Incidental Mutation 'R8786:Vmn2r100'
| ID |
670665 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r100
|
| Ensembl Gene |
ENSMUSG00000091859 |
| Gene Name |
vomeronasal 2, receptor 100 |
| Synonyms |
EG627537 |
| MMRRC Submission |
068632-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.093)
|
| Stock # |
R8786 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
17 |
| Chromosomal Location |
19725073-19752322 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 19742838 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Valine to Alanine
at position 404
(V404A)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000128350
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000166081]
[ENSMUST00000231465]
|
| AlphaFold |
E9QAZ9 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000166081
AA Change: V404A
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000128350
Gene: ENSMUSG00000091859
AA Change: V404A
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
20 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
83 |
456 |
7.4e-41 |
PFAM |
|
Pfam:NCD3G
|
510 |
563 |
1.9e-21 |
PFAM |
|
Pfam:7tm_3
|
594 |
831 |
2.6e-51 |
PFAM |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000231465
AA Change: V404A
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 100.0%
- 10x: 99.7%
- 20x: 99.1%
|
| Validation Efficiency |
100% (72/72) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 72 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Adamtsl4 |
A |
T |
3: 95,592,784 (GRCm39) |
M1K |
probably null |
Het |
| Atg2a |
G |
T |
19: 6,294,460 (GRCm39) |
V59L |
probably damaging |
Het |
| Atxn7 |
C |
A |
14: 14,103,316 (GRCm38) |
T888K |
possibly damaging |
Het |
| Btbd9 |
T |
C |
17: 30,749,144 (GRCm39) |
R57G |
probably damaging |
Het |
| Catspere2 |
T |
A |
1: 177,843,362 (GRCm39) |
|
probably benign |
Het |
| Catspere2 |
G |
A |
1: 177,843,555 (GRCm39) |
|
probably benign |
Het |
| Ccdc9b |
C |
A |
2: 118,587,732 (GRCm39) |
S534I |
unknown |
Het |
| Crp |
T |
C |
1: 172,526,293 (GRCm39) |
V126A |
probably benign |
Het |
| Csf1r |
A |
T |
18: 61,247,942 (GRCm39) |
T337S |
probably damaging |
Het |
| Dcaf12 |
T |
C |
4: 41,296,439 (GRCm39) |
N299S |
probably damaging |
Het |
| Dcaf17 |
T |
C |
2: 70,917,744 (GRCm39) |
|
probably null |
Het |
| Dip2c |
A |
G |
13: 9,665,830 (GRCm39) |
D985G |
probably damaging |
Het |
| Dtna |
A |
G |
18: 23,716,190 (GRCm39) |
T138A |
probably benign |
Het |
| Emid1 |
T |
C |
11: 5,081,517 (GRCm39) |
D212G |
probably benign |
Het |
| Epyc |
G |
A |
10: 97,511,525 (GRCm39) |
D173N |
probably damaging |
Het |
| Fanci |
A |
G |
7: 79,052,298 (GRCm39) |
D162G |
probably benign |
Het |
| Firrm |
A |
T |
1: 163,792,040 (GRCm39) |
L626Q |
probably damaging |
Het |
| Fry |
T |
C |
5: 150,317,501 (GRCm39) |
V827A |
probably benign |
Het |
| Ggps1 |
T |
C |
13: 14,228,505 (GRCm39) |
E226G |
probably benign |
Het |
| Gopc |
G |
A |
10: 52,230,750 (GRCm39) |
R183* |
probably null |
Het |
| Grik4 |
C |
T |
9: 42,453,130 (GRCm39) |
G752S |
probably damaging |
Het |
| H2-D1 |
T |
A |
17: 35,482,844 (GRCm39) |
C125S |
probably damaging |
Het |
| H2-Q1 |
T |
A |
17: 35,539,869 (GRCm39) |
V46D |
probably damaging |
Het |
| Hsd17b3 |
T |
C |
13: 64,219,862 (GRCm39) |
N126S |
probably damaging |
Het |
| Igsf10 |
G |
A |
3: 59,238,063 (GRCm39) |
T706I |
probably benign |
Het |
| Kmt2e |
A |
G |
5: 23,669,864 (GRCm39) |
D117G |
probably damaging |
Het |
| Kmt5a |
C |
T |
5: 124,584,074 (GRCm39) |
A18V |
probably benign |
Het |
| Krtap29-1 |
C |
T |
11: 99,869,465 (GRCm39) |
G139R |
probably damaging |
Het |
| Lama5 |
T |
C |
2: 179,838,100 (GRCm39) |
Y872C |
probably damaging |
Het |
| Lrriq4 |
T |
A |
3: 30,704,752 (GRCm39) |
M260K |
probably benign |
Het |
| Map2 |
G |
A |
1: 66,472,755 (GRCm39) |
