Incidental Mutation 'R8786:Wdr64'
ID 670609
Institutional Source Beutler Lab
Gene Symbol Wdr64
Ensembl Gene ENSMUSG00000026523
Gene Name WD repeat domain 64
Synonyms 4930415O10Rik, 4930511H01Rik
MMRRC Submission 068632-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.065) question?
Stock # R8786 (G1)
Quality Score 225.009
Status Validated
Chromosome 1
Chromosomal Location 175526159-175643300 bp(+) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) A to T at 175636327 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Lysine to Stop codon at position 982 (K982*)
Ref Sequence ENSEMBL: ENSMUSP00000128678 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000094288] [ENSMUST00000171939] [ENSMUST00000194087] [ENSMUST00000194783]
AlphaFold Q9D565
Predicted Effect probably null
Transcript: ENSMUST00000094288
AA Change: K992*
SMART Domains Protein: ENSMUSP00000091846
Gene: ENSMUSG00000026523
AA Change: K992*

DomainStartEndE-ValueType
WD40 118 159 2.65e1 SMART
WD40 162 200 2.13e1 SMART
low complexity region 259 271 N/A INTRINSIC
Blast:WD40 277 316 5e-19 BLAST
WD40 323 361 2.4e-1 SMART
WD40 365 404 8.29e-1 SMART
WD40 407 449 1.7e2 SMART
WD40 457 493 1.19e1 SMART
WD40 497 538 4.55e-3 SMART
WD40 643 684 3.31e0 SMART
WD40 742 806 7.4e0 SMART
Blast:WD40 811 851 7e-17 BLAST
WD40 864 903 4.62e-4 SMART
Blast:XPGN 921 964 9e-19 BLAST
Predicted Effect probably null
Transcript: ENSMUST00000171939
AA Change: K982*
SMART Domains Protein: ENSMUSP00000128678
Gene: ENSMUSG00000026523
AA Change: K982*

DomainStartEndE-ValueType
WD40 151 190 5.73e0 SMART
low complexity region 249 261 N/A INTRINSIC
Blast:WD40 267 306 4e-19 BLAST
WD40 313 351 2.4e-1 SMART
WD40 355 394 8.29e-1 SMART
WD40 397 439 1.7e2 SMART
WD40 447 483 1.19e1 SMART
WD40 487 528 4.55e-3 SMART
WD40 633 674 3.31e0 SMART
WD40 732 796 7.4e0 SMART
Blast:WD40 801 841 5e-17 BLAST
WD40 854 893 4.62e-4 SMART
Blast:XPGN 911 954 1e-18 BLAST
Predicted Effect probably null
Transcript: ENSMUST00000194087
AA Change: K982*
SMART Domains Protein: ENSMUSP00000141740
Gene: ENSMUSG00000026523
AA Change: K982*

DomainStartEndE-ValueType
WD40 151 190 3.6e-2 SMART
low complexity region 249 261 N/A INTRINSIC
Blast:WD40 267 305 5e-19 BLAST
WD40 313 351 1.5e-3 SMART
WD40 355 394 5.2e-3 SMART
WD40 397 439 1.1e0 SMART
WD40 447 483 7.6e-2 SMART
WD40 487 528 2.9e-5 SMART
WD40 633 674 2.1e-2 SMART
WD40 732 796 4.7e-2 SMART
Blast:WD40 801 841 6e-17 BLAST
WD40 854 893 2.9e-6 SMART
Blast:XPGN 911 954 1e-18 BLAST
Predicted Effect probably benign
Transcript: ENSMUST00000194783
SMART Domains Protein: ENSMUSP00000141384
Gene: ENSMUSG00000026523

DomainStartEndE-ValueType
WD40 6 42 7.6e-2 SMART
WD40 46 87 2.9e-5 SMART
WD40 192 233 2.1e-2 SMART
