Incidental Mutation 'R8787:Or14j7'
ID 670731
Institutional Source Beutler Lab
Gene Symbol Or14j7
Ensembl Gene ENSMUSG00000059030
Gene Name olfactory receptor family 14 subfamily J member 7
Synonyms MOR218-13, GA_x6K02T2PSCP-2374126-2375048, Olfr128
MMRRC Submission 068633-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.073) question?
Stock # R8787 (G1)
Quality Score 225.009
Status Validated
Chromosome 17
Chromosomal Location 38234459-38235385 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 38235075 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Lysine at position 206 (M206K)
Ref Sequence ENSEMBL: ENSMUSP00000151065 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000080231] [ENSMUST00000216440]
AlphaFold Q7TRJ1
Predicted Effect probably benign
Transcript: ENSMUST00000080231
AA Change: M206K

PolyPhen 2 Score 0.057 (Sensitivity: 0.94; Specificity: 0.84)
SMART Domains Protein: ENSMUSP00000079121
Gene: ENSMUSG00000059030
AA Change: M206K

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 1.3e-46 PFAM
Pfam:7TM_GPCR_Srsx 35 305 1.1e-5 PFAM
Pfam:7tm_1 41 290 1.6e-21 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000216440
AA Change: M206K

PolyPhen 2 Score 0.057 (Sensitivity: 0.94; Specificity: 0.84)
Meta Mutation Damage Score 0.0846 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.7%
  • 20x: 99.1%
Validation Efficiency 98% (62/63)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 63 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca13 C T 11: 9,225,053 (GRCm39) H511Y possibly damaging Het
Acp5 G A 9: 22,038,489 (GRCm39) R271* probably null Het
Adamts20 A T 15: 94,184,294 (GRCm39) V1503E possibly damaging Het
Adra2b A T 2: 127,206,417 (GRCm39) E311D probably benign Het
Aldh18a1 T C 19: 40,546,230 (GRCm39) I556V possibly damaging Het
Alox12 C A 11: 70,144,146 (GRCm39) A116S probably benign Het
Alox5 G T 6: 116,390,102 (GRCm39) A552E probably damaging Het
Angpt1 G T 15: 42,375,780 (GRCm39) L159I probably damaging Het
Atp2b4 CTT CTTTTT 1: 133,629,485 (GRCm39) probably benign Het
Bub1b T A 2: 118,462,305 (GRCm39) L726I probably damaging Het
Ccdc78 A T 17: 26,006,807 (GRCm39) T165S probably benign Het
Ccdc88b T C 19: 6,824,791 (GRCm39) D1323G probably damaging Het
Chek1 A T 9: 36,625,033 (GRCm39) C349* probably null Het
Clec1a A T 6: 129,428,617 (GRCm39) L21Q possibly damaging Het
Col1a1 T C 11: 94,833,634 (GRCm39) V445A possibly damaging Het
Efcab7 A G 4: 99,757,791 (GRCm39) T313A probably null Het
Fads1 T A 19: 10,170,325 (GRCm39) Y288* probably null Het
Fgb T A 3: 82,953,969 (GRCm39) T90S probably benign Het
Glg1 C A 8: 111,888,114 (GRCm39) V1026L probably damaging Het
Hadh T A 3: 131,027,825 (GRCm39) Y313F probably damaging Het
Htr4 A G 18: 62,570,853 (GRCm39) I303V possibly damaging Het
Kcnn3 A G 3: 89,552,757 (GRCm39) D487G possibly damaging Het
L1td1 G A 4: 98,625,814 (GRCm39) V604I probably benign Het
Lao1 A G 4: 118,825,565 (GRCm39) T462A probably damaging Het
Lefty1 C A 1: 180,764,118 (GRCm39) A86E probably damaging Het
Lmx1b T C 2: 33,529,522 (GRCm39) Y79C Het
Lrp2 A G 2: 69,382,745 (GRCm39) C47R probably damaging Het
Mrc2 A T 11: 105,238,465 (GRCm39) N1204I probably benign Het
Ncf1 A C 5: 134,254,145 (GRCm39) Y209* probably null Het
Or2ad1 A T 13: 21,326,453 (GRCm39) M258K possibly damaging Het
Or8k33 G A 2: 86,384,297 (GRCm39) T57M probably damaging Het
Oxtr T G 6: 112,466,871 (GRCm39) probably benign Het
Pcdhac1 T C 18: 37,224,942 (GRCm39) V585A probably damaging Het
Pdcd11 T G 19: 47,097,019 (GRCm39) L755R probably damaging Het
Pkhd1 A G 1: 20,358,461 (GRCm39) V2705A probably damaging Het
Plch2 C A 4: 155,070,875 (GRCm39) G1168V probably benign Het
Prpf39 T C 12: 65,089,555 (GRCm39) Y98H possibly damaging Het
