Incidental Mutation 'R8781:Or2b2b'
ID 670269
Institutional Source Beutler Lab
Gene Symbol Or2b2b
Ensembl Gene ENSMUSG00000108534
Gene Name olfactory receptor family 2 subfamily B member 2B
Synonyms MOR256-10, MOR256-35, GA_x6K02T2QHY8-11561962-11562903, Olfr1360
MMRRC Submission 068605-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.116) question?
Stock # R8781 (G1)
Quality Score 225.009
Status Not validated
Chromosome 13
Chromosomal Location 21858171-21859150 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 21859013 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Proline at position 34 (S34P)
Ref Sequence ENSEMBL: ENSMUSP00000146159 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000079135] [ENSMUST00000205788] [ENSMUST00000216083]
AlphaFold K9J6X0
Predicted Effect probably damaging
Transcript: ENSMUST00000079135
AA Change: S34P

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
SMART Domains Protein: ENSMUSP00000074361
Gene: ENSMUSG00000108534
AA Change: S34P

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 3e-55 PFAM
Pfam:7tm_1 41 290 1.1e-30 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000205788
AA Change: S34P

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
Predicted Effect probably damaging
Transcript: ENSMUST00000216083
AA Change: S34P

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.8%
  • 20x: 99.3%
Validation Efficiency 100% (59/59)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 62 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1810055G02Rik A G 19: 3,767,538 (GRCm39) D375G possibly damaging Het
Abi3bp C T 16: 56,426,512 (GRCm39) T509I probably damaging Het
Atp13a2 T A 4: 140,723,691 (GRCm39) C257S probably benign Het
Ccdc183 T A 2: 25,502,208 (GRCm39) probably benign Het
Cd109 C T 9: 78,543,929 (GRCm39) P158S probably damaging Het
Cdh23 C T 10: 60,167,567 (GRCm39) E1810K probably damaging Het
Cog5 T A 12: 31,883,249 (GRCm39) W393R probably damaging Het
Cyth1 C T 11: 118,073,069 (GRCm39) R277Q probably damaging Het
Ddx54 G T 5: 120,751,217 (GRCm39) R6L probably benign Het
Dnah8 T A 17: 30,944,078 (GRCm39) I1765N probably damaging Het
Erp27 G A 6: 136,886,458 (GRCm39) Q192* probably null Het
Fam81a T A 9: 70,032,381 (GRCm39) H37L probably damaging Het
Fbn2 A G 18: 58,194,719 (GRCm39) S1481P possibly damaging Het
Fbp1 T G 13: 63,016,831 (GRCm39) I224L probably benign Het
Fhit A G 14: 10,421,503 (GRCm38) V32A probably damaging Het
Gapvd1 T A 2: 34,610,698 (GRCm39) H495L probably benign Het
Gas2l3 T C 10: 89,266,841 (GRCm39) D33G probably damaging Het
Heatr5b A T 17: 79,102,738 (GRCm39) D1213E probably benign Het
Hsf2bp C G 17: 32,252,241 (GRCm39) E65Q possibly damaging Het
Kif28 G T 1: 179,525,481 (GRCm39) T937K probably benign Het
Klf6 T A 13: 5,915,071 (GRCm39) V170D probably benign Het
Kri1 A T 9: 21,191,748 (GRCm39) S283T Het
Lcor C T 19: 41,573,698 (GRCm39) R818W probably damaging Het
Lct A G 1: 128,215,261 (GRCm39) Y1772H probably damaging Het
Lrrc37 T A 11: 103,508,958 (GRCm39) E1003D unknown Het
Naip5 T A 13: 100,356,338 (GRCm39) E1092D probably benign Het
Or52j3 T A 7: 102,836,082 (GRCm39) D91E probably benign Het
Or8c14-ps1 T G 9: 38,101,385 (GRCm39) D121E probably damaging Het
Parg T A 14: 31,936,400 (GRCm39) D518E probably benign Het
