Incidental Mutation 'R8783:Muc21'
| ID |
670442 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Muc21
|
| Ensembl Gene |
ENSMUSG00000090588 |
| Gene Name |
mucin 21 |
| Synonyms |
epiglycanin, Gm9573 |
| MMRRC Submission |
068631-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.087)
|
| Stock # |
R8783 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
17 |
| Chromosomal Location |
35928815-35937529 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 35930875 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Threonine to Alanine
at position 1104
(T1104A)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000130987
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000164502]
[ENSMUST00000174521]
|
| AlphaFold |
F7C950 |
| Predicted Effect |
unknown
Transcript: ENSMUST00000164502
AA Change: T1104A
|
| SMART Domains |
Protein: ENSMUSP00000130987
Gene: ENSMUSG00000090588
AA Change: T1104A
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
23 |
N/A |
INTRINSIC |
|
low complexity region
|
26 |
39 |
N/A |
INTRINSIC |
|
low complexity region
|
42 |
59 |
N/A |
INTRINSIC |
|
low complexity region
|
76 |
144 |
N/A |
INTRINSIC |
|
low complexity region
|
149 |
578 |
N/A |
INTRINSIC |
|
low complexity region
|
580 |
653 |
N/A |
INTRINSIC |
|
low complexity region
|
655 |
1179 |
N/A |
INTRINSIC |
|
low complexity region
|
1183 |
1373 |
N/A |
INTRINSIC |
|
low complexity region
|
1383 |
1436 |
N/A |
INTRINSIC |
|
low complexity region
|
1438 |
1479 |
N/A |
INTRINSIC |
|
Pfam:Epiglycanin_C
|
1518 |
1605 |
3.8e-22 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000174521
|
| SMART Domains |
Protein: ENSMUSP00000134221
Gene: ENSMUSG00000090509
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:SFTA2
|
80 |
117 |
9.2e-18 |
PFAM |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 100.0%
- 10x: 99.8%
- 20x: 99.3%
|
| Validation Efficiency |
100% (75/75) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 79 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 4833439L19Rik |
T |
A |
13: 54,700,520 (GRCm39) |
M273L |
probably benign |
Het |
| Aars1 |
A |
G |
8: 111,776,515 (GRCm39) |
N657S |
probably benign |
Het |
| Ahnak |
A |
T |
19: 8,988,837 (GRCm39) |
N3374Y |
probably damaging |
Het |
| Ank2 |
T |
C |
3: 126,846,455 (GRCm39) |
E180G |
probably damaging |
Het |
| Arhgap20 |
T |
A |
9: 51,727,967 (GRCm39) |
|
probably benign |
Het |
| Armc5 |
G |
A |
7: 127,837,425 (GRCm39) |
A43T |
probably damaging |
Het |
| Atad3a |
T |
A |
4: 155,840,152 (GRCm39) |
D142V |
probably damaging |
Het |
| B4galnt4 |
A |
T |
7: 140,643,759 (GRCm39) |
K54M |
probably damaging |
Het |
| Bcl11b |
T |
C |
12: 107,883,562 (GRCm39) |
E251G |
probably damaging |
Het |
| Bptf |
A |
G |
11: 107,022,357 (GRCm39) |
V131A |
unknown |
Het |
| Btbd7 |
T |
A |
12: 102,754,501 (GRCm39) |
