Incidental Mutation 'R8781:Vmn2r91'
| ID |
670279 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r91
|
| Ensembl Gene |
ENSMUSG00000091206 |
| Gene Name |
vomeronasal 2, receptor 91 |
| Synonyms |
EG665210 |
| MMRRC Submission |
068605-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.072)
|
| Stock # |
R8781 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
17 |
| Chromosomal Location |
18305319-18356905 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to A
at 18305323 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Methionine to Lysine
at position 2
(M2K)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000127465
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000172359]
|
| AlphaFold |
E9Q2U5 |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000172359
AA Change: M2K
PolyPhen 2
Score 0.780 (Sensitivity: 0.85; Specificity: 0.93)
|
| SMART Domains |
Protein: ENSMUSP00000127465
Gene: ENSMUSG00000091206
AA Change: M2K
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
20 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
83 |
462 |
2.2e-38 |
PFAM |
|
Pfam:NCD3G
|
510 |
564 |
6.7e-20 |
PFAM |
|
Pfam:7tm_3
|
597 |
832 |
2.1e-53 |
PFAM |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 100.0%
- 10x: 99.8%
- 20x: 99.3%
|
| Validation Efficiency |
100% (59/59) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 62 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 1810055G02Rik |
A |
G |
19: 3,767,538 (GRCm39) |
D375G |
possibly damaging |
Het |
| Abi3bp |
C |
T |
16: 56,426,512 (GRCm39) |
T509I |
probably damaging |
Het |
| Atp13a2 |
T |
A |
4: 140,723,691 (GRCm39) |
C257S |
probably benign |
Het |
| Ccdc183 |
T |
A |
2: 25,502,208 (GRCm39) |
|
probably benign |
Het |
| Cd109 |
C |
T |
9: 78,543,929 (GRCm39) |
P158S |
probably damaging |
Het |
| Cdh23 |
C |
T |
10: 60,167,567 (GRCm39) |
E1810K |
probably damaging |
Het |
| Cog5 |
T |
A |
12: 31,883,249 (GRCm39) |
W393R |
probably damaging |
Het |
| Cyth1 |
C |
T |
11: 118,073,069 (GRCm39) |
R277Q |
probably damaging |
Het |
| Ddx54 |
G |
T |
5: 120,751,217 (GRCm39) |
R6L |
probably benign |
Het |
| Dnah8 |
T |
A |
17: 30,944,078 (GRCm39) |
I1765N |
probably damaging |
Het |
| Erp27 |
G |
A |
6: 136,886,458 (GRCm39) |
Q192* |
probably null |
Het |
| Fam81a |
T |
A |
9: 70,032,381 (GRCm39) |
H37L |
probably damaging |
Het |
| Fbn2 |
A |
G |
18: 58,194,719 (GRCm39) |
S1481P |
possibly damaging |
Het |
| Fbp1 |
T |
G |
13: 63,016,831 (GRCm39) |
I224L |
probably benign |
Het |
| Fhit |
A |
G |
14: 10,421,503 (GRCm38) |
V32A |
probably damaging |
Het |
| Gapvd1 |
T |
A |
2: 34,610,698 (GRCm39) |
H495L |
probably benign |
Het |
| Gas2l3 |
T |
C |
10: 89,266,841 (GRCm39) |
D33G |
probably damaging |
Het |
| Heatr5b |
A |
T |
17: 79,102,738 (GRCm39) |
D1213E |
probably benign |
Het |
| Hsf2bp |
C |
G |
17: 32,252,241 (GRCm39) |
E65Q |
possibly damaging |
Het |
| Kif28 |
G |
T |
1: 179,525,481 (GRCm39) |
T937K |
probably benign |
Het |
| Klf6 |
T |
A |
13: 5,915,071 (GRCm39) |
V170D |
probably benign |
Het |
| Kri1 |
A |
T |
9: 21,191,748 (GRCm39) |
S283T |
|
Het |
