Incidental Mutation 'R8781:Vmn2r8'
ID |
670239 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Vmn2r8
|
Ensembl Gene |
ENSMUSG00000090961 |
Gene Name |
vomeronasal 2, receptor 8 |
Synonyms |
EG627479 |
MMRRC Submission |
068605-MU
|
Accession Numbers |
|
Essential gene? |
Probably non essential
(E-score: 0.079)
|
Stock # |
R8781 (G1)
|
Quality Score |
225.009 |
Status
|
Not validated
|
Chromosome |
5 |
Chromosomal Location |
108945059-108956620 bp(-) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
A to G
at 108945597 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Isoleucine to Threonine
at position 670
(I670T)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000126953
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000004943]
[ENSMUST00000172140]
|
AlphaFold |
L7N472 |
Predicted Effect |
probably benign
Transcript: ENSMUST00000004943
|
SMART Domains |
Protein: ENSMUSP00000004943 Gene: ENSMUSG00000004821
Domain | Start | End | E-Value | Type |
EMP24_GP25L
|
17 |
210 |
1.11e-59 |
SMART |
|
Predicted Effect |
possibly damaging
Transcript: ENSMUST00000172140
AA Change: I670T
PolyPhen 2
Score 0.948 (Sensitivity: 0.79; Specificity: 0.95)
|
SMART Domains |
Protein: ENSMUSP00000126953 Gene: ENSMUSG00000090961 AA Change: I670T
Domain | Start | End | E-Value | Type |
signal peptide
|
1 |
21 |
N/A |
INTRINSIC |
Pfam:ANF_receptor
|
78 |
419 |
1.1e-28 |
PFAM |
Pfam:NCD3G
|
507 |
561 |
8.2e-18 |
PFAM |
Pfam:7tm_3
|
594 |
829 |
1.1e-54 |
PFAM |
|
Coding Region Coverage |
- 1x: 100.0%
- 3x: 100.0%
- 10x: 99.8%
- 20x: 99.3%
|
Validation Efficiency |
100% (59/59) |
Allele List at MGI |
|
Other mutations in this stock |
Total: 62 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
1810055G02Rik |
A |
G |
19: 3,767,538 (GRCm39) |
D375G |
possibly damaging |
Het |
Abi3bp |
C |
T |
16: 56,426,512 (GRCm39) |
T509I |
probably damaging |
Het |
Atp13a2 |
T |
A |
4: 140,723,691 (GRCm39) |
C257S |
probably benign |
Het |
Ccdc183 |
T |
A |
2: 25,502,208 (GRCm39) |
|
probably benign |
Het |
Cd109 |
C |
T |
9: 78,543,929 (GRCm39) |
P158S |
probably damaging |
Het |
Cdh23 |
C |
T |
10: 60,167,567 (GRCm39) |
E1810K |
probably damaging |
Het |
Cog5 |
T |
A |
12: 31,883,249 (GRCm39) |
W393R |
probably damaging |
Het |
Cyth1 |
C |
T |
11: 118,073,069 (GRCm39) |
R277Q |
probably damaging |
Het |
Ddx54 |
G |
T |
5: 120,751,217 (GRCm39) |
R6L |
probably benign |
Het |
Dnah8 |
T |
A |
17: 30,944,078 (GRCm39) |
I1765N |
probably damaging |
Het |
Erp27 |
G |
A |
6: 136,886,458 (GRCm39) |
Q192* |
probably null |
Het |
Fam81a |
T |
A |
9: 70,032,381 (GRCm39) |
H37L |
probably damaging |
Het |
Fbn2 |
A |
G |
18: 58,194,719 (GRCm39) |
S1481P |
possibly damaging |
Het |
Fbp1 |
T |
G |
13: 63,016,831 (GRCm39) |
I224L |
probably benign |
Het |
Fhit |
A |
G |