WD40 291 355 4.7e-2 SMART
Blast:WD40 360 400 4e-17 BLAST
WD40 413 452 2.9e-6 SMART
Blast:XPGN 470 519 3e-19 BLAST
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.7%
  • 20x: 99.1%
Validation Efficiency 100% (72/72)
Allele List at MGI

All alleles(1) : Gene trapped(1)

Other mutations in this stock
Total: 72 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adamtsl4 A T 3: 95,592,784 (GRCm39) M1K probably null Het
Atg2a G T 19: 6,294,460 (GRCm39) V59L probably damaging Het
Atxn7 C A 14: 14,103,316 (GRCm38) T888K possibly damaging Het
Btbd9 T C 17: 30,749,144 (GRCm39) R57G probably damaging Het
Catspere2 T A 1: 177,843,362 (GRCm39) probably benign Het
Catspere2 G A 1: 177,843,555 (GRCm39) probably benign Het
Ccdc9b C A 2: 118,587,732 (GRCm39) S534I unknown Het
Crp T C 1: 172,526,293 (GRCm39) V126A probably benign Het
Csf1r A T 18: 61,247,942 (GRCm39) T337S probably damaging Het
Dcaf12 T C 4: 41,296,439 (GRCm39) N299S probably damaging Het
Dcaf17 T C 2: 70,917,744 (GRCm39) probably null Het
Dip2c A G 13: 9,665,830 (GRCm39) D985G probably damaging Het
Dtna A G 18: 23,716,190 (GRCm39) T138A probably benign Het
Emid1 T C 11: 5,081,517 (GRCm39) D212G probably benign Het
Epyc G A 10: 97,511,525 (GRCm39) D173N probably damaging Het
Fanci A G 7: 79,052,298 (GRCm39) D162G probably benign Het
Firrm A T 1: 163,792,040 (GRCm39) L626Q probably damaging Het
Fry T C 5: 150,317,501 (GRCm39) V827A probably benign Het
Ggps1 T C 13: 14,228,505 (GRCm39) E226G probably benign Het
Gopc G A 10: 52,230,750 (GRCm39) R183* probably null Het
Grik4 C T 9: 42,453,130 (GRCm39) G752S probably damaging Het
H2-D1 T A 17: 35,482,844 (GRCm39) C125S probably damaging Het
H2-Q1 T A 17: 35,539,869 (GRCm39) V46D probably damaging Het
Hsd17b3 T C 13: 64,219,862 (GRCm39) N126S probably damaging Het
Igsf10 G A 3: 59,238,063 (GRCm39) T706I probably benign Het
Kmt2e A G 5: 23,669,864 (GRCm39) D117G probably damaging Het
Kmt5a C T 5: 124,584,074 (GRCm39) A18V probably benign Het
Krtap29-1 C T 11: 99,869,465 (GRCm39) G139R probably damaging Het
Lama5 T C 2: 179,838,100 (GRCm39) Y872C probably damaging Het
Lrriq4 T A 3: 30,704,752 (GRCm39) M260K probably benign Het
Map2 G A 1: 66,472,755 (GRCm39) probably benign Het
Mrpl51 C T 6: 125,169,340 (GRCm39) A8V probably benign Het
Ndufs3 T C 2: 90,732,778 (GRCm39) T103A probably benign Het
Numa1 T G 7: 101,647,616 (GRCm39) L449R probably benign Het
Or10g3b C T 14: 52,587,021 (GRCm39) A161T possibly damaging Het
Pan3 C T 5: 147,424,951 (GRCm39) P295S possibly damaging Het
Pds5b T C 5: 150,704,134 (GRCm39) S846P probably damaging Het
Phf2 A T 13: 48,967,219 (GRCm39) M712K unknown Het
Phlda2 A T 7: 143,056,211 (GRCm39) V6E probably benign Het
