Incidental Mutation 'R8789:Or2z9'
ID 670820
Institutional Source Beutler Lab
Gene Symbol Or2z9
Ensembl Gene ENSMUSG00000061561
Gene Name olfactory receptor family 2 subfamily Z member 9
Synonyms MOR282-1, GA_x6K02T2NUPS-231686-232630, Olfr373, MOR282-2
MMRRC Submission 068608-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.187) question?
Stock # R8789 (G1)
Quality Score 225.009
Status Validated
Chromosome 8
Chromosomal Location 72853606-72854550 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 72854135 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Phenylalanine to Serine at position 177 (F177S)
Ref Sequence ENSEMBL: ENSMUSP00000149853 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000074540] [ENSMUST00000213940] [ENSMUST00000215198]
AlphaFold E9Q4J3
Predicted Effect probably damaging
Transcript: ENSMUST00000074540
AA Change: F177S

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000074128
Gene: ENSMUSG00000061561
AA Change: F177S

DomainStartEndE-ValueType
Pfam:7tm_4 31 307 6.1e-57 PFAM
Pfam:7TM_GPCR_Srsx 35 253 6.5e-8 PFAM
Pfam:7tm_1 41 290 4.9e-25 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000213940
AA Change: F177S

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Predicted Effect probably damaging
Transcript: ENSMUST00000215198
AA Change: F177S

