Mutagenetix > Incidental Mutation

Incidental Mutation 'R8780:Vmn2r45'

670203

Institutional Source

Beutler Lab

Gene Symbol

Vmn2r45

Ensembl Gene

ENSMUSG00000090662

Gene Name

vomeronasal 2, receptor 45

Synonyms

MMRRC Submission

068604-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.073) question?

Stock #

R8780 (G1)

Quality Score

214.009

Status

Not validated

Chromosome

Chromosomal Location

8474468-8491958 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 8484371 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Threonine at position 478 (I478T)

Ref Sequence

ENSEMBL: ENSMUSP00000129466 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000164845]

AlphaFold

L7N2B5

Predicted Effect

possibly damaging
Transcript: ENSMUST00000164845
AA Change: I478T

PolyPhen 2 Score 0.938 (Sensitivity: 0.80; Specificity: 0.94)

SMART Domains

Protein: ENSMUSP00000129466
Gene: ENSMUSG00000090662
AA Change: I478T

Domain	Start	End	E-Value	Type
signal peptide	1	18	N/A	INTRINSIC
Pfam:ANF_receptor	154	469	4.5e-26	PFAM
Pfam:NCD3G	512	565	6.4e-21	PFAM
Pfam:7tm_3	598	833	2.1e-54	PFAM

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.7%
20x: 98.9%

Validation Efficiency

100% (38/38)

Allele List at MGI

Other mutations in this stock

Total: 39 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Ace3	A	G	11: 105,888,364 (GRCm39)	D358G	probably damaging	Het
Actmap	T	C	7: 26,900,503 (GRCm39)	S161P	probably benign	Het
Adgrd1	G	A	5: 129,174,138 (GRCm39)		probably benign	Het
Aff4	C	A	11: 53,271,444 (GRCm39)	T327K	probably damaging	Het
Ajap1	A	G	4: 153,470,961 (GRCm39)	V282A	probably damaging	Het
Arrb1	A	G	7: 99,240,568 (GRCm39)	D194G	probably benign	Het
Atp1a3	T	C	7: 24,680,979 (GRCm39)	N836S	probably damaging	Het
C1ql3	A	G	2: 13,015,567 (GRCm39)	V31A	probably benign	Het
Cc2d2a	A	G	5: 43,896,692 (GRCm39)	T1530A	probably damaging	Het
Cenpc1	A	T	5: 86,164,209 (GRCm39)	I804K	probably damaging	Het
Chmp2b	G	A	16: 65,359,422 (GRCm39)		probably benign	Het
Chrm5	T	A	2: 112,310,453 (GRCm39)	E221V	possibly damaging	Het
Col22a1	A	T	15: 71,878,796 (GRCm39)	H120Q	probably damaging	Het
Esp16	C	T	17: 39,850,729 (GRCm39)	A36V	probably damaging	Het
Fn1	A	T	1: 71,682,308 (GRCm39)	S283T	probably benign	Het
Hipk3	A	G	2: 104,264,179 (GRCm39)	L773S	probably damaging	Het
Lcor	C	T	19: 41,573,698 (GRCm39)	R818W	probably damaging	Het
Morn3	A	G	5: 123,175,825 (GRCm39)	W188R	probably damaging	Het
Msantd2	T	G	9: 37,434,798 (GRCm39)	L547R	probably damaging	Het
Naip5	T	A	13: 100,356,338 (GRCm39)	E1092D	probably benign	Het
Obi1	A	T	14: 104,717,082 (GRCm39)	C430*	probably null	Het
Or4a15	A	T	2: 89,193,652 (GRCm39)	N40K	probably damaging	Het
Or7e166	T	C	9: 19,624,653 (GRCm39)	F177L	possibly damaging	Het
Pcdhga5	G	A	18: 37,828,826 (GRCm39)	V425I	probably benign	Het
Pdxk	T	A	10: 78,283,786 (GRCm39)	Y136F	probably benign	Het
Prr14	T	C	7: 127,075,410 (GRCm39)	F503L	probably benign	Het
Prss54	T	C	8: 96,286,057 (GRCm39)	I339V	probably benign	Het
Repin1	T	C	6: 48,574,073 (GRCm39)	I334T	probably damaging	Het
Runx3	A	G	4: 134,882,720 (GRCm39)	D152G	probably damaging	Het
She	T	A	3: 89,739,256 (GRCm39)	I149N	probably damaging	Het
Stra6	A	G	9: 58,042,254 (GRCm39)		probably benign	Het
Svil	A	G	18: 5,063,449 (GRCm39)	T907A	probably benign	Het
Syvn1	A	G	19: 6,100,393 (GRCm39)	D288G	probably damaging	Het
Tacc1	T	C	8: 25,672,077 (GRCm39)	S384G	probably benign	Het
Tmc8	ACTTCCT	ACT	11: 117,681,558 (GRCm39)		probably null	Het
Trhr	T	C	15: 44,061,149 (GRCm39)	I223T	possibly damaging	Het
Zbtb3	G	T	19: 8,781,173 (GRCm39)	R262M	possibly damaging	Het
Zfp516	T	C	18: 83,006,080 (GRCm39)	S995P	probably benign	Het
Zfp985	A	G	4: 147,668,412 (GRCm39)	I427V	possibly damaging	Het

