm39) |
F88Y |
probably benign |
Het |
| Cpox |
G |
C |
16: 58,491,229 (GRCm39) |
E147Q |
probably damaging |
Het |
| Dip2c |
T |
C |
13: 9,660,845 (GRCm39) |
F902S |
probably damaging |
Het |
| Eif3c |
T |
C |
7: 126,162,900 (GRCm39) |
K128E |
possibly damaging |
Het |
| Fat4 |
A |
T |
3: 39,033,898 (GRCm39) |
I2517F |
probably damaging |
Het |
| Galnt7 |
T |
C |
8: 58,037,245 (GRCm39) |
N48S |
probably benign |
Het |
| Gcfc2 |
C |
T |
6: 81,925,298 (GRCm39) |
T571I |
probably benign |
Het |
| Gem |
T |
C |
4: 11,711,166 (GRCm39) |
V119A |
possibly damaging |
Het |
| Gm3248 |
A |
T |
14: 5,943,869 (GRCm38) |
N118K |
probably benign |
Het |
| Idh1 |
CA |
CAA |
1: 65,204,347 (GRCm39) |
|
probably null |
Het |
| Igkv14-130 |
T |
A |
6: 67,768,311 (GRCm39) |
W57R |
probably damaging |
Het |
| Irag2 |
A |
G |
6: 145,083,925 (GRCm39) |
E30G |
probably benign |
Het |
| Itch |
T |
A |
2: 155,014,440 (GRCm39) |
D92E |
probably benign |
Het |
| Jakmip1 |
G |
C |
5: 37,386,672 (GRCm39) |
E1428Q |
unknown |
Het |
| Kazn |
T |
C |
4: 141,881,856 (GRCm39) |
E128G |
|
Het |
| Myo3a |
C |
A |
2: 22,250,404 (GRCm39) |
Y90* |
probably null |
Het |
| Npas2 |
A |
C |
1: 39,377,267 (GRCm39) |
D543A |
probably damaging |
Het |
| Or5ae1 |
A |
G |
7: 84,565,397 (GRCm39) |
T137A |
possibly damaging |
Het |
| Or5v1 |
A |
G |
17: 37,809,718 (GRCm39) |
M59V |
probably damaging |
Het |
| Or8g52 |
A |
G |
9: 39,630,636 (GRCm39) |
T38A |
probably damaging |
Het |
| Pcdhgb4 |
G |
T |
18: 37,854,835 (GRCm39) |
R410L |
probably damaging |
Het |
| Rmnd5b |
T |
C |
11: 51,518,459 (GRCm39) |
E139G |
possibly damaging |
Het |
| Scn1a |
C |
T |
2: 66,181,257 (GRCm39) |
|
probably benign |
Het |
| Sdk1 |
T |
C |
5: 141,948,457 (GRCm39) |
S601P |
probably benign |
Het |
| Smpd3 |
A |
G |
8: 106,992,121 (GRCm39) |
V144A |
probably benign |
Het |
| Snrk |
T |
C |
9: 121,995,688 (GRCm39) |
I489T |
probably damaging |
Het |
| Thoc1 |
A |
G |
18: 9,993,366 (GRCm39) |
E575G |
probably benign |
Het |
| Usp16 |
A |
G |
16: 87,276,297 (GRCm39) |
D545G |
probably benign |
Het |
| Vmn2r81 |
G |
A |
10: 79,103,218 (GRCm39) |
C137Y |
possibly damaging |
Het |
| Zfp536 |
T |
A |
7: 37,267,692 (GRCm39) |
K575* |
probably null |
Het |
|
| Other mutations in Rexo1 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00970:Rexo1
|
APN |
10 |
80,386,798 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01128:Rexo1
|
APN |
10 |
80,385,573 (GRCm39) |
missense |
probably benign |
|
|
IGL01890:Rexo1
|
APN |
10 |
80,378,845 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
PIT4453001:Rexo1
|
UTSW |
10 |
80,386,231 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R0044:Rexo1
|
UTSW |
10 |
80,380,212 (GRCm39) |
missense |
probably benign |
0.16 |
|
R0365:Rexo1
|
UTSW |
10 |
80,378,410 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0573:Rexo1
|
UTSW |
10 |
80,380,684 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1146:Rexo1
|
UTSW |
10 |
80,380,239 (GRCm39) |
missense |
probably benign |
0.04 |
|
R1146:Rexo1
|
UTSW |
10 |
80,380,239 (GRCm39) |
missense |
probably benign |
0.04 |
|
R1511:Rexo1
|
UTSW |
10 |
80,385,884 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R1523:Rexo1
|
UTSW |
10 |
80,378,585 (GRCm39) |
missense |
probably benign |
0.41 |
|
R1807:Rexo1
|
UTSW |
10 |
80,378,413 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R1868:Rexo1
|
UTSW |
10 |
80,378,754 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1935:Rexo1
|
UTSW |
10 |
80,386,303 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1936:Rexo1
|
UTSW |
10 |
80,386,303 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1957:Rexo1
|
UTSW |
10 |
80,379,200 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R2084:Rexo1
|
UTSW |
10 |
80,397,100 (GRCm39) |
missense |
probably benign |
0.01 |
|
R2153:Rexo1
|
UTSW |
10 |
80,379,943 (GRCm39) |
nonsense |
probably null |
|
|
R2262:Rexo1
|
UTSW |
10 |
80,385,403 (GRCm39) |
missense |
probably benign |
0.02 |
|
R4471:Rexo1
|
UTSW |
10 |
80,378,492 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4472:Rexo1
|
UTSW |
10 |
80,378,492 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4690:Rexo1
|
UTSW |
10 |
80,382,255 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4972:Rexo1
|
UTSW |
10 |
80,385,527 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R6335:Rexo1
|
UTSW |
10 |
80,379,915 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6505:Rexo1
|
UTSW |
10 |
80,378,845 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R6615:Rexo1
|
UTSW |
10 |
80,379,848 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
R6949:Rexo1
|
UTSW |
10 |
80,386,470 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R7612:Rexo1
|
UTSW |
10 |
80,385,497 (GRCm39) |
missense |
probably benign |
0.40 |
|
R7807:Rexo1
|
UTSW |
10 |
80,385,970 (GRCm39) |
missense |
probably benign |
0.09 |
|
R7840:Rexo1
|
UTSW |
10 |
80,386,572 (GRCm39) |
missense |
probably benign |
|
|
R8897:Rexo1
|
UTSW |
10 |
80,378,437 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8995:Rexo1
|
UTSW |
10 |
80,386,095 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R9094:Rexo1
|
UTSW |
10 |
80,378,854 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9411:Rexo1
|
UTSW |
10 |
80,397,248 (GRCm39) |
missense |
|
|
|
R9438:Rexo1
|
UTSW |
10 |
80,378,848 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R9524:Rexo1
|
UTSW |
10 |
80,386,872 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9648:Rexo1
|
UTSW |
10 |
80,385,540 (GRCm39) |
missense |
probably damaging |
0.97 |
|
Z1177:Rexo1
|
UTSW |
10 |
80,385,609 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- TGTTCCTGTGCCCAGATCTG -3'
(R):5'- TCTGAACTGTCATCCTGGGC -3'
Sequencing Primer
(F):5'- TGGTGGCAAATCTCCTTC -3'
(R):5'- TAGGGCTCTCATTGGCAGGAC -3'
|
| Posted On |
2021-04-30 |
Incidental Mutation