Pkdrej C A 15: 85,704,044 (GRCm39) A631S probably benign Het
Plcd3 G T 11: 102,962,569 (GRCm39) N627K probably damaging Het
Prpf6 T C 2: 181,262,415 (GRCm39) I138T possibly damaging Het
Psd4 G A 2: 24,295,444 (GRCm39) S866N probably benign Het
Ptprb A C 10: 116,155,306 (GRCm39) T400P probably benign Het
Rxfp1 T C 3: 79,570,677 (GRCm39) probably null Het
Sbf2 A G 7: 110,063,793 (GRCm39) probably null Het
Serpinb9h G A 13: 33,588,204 (GRCm39) R263H probably benign Het
Setd4 C T 16: 93,390,162 (GRCm39) R89Q probably benign Het
Sgpp1 A G 12: 75,763,152 (GRCm39) I343T probably benign Het
Sh2b2 T C 5: 136,260,658 (GRCm39) D186G probably benign Het
Slc12a4 A T 8: 106,680,549 (GRCm39) I191N probably damaging Het
Slc4a4 A T 5: 89,232,549 (GRCm39) D251V probably benign Het
Slc6a5 A T 7: 49,561,843 (GRCm39) D125V possibly damaging Het
Slf1 T A 13: 77,274,806 (GRCm39) I16F possibly damaging Het
Sncaip T C 18: 53,031,334 (GRCm39) V521A probably damaging Het
Spmip10 T C 18: 56,727,568 (GRCm39) F89L probably damaging Het
Stx19 T C 16: 62,642,775 (GRCm39) L197P probably damaging Het
Sucla2 A G 14: 73,797,905 (GRCm39) N39D probably benign Het
Sult1d1 T A 5: 87,712,575 (GRCm39) T90S probably benign Het
Syna C T 5: 134,588,723 (GRCm39) M75I probably benign Het
Tas2r138 A G 6: 40,589,611 (GRCm39) S212P probably damaging Het
Tdrd3 T A 14: 87,709,637 (GRCm39) C106* probably null Het
Tlk2 C T 11: 105,172,059 (GRCm39) A743V unknown Het
Tlr3 T C 8: 45,851,286 (GRCm39) D537G possibly damaging Het
Tmc1 A G 19: 20,803,953 (GRCm39) Y375H probably damaging Het
Tsen54 T A 11: 115,711,498 (GRCm39) M305K probably damaging Het
Umod C T 7: 119,076,581 (GRCm39) V62M possibly damaging Het
Vmn1r10 A G 6: 57,091,010 (GRCm39) T201A probably benign Het
Vmn1r103 T C 7: 20,243,676 (GRCm39) T262A probably benign Het
Vmn2r100 T C 17: 19,742,838 (GRCm39) V404A probably damaging Het
Vmn2r56 A G 7: 12,449,393 (GRCm39) F282L probably damaging Het
Xpo6 A T 7: 125,712,127 (GRCm39) probably benign Het
Other mutations in Wdr64
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00563:Wdr64 APN 1 175,526,366 (GRCm39) missense probably benign 0.00
IGL00902:Wdr64 APN 1 175,556,391 (GRCm39) missense probably damaging 1.00
IGL01347:Wdr64 APN 1 175,547,899 (GRCm39) missense probably benign 0.12
IGL01353:Wdr64 APN 1 175,559,151 (GRCm39) missense probably damaging 0.96
IGL01583:Wdr64 APN 1 175,594,722 (GRCm39) critical splice donor site probably null
IGL01643:Wdr64 APN 1 175,599,877 (GRCm39) missense probably damaging 1.00
IGL01673:Wdr64 APN 1 175,627,922 (GRCm39) missense possibly damaging 0.68
IGL01992:Wdr64 APN 1 175,533,637 (GRCm39) missense probably damaging 1.00
IGL02613:Wdr64 APN 1 175,594,613 (GRCm39) nonsense probably null
