Incidental Mutation 'R8781:Vmn2r8'
ID 670239
Institutional Source Beutler Lab
Gene Symbol Vmn2r8
Ensembl Gene ENSMUSG00000090961
Gene Name vomeronasal 2, receptor 8
Synonyms EG627479
MMRRC Submission 068605-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.079) question?
Stock # R8781 (G1)
Quality Score 225.009
Status Not validated
Chromosome 5
Chromosomal Location 108945059-108956620 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 108945597 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Threonine at position 670 (I670T)
Ref Sequence ENSEMBL: ENSMUSP00000126953 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000004943] [ENSMUST00000172140]
AlphaFold L7N472
Predicted Effect probably benign
Transcript: ENSMUST00000004943
SMART Domains Protein: ENSMUSP00000004943
Gene: ENSMUSG00000004821

DomainStartEndE-ValueType
EMP24_GP25L 17 210 1.11e-59 SMART
Predicted Effect possibly damaging
Transcript: ENSMUST00000172140
AA Change: I670T

PolyPhen 2 Score 0.948 (Sensitivity: 0.79; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000126953
Gene: ENSMUSG00000090961
AA Change: I670T

DomainStartEndE-ValueType
signal peptide 1 21 N/A INTRINSIC
Pfam:ANF_receptor 78 419 1.1e-28 PFAM
Pfam:NCD3G 507 561 8.2e-18 PFAM
Pfam:7tm_3 594 829 1.1e-54 PFAM
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.8%
  • 20x: 99.3%
Validation Efficiency 100% (59/59)
Allele List at MGI
Other mutations in this stock
Total: 62 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1810055G02Rik A G 19: 3,767,538 (GRCm39) D375G possibly damaging Het
Abi3bp C T 16: 56,426,512 (GRCm39) T509I probably damaging Het
Atp13a2 T A 4: 140,723,691 (GRCm39) C257S probably benign Het
Ccdc183 T A 2: 25,502,208 (GRCm39) probably benign Het
Cd109 C T 9: 78,543,929 (GRCm39) P158S probably damaging Het
Cdh23 C T 10: 60,167,567 (GRCm39) E1810K probably damaging Het
Cog5 T A 12: 31,883,249 (GRCm39) W393R probably damaging Het
Cyth1 C T 11: 118,073,069 (GRCm39) R277Q probably damaging Het
Ddx54 G T 5: 120,751,217 (GRCm39) R6L probably benign Het
Dnah8 T A 17: 30,944,078 (GRCm39) I1765N probably damaging Het
Erp27 G A 6: 136,886,458 (GRCm39) Q192* probably null Het
Fam81a T A 9: 70,032,381 (GRCm39) H37L probably damaging Het
Fbn2 A G 18: 58,194,719 (GRCm39) S1481P possibly damaging Het
Fbp1 T G 13: 63,016,831 (GRCm39) I224L probably benign Het
Fhit A G 14: 10,421,503 (GRCm38) V32A probably damaging Het
Gapvd1 T A 2: 34,610,698 (GRCm39) H495L probably benign Het
Gas2l3 T C 10: 89,266,841 (GRCm39) D33G probably damaging Het
Heatr5b A T 17: 79,102,738 (GRCm39) D1213E probably benign Het
Hsf2bp C G 17: 32,252,241 (GRCm39) E65Q possibly damaging Het
Kif28 G T 1: 179,525,481 (GRCm39) T937K probably benign Het
Klf6 T A 13: 5,915,071 (GRCm39) V170D probably benign Het
Kri1 A T 9: 21,191,748 (GRCm39) S283T Het
Lcor C T 19: 41,573,698 (GRCm39) R818W probably damaging Het
Lct A G 1: 128,215,261 (GRCm39) Y1772H probably damaging Het
Lrrc37 T A 11: 103,508,958 (GRCm39) E1003D unknown Het
Naip5 T A 13: 100,356,338 (GRCm39) E1092D probably benign Het
Or2b2b A G 13: 21,859,013 (GRCm39) S34P probably damaging Het