R3hdm2 T G 10: 127,293,521 (GRCm39) S142A probably damaging Het
Rassf10 T A 7: 112,554,738 (GRCm39) D446E probably benign Het
Rgs13 T C 1: 144,016,482 (GRCm39) Y87C probably damaging Het
Serpinb9h G A 13: 33,588,204 (GRCm39) R263H probably benign Het
Smpd3 G A 8: 106,982,377 (GRCm39) R576C probably damaging Het
Spata31e1 T C 13: 49,938,704 (GRCm39) Y1002C probably damaging Het
Srsf11 A T 3: 157,718,037 (GRCm39) D382E unknown Het
Stpg1 T A 4: 135,261,108 (GRCm39) M306K probably benign Het
Svil C T 18: 5,059,332 (GRCm39) Q696* probably null Het
Syna C T 5: 134,588,723 (GRCm39) M75I probably benign Het
Synj2 T C 17: 6,036,514 (GRCm39) F161S possibly damaging Het
Tek T C 4: 94,738,037 (GRCm39) Y696H probably damaging Het
Tgfbr1 A T 4: 47,405,555 (GRCm39) D386V possibly damaging Het
Tgm4 G T 9: 122,890,910 (GRCm39) G503V probably damaging Het
Tnni3k T C 3: 154,645,691 (GRCm39) E461G probably damaging Het
Tom1l1 A T 11: 90,561,931 (GRCm39) H232Q probably benign Het
Ubqln5 T C 7: 103,778,329 (GRCm39) N165S probably benign Het
Vmn1r24 G A 6: 57,932,958 (GRCm39) L187F probably benign Het
Vmn2r82 C T 10: 79,213,894 (GRCm39) T160I probably damaging Het
Vmn2r96 G T 17: 18,818,250 (GRCm39) G801V probably damaging Het
Vps39 A G 2: 120,172,506 (GRCm39) S176P probably damaging Het
Vsig10 C A 5: 117,472,981 (GRCm39) H191Q probably benign Het
Wtap G A 17: 13,186,488 (GRCm39) S353L possibly damaging Het
Zmym4 T G 4: 126,816,953 (GRCm39) R248S probably benign Het
Zscan10 A G 17: 23,829,011 (GRCm39) S518G probably benign Het
Zscan29 A T 2: 120,996,876 (GRCm39) Y282N probably damaging Het
Other mutations in Or14j7
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01922:Or14j7 APN 17 38,234,850 (GRCm39) missense possibly damaging 0.73
IGL01940:Or14j7 APN 17 38,235,177 (GRCm39) missense probably damaging 1.00
R0427:Or14j7 UTSW 17 38,234,520 (GRCm39) missense probably benign 0.00
R0462:Or14j7 UTSW 17 38,234,667 (GRCm39) missense probably damaging 1.00
R0546:Or14j7 UTSW 17 38,235,229 (GRCm39) nonsense probably null
R0760:Or14j7 UTSW 17 38,235,005 (GRCm39) nonsense probably null
R0940:Or14j7 UTSW 17 38,234,591 (GRCm39) missense probably damaging 0.98
R1898:Or14j7 UTSW 17 38,234,516 (GRCm39) missense possibly damaging 0.91
R1935:Or14j7 UTSW 17 38,234,993 (GRCm39) missense probably damaging 1.00
R2060:Or14j7 UTSW 17 38,234,771 (GRCm39) missense probably benign 0.00
R4680:Or14j7 UTSW 17 38,234,813 (GRCm39) missense probably damaging 1.00
R5165:Or14j7 UTSW 17 38,235,252 (GRCm39) missense probably benign 0.14
R5526:Or14j7 UTSW 17 38,235,383 (GRCm39) makesense probably null
R5594:Or14j7 UTSW 17 38,234,502 (GRCm39) missense probably benign 0.00
R5751:Or14j7 UTSW 17 38,234,861 (GRCm39) missense probably benign 0.44
R6330:Or14j7 UTSW 17 38,234,685 (GRCm39) missense possibly damaging 0.77
R7123:Or14j7 UTSW 17 38,234,567 (GRCm39) missense probably benign 0.33
R7354:Or14j7 UTSW 17 38,235,284 (GRCm39) missense probably benign 0.00
R7827:Or14j7 UTSW 17 38,234,568 (GRCm39) nonsense probably null
R8258:Or14j7 UTSW 17 38,234,847 (GRCm39) missense probably damaging 1.00
R8259:Or14j7 UTSW 17 38,234,847 (GRCm39) missense probably damaging 1.00
R8686:Or14j7 UTSW 17 38,235,168 (GRCm39) missense probably benign 0.00
R9036:Or14j7 UTSW 17 38,235,168 (GRCm39) missense probably benign 0.03
R9278:Or14j7 UTSW 17 38,235,275 (GRCm39) missense probably benign
R9761:Or14j7 UTSW 17 38,234,934 (GRCm39) missense probably benign 0.03
Z1177:Or14j7 UTSW 17 38,234,618 (GRCm39) missense probably benign 0.02
Predicted Primers PCR Primer
(F):5'- GAAAGTGCACTTGGGCTGTG -3'
(R):5'- GCATGAAGTCTAAAGTAGTTGGTG -3'

Sequencing Primer
(F):5'- GGCAGCTGTGTGGCTAAG -3'
(R):5'- AAGTCTAAAGTAGTTGGTGAGTCTG -3'
Posted On 2021-04-30