Other mutations in Vmn2r45

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01287:Vmn2r45	APN	7	8,488,622 (GRCm39)	missense	probably benign	0.00
IGL01322:Vmn2r45	APN	7	8,484,332 (GRCm39)	missense	possibly damaging	0.49
IGL01402:Vmn2r45	APN	7	8,484,467 (GRCm39)	missense	probably damaging	0.98
IGL01404:Vmn2r45	APN	7	8,484,467 (GRCm39)	missense	probably damaging	0.98
IGL01529:Vmn2r45	APN	7	8,486,493 (GRCm39)	missense	probably benign
IGL01596:Vmn2r45	APN	7	8,486,272 (GRCm39)	missense	probably damaging	0.98
IGL01646:Vmn2r45	APN	7	8,486,337 (GRCm39)	missense	probably benign	0.18
IGL01819:Vmn2r45	APN	7	8,488,556 (GRCm39)	missense	probably benign	0.00
IGL02096:Vmn2r45	APN	7	8,484,443 (GRCm39)	missense	probably damaging	0.99
IGL02130:Vmn2r45	APN	7	8,486,556 (GRCm39)	missense	possibly damaging	0.46
IGL02409:Vmn2r45	APN	7	8,488,727 (GRCm39)	missense	probably benign	0.03
IGL02517:Vmn2r45	APN	7	8,486,185 (GRCm39)	nonsense	probably null
IGL02633:Vmn2r45	APN	7	8,488,728 (GRCm39)	missense	probably benign	0.01
IGL02940:Vmn2r45	APN	7	8,475,369 (GRCm39)	missense	probably damaging	0.99
IGL03281:Vmn2r45	APN	7	8,486,603 (GRCm39)	missense	probably damaging	1.00
IGL03358:Vmn2r45	APN	7	8,474,715 (GRCm39)	missense	probably damaging	1.00
BB004:Vmn2r45	UTSW	7	8,486,513 (GRCm39)	missense	probably benign
BB014:Vmn2r45	UTSW	7	8,486,513 (GRCm39)	missense	probably benign
R0382:Vmn2r45	UTSW	7	8,486,098 (GRCm39)	missense	probably benign	0.06
R0532:Vmn2r45	UTSW	7	8,474,820 (GRCm39)	missense	probably damaging	0.99
R0932:Vmn2r45	UTSW	7	8,478,380 (GRCm39)	missense	probably damaging	1.00
R1125:Vmn2r45	UTSW	7	8,488,542 (GRCm39)	missense	probably benign	0.00
R1580:Vmn2r45	UTSW	7	8,474,746 (GRCm39)	missense	possibly damaging	0.95
R1817:Vmn2r45	UTSW	7	8,475,372 (GRCm39)	missense	probably damaging	1.00
R1996:Vmn2r45	UTSW	7	8,475,024 (GRCm39)	missense	probably damaging	1.00
R2050:Vmn2r45	UTSW	7	8,475,021 (GRCm39)	missense	probably damaging	1.00
R2284:Vmn2r45	UTSW	7	8,488,765 (GRCm39)	missense	probably benign	0.02
R4019:Vmn2r45	UTSW	7	8,474,580 (GRCm39)	nonsense	probably null
R4227:Vmn2r45	UTSW	7	8,486,277 (GRCm39)	missense	probably damaging	0.98
R4381:Vmn2r45	UTSW	7	8,474,912 (GRCm39)	nonsense	probably null
R4618:Vmn2r45	UTSW	7	8,486,436 (GRCm39)	missense	probably benign	0.00
R4624:Vmn2r45	UTSW	7	8,484,341 (GRCm39)	missense	probably damaging	1.00
R4704:Vmn2r45	UTSW	7	8,486,535 (GRCm39)	nonsense	probably null