Or52j3 T A 7: 102,836,082 (GRCm39) D91E probably benign Het
Or8c14-ps1 T G 9: 38,101,385 (GRCm39) D121E probably damaging Het
Parg T A 14: 31,936,400 (GRCm39) D518E probably benign Het
Pcx G A 19: 4,670,980 (GRCm39) A1095T probably damaging Het
Pde1b G A 15: 103,433,727 (GRCm39) V342M probably damaging Het
Pik3r2 C T 8: 71,222,046 (GRCm39) G579D possibly damaging Het
Pknox1 G A 17: 31,821,837 (GRCm39) probably benign Het
Pla2g3 C A 11: 3,438,530 (GRCm39) T60K probably benign Het
Ppfia3 C T 7: 44,997,953 (GRCm39) E725K possibly damaging Het
Ppl C T 16: 4,915,800 (GRCm39) V588I possibly damaging Het
Sardh T A 2: 27,086,715 (GRCm39) E815V possibly damaging Het
Scn7a T C 2: 66,567,775 (GRCm39) E273G probably benign Het
Slc7a8 A T 14: 54,996,996 (GRCm39) probably benign Het
Smg8 G A 11: 86,971,147 (GRCm39) P875S possibly damaging Het
Sncaip T C 18: 53,039,614 (GRCm39) S603P probably benign Het
Speg G A 1: 75,383,665 (GRCm39) G1218S probably damaging Het
Stk31 A T 6: 49,383,709 (GRCm39) D92V probably damaging Het
Suco A G 1: 161,645,951 (GRCm39) V1250A probably damaging Het
Tas2r138 A G 6: 40,589,850 (GRCm39) V132A probably benign Het
Tcp1 T C 17: 13,143,263 (GRCm39) I524T probably damaging Het
Tenm3 CTGCTGTGAAATG C 8: 48,795,484 (GRCm39) probably null Het
Tln2 C A 9: 67,163,233 (GRCm39) V1105L probably damaging Het
Tmem19 T C 10: 115,195,563 (GRCm39) probably benign Het
Tmprss4 T C 9: 45,087,740 (GRCm39) Y283C possibly damaging Het
Trim29 T A 9: 43,222,615 (GRCm39) V148D probably benign Het
Trip10 C T 17: 57,562,313 (GRCm39) A277V probably benign Het
Usp12 C A 5: 146,700,172 (GRCm39) R61L probably benign Het
Vmn1r58 T G 7: 5,413,482 (GRCm39) L249F probably benign Het
Vmn2r31 C T 7: 7,387,400 (GRCm39) V724I possibly damaging Het
Vmn2r66 C T 7: 84,644,355 (GRCm39) W685* probably null Het
Vmn2r91 T A 17: 18,305,323 (GRCm39) M2K possibly damaging Het
Wdr12 A G 1: 60,126,300 (GRCm39) W172R probably damaging Het
Yipf5 A T 18: 40,340,752 (GRCm39) V200E possibly damaging Het
Zfp608 T C 18: 55,031,801 (GRCm39) K713R probably damaging Het
Zfp768 A G 7: 126,942,476 (GRCm39) S554P probably damaging Het
Other mutations in Vmn2r8
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02957:Vmn2r8 APN 5 108,950,091 (GRCm39) missense probably benign 0.01
R0324:Vmn2r8 UTSW 5 108,945,807 (GRCm39) splice site probably null
R0335:Vmn2r8 UTSW 5 108,945,317 (GRCm39) splice site probably null
R0394:Vmn2r8 UTSW 5 108,949,938 (GRCm39) missense probably benign 0.12
R0501:Vmn2r8 UTSW 5 108,951,049 (GRCm39) missense probably benign 0.03
R0615:Vmn2r8 UTSW 5 108,947,195 (GRCm39) missense probably damaging 1.00
R0678:Vmn2r8 UTSW 5 108,948,412 (GRCm39) missense probably benign 0.00
R1167:Vmn2r8 UTSW 5 108,951,042 (GRCm39) missense probably benign 0.01
R1187:Vmn2r8 UTSW 5 108,951,085 (GRCm39) nonsense probably null
R1406:Vmn2r8 UTSW 5 108,950,234 (GRCm39) missense probably benign
R1406:Vmn2r8 UTSW 5 108,950,234 (GRCm39) missense probably benign
R1451:Vmn2r8 UTSW 5 108,945,933 (GRCm39) missense probably damaging 1.00
R1535:Vmn2r8 UTSW 5 108,950,040 (GRCm39) missense probably damaging 1.00