14: 10,421,503 (GRCm38) |
V32A |
probably damaging |
Het |
Gapvd1 |
T |
A |
2: 34,610,698 (GRCm39) |
H495L |
probably benign |
Het |
Gas2l3 |
T |
C |
10: 89,266,841 (GRCm39) |
D33G |
probably damaging |
Het |
Heatr5b |
A |
T |
17: 79,102,738 (GRCm39) |
D1213E |
probably benign |
Het |
Hsf2bp |
C |
G |
17: 32,252,241 (GRCm39) |
E65Q |
possibly damaging |
Het |
Kif28 |
G |
T |
1: 179,525,481 (GRCm39) |
T937K |
probably benign |
Het |
Klf6 |
T |
A |
13: 5,915,071 (GRCm39) |
V170D |
probably benign |
Het |
Kri1 |
A |
T |
9: 21,191,748 (GRCm39) |
S283T |
|
Het |
Lcor |
C |
T |
19: 41,573,698 (GRCm39) |
R818W |
probably damaging |
Het |
Lct |
A |
G |
1: 128,215,261 (GRCm39) |
Y1772H |
probably damaging |
Het |
Lrrc37 |
T |
A |
11: 103,508,958 (GRCm39) |
E1003D |
unknown |
Het |
Naip5 |
T |
A |
13: 100,356,338 (GRCm39) |
E1092D |
probably benign |
Het |
Or2b2b |
A |
G |
13: 21,859,013 (GRCm39) |
S34P |
probably damaging |
Het |
Or52j3 |
T |
A |
7: 102,836,082 (GRCm39) |
D91E |
probably benign |
Het |
Or8c14-ps1 |
T |
G |
9: 38,101,385 (GRCm39) |
D121E |
probably damaging |
Het |
Parg |
T |
A |
14: 31,936,400 (GRCm39) |
D518E |
probably benign |
Het |
Pcx |
G |
A |
19: 4,670,980 (GRCm39) |
A1095T |
probably damaging |
Het |
Pde1b |
G |
A |
15: 103,433,727 (GRCm39) |
V342M |
probably damaging |
Het |
Pik3r2 |
C |
T |
8: 71,222,046 (GRCm39) |
G579D |
possibly damaging |
Het |
Pknox1 |
G |
A |
17: 31,821,837 (GRCm39) |
|
probably benign |
Het |
Pla2g3 |
C |
A |
11: 3,438,530 (GRCm39) |
T60K |
probably benign |
Het |
Ppfia3 |
C |
T |
7: 44,997,953 (GRCm39) |
E725K |
possibly damaging |
Het |
Ppl |
C |
T |
16: 4,915,800 (GRCm39) |
V588I |
possibly damaging |
Het |
Sardh |
T |
A |
2: 27,086,715 (GRCm39) |
E815V |
possibly damaging |
Het |
Scn7a |
T |
C |
2: 66,567,775 (GRCm39) |
E273G |
probably benign |
Het |
Slc7a8 |
A |
T |
14: 54,996,996 (GRCm39) |
|
probably benign |
Het |
Smg8 |
G |
A |
11: 86,971,147 (GRCm39) |
P875S |
possibly damaging |
Het |
Sncaip |
T |
C |
18: 53,039,614 (GRCm39) |
S603P |
probably benign |
Het |
Speg |
G |
A |
1: 75,383,665 (GRCm39) |
G1218S |
probably damaging |
Het |
Stk31 |
A |
T |
6: 49,383,709 (GRCm39) |
D92V |
probably damaging |
Het |
Suco |
A |
G |
1: 161,645,951 (GRCm39) |
V1250A |
probably damaging |
Het |
Tas2r138 |
A |
G |
6: 40,589,850 (GRCm39) |
V132A |
probably benign |
Het |
Tcp1 |
T |
C |
17: 13,143,263 (GRCm39) |
I524T |
probably damaging |
Het |
Tenm3 |
CTGCTGTGAAATG |
C |
8: 48,795,484 (GRCm39) |
|
probably null |
Het |
Tln2 |
C |
A |
9: 67,163,233 (GRCm39) |
V1105L |
probably damaging |
Het |
Tmem19 |
T |
C |
10: 115,195,563 (GRCm39) |
|
probably benign |
Het |
Tmprss4 |
T |
C |
9: 45,087,740 (GRCm39) |
Y283C |
possibly damaging |
Het |
Trim29 |
T |
A |
9: 43,222,615 (GRCm39) |
V148D |
probably benign |
Het |
Trip10 |