H755L |
probably benign |
Het |
| Cadps2 |
A |
G |
6: 23,302,303 (GRCm39) |
V1128A |
possibly damaging |
Het |
| Ccl2 |
T |
C |
11: 81,927,360 (GRCm39) |
I43T |
probably damaging |
Het |
| Cdc25b |
T |
G |
2: 131,033,772 (GRCm39) |
S207A |
probably benign |
Het |
| Chd4 |
A |
G |
6: 125,100,347 (GRCm39) |
T1725A |
possibly damaging |
Het |
| Cmya5 |
A |
T |
13: 93,225,888 (GRCm39) |
S3067T |
possibly damaging |
Het |
| Col9a3 |
G |
A |
2: 180,255,970 (GRCm39) |
D448N |
probably damaging |
Het |
| Cpxm1 |
C |
A |
2: 130,237,643 (GRCm39) |
R187S |
probably benign |
Het |
| Cramp1 |
T |
A |
17: 25,193,732 (GRCm39) |
N916I |
probably damaging |
Het |
| Creld1 |
A |
G |
6: 113,468,686 (GRCm39) |
Y269C |
probably damaging |
Het |
| Ctsz |
G |
T |
2: 174,280,675 (GRCm39) |
S6* |
probably null |
Het |
| Cul7 |
T |
C |
17: 46,966,575 (GRCm39) |
S633P |
probably benign |
Het |
| Eci2 |
T |
A |
13: 35,174,180 (GRCm39) |
N160I |
probably damaging |
Het |
| Eef2 |
T |
A |
10: 81,015,499 (GRCm39) |
M340K |
probably damaging |
Het |
| Enpp6 |
A |
T |
8: 47,440,220 (GRCm39) |
Y72F |
possibly damaging |
Het |
| Erbb4 |
A |
C |
1: 68,079,331 (GRCm39) |
Y1250D |
possibly damaging |
Het |
| Fhad1 |
C |
T |
4: 141,636,403 (GRCm39) |
V1146M |
probably benign |
Het |
| Fryl |
T |
C |
5: 73,226,185 (GRCm39) |
Y1826C |
probably benign |
Het |
| Gm3252 |
A |
G |
14: 4,743,761 (GRCm38) |
K200E |
probably benign |
Het |
| Gramd1a |
T |
C |
7: 30,832,220 (GRCm39) |
T640A |
possibly damaging |
Het |
| Gse1 |
A |
T |
8: 121,303,117 (GRCm39) |
Q1086L |
unknown |
Het |
| Gtf2f2 |
C |
A |
14: 76,245,164 (GRCm39) |
G41W |
probably damaging |
Het |
| Hhat |
A |
G |
1: 192,196,245 (GRCm39) |
Y483H |
probably damaging |
Het |
| Ifna13 |
T |
A |
4: 88,562,526 (GRCm39) |
R33W |
probably damaging |
Het |
| Ighg2c |
T |
A |
12: 113,252,412 (GRCm39) |
S47C |
|
Het |
| Ing5 |
A |
T |
1: 93,740,154 (GRCm39) |
D101V |
probably damaging |
Het |
| Kif23 |
T |
C |
9: 61,834,853 (GRCm39) |
T379A |
probably benign |
Het |
| Ltn1 |
A |
T |
16: 87,207,247 (GRCm39) |
S898T |
probably benign |
Het |
| Mep1a |
T |
C |
17: 43,789,081 (GRCm39) |
D578G |
probably benign |
Het |
| Mgam |
A |
T |
6: 40,633,423 (GRCm39) |
H243L |
probably damaging |
Het |
| Mlf1 |
G |
A |
3: 67,291,997 (GRCm39) |
R54H |
probably benign |
Het |
| Mtus2 |
A |
T |
5: 148,019,861 (GRCm39) |
K752M |
probably damaging |
Het |
| Mup18 |
T |
A |
4: 61,591,767 (GRCm39) |
D53V |
probably benign |
Het |
| Neb |
A |
T |
2: 52,148,644 (GRCm39) |
D2634E |
probably damaging |
Het |
| Nfatc3 |
A |
T |
8: 106,825,784 (GRCm39) |
I620F |
possibly damaging |
Het |
| Nrg1 |
A |
T |
8: 32,448,629 (GRCm39) |
L104Q |
probably benign |
Het |
| Nsd2 |
T |
A |
5: 34,036,455 (GRCm39) |
D646E |
possibly damaging |
Het |
| Or10w1 |
A |
T |
19: 13,632,323 (GRCm39) |