R1795:Vmn2r8 UTSW 5 108,950,972 (GRCm39) missense probably benign
R1874:Vmn2r8 UTSW 5 108,950,284 (GRCm39) missense possibly damaging 0.74
R1908:Vmn2r8 UTSW 5 108,945,436 (GRCm39) missense probably benign 0.03
R1925:Vmn2r8 UTSW 5 108,950,019 (GRCm39) missense probably damaging 0.97
R1960:Vmn2r8 UTSW 5 108,947,152 (GRCm39) missense probably damaging 0.99
R1961:Vmn2r8 UTSW 5 108,945,961 (GRCm39) missense probably benign 0.45
R1967:Vmn2r8 UTSW 5 108,950,249 (GRCm39) missense probably benign 0.01
R2095:Vmn2r8 UTSW 5 108,956,487 (GRCm39) missense possibly damaging 0.94
R2159:Vmn2r8 UTSW 5 108,950,169 (GRCm39) missense probably benign 0.22
R4240:Vmn2r8 UTSW 5 108,945,369 (GRCm39) missense probably damaging 0.99
R4581:Vmn2r8 UTSW 5 108,949,570 (GRCm39) missense probably benign 0.03
R4744:Vmn2r8 UTSW 5 108,956,447 (GRCm39) missense probably benign 0.00
R4755:Vmn2r8 UTSW 5 108,949,566 (GRCm39) missense probably benign 0.03
R4917:Vmn2r8 UTSW 5 108,945,264 (GRCm39) missense probably damaging 1.00
R4957:Vmn2r8 UTSW 5 108,947,129 (GRCm39) missense probably benign 0.16
R5141:Vmn2r8 UTSW 5 108,956,572 (GRCm39) missense probably damaging 0.96
R5481:Vmn2r8 UTSW 5 108,949,636 (GRCm39) missense probably benign 0.09
R5571:Vmn2r8 UTSW 5 108,950,106 (GRCm39) missense probably damaging 1.00
R5624:Vmn2r8 UTSW 5 108,950,325 (GRCm39) missense probably damaging 0.99
R6003:Vmn2r8 UTSW 5 108,945,248 (GRCm39) missense probably damaging 1.00
R6243:Vmn2r8 UTSW 5 108,947,211 (GRCm39) missense probably benign 0.01
R6265:Vmn2r8 UTSW 5 108,956,463 (GRCm39) missense probably benign
R6315:Vmn2r8 UTSW 5 108,949,757 (GRCm39) missense probably benign
R6413:Vmn2r8 UTSW 5 108,949,589 (GRCm39) missense probably benign 0.09
R7120:Vmn2r8 UTSW 5 108,956,504 (GRCm39) missense possibly damaging 0.56
R7406:Vmn2r8 UTSW 5 108,948,442 (GRCm39) missense probably benign 0.00
R7409:Vmn2r8 UTSW 5 108,956,449 (GRCm39) nonsense probably null
R7489:Vmn2r8 UTSW 5 108,945,522 (GRCm39) missense possibly damaging 0.95
R7532:Vmn2r8 UTSW 5 108,950,106 (GRCm39) missense probably benign 0.22
R7534:Vmn2r8 UTSW 5 108,950,040 (GRCm39) missense possibly damaging 0.94
R7739:Vmn2r8 UTSW 5 108,950,043 (GRCm39) missense probably damaging 1.00
R8099:Vmn2r8 UTSW 5 108,949,700 (GRCm39) missense probably benign
R8245:Vmn2r8 UTSW 5 108,945,936 (GRCm39) missense probably damaging 1.00
R8711:Vmn2r8 UTSW 5 108,945,962 (GRCm39) missense possibly damaging 0.89
R8874:Vmn2r8 UTSW 5 108,956,617 (GRCm39) missense probably damaging 1.00
R8927:Vmn2r8 UTSW 5 108,950,131 (GRCm39) missense
R8928:Vmn2r8 UTSW 5 108,950,131 (GRCm39) missense
R9288:Vmn2r8 UTSW 5 108,950,185 (GRCm39) missense probably benign 0.39
R9596:Vmn2r8 UTSW 5 108,947,196 (GRCm39) missense possibly damaging 0.94
R9652:Vmn2r8 UTSW 5 108,951,107 (GRCm39) missense probably benign 0.18
Z1088:Vmn2r8 UTSW 5 108,949,864 (GRCm39) missense probably damaging 0.99
Predicted Primers PCR Primer
(F):5'- TGGAAGGCAATGACTGAGCC -3'
(R):5'- TCCCATTGTGAAGGCCAATAAC -3'

Sequencing Primer
(F):5'- GAAGGCAATGACTGAGCCTTTGTTAC -3'
(R):5'- TTGTGAAGGCCAATAACCGCATTC -3'
Posted On 2021-04-30