C |
T |
17: 57,562,313 (GRCm39) |
A277V |
probably benign |
Het |
Usp12 |
C |
A |
5: 146,700,172 (GRCm39) |
R61L |
probably benign |
Het |
Vmn1r58 |
T |
G |
7: 5,413,482 (GRCm39) |
L249F |
probably benign |
Het |
Vmn2r31 |
C |
T |
7: 7,387,400 (GRCm39) |
V724I |
possibly damaging |
Het |
Vmn2r66 |
C |
T |
7: 84,644,355 (GRCm39) |
W685* |
probably null |
Het |
Vmn2r91 |
T |
A |
17: 18,305,323 (GRCm39) |
M2K |
possibly damaging |
Het |
Wdr12 |
A |
G |
1: 60,126,300 (GRCm39) |
W172R |
probably damaging |
Het |
Yipf5 |
A |
T |
18: 40,340,752 (GRCm39) |
V200E |
possibly damaging |
Het |
Zfp608 |
T |
C |
18: 55,031,801 (GRCm39) |
K713R |
probably damaging |
Het |
Zfp768 |
A |
G |
7: 126,942,476 (GRCm39) |
S554P |
probably damaging |
Het |
|
Other mutations in Vmn2r8 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL02957:Vmn2r8
|
APN |
5 |
108,950,091 (GRCm39) |
missense |
probably benign |
0.01 |
R0324:Vmn2r8
|
UTSW |
5 |
108,945,807 (GRCm39) |
splice site |
probably null |
|
R0335:Vmn2r8
|
UTSW |
5 |
108,945,317 (GRCm39) |
splice site |
probably null |
|
R0394:Vmn2r8
|
UTSW |
5 |
108,949,938 (GRCm39) |
missense |
probably benign |
0.12 |
R0501:Vmn2r8
|
UTSW |
5 |
108,951,049 (GRCm39) |
missense |
probably benign |
0.03 |
R0615:Vmn2r8
|
UTSW |
5 |
108,947,195 (GRCm39) |
missense |
probably damaging |
1.00 |
R0678:Vmn2r8
|
UTSW |
5 |
108,948,412 (GRCm39) |
missense |
probably benign |
0.00 |
R1167:Vmn2r8
|
UTSW |
5 |
108,951,042 (GRCm39) |
missense |
probably benign |
0.01 |
R1187:Vmn2r8
|
UTSW |
5 |
108,951,085 (GRCm39) |
nonsense |
probably null |
|
R1406:Vmn2r8
|
UTSW |
5 |
108,950,234 (GRCm39) |
missense |
probably benign |
|
R1406:Vmn2r8
|
UTSW |
5 |
108,950,234 (GRCm39) |
missense |
probably benign |
|
R1451:Vmn2r8
|
UTSW |
5 |
108,945,933 (GRCm39) |
missense |
probably damaging |
1.00 |
R1535:Vmn2r8
|
UTSW |
5 |
108,950,040 (GRCm39) |
missense |
probably damaging |
1.00 |
R1795:Vmn2r8
|
UTSW |
5 |
108,950,972 (GRCm39) |
missense |
probably benign |
|
R1874:Vmn2r8
|
UTSW |
5 |
108,950,284 (GRCm39) |
missense |
possibly damaging |
0.74 |
R1908:Vmn2r8
|
UTSW |
5 |
108,945,436 (GRCm39) |
missense |
probably benign |
0.03 |
R1925:Vmn2r8
|
UTSW |
5 |
108,950,019 (GRCm39) |
missense |
probably damaging |
0.97 |
R1960:Vmn2r8
|
UTSW |
5 |
108,947,152 (GRCm39) |
missense |
probably damaging |
0.99 |
R1961:Vmn2r8
|
UTSW |
5 |
108,945,961 (GRCm39) |
missense |
probably benign |
0.45 |
R1967:Vmn2r8
|
UTSW |
5 |
108,950,249 (GRCm39) |
missense |
probably benign |
0.01 |
R2095:Vmn2r8
|
UTSW |
5 |
108,956,487 (GRCm39) |
missense |
possibly damaging |
0.94 |
R2159:Vmn2r8
|
UTSW |
5 |
108,950,169 (GRCm39) |
missense |
probably benign |
0.22 |
R4240:Vmn2r8
|
UTSW |
5 |
108,945,369 (GRCm39) |
missense |
probably damaging |
0.99 |
R4581:Vmn2r8
|
UTSW |
5 |