| Lcor |
C |
T |
19: 41,573,698 (GRCm39) |
R818W |
probably damaging |
Het |
| Lct |
A |
G |
1: 128,215,261 (GRCm39) |
Y1772H |
probably damaging |
Het |
| Lrrc37 |
T |
A |
11: 103,508,958 (GRCm39) |
E1003D |
unknown |
Het |
| Naip5 |
T |
A |
13: 100,356,338 (GRCm39) |
E1092D |
probably benign |
Het |
| Or2b2b |
A |
G |
13: 21,859,013 (GRCm39) |
S34P |
probably damaging |
Het |
| Or52j3 |
T |
A |
7: 102,836,082 (GRCm39) |
D91E |
probably benign |
Het |
| Or8c14-ps1 |
T |
G |
9: 38,101,385 (GRCm39) |
D121E |
probably damaging |
Het |
| Parg |
T |
A |
14: 31,936,400 (GRCm39) |
D518E |
probably benign |
Het |
| Pcx |
G |
A |
19: 4,670,980 (GRCm39) |
A1095T |
probably damaging |
Het |
| Pde1b |
G |
A |
15: 103,433,727 (GRCm39) |
V342M |
probably damaging |
Het |
| Pik3r2 |
C |
T |
8: 71,222,046 (GRCm39) |
G579D |
possibly damaging |
Het |
| Pknox1 |
G |
A |
17: 31,821,837 (GRCm39) |
|
probably benign |
Het |
| Pla2g3 |
C |
A |
11: 3,438,530 (GRCm39) |
T60K |
probably benign |
Het |
| Ppfia3 |
C |
T |
7: 44,997,953 (GRCm39) |
E725K |
possibly damaging |
Het |
| Ppl |
C |
T |
16: 4,915,800 (GRCm39) |
V588I |
possibly damaging |
Het |
| Sardh |
T |
A |
2: 27,086,715 (GRCm39) |
E815V |
possibly damaging |
Het |
| Scn7a |
T |
C |
2: 66,567,775 (GRCm39) |
E273G |
probably benign |
Het |
| Slc7a8 |
A |
T |
14: 54,996,996 (GRCm39) |
|
probably benign |
Het |
| Smg8 |
G |
A |
11: 86,971,147 (GRCm39) |
P875S |
possibly damaging |
Het |
| Sncaip |
T |
C |
18: 53,039,614 (GRCm39) |
S603P |
probably benign |
Het |
| Speg |
G |
A |
1: 75,383,665 (GRCm39) |
G1218S |
probably damaging |
Het |
| Stk31 |
A |
T |
6: 49,383,709 (GRCm39) |
D92V |
probably damaging |
Het |
| Suco |
A |
G |
1: 161,645,951 (GRCm39) |
V1250A |
probably damaging |
Het |
| Tas2r138 |
A |
G |
6: 40,589,850 (GRCm39) |
V132A |
probably benign |
Het |
| Tcp1 |
T |
C |
17: 13,143,263 (GRCm39) |
I524T |
probably damaging |
Het |
| Tenm3 |
CTGCTGTGAAATG |
C |
8: 48,795,484 (GRCm39) |
|
probably null |
Het |
| Tln2 |
C |
A |
9: 67,163,233 (GRCm39) |
V1105L |
probably damaging |
Het |
| Tmem19 |
T |
C |
10: 115,195,563 (GRCm39) |
|
probably benign |
Het |
| Tmprss4 |
T |
C |
9: 45,087,740 (GRCm39) |
Y283C |
possibly damaging |
Het |
| Trim29 |
T |
A |
9: 43,222,615 (GRCm39) |
V148D |
probably benign |
Het |
| Trip10 |
C |
T |
17: 57,562,313 (GRCm39) |
A277V |
probably benign |
Het |
| Usp12 |
C |
A |
5: 146,700,172 (GRCm39) |
R61L |
probably benign |
Het |
| Vmn1r58 |
T |
G |
7: 5,413,482 (GRCm39) |
L249F |
probably benign |
Het |
| Vmn2r31 |
C |
T |
7: 7,387,400 (GRCm39) |
V724I |
possibly damaging |
Het |
| Vmn2r66 |
C |
T |
7: 84,644,355 (GRCm39) |
W685* |
probably null |
Het |
| Vmn2r8 |
A |
G |
5: 108,945,597 (GRCm39) |
I670T |
possibly damaging |
Het |
| Wdr12 |
A |
G |
1: 60,126,300 (GRCm39) |
W172R |
probably damaging |
Het |
| Yipf5 |
A |
T |
18: 40,340,752 (GRCm39) |
V200E |
possibly damaging |
Het |
| Zfp608 |
T |
C |
18: 55,031,801 (GRCm39) |
K713R |
probably damaging |
Het |
| Zfp768 |
A |
G |
7: 126,942,476 (GRCm39) |
S554P |
probably damaging |
Het |
|