Pcx G A 19: 4,670,980 (GRCm39) A1095T probably damaging Het
Pde1b G A 15: 103,433,727 (GRCm39) V342M probably damaging Het
Pik3r2 C T 8: 71,222,046 (GRCm39) G579D possibly damaging Het
Pknox1 G A 17: 31,821,837 (GRCm39) probably benign Het
Pla2g3 C A 11: 3,438,530 (GRCm39) T60K probably benign Het
Ppfia3 C T 7: 44,997,953 (GRCm39) E725K possibly damaging Het
Ppl C T 16: 4,915,800 (GRCm39) V588I possibly damaging Het
Sardh T A 2: 27,086,715 (GRCm39) E815V possibly damaging Het
Scn7a T C 2: 66,567,775 (GRCm39) E273G probably benign Het
Slc7a8 A T 14: 54,996,996 (GRCm39) probably benign Het
Smg8 G A 11: 86,971,147 (GRCm39) P875S possibly damaging Het
Sncaip T C 18: 53,039,614 (GRCm39) S603P probably benign Het
Speg G A 1: 75,383,665 (GRCm39) G1218S probably damaging Het
Stk31 A T 6: 49,383,709 (GRCm39) D92V probably damaging Het
Suco A G 1: 161,645,951 (GRCm39) V1250A probably damaging Het
Tas2r138 A G 6: 40,589,850 (GRCm39) V132A probably benign Het
Tcp1 T C 17: 13,143,263 (GRCm39) I524T probably damaging Het
Tenm3 CTGCTGTGAAATG C 8: 48,795,484 (GRCm39) probably null Het
Tln2 C A 9: 67,163,233 (GRCm39) V1105L probably damaging Het
Tmem19 T C 10: 115,195,563 (GRCm39) probably benign Het
Tmprss4 T C 9: 45,087,740 (GRCm39) Y283C possibly damaging Het
Trim29 T A 9: 43,222,615 (GRCm39) V148D probably benign Het
Trip10 C T 17: 57,562,313 (GRCm39) A277V probably benign Het
Usp12 C A 5: 146,700,172 (GRCm39) R61L probably benign Het
Vmn1r58 T G 7: 5,413,482 (GRCm39) L249F probably benign Het
Vmn2r31 C T 7: 7,387,400 (GRCm39) V724I possibly damaging Het
Vmn2r66 C T 7: 84,644,355 (GRCm39) W685* probably null Het
Vmn2r8 A G 5: 108,945,597 (GRCm39) I670T possibly damaging Het
Vmn2r91 T A 17: 18,305,323 (GRCm39) M2K possibly damaging Het
Wdr12 A G 1: 60,126,300 (GRCm39) W172R probably damaging Het
Yipf5 A T 18: 40,340,752 (GRCm39) V200E possibly damaging Het
Zfp608 T C 18: 55,031,801 (GRCm39) K713R probably damaging Het
Zfp768 A G 7: 126,942,476 (GRCm39) S554P probably damaging Het
Other mutations in Or2b2b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01736:Or2b2b APN 13 21,858,787 (GRCm39) missense probably benign 0.12
IGL02886:Or2b2b APN 13 21,859,122 (GRCm39) utr 5 prime probably benign
IGL03157:Or2b2b APN 13 21,859,112 (GRCm39) start codon destroyed probably null 0.48
R1540:Or2b2b UTSW 13 21,858,700 (GRCm39) missense probably benign 0.11
R1756:Or2b2b UTSW 13 21,858,865 (GRCm39) missense probably benign 0.00
R1843:Or2b2b UTSW 13 21,858,842 (GRCm39) missense probably benign 0.00
R3793:Or2b2b UTSW 13 21,859,153 (GRCm39) splice site probably null
R5707:Or2b2b UTSW 13 21,858,769 (GRCm39) missense probably damaging 1.00
R7566:Or2b2b UTSW 13 21,858,737 (GRCm39) missense possibly damaging 0.61
R8849:Or2b2b UTSW 13 21,858,226 (GRCm39) missense possibly damaging 0.67
R9070:Or2b2b UTSW 13 21,858,985 (GRCm39) missense probably benign 0.03
R9462:Or2b2b UTSW 13 21,859,015 (GRCm39) missense probably benign 0.19
Z1177:Or2b2b UTSW 13 21,859,324 (GRCm39) start gained probably benign
Predicted Primers PCR Primer
(F):5'- ATAGCTGATCACCTTCCGGG -3'
(R):5'- GCGAATGCACAAAATTCTCCAG -3'

Sequencing Primer
(F):5'- GTGCTGCAGATGTTGATGAGCATC -3'
(R):5'- GAGTCATCACTTCATAACTAGCTGAC -3'
Posted On 2021-04-30