|
probably benign |
Het |
| Mrpl51 |
C |
T |
6: 125,169,340 (GRCm39) |
A8V |
probably benign |
Het |
| Ndufs3 |
T |
C |
2: 90,732,778 (GRCm39) |
T103A |
probably benign |
Het |
| Numa1 |
T |
G |
7: 101,647,616 (GRCm39) |
L449R |
probably benign |
Het |
| Or10g3b |
C |
T |
14: 52,587,021 (GRCm39) |
A161T |
possibly damaging |
Het |
| Pan3 |
C |
T |
5: 147,424,951 (GRCm39) |
P295S |
possibly damaging |
Het |
| Pds5b |
T |
C |
5: 150,704,134 (GRCm39) |
S846P |
probably damaging |
Het |
| Phf2 |
A |
T |
13: 48,967,219 (GRCm39) |
M712K |
unknown |
Het |
| Phlda2 |
A |
T |
7: 143,056,211 (GRCm39) |
V6E |
probably benign |
Het |
| Pkdrej |
C |
A |
15: 85,704,044 (GRCm39) |
A631S |
probably benign |
Het |
| Plcd3 |
G |
T |
11: 102,962,569 (GRCm39) |
N627K |
probably damaging |
Het |
| Prpf6 |
T |
C |
2: 181,262,415 (GRCm39) |
I138T |
possibly damaging |
Het |
| Psd4 |
G |
A |
2: 24,295,444 (GRCm39) |
S866N |
probably benign |
Het |
| Ptprb |
A |
C |
10: 116,155,306 (GRCm39) |
T400P |
probably benign |
Het |
| Rxfp1 |
T |
C |
3: 79,570,677 (GRCm39) |
|
probably null |
Het |
| Sbf2 |
A |
G |
7: 110,063,793 (GRCm39) |
|
probably null |
Het |
| Serpinb9h |
G |
A |
13: 33,588,204 (GRCm39) |
R263H |
probably benign |
Het |
| Setd4 |
C |
T |
16: 93,390,162 (GRCm39) |
R89Q |
probably benign |
Het |
| Sgpp1 |
A |
G |
12: 75,763,152 (GRCm39) |
I343T |
probably benign |
Het |
| Sh2b2 |
T |
C |
5: 136,260,658 (GRCm39) |
D186G |
probably benign |
Het |
| Slc12a4 |
A |
T |
8: 106,680,549 (GRCm39) |
I191N |
probably damaging |
Het |
| Slc4a4 |
A |
T |
5: 89,232,549 (GRCm39) |
D251V |
probably benign |
Het |
| Slc6a5 |
A |
T |
7: 49,561,843 (GRCm39) |
D125V |
possibly damaging |
Het |
| Slf1 |
T |
A |
13: 77,274,806 (GRCm39) |
I16F |
possibly damaging |
Het |
| Sncaip |
T |
C |
18: 53,031,334 (GRCm39) |
V521A |
probably damaging |
Het |
| Spmip10 |
T |
C |
18: 56,727,568 (GRCm39) |
F89L |
probably damaging |
Het |
| Stx19 |
T |
C |
16: 62,642,775 (GRCm39) |
L197P |
probably damaging |
Het |
| Sucla2 |
A |
G |
14: 73,797,905 (GRCm39) |
N39D |
probably benign |
Het |
| Sult1d1 |
T |
A |
5: 87,712,575 (GRCm39) |
T90S |
probably benign |
Het |
| Syna |
C |
T |
5: 134,588,723 (GRCm39) |
M75I |
probably benign |
Het |
| Tas2r138 |
A |
G |
6: 40,589,611 (GRCm39) |
S212P |
probably damaging |
Het |
| Tdrd3 |
T |
A |
14: 87,709,637 (GRCm39) |
C106* |
probably null |
Het |
| Tlk2 |
C |
T |
11: 105,172,059 (GRCm39) |
A743V |
unknown |
Het |
| Tlr3 |
T |
C |
8: 45,851,286 (GRCm39) |
D537G |
possibly damaging |
Het |
| Tmc1 |
A |
G |
19: 20,803,953 (GRCm39) |
Y375H |
probably damaging |
Het |
| Tsen54 |
T |
A |
11: 115,711,498 (GRCm39) |
M305K |
probably damaging |
Het |
| Umod |
C |
T |
7: 119,076,581 (GRCm39) |
V62M |
possibly damaging |
Het |
| Vmn1r10 |
A |
G |
6: 57,091,010 (GRCm39) |
T201A |
probably benign |
Het |
| Vmn1r103 |
T |
C |
7: 20,243,676 (GRCm39) |
T262A |
probably benign |
Het |
| Vmn2r56 |
A |
G |
7: 12,449,393 (GRCm39) |
F282L |
probably damaging |
Het |
| Wdr64 |
A |
T |
1: 175,636,327 (GRCm39) |
K982* |
probably null |
Het |
| Xpo6 |
A |
T |
7: 125,712,127 (GRCm39) |
|
probably benign |
Het |
|
| Other mutations in Vmn2r100 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00904:Vmn2r100
|
APN |
17 |
19,746,262 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00912:Vmn2r100
|
APN |
17 |
19,751,654 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
IGL01107:Vmn2r100
|
APN |
17 |
19,741,618 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01517:Vmn2r100
|
APN |
17 |
19,742,225 (GRCm39) |
missense |
probably benign |
0.37 |
|
IGL01594:Vmn2r100
|
APN |
17 |
19,751,495 (GRCm39) |
missense |
possibly damaging |
0.52 |
|
IGL01657:Vmn2r100
|
APN |
17 |
19,746,178 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