IGL02834:Wdr64 APN 1 175,633,415 (GRCm39) splice site probably benign
IGL03214:Wdr64 APN 1 175,571,201 (GRCm39) splice site probably benign
IGL03305:Wdr64 APN 1 175,583,152 (GRCm39) missense possibly damaging 0.94
IGL03308:Wdr64 APN 1 175,594,562 (GRCm39) unclassified probably benign
PIT4418001:Wdr64 UTSW 1 175,571,160 (GRCm39) nonsense probably null
R0036:Wdr64 UTSW 1 175,556,496 (GRCm39) nonsense probably null
R0041:Wdr64 UTSW 1 175,554,037 (GRCm39) nonsense probably null
R0041:Wdr64 UTSW 1 175,554,037 (GRCm39) nonsense probably null
R0079:Wdr64 UTSW 1 175,622,668 (GRCm39) missense probably benign 0.02
R0380:Wdr64 UTSW 1 175,597,208 (GRCm39) splice site probably benign
R0486:Wdr64 UTSW 1 175,622,769 (GRCm39) splice site probably benign
R0520:Wdr64 UTSW 1 175,553,958 (GRCm39) missense probably damaging 1.00
R0598:Wdr64 UTSW 1 175,633,465 (GRCm39) missense probably damaging 1.00
R0711:Wdr64 UTSW 1 175,599,751 (GRCm39) missense probably benign 0.39
R0746:Wdr64 UTSW 1 175,620,539 (GRCm39) missense possibly damaging 0.92
R0927:Wdr64 UTSW 1 175,620,647 (GRCm39) missense probably damaging 0.97
R0947:Wdr64 UTSW 1 175,603,315 (GRCm39) missense probably benign
R1014:Wdr64 UTSW 1 175,583,192 (GRCm39) missense probably damaging 1.00
R1332:Wdr64 UTSW 1 175,622,706 (GRCm39) missense possibly damaging 0.82
R1416:Wdr64 UTSW 1 175,633,568 (GRCm39) missense probably benign 0.01
R1421:Wdr64 UTSW 1 175,594,716 (GRCm39) missense possibly damaging 0.85
R1467:Wdr64 UTSW 1 175,603,288 (GRCm39) missense probably benign 0.00
R1467:Wdr64 UTSW 1 175,603,288 (GRCm39) missense probably benign 0.00
R1796:Wdr64 UTSW 1 175,544,897 (GRCm39) missense probably damaging 1.00
R1797:Wdr64 UTSW 1 175,639,585 (GRCm39) missense probably damaging 1.00
R2145:Wdr64 UTSW 1 175,594,661 (GRCm39) missense probably benign 0.01
R2321:Wdr64 UTSW 1 175,622,653 (GRCm39) missense possibly damaging 0.57
R2449:Wdr64 UTSW 1 175,526,479 (GRCm39) missense probably benign
R4049:Wdr64 UTSW 1 175,633,422 (GRCm39) missense probably benign 0.21
R4155:Wdr64 UTSW 1 175,597,172 (GRCm39) missense probably benign 0.03
R4624:Wdr64 UTSW 1 175,599,829 (GRCm39) missense probably benign
R4661:Wdr64 UTSW 1 175,554,060 (GRCm39) missense probably damaging 1.00
R4711:Wdr64 UTSW 1 175,626,795 (GRCm39) missense probably damaging 1.00
R4891:Wdr64 UTSW 1 175,526,345 (GRCm39) unclassified probably benign
R4925:Wdr64 UTSW 1 175,552,268 (GRCm39) splice site probably null
R4943:Wdr64 UTSW 1 175,547,882 (GRCm39) missense probably benign 0.01
R5000:Wdr64 UTSW 1 175,553,941 (GRCm39) splice site probably null
R5001:Wdr64 UTSW 1 175,620,525 (GRCm39) critical splice acceptor site probably null
R5143:Wdr64 UTSW 1 175,553,979 (GRCm39) missense probably damaging 1.00