R177W |
probably damaging |
Het |
| Or4p19 |
T |
C |
2: 88,242,951 (GRCm39) |
N17S |
probably benign |
Het |
| Or51ai2 |
A |
T |
7: 103,586,751 (GRCm39) |
T55S |
possibly damaging |
Het |
| Pbp2 |
T |
C |
6: 135,287,330 (GRCm39) |
S6G |
probably benign |
Het |
| Pcdhga5 |
T |
C |
18: 37,828,596 (GRCm39) |
I348T |
probably benign |
Het |
| Pdxk |
A |
G |
10: 78,287,339 (GRCm39) |
V74A |
probably benign |
Het |
| Pdzrn3 |
C |
T |
6: 101,132,841 (GRCm39) |
R469H |
probably damaging |
Het |
| Pla2g4a |
A |
T |
1: 149,740,741 (GRCm39) |
S395R |
probably damaging |
Het |
| Polr2i |
A |
G |
7: 29,931,790 (GRCm39) |
Y7C |
possibly damaging |
Het |
| Psmc5 |
A |
T |
11: 106,153,858 (GRCm39) |
K397N |
possibly damaging |
Het |
| Ptprz1 |
A |
G |
6: 23,002,026 (GRCm39) |
D1372G |
probably benign |
Het |
| R3hdm2 |
T |
G |
10: 127,293,521 (GRCm39) |
S142A |
probably damaging |
Het |
| Rapgef2 |
A |
T |
3: 79,005,651 (GRCm39) |
V181E |
probably damaging |
Het |
| Rassf3 |
T |
G |
10: 121,253,069 (GRCm39) |
N46T |
probably benign |
Het |
| Rnf123 |
T |
C |
9: 107,946,272 (GRCm39) |
E301G |
probably benign |
Het |
| Sec24b |
T |
A |
3: 129,783,342 (GRCm39) |
M1099L |
probably benign |
Het |
| Shisa4 |
A |
G |
1: 135,300,944 (GRCm39) |
C109R |
probably damaging |
Het |
| Slc7a1 |
T |
A |
5: 148,279,643 (GRCm39) |
E237V |
probably benign |
Het |
| Syna |
C |
T |
5: 134,588,723 (GRCm39) |
M75I |
probably benign |
Het |
| Tas2r105 |
A |
G |
6: 131,663,732 (GRCm39) |
I232T |
possibly damaging |
Het |
| Tas2r136 |
T |
C |
6: 132,754,612 (GRCm39) |
T172A |
probably benign |
Het |
| Tdpoz8 |
A |
G |
3: 92,981,780 (GRCm39) |
Y192C |
probably damaging |
Het |
| Trim6 |
G |
A |
7: 103,874,853 (GRCm39) |
C30Y |
probably damaging |
Het |
| Trim65 |
T |
A |
11: 116,017,143 (GRCm39) |
N440Y |
probably damaging |
Het |
| Ttn |
A |
C |
2: 76,573,694 (GRCm39) |
I25733S |
probably damaging |
Het |
| Ttn |
T |
G |
2: 76,619,358 (GRCm39) |
T16035P |
probably damaging |
Het |
| Vmn2r73 |
A |
T |
7: 85,507,668 (GRCm39) |
M548K |
probably damaging |
Het |
| Vmn2r88 |
A |
T |
14: 51,651,523 (GRCm39) |
E279V |
|
Het |
| Wfdc8 |
G |
A |
2: 164,447,769 (GRCm39) |
S97F |
probably benign |
Het |
| Wrn |
G |
A |
8: 33,826,041 (GRCm39) |
A207V |
probably null |
Het |
| Xrcc2 |
T |
C |
5: 25,897,217 (GRCm39) |
D244G |
possibly damaging |
Het |
| Zfp251 |
C |
T |
15: 76,737,413 (GRCm39) |
G560E |
probably damaging |
Het |
|
| Other mutations in Muc21 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
BB009:Muc21
|
UTSW |
17 |
35,933,525 (GRCm39) |
intron |
probably benign |
|
|
FR4304:Muc21
|
UTSW |
17 |
35,933,013 (GRCm39) |
intron |
probably benign |
|
|
R0334:Muc21
|
UTSW |
17 |
35,933,614 (GRCm39) |
intron |
probably benign |
|
|
R0946:Muc21
|
UTSW |
17 |
35,929,105 (GRCm39) |
missense |
probably benign |