| Other mutations in Vmn2r91 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00983:Vmn2r91
|
APN |
17 |
18,325,820 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01121:Vmn2r91
|
APN |
17 |
18,356,766 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
IGL01464:Vmn2r91
|
APN |
17 |
18,327,864 (GRCm39) |
missense |
probably null |
0.00 |
|
IGL02003:Vmn2r91
|
APN |
17 |
18,327,921 (GRCm39) |
missense |
probably benign |
|
|
IGL02709:Vmn2r91
|
APN |
17 |
18,325,711 (GRCm39) |
missense |
possibly damaging |
0.74 |
|
IGL02795:Vmn2r91
|
APN |
17 |
18,305,539 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL02813:Vmn2r91
|
APN |
17 |
18,356,348 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
IGL02830:Vmn2r91
|
APN |
17 |
18,356,884 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL03130:Vmn2r91
|
APN |
17 |
18,330,373 (GRCm39) |
splice site |
probably benign |
|
|
BB006:Vmn2r91
|
UTSW |
17 |
18,327,906 (GRCm39) |
missense |
probably damaging |
1.00 |
|
BB016:Vmn2r91
|
UTSW |
17 |
18,327,906 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0164:Vmn2r91
|
UTSW |
17 |
18,326,399 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0164:Vmn2r91
|
UTSW |
17 |
18,326,399 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0393:Vmn2r91
|
UTSW |
17 |
18,325,712 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1142:Vmn2r91
|
UTSW |
17 |
18,356,705 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1603:Vmn2r91
|
UTSW |
17 |
18,326,405 (GRCm39) |
missense |
probably benign |
0.04 |
|
R1992:Vmn2r91
|
UTSW |
17 |
18,356,142 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2182:Vmn2r91
|
UTSW |
17 |
18,325,691 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R2424:Vmn2r91
|
UTSW |
17 |
18,356,431 (GRCm39) |
nonsense |
probably null |
|
|
R2512:Vmn2r91
|
UTSW |
17 |
18,356,048 (GRCm39) |
missense |
probably benign |
|
|
R2885:Vmn2r91
|
UTSW |
17 |
18,325,628 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2909:Vmn2r91
|
UTSW |
17 |
18,356,661 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3009:Vmn2r91
|
UTSW |
17 |
18,325,717 (GRCm39) |
missense |
probably benign |
0.11 |
|
R3079:Vmn2r91
|
UTSW |
17 |
18,355,973 (GRCm39) |
splice site |
probably null |
|
|
R3080:Vmn2r91
|
UTSW |
17 |
18,355,973 (GRCm39) |
splice site |
probably null |
|
|
R3434:Vmn2r91
|
UTSW |
17 |
18,330,370 (GRCm39) |
splice site |
probably benign |
|
|
R3723:Vmn2r91
|
UTSW |
17 |
18,305,540 (GRCm39) |
critical splice donor site |
probably null |
|
|
R3829:Vmn2r91
|
UTSW |
17 |
18,325,759 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3845:Vmn2r91
|
UTSW |
17 |
18,327,860 (GRCm39) |
missense |
probably benign |
0.00 |
|
R3846:Vmn2r91
|
UTSW |
17 |
18,327,860 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4118:Vmn2r91
|
UTSW |
17 |
18,330,358 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4285:Vmn2r91
|
UTSW |
17 |
18,356,030 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4729:Vmn2r91
|
UTSW |
17 |
18,327,906 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4793:Vmn2r91
|
UTSW |
17 |
18,325,658 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4932:Vmn2r91