R5395:Wdr64 UTSW 1 175,583,164 (GRCm39) missense probably damaging 1.00
R5813:Wdr64 UTSW 1 175,639,623 (GRCm39) missense possibly damaging 0.89
R6014:Wdr64 UTSW 1 175,633,556 (GRCm39) missense possibly damaging 0.56
R6417:Wdr64 UTSW 1 175,553,956 (GRCm39) missense probably damaging 1.00
R6456:Wdr64 UTSW 1 175,613,175 (GRCm39) critical splice donor site probably null
R6555:Wdr64 UTSW 1 175,547,856 (GRCm39) missense probably damaging 1.00
R6576:Wdr64 UTSW 1 175,633,494 (GRCm39) missense possibly damaging 0.82
R6797:Wdr64 UTSW 1 175,638,176 (GRCm39) critical splice donor site probably null
R6891:Wdr64 UTSW 1 175,533,634 (GRCm39) missense probably damaging 1.00
R6959:Wdr64 UTSW 1 175,533,555 (GRCm39) missense probably damaging 1.00
R7205:Wdr64 UTSW 1 175,617,499 (GRCm39) missense probably benign 0.34
R7252:Wdr64 UTSW 1 175,603,240 (GRCm39) missense probably benign 0.00
R7552:Wdr64 UTSW 1 175,613,147 (GRCm39) missense possibly damaging 0.71
R7732:Wdr64 UTSW 1 175,617,495 (GRCm39) missense probably benign
R7777:Wdr64 UTSW 1 175,617,564 (GRCm39) missense possibly damaging 0.71
R7780:Wdr64 UTSW 1 175,556,542 (GRCm39) missense probably damaging 1.00
R7810:Wdr64 UTSW 1 175,559,092 (GRCm39) missense probably benign 0.01
R7833:Wdr64 UTSW 1 175,591,511 (GRCm39) missense probably damaging 1.00
R7843:Wdr64 UTSW 1 175,639,668 (GRCm39) missense probably benign 0.00
R7887:Wdr64 UTSW 1 175,613,111 (GRCm39) missense not run
R7991:Wdr64 UTSW 1 175,554,051 (GRCm39) missense probably benign 0.36
R8124:Wdr64 UTSW 1 175,626,844 (GRCm39) splice site probably null
R8129:Wdr64 UTSW 1 175,603,154 (GRCm39) missense probably damaging 0.96
R8673:Wdr64 UTSW 1 175,633,584 (GRCm39) missense probably damaging 1.00
R8728:Wdr64 UTSW 1 175,559,079 (GRCm39) missense probably benign 0.01
R8822:Wdr64 UTSW 1 175,544,920 (GRCm39) missense probably damaging 1.00
R8842:Wdr64 UTSW 1 175,599,893 (GRCm39) missense probably benign 0.02
R8887:Wdr64 UTSW 1 175,599,850 (GRCm39) missense probably benign 0.17
R9014:Wdr64 UTSW 1 175,526,395 (GRCm39) missense probably benign
R9330:Wdr64 UTSW 1 175,554,024 (GRCm39) missense possibly damaging 0.93
R9332:Wdr64 UTSW 1 175,599,871 (GRCm39) missense possibly damaging 0.71
R9465:Wdr64 UTSW 1 175,618,823 (GRCm39) missense possibly damaging 0.53
R9716:Wdr64 UTSW 1 175,622,658 (GRCm39) missense probably benign
R9717:Wdr64 UTSW 1 175,544,854 (GRCm39) missense probably damaging 1.00
Z1088:Wdr64 UTSW 1 175,533,551 (GRCm39) missense possibly damaging 0.71
Predicted Primers PCR Primer
(F):5'- ACATGGATACTTGACCATTTGGC -3'
(R):5'- TACTTTGATGATGCCGGGAG -3'

Sequencing Primer
(F):5'- CTTGACCATTTGGCAAGGAATG -3'
(R):5'- AACCTCAGTTTCAGTCCCATGAG -3'
Posted On 2021-04-30