Mutagenetix > Incidental Mutations

Incidental Mutation 'R8784:Slc16a14'

670451

Institutional Source

Beutler Lab

Gene Symbol

Slc16a14

Ensembl Gene

ENSMUSG00000026220

Gene Name

solute carrier family 16 (monocarboxylic acid transporters), member 14

Synonyms

1110004H10Rik

MMRRC Submission

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.087) question?

Stock #

R8784 (G1)

Quality Score

225.009

Status

Validated

Chromosome

Chromosomal Location

84905898-84935134 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 84913063 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Threonine to Alanine at position 174 (T174A)

Ref Sequence

ENSEMBL: ENSMUSP00000027422 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000027422]

AlphaFold

Q8K1C7

Predicted Effect

probably benign
Transcript: ENSMUST00000027422
AA Change: T174A

PolyPhen 2 Score 0.006 (Sensitivity: 0.97; Specificity: 0.75)

SMART Domains

Protein: ENSMUSP00000027422
Gene: ENSMUSG00000026220
AA Change: T174A

Domain	Start	End	E-Value	Type
Pfam:MFS_1	42	427	6.7e-42	PFAM
Pfam:MFS_1	419	509	7.9e-10	PFAM

Coding Region Coverage

1x: 100.0%
3x: 100.0%
10x: 99.7%
20x: 99.2%

Validation Efficiency

100% (87/87)

Allele List at MGI

Other mutations in this stock

Total: 86 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abcc6	A	T	7: 46,002,601	M614K	probably benign	Het
Adamts7	G	T	9: 90,193,865	V1217L	probably null	Het
Adcyap1r1	T	A	6: 55,481,115	N300K	probably damaging	Het
Atf7ip	A	G	6: 136,599,650	D1017G	probably damaging	Het
Atg2b	A	C	12: 105,639,241	D1488E	probably damaging	Het
Atxn2	A	G	5: 121,795,028	T805A	probably benign	Het
Azi2	A	T	9: 118,055,892	H223L	probably benign	Het
Banp	T	A	8: 122,001,113	S349T	probably damaging	Het
Bicra	A	T	7: 15,971,950	I1522N	probably damaging	Het
Brca2	A	T	5: 150,548,661	R2342*	probably null	Het
C6	T	C	15: 4,793,140	C623R	probably damaging	Het
Cc2d2a	T	C	5: 43,703,303	Y574H	possibly damaging	Het
Cdk5rap3	C	T	11: 96,912,386	C115Y	probably benign	Het
Chrm4	T	A	2: 91,927,688	M147K	probably benign	Het
Cit	A	T	5: 115,846,383	K5*	probably null	Het
Ciz1	T	A	2: 32,370,250	S231T	probably benign	Het
Crebrf	A	G	17: 26,742,546	I206V	probably benign	Het
Cyc1	T	C	15: 76,343,663	S34P	probably benign	Het
Dnah5	A	G	15: 28,387,951	I3185M	probably benign	Het
Dtnbp1	T	C	13: 44,922,226	D347G	unknown	Het
Dzip3	A	T	16: 48,931,265	V767E	probably damaging	Het
E330021D16Rik	G	A	6: 136,401,731	Q34*	probably null	Het
Fam57a	T	C	11: 76,208,115	F237S	probably damaging	Het
Gdf3	A	T	6: 122,606,320	C363S	probably damaging	Het
Glb1l	T	C	1: 75,200,331	K487R	probably damaging	Het
Gm9747	T	C	1: 82,234,281	V67A	unknown	Het
Hoxb2	A	G	11: 96,351,910	T34A	possibly damaging	Het
Ifnk	C	T	4: 35,152,383	R104C	probably damaging	Het
Igfbp1	A	T	11: 7,201,952	I252F	probably damaging	Het
Ighv1-74	T	C	12: 115,802,860	T47A	probably benign	Het
Igkv4-62	A	T	6: 69,399,962	W68R	probably damaging	Het
Il23r	A	G	6: 67,466,417	I234T	probably damaging	Het
Ints2	T	A	11: 86,222,137	I852F	probably damaging	Het
Ints2	G	A	11: 86,225,115	Q763*	probably null	Het
Jhy	T	G	9: 40,960,886	H109P	probably benign	Het
Katna1	T	A	10: 7,738,815	V29D	possibly damaging	Het
Kcng4	T	A	8: 119,626,231	E313D	probably benign	Het
Klf14	T	A	6: 30,958,114	H195L	probably damaging	Het
Lama3	A	G	18: 12,421,155	N472S	probably benign	Het
Layn	A	T	9: 51,059,481	V254E	possibly damaging	Het
Lrba	A	T	3: 86,375,928	S1850C	probably damaging	Het
Map1s	A	G	8: 70,906,265	I2V	unknown	Het
Map3k12	T	A	15: 102,505,362	Q58L	possibly damaging	Het
Minpp1	T	C	19: 32,513,996	V358A	probably benign	Het
Mymk	C	G	2: 27,071,935	K27N	possibly damaging	Het
Nek8	T	C	11: 78,172,549	K130E	probably damaging	Het
Ngef	T	A	1: 87,477,571	S706C	probably damaging	Het
Nsun6	G	A	2: 14,996,495	Q417*	probably null	Het
Ntsr2	G	T	12: 16,656,851	Q293H	probably damaging	Het
Ocln	T	A	13: 100,539,542	I148F	probably damaging	Het
Olfr101	A	G	17: 37,299,810	I204T	probably benign	Het
Olfr1180	A	T	2: 88,411,747	Y304N	probably benign	Het
Olfr948	T	A	9: 39,318,693	Q307L	probably benign	Het
Pank3	T	G	11: 35,781,585	F272V	probably damaging	Het
Piezo1	A	T	8: 122,496,589		probably benign	Het
Plppr4	G	A	3: 117,322,541	R556*	probably null	Het
Polr1a	G	T	6: 71,950,628	R821L	probably benign	Het
Ppp1r36	C	T	12: 76,439,193	T375I	probably benign	Het
Ptprj	T	A	2: 90,460,512	I628F	possibly damaging	Het
Puf60	C	A	15: 76,077,676	V29F	unknown	Het
R3hdm2	T	G	10: 127,457,652	S142A	probably damaging	Het
Rassf1	A	G	9: 107,557,842	S179G	probably benign	Het
Rbm6	A	G	9: 107,788,138	S772P	possibly damaging	Het
Rnf103	T	G	6: 71,509,998	S538A	probably benign	Het
Scoc	C	A	8: 83,437,616	V58L	probably benign	Het
Secisbp2l	G	A	2: 125,760,343	Q366*	probably null	Het
Slc25a22	A	C	7: 141,431,107	*324G	probably null	Het
Smarca2	C	T	19: 26,776,158	T197I	probably benign	Het
Speg	T	C	1: 75,405,149		probably benign	Het
Srgap2	T	A	1: 131,295,474	N858I	unknown	Het
Syna	C	T	5: 134,559,869	M75I	probably benign	Het
Tbc1d22b	T	C	17: 29,599,944	I424T	probably damaging	Het
Tcaf1	T	G	6: 42,679,287	T252P	probably benign	Het
Thbs1	A	G	2: 118,113,132	D77G	probably damaging	Het
Trim21	T	C	7: 102,559,468	E348G	probably benign	Het
Trpm3	A	G	19: 22,918,676	D959G	probably benign	Het
Ttc24	A	T	3: 88,072,726	C182*	probably null	Het
Tti1	T	C	2: 158,008,594	T242A	probably benign	Het
Ube3b	G	T	5: 114,388,739	C100F	probably damaging	Het
Vmn1r26	T	A	6: 58,008,455	T250S	possibly damaging	Het
Vnn1	A	G	10: 23,904,628	T505A	probably benign	Het
Vps13a	C	A	19: 16,664,789	W2158L	probably damaging	Het
Vwa1	A	T	4: 155,772,888	V151E	probably damaging	Het
Zfp14	A	G	7: 30,043,536	S46P	probably damaging	Het
Zfp773	C	A	7: 7,132,571	C342F	probably benign	Het
Zscan12	T	A	13: 21,363,821	S58T	possibly damaging	Het