0.32 |
|
R1117:Muc21
|
UTSW |
17 |
35,930,920 (GRCm39) |
intron |
probably benign |
|
|
R1345:Muc21
|
UTSW |
17 |
35,932,489 (GRCm39) |
intron |
probably benign |
|
|
R1697:Muc21
|
UTSW |
17 |
35,931,540 (GRCm39) |
intron |
probably benign |
|
|
R1750:Muc21
|
UTSW |
17 |
35,931,940 (GRCm39) |
intron |
probably benign |
|
|
R1756:Muc21
|
UTSW |
17 |
35,930,131 (GRCm39) |
intron |
probably benign |
|
|
R1946:Muc21
|
UTSW |
17 |
35,933,416 (GRCm39) |
intron |
probably benign |
|
|
R1978:Muc21
|
UTSW |
17 |
35,933,857 (GRCm39) |
intron |
probably benign |
|
|
R1991:Muc21
|
UTSW |
17 |
35,929,600 (GRCm39) |
missense |
probably benign |
0.32 |
|
R1992:Muc21
|
UTSW |
17 |
35,929,600 (GRCm39) |
missense |
probably benign |
0.32 |
|
R2063:Muc21
|
UTSW |
17 |
35,932,297 (GRCm39) |
intron |
probably benign |
|
|
R2356:Muc21
|
UTSW |
17 |
35,932,563 (GRCm39) |
intron |
probably benign |
|
|
R2866:Muc21
|
UTSW |
17 |
35,930,599 (GRCm39) |
intron |
probably benign |
|
|
R3826:Muc21
|
UTSW |
17 |
35,932,504 (GRCm39) |
intron |
probably benign |
|
|
R4020:Muc21
|
UTSW |
17 |
35,930,953 (GRCm39) |
intron |
probably benign |
|
|
R4474:Muc21
|
UTSW |
17 |
35,931,496 (GRCm39) |
intron |
probably benign |
|
|
R4677:Muc21
|
UTSW |
17 |
35,930,599 (GRCm39) |
intron |
probably benign |
|
|
R4786:Muc21
|
UTSW |
17 |
35,930,221 (GRCm39) |
intron |
probably benign |
|
|
R5071:Muc21
|
UTSW |
17 |
35,931,444 (GRCm39) |
intron |
probably benign |
|
|
R5173:Muc21
|
UTSW |
17 |
35,931,633 (GRCm39) |
intron |
probably benign |
|
|
R5283:Muc21
|
UTSW |
17 |
35,932,224 (GRCm39) |
intron |
probably benign |
|
|
R5446:Muc21
|
UTSW |
17 |
35,933,395 (GRCm39) |
intron |
probably benign |
|
|
R5542:Muc21
|
UTSW |
17 |
35,933,395 (GRCm39) |
intron |
probably benign |
|
|
R5716:Muc21
|
UTSW |
17 |
35,931,675 (GRCm39) |
intron |
probably benign |
|
|
R5913:Muc21
|
UTSW |
17 |
35,934,123 (GRCm39) |
intron |
probably benign |
|
|
R6011:Muc21
|
UTSW |
17 |
35,933,074 (GRCm39) |
intron |
probably benign |
|
|
R6198:Muc21
|
UTSW |
17 |
35,931,808 (GRCm39) |
intron |
probably benign |
|
|
R6394:Muc21
|
UTSW |
17 |
35,931,058 (GRCm39) |
intron |
probably benign |
|
|
R6786:Muc21
|
UTSW |
17 |
35,934,057 (GRCm39) |
intron |
probably benign |
|
|
R6940:Muc21
|
UTSW |
17 |
35,934,118 (GRCm39) |
intron |
probably benign |
|
|
R7082:Muc21
|
UTSW |
17 |
35,932,093 (GRCm39) |
missense |
unknown |
|
|
R7103:Muc21
|
UTSW |
17 |
35,932,432 (GRCm39) |
missense |
unknown |
|
|
R7110:Muc21
|
UTSW |
17 |
35,933,510 (GRCm39) |
intron |
probably benign |
|
|
R7139:Muc21
|
UTSW |
17 |
35,933,525 (GRCm39) |
intron |
probably benign |
|
|
R7165:Muc21
|
UTSW |
17 |
35,932,870 (GRCm39) |
missense |
unknown |
|
|
R7200:Muc21
|
UTSW |
17 |
35,933,525 (GRCm39) |
intron |
probably benign |
|
|
R7204:Muc21
|
UTSW |
17 |
35,932,105 (GRCm39) |