IGL01822:Vmn2r100
|
APN |
17 |
19,725,100 (GRCm39) |
missense |
probably null |
0.00 |
|
IGL02020:Vmn2r100
|
APN |
17 |
19,725,200 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
IGL02060:Vmn2r100
|
APN |
17 |
19,741,516 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
IGL02126:Vmn2r100
|
APN |
17 |
19,741,504 (GRCm39) |
splice site |
probably benign |
|
|
IGL02142:Vmn2r100
|
APN |
17 |
19,742,583 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02308:Vmn2r100
|
APN |
17 |
19,741,597 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
IGL02407:Vmn2r100
|
APN |
17 |
19,741,770 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL02469:Vmn2r100
|
APN |
17 |
19,751,547 (GRCm39) |
nonsense |
probably null |
|
|
IGL03088:Vmn2r100
|
APN |
17 |
19,742,301 (GRCm39) |
missense |
probably benign |
0.27 |
|
IGL03181:Vmn2r100
|
APN |
17 |
19,752,207 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03405:Vmn2r100
|
APN |
17 |
19,752,186 (GRCm39) |
missense |
probably damaging |
1.00 |
|
H8562:Vmn2r100
|
UTSW |
17 |
19,741,752 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R0012:Vmn2r100
|
UTSW |
17 |
19,746,296 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0012:Vmn2r100
|
UTSW |
17 |
19,725,136 (GRCm39) |
missense |
probably benign |
|
|
R0044:Vmn2r100
|
UTSW |
17 |
19,742,441 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R0109:Vmn2r100
|
UTSW |
17 |
19,742,382 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R0111:Vmn2r100
|
UTSW |
17 |
19,742,382 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R0112:Vmn2r100
|
UTSW |
17 |
19,742,382 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R0149:Vmn2r100
|
UTSW |
17 |
19,741,509 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R0355:Vmn2r100
|
UTSW |
17 |
19,751,582 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0395:Vmn2r100
|
UTSW |
17 |
19,742,382 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R0396:Vmn2r100
|
UTSW |
17 |
19,742,382 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R0453:Vmn2r100
|
UTSW |
17 |
19,742,382 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R0465:Vmn2r100
|
UTSW |
17 |
19,751,792 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0477:Vmn2r100
|
UTSW |
17 |
19,742,776 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0510:Vmn2r100
|
UTSW |
17 |
19,742,382 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R0512:Vmn2r100
|
UTSW |
17 |
19,742,382 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R0514:Vmn2r100
|
UTSW |
17 |
19,742,382 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R0518:Vmn2r100
|
UTSW |
17 |
19,742,178 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0521:Vmn2r100
|
UTSW |
17 |
19,742,178 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0555:Vmn2r100
|
UTSW |
17 |
19,742,382 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R0608:Vmn2r100
|
UTSW |
17 |
19,742,382 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R0959:Vmn2r100
|
UTSW |
17 |
19,743,786 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R1114:Vmn2r100
|
UTSW |
17 |
19,752,261 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2027:Vmn2r100
|
UTSW |
17 |
19,742,334 (GRCm39) |
missense |
probably benign |
0.02 |
|
R2049:Vmn2r100
|
UTSW |
17 |
19,742,312 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2224:Vmn2r100
|
UTSW |
17 |
19,742,634 (GRCm39) |
missense |
probably benign |
0.03 |
|
R2226:Vmn2r100
|
UTSW |
17 |
19,742,634 (GRCm39) |
missense |
probably benign |
0.03 |
|
R3618:Vmn2r100
|
UTSW |
17 |
19,743,692 (GRCm39) |
missense |
probably benign |
|
|
R3715:Vmn2r100
|
UTSW |
17 |
19,752,272 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4120:Vmn2r100
|
UTSW |
17 |
19,752,215 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4152:Vmn2r100
|
UTSW |
17 |