108,949,570 (GRCm39) |
missense |
probably benign |
0.03 |
R4744:Vmn2r8
|
UTSW |
5 |
108,956,447 (GRCm39) |
missense |
probably benign |
0.00 |
R4755:Vmn2r8
|
UTSW |
5 |
108,949,566 (GRCm39) |
missense |
probably benign |
0.03 |
R4917:Vmn2r8
|
UTSW |
5 |
108,945,264 (GRCm39) |
missense |
probably damaging |
1.00 |
R4957:Vmn2r8
|
UTSW |
5 |
108,947,129 (GRCm39) |
missense |
probably benign |
0.16 |
R5141:Vmn2r8
|
UTSW |
5 |
108,956,572 (GRCm39) |
missense |
probably damaging |
0.96 |
R5481:Vmn2r8
|
UTSW |
5 |
108,949,636 (GRCm39) |
missense |
probably benign |
0.09 |
R5571:Vmn2r8
|
UTSW |
5 |
108,950,106 (GRCm39) |
missense |
probably damaging |
1.00 |
R5624:Vmn2r8
|
UTSW |
5 |
108,950,325 (GRCm39) |
missense |
probably damaging |
0.99 |
R6003:Vmn2r8
|
UTSW |
5 |
108,945,248 (GRCm39) |
missense |
probably damaging |
1.00 |
R6243:Vmn2r8
|
UTSW |
5 |
108,947,211 (GRCm39) |
missense |
probably benign |
0.01 |
R6265:Vmn2r8
|
UTSW |
5 |
108,956,463 (GRCm39) |
missense |
probably benign |
|
R6315:Vmn2r8
|
UTSW |
5 |
108,949,757 (GRCm39) |
missense |
probably benign |
|
R6413:Vmn2r8
|
UTSW |
5 |
108,949,589 (GRCm39) |
missense |
probably benign |
0.09 |
R7120:Vmn2r8
|
UTSW |
5 |
108,956,504 (GRCm39) |
missense |
possibly damaging |
0.56 |
R7406:Vmn2r8
|
UTSW |
5 |
108,948,442 (GRCm39) |
missense |
probably benign |
0.00 |
R7409:Vmn2r8
|
UTSW |
5 |
108,956,449 (GRCm39) |
nonsense |
probably null |
|
R7489:Vmn2r8
|
UTSW |
5 |
108,945,522 (GRCm39) |
missense |
possibly damaging |
0.95 |
R7532:Vmn2r8
|
UTSW |
5 |
108,950,106 (GRCm39) |
missense |
probably benign |
0.22 |
R7534:Vmn2r8
|
UTSW |
5 |
108,950,040 (GRCm39) |
missense |
possibly damaging |
0.94 |
R7739:Vmn2r8
|
UTSW |
5 |
108,950,043 (GRCm39) |
missense |
probably damaging |
1.00 |
R8099:Vmn2r8
|
UTSW |
5 |
108,949,700 (GRCm39) |
missense |
probably benign |
|
R8245:Vmn2r8
|
UTSW |
5 |
108,945,936 (GRCm39) |
missense |
probably damaging |
1.00 |
R8711:Vmn2r8
|
UTSW |
5 |
108,945,962 (GRCm39) |
missense |
possibly damaging |
0.89 |
R8874:Vmn2r8
|
UTSW |
5 |
108,956,617 (GRCm39) |
missense |
probably damaging |
1.00 |
R8927:Vmn2r8
|
UTSW |
5 |
108,950,131 (GRCm39) |
missense |
|
|
R8928:Vmn2r8
|
UTSW |
5 |
108,950,131 (GRCm39) |
missense |
|
|
R9288:Vmn2r8
|
UTSW |
5 |
108,950,185 (GRCm39) |
missense |
probably benign |
0.39 |
R9596:Vmn2r8
|
UTSW |
5 |
108,947,196 (GRCm39) |
missense |
possibly damaging |
0.94 |
R9652:Vmn2r8
|
UTSW |
5 |
108,951,107 (GRCm39) |
missense |
probably benign |
0.18 |
Z1088:Vmn2r8
|
UTSW |
5 |
108,949,864 (GRCm39) |
missense |
probably damaging |
0.99 |
|
Predicted Primers |
PCR Primer
(F):5'- TGGAAGGCAATGACTGAGCC -3'
(R):5'- TCCCATTGTGAAGGCCAATAAC -3'
Sequencing Primer
(F):5'- GAAGGCAATGACTGAGCCTTTGTTAC -3'
(R):5'- TTGTGAAGGCCAATAACCGCATTC -3'
|
Posted On |
2021-04-30 |