|
UTSW |
17 |
18,356,751 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R5016:Vmn2r91
|
UTSW |
17 |
18,330,322 (GRCm39) |
nonsense |
probably null |
|
|
R5018:Vmn2r91
|
UTSW |
17 |
18,356,700 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5605:Vmn2r91
|
UTSW |
17 |
18,356,763 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5815:Vmn2r91
|
UTSW |
17 |
18,326,464 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6146:Vmn2r91
|
UTSW |
17 |
18,356,518 (GRCm39) |
missense |
probably benign |
0.07 |
|
R6187:Vmn2r91
|
UTSW |
17 |
18,326,888 (GRCm39) |
missense |
probably benign |
0.05 |
|
R6426:Vmn2r91
|
UTSW |
17 |
18,355,865 (GRCm39) |
splice site |
probably null |
|
|
R6450:Vmn2r91
|
UTSW |
17 |
18,305,527 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R6767:Vmn2r91
|
UTSW |
17 |
18,327,807 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R6986:Vmn2r91
|
UTSW |
17 |
18,356,271 (GRCm39) |
missense |
probably benign |
0.10 |
|
R7112:Vmn2r91
|
UTSW |
17 |
18,325,880 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R7178:Vmn2r91
|
UTSW |
17 |
18,356,424 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7330:Vmn2r91
|
UTSW |
17 |
18,326,429 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7368:Vmn2r91
|
UTSW |
17 |
18,356,540 (GRCm39) |
missense |
possibly damaging |
0.75 |
|
R7380:Vmn2r91
|
UTSW |
17 |
18,356,838 (GRCm39) |
nonsense |
probably null |
|
|
R7397:Vmn2r91
|
UTSW |
17 |
18,356,060 (GRCm39) |
missense |
probably benign |
0.02 |
|
R7625:Vmn2r91
|
UTSW |
17 |
18,325,693 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7739:Vmn2r91
|
UTSW |
17 |
18,356,080 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7749:Vmn2r91
|
UTSW |
17 |
18,356,540 (GRCm39) |
missense |
possibly damaging |
0.75 |
|
R7755:Vmn2r91
|
UTSW |
17 |
18,330,311 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R7929:Vmn2r91
|
UTSW |
17 |
18,327,906 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7981:Vmn2r91
|
UTSW |
17 |
18,327,887 (GRCm39) |
missense |
probably benign |
0.02 |
|
R8211:Vmn2r91
|
UTSW |
17 |
18,326,762 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8325:Vmn2r91
|
UTSW |
17 |
18,356,625 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8974:Vmn2r91
|
UTSW |
17 |
18,325,636 (GRCm39) |
missense |
probably benign |
0.27 |
|
R9047:Vmn2r91
|
UTSW |
17 |
18,326,296 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9048:Vmn2r91
|
UTSW |
17 |
18,356,122 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9109:Vmn2r91
|
UTSW |
17 |
18,327,905 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9211:Vmn2r91
|
UTSW |
17 |
18,356,819 (GRCm39) |
nonsense |
probably null |
|
|
R9555:Vmn2r91
|
UTSW |
17 |
18,325,792 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
R9616:Vmn2r91
|
UTSW |
17 |
18,356,305 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
| Predicted Primers |
PCR Primer
(F):5'- AAGTCATAGGGCCTTTGGGTAG -3'
(R):5'- GCATTTTCTTCCCAGTGTAGAAAG -3'
Sequencing Primer
(F):5'- TCACTTGAATAGAGGGCTTCAG -3'
(R):5'- TCTTCCCAGTGTAGAAAGTATGAAG -3'
|
| Posted On |
2021-04-30 |
Incidental Mutation