19,743,681 (GRCm39) |
frame shift |
probably null |
|
|
R4153:Vmn2r100
|
UTSW |
17 |
19,743,681 (GRCm39) |
frame shift |
probably null |
|
|
R4154:Vmn2r100
|
UTSW |
17 |
19,743,681 (GRCm39) |
frame shift |
probably null |
|
|
R4200:Vmn2r100
|
UTSW |
17 |
19,742,797 (GRCm39) |
missense |
probably benign |
0.29 |
|
R4632:Vmn2r100
|
UTSW |
17 |
19,752,216 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4720:Vmn2r100
|
UTSW |
17 |
19,742,788 (GRCm39) |
missense |
probably benign |
0.02 |
|
R4761:Vmn2r100
|
UTSW |
17 |
19,741,630 (GRCm39) |
missense |
possibly damaging |
0.47 |
|
R4831:Vmn2r100
|
UTSW |
17 |
19,741,672 (GRCm39) |
missense |
probably benign |
0.28 |
|
R4951:Vmn2r100
|
UTSW |
17 |
19,752,300 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5211:Vmn2r100
|
UTSW |
17 |
19,746,257 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R5553:Vmn2r100
|
UTSW |
17 |
19,725,110 (GRCm39) |
missense |
possibly damaging |
0.64 |
|
R5657:Vmn2r100
|
UTSW |
17 |
19,725,178 (GRCm39) |
missense |
probably benign |
0.31 |
|
R5883:Vmn2r100
|
UTSW |
17 |
19,743,786 (GRCm39) |
missense |
probably benign |
|
|
R5912:Vmn2r100
|
UTSW |
17 |
19,752,071 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6141:Vmn2r100
|
UTSW |
17 |
19,742,576 (GRCm39) |
missense |
probably benign |
0.07 |
|
R6146:Vmn2r100
|
UTSW |
17 |
19,742,522 (GRCm39) |
missense |
probably benign |
0.04 |
|
R6500:Vmn2r100
|
UTSW |
17 |
19,742,355 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6575:Vmn2r100
|
UTSW |
17 |
19,741,671 (GRCm39) |
missense |
probably benign |
0.12 |
|
R6647:Vmn2r100
|
UTSW |
17 |
19,742,785 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7038:Vmn2r100
|
UTSW |
17 |
19,725,263 (GRCm39) |
missense |
possibly damaging |
0.76 |
|
R7052:Vmn2r100
|
UTSW |
17 |
19,751,556 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R7170:Vmn2r100
|
UTSW |
17 |
19,752,233 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7209:Vmn2r100
|
UTSW |
17 |
19,751,576 (GRCm39) |
missense |
not run |
|
|
R7312:Vmn2r100
|
UTSW |
17 |
19,742,296 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7734:Vmn2r100
|
UTSW |
17 |
19,742,296 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7750:Vmn2r100
|
UTSW |
17 |
19,742,726 (GRCm39) |
missense |
probably benign |
|
|
R8103:Vmn2r100
|
UTSW |
17 |
19,751,415 (GRCm39) |
splice site |
probably null |
|
|
R8193:Vmn2r100
|
UTSW |
17 |
19,725,102 (GRCm39) |
nonsense |
probably null |
|
|
R8267:Vmn2r100
|
UTSW |
17 |
19,742,752 (GRCm39) |
nonsense |
probably null |
|
|
R8290:Vmn2r100
|
UTSW |
17 |
19,751,612 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8531:Vmn2r100
|
UTSW |
17 |
19,742,459 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R8920:Vmn2r100
|
UTSW |
17 |
19,741,620 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8938:Vmn2r100
|
UTSW |
17 |
19,751,825 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9555:Vmn2r100
|
UTSW |
17 |
19,743,857 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9572:Vmn2r100
|
UTSW |
17 |
19,741,513 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9609:Vmn2r100
|
UTSW |
17 |
19,743,732 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9618:Vmn2r100
|
UTSW |
17 |
19,742,583 (GRCm39) |
missense |
probably damaging |
1.00 |
|
X0062:Vmn2r100
|
UTSW |
17 |
19,751,652 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
Z1176:Vmn2r100
|
UTSW |
17 |
19,741,792 (GRCm39) |
missense |
probably benign |
0.00 |
|
Z1177:Vmn2r100
|
UTSW |
17 |
19,725,251 (GRCm39) |
missense |
probably benign |
0.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- GTTAGACTCATTTCATGGAAGCC -3'
(R):5'- TTGCACACCATTTTGCAACATC -3'
Sequencing Primer
(F):5'- GGAAGCCTTATTTTTAAGCACAAC -3'
(R):5'- ATCATACACTTAAATCCATCTTGCC -3'
|
| Posted On |
2021-04-30 |
Incidental Mutation