Other mutations in Slc16a14

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00942:Slc16a14	APN	1	84922871	missense	probably damaging	0.99
IGL01563:Slc16a14	APN	1	84912187	splice site	probably benign
R0315:Slc16a14	UTSW	1	84912496	missense	possibly damaging	0.46
R0380:Slc16a14	UTSW	1	84929530	missense	possibly damaging	0.72
R1469:Slc16a14	UTSW	1	84929461	missense	probably damaging	1.00
R1469:Slc16a14	UTSW	1	84929461	missense	probably damaging	1.00
R1837:Slc16a14	UTSW	1	84912399	missense	probably benign	0.02
R2149:Slc16a14	UTSW	1	84907399	missense	probably damaging	1.00
R2293:Slc16a14	UTSW	1	84912843	missense	probably benign
R3790:Slc16a14	UTSW	1	84929280	unclassified	probably benign
R4016:Slc16a14	UTSW	1	84912507	nonsense	probably null
R4596:Slc16a14	UTSW	1	84929357	missense	probably damaging	1.00
R4637:Slc16a14	UTSW	1	84907282	missense	possibly damaging	0.86
R4723:Slc16a14	UTSW	1	84913020	missense	probably damaging	1.00
R5137:Slc16a14	UTSW	1	84912597	missense	probably damaging	1.00
R5262:Slc16a14	UTSW	1	84912891	missense	probably benign	0.00
R5410:Slc16a14	UTSW	1	84907424	missense	probably damaging	0.98
R5927:Slc16a14	UTSW	1	84912267	missense	possibly damaging	0.91
R5968:Slc16a14	UTSW	1	84912505	missense	possibly damaging	0.70
R6052:Slc16a14	UTSW	1	84912709	missense	possibly damaging	0.75
R6264:Slc16a14	UTSW	1	84907409	missense	probably benign	0.30
R6290:Slc16a14	UTSW	1	84907385	missense	probably benign	0.10
R7383:Slc16a14	UTSW	1	84912571	missense	probably damaging	1.00
R7390:Slc16a14	UTSW	1	84929466	missense	probably benign	0.25
R7535:Slc16a14	UTSW	1	84913122	missense	probably damaging	1.00
R8326:Slc16a14	UTSW	1	84912345	missense	possibly damaging	0.94
R8669:Slc16a14	UTSW	1	84922884	missense	probably benign	0.00
R9409:Slc16a14	UTSW	1	84929395	nonsense	probably null

Predicted Primers

PCR Primer
(F):5'- GTCCTCCAGACTTAACAGATTCAG -3'
(R):5'- GGAATTCTGCCTGACACAGC -3'

Sequencing Primer
(F):5'- CTCCAGACTTAACAGATTCAGTGGAG -3'
(R):5'- TGCCTGACACAGCAGGTCTATATG -3'

Posted On

2021-04-30