R4735:Vmn2r45	UTSW	7	8,486,472 (GRCm39)	missense	probably damaging	1.00
R4868:Vmn2r45	UTSW	7	8,484,480 (GRCm39)	missense	probably benign	0.06
R4983:Vmn2r45	UTSW	7	8,486,116 (GRCm39)	missense	probably damaging	0.99
R5246:Vmn2r45	UTSW	7	8,486,251 (GRCm39)	missense	probably benign	0.00
R5430:Vmn2r45	UTSW	7	8,486,333 (GRCm39)	nonsense	probably null
R5504:Vmn2r45	UTSW	7	8,486,176 (GRCm39)	missense	probably benign	0.03
R5511:Vmn2r45	UTSW	7	8,474,832 (GRCm39)	missense	probably benign	0.19
R5745:Vmn2r45	UTSW	7	8,486,074 (GRCm39)	missense	probably benign	0.00
R5814:Vmn2r45	UTSW	7	8,474,475 (GRCm39)	missense	probably benign	0.00
R6223:Vmn2r45	UTSW	7	8,486,301 (GRCm39)	missense	probably benign
R6267:Vmn2r45	UTSW	7	8,475,207 (GRCm39)	missense	probably benign	0.26
R6623:Vmn2r45	UTSW	7	8,474,500 (GRCm39)	missense	probably benign	0.09
R6999:Vmn2r45	UTSW	7	8,486,219 (GRCm39)	missense	probably benign
R7242:Vmn2r45	UTSW	7	8,488,612 (GRCm39)	nonsense	probably null
R7491:Vmn2r45	UTSW	7	8,484,342 (GRCm39)	missense	probably benign	0.27
R7620:Vmn2r45	UTSW	7	8,486,222 (GRCm39)	nonsense	probably null
R7719:Vmn2r45	UTSW	7	8,486,460 (GRCm39)	missense	probably damaging	0.99
R7720:Vmn2r45	UTSW	7	8,486,460 (GRCm39)	missense	probably damaging	0.99
R7853:Vmn2r45	UTSW	7	8,485,987 (GRCm39)	missense	possibly damaging	0.90
R7873:Vmn2r45	UTSW	7	8,486,074 (GRCm39)	missense	probably benign	0.00
R7882:Vmn2r45	UTSW	7	8,486,409 (GRCm39)	missense	possibly damaging	0.82
R7927:Vmn2r45	UTSW	7	8,486,513 (GRCm39)	missense	probably benign
R8684:Vmn2r45	UTSW	7	8,486,511 (GRCm39)	missense	probably damaging	0.99
R8811:Vmn2r45	UTSW	7	8,474,881 (GRCm39)	missense	probably damaging	1.00
R8893:Vmn2r45	UTSW	7	8,488,619 (GRCm39)	missense	probably damaging	1.00
R9043:Vmn2r45	UTSW	7	8,474,904 (GRCm39)	missense	possibly damaging	0.92
R9208:Vmn2r45	UTSW	7	8,486,298 (GRCm39)	missense	probably damaging	1.00
R9327:Vmn2r45	UTSW	7	8,474,532 (GRCm39)	missense	probably damaging	1.00
R9586:Vmn2r45	UTSW	7	8,486,050 (GRCm39)	missense	probably benign	0.01
R9599:Vmn2r45	UTSW	7	8,478,457 (GRCm39)	critical splice acceptor site	probably null
U24488:Vmn2r45	UTSW	7	8,475,361 (GRCm39)	missense	probably damaging	1.00
Z1088:Vmn2r45	UTSW	7	8,474,484 (GRCm39)	missense	probably benign	0.16

Predicted Primers

PCR Primer
(F):5'- ATGTTGCCGTGTATTCACCTG -3'
(R):5'- GCATACCTGTGTTGGATCTGC -3'

Sequencing Primer
(F):5'- GCCGTGTATTCACCTGACACTG -3'
(R):5'- TGCCTTTGCTATGAAATCAGAATG -3'

Posted On

2021-04-30