intron |
probably benign |
|
|
R7289:Muc21
|
UTSW |
17 |
35,929,761 (GRCm39) |
missense |
unknown |
|
|
R7290:Muc21
|
UTSW |
17 |
35,929,761 (GRCm39) |
missense |
unknown |
|
|
R7295:Muc21
|
UTSW |
17 |
35,929,761 (GRCm39) |
missense |
unknown |
|
|
R7319:Muc21
|
UTSW |
17 |
35,932,935 (GRCm39) |
intron |
probably benign |
|
|
R7462:Muc21
|
UTSW |
17 |
35,931,568 (GRCm39) |
missense |
unknown |
|
|
R7529:Muc21
|
UTSW |
17 |
35,930,123 (GRCm39) |
missense |
unknown |
|
|
R7718:Muc21
|
UTSW |
17 |
35,933,728 (GRCm39) |
missense |
unknown |
|
|
R7762:Muc21
|
UTSW |
17 |
35,932,977 (GRCm39) |
missense |
unknown |
|
|
R7788:Muc21
|
UTSW |
17 |
35,929,798 (GRCm39) |
missense |
unknown |
|
|
R7798:Muc21
|
UTSW |
17 |
35,932,146 (GRCm39) |
missense |
unknown |
|
|
R7831:Muc21
|
UTSW |
17 |
35,929,651 (GRCm39) |
missense |
unknown |
|
|
R7896:Muc21
|
UTSW |
17 |
35,930,917 (GRCm39) |
missense |
unknown |
|
|
R7899:Muc21
|
UTSW |
17 |
35,931,493 (GRCm39) |
intron |
probably benign |
|
|
R7932:Muc21
|
UTSW |
17 |
35,933,525 (GRCm39) |
intron |
probably benign |
|
|
R8025:Muc21
|
UTSW |
17 |
35,931,879 (GRCm39) |
intron |
probably benign |
|
|
R8077:Muc21
|
UTSW |
17 |
35,930,628 (GRCm39) |
intron |
probably benign |
|
|
R8090:Muc21
|
UTSW |
17 |
35,932,617 (GRCm39) |
missense |
unknown |
|
|
R8169:Muc21
|
UTSW |
17 |
35,932,072 (GRCm39) |
missense |
unknown |
|
|
R8184:Muc21
|
UTSW |
17 |
35,933,722 (GRCm39) |
missense |
unknown |
|
|
R8209:Muc21
|
UTSW |
17 |
35,930,599 (GRCm39) |
intron |
probably benign |
|
|
R8226:Muc21
|
UTSW |
17 |
35,930,599 (GRCm39) |
intron |
probably benign |
|
|
R8464:Muc21
|
UTSW |
17 |
35,933,098 (GRCm39) |
intron |
probably benign |
|
|
R8670:Muc21
|
UTSW |
17 |
35,932,540 (GRCm39) |
missense |
unknown |
|
|
R8856:Muc21
|
UTSW |
17 |
35,931,865 (GRCm39) |
missense |
unknown |
|
|
R9155:Muc21
|
UTSW |
17 |
35,932,131 (GRCm39) |
missense |
unknown |
|
|
R9214:Muc21
|
UTSW |
17 |
35,931,838 (GRCm39) |
missense |
unknown |
|
|
R9353:Muc21
|
UTSW |
17 |
35,930,545 (GRCm39) |
missense |
unknown |
|
|
R9618:Muc21
|
UTSW |
17 |
35,932,935 (GRCm39) |
intron |
probably benign |
|
|
R9621:Muc21
|
UTSW |
17 |
35,932,720 (GRCm39) |
missense |
unknown |
|
|
R9679:Muc21
|
UTSW |
17 |
35,930,491 (GRCm39) |
missense |
unknown |
|
|
RF025:Muc21
|
UTSW |
17 |
35,933,771 (GRCm39) |
intron |
probably benign |
|
|
Z1176:Muc21
|
UTSW |
17 |
35,932,137 (GRCm39) |
missense |
unknown |
|
|
Z1177:Muc21
|
UTSW |
17 |
35,931,951 (GRCm39) |
missense |
unknown |
|
|
Z1177:Muc21
|
UTSW |
17 |
35,931,817 (GRCm39) |
missense |
unknown |
|
|
| Predicted Primers |
PCR Primer
(F):5'- AGGCAGTGCTGGATTCAGTG -3'
(R):5'- TCTAGCACTGCCTCAGGATCTAC -3'
Sequencing Primer
(F):5'- CACTCCTGGATGCAGTGGTG -3'
(R):5'- GCCTCAGGATCTACGCCCAC -3'
|
| Posted On |
2021-04-30 |
Incidental Mutation