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.5%
  • 20x: 98.1%
Validation Efficiency 100% (45/45)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 46 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Actr5 C T 2: 158,478,604 (GRCm39) Q485* probably null Het
Arsa C T 15: 89,358,260 (GRCm39) V350I probably benign Het
Bean1 CT C 8: 104,908,664 (GRCm39) probably null Het
Cav2 T C 6: 17,281,996 (GRCm39) Y85H probably damaging Het
Ccdc93 A G 1: 121,424,784 (GRCm39) Q570R probably damaging Het
Cd72 A G 4: 43,452,628 (GRCm39) S122P probably damaging Het
Cep72 A G 13: 74,186,367 (GRCm39) M619T possibly damaging Het
Cers5 C A 15: 99,637,551 (GRCm39) V233F possibly damaging Het
Cntn5 A G 9: 9,673,292 (GRCm39) Y803H probably damaging Het
Crybg2 T C 4: 133,801,554 (GRCm39) S596P probably benign Het
Crybg3 T C 16: 59,375,359 (GRCm39) E251G probably benign Het
Csmd1 T A 8: 17,266,722 (GRCm39) N68I probably damaging Het
Ctr9 A G 7: 110,642,933 (GRCm39) N466S possibly damaging Het
Cyp2a4 T A 7: 26,007,106 (GRCm39) I71N probably damaging Het
Cyp2j11 C T 4: 96,227,405 (GRCm39) E204K probably damaging Het
Cyp4f39 T C 17: 32,710,848 (GRCm39) F469S probably damaging Het
Dmac2 T A 7: 25,320,495 (GRCm39) S65T probably benign Het
Duxf1 T C 10: 58,059,426 (GRCm39) N443D unknown Het
Elp3 G A 14: 65,802,870 (GRCm39) P243S probably damaging Het
Foxg1 T A 12: 49,432,143 (GRCm39) M292K probably benign Het
Fsip2 T C 2: 82,815,822 (GRCm39) S3852P possibly damaging Het
Gm10800 CAAGAAAACTGAAAATCAAAGAAAACTGAAAATCA CAAGAAAACTGAAAATCA 2: 98,497,361 (GRCm39) probably null Het
Gm10912 A C 2: 103,897,046 (GRCm39) K62Q possibly damaging Het
Grk2 G A 19: 4,338,511 (GRCm39) R474C probably damaging Het
Hapstr1 T C 16: 8,660,865 (GRCm39) I114T probably benign Het
Hoxc12 T C 15: 102,846,732 (GRCm39) I208T probably benign Het
Htra3 G A 5: 35,836,602 (GRCm39) P30L unknown Het
Itgal A G 7: 126,904,421 (GRCm39) H298R probably benign Het
Klrb1c A G 6: 128,761,148 (GRCm39) S160P probably benign Het
Or13c7d A T 4: 43,770,793 (GRCm39) C73S probably damaging Het
Phrf1 T A 7: 140,836,581 (GRCm39) D284E unknown Het
Pmp2 T A 3: 10,247,564 (GRCm39) I42F probably damaging Het
Psg26 T C 7: 18,216,494 (GRCm39) D115G probably damaging Het
Pym1 T C 10: 128,601,073 (GRCm39) V32A probably benign Het
R3hdm2 T G 10: 127,293,521 (GRCm39) S142A probably damaging Het
Recql4 T C 15: 76,588,546 (GRCm39) H1105R probably benign Het
Rimkla T C 4: 119,349,607 (GRCm39) Y17C probably damaging Het
Rnf207 C T 4: 152,391,924 (GRCm39) R623K probably benign Het
Ros1 A T 10: 51,999,328 (GRCm39) N1207K probably damaging Het
Scg2 G T 1: 79,413,500 (GRCm39) Q368K probably benign Het
Serpinb6e G A 13: 34,017,213 (GRCm39) T269I probably damaging Het
Tsc22d2 A T 3: 58,367,438 (GRCm39) K663* probably null Het
Ubr4 T A 4: 139,137,494 (GRCm39) N1026K possibly damaging Het
Ubtfl1 A G 9: 18,321,609 (GRCm39) D379G unknown Het
Vps13d T C 4: 144,795,743 (GRCm39) M3700V Het
Zscan4-ps3 T C 7: 11,346,288 (GRCm39) L136P probably damaging Het
Other mutations in Or2z9
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01592:Or2z9 APN 8 72,854,356 (GRCm39) missense probably damaging 1.00
IGL02440:Or2z9 APN 8 72,854,374 (GRCm39) missense probably damaging 1.00
IGL03403:Or2z9 APN 8 72,854,341 (GRCm39) missense probably benign 0.00
R1099:Or2z9 UTSW 8 72,854,503 (GRCm39) missense probably benign 0.00
R1418:Or2z9 UTSW 8 72,854,231 (GRCm39) missense probably damaging 1.00
R1452:Or2z9 UTSW 8 72,854,020 (GRCm39) nonsense probably null
R1621:Or2z9 UTSW 8 72,853,973 (GRCm39) missense probably damaging 1.00
R2021:Or2z9 UTSW 8 72,853,930 (GRCm39) missense possibly damaging 0.90
R4230:Or2z9 UTSW 8 72,854,188 (GRCm39) missense probably damaging 1.00
R4290:Or2z9 UTSW 8 72,853,612 (GRCm39) missense probably benign
R5035:Or2z9 UTSW 8 72,853,922 (GRCm39) missense probably damaging 1.00
R6884:Or2z9 UTSW 8 72,854,345 (GRCm39) missense probably benign 0.26
R6909:Or2z9 UTSW 8 72,854,372 (GRCm39) missense possibly damaging 0.95
R7233:Or2z9 UTSW 8 72,853,900 (GRCm39) missense probably benign
R7304:Or2z9 UTSW 8 72,854,190 (GRCm39) nonsense probably null
R7312:Or2z9 UTSW 8 72,853,793 (GRCm39) missense probably damaging 1.00
R7701:Or2z9 UTSW 8 72,854,030 (GRCm39) missense probably damaging 1.00
Z1088:Or2z9 UTSW 8 72,854,361 (GRCm39) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- CATGCTCATGGGTGTCTCTGAG -3'
(R):5'- AGCCTTGTGTCTAGCTTCAG -3'

Sequencing Primer
(F):5'- CTCATGTCTTATGACCGCTACGTG -3'
(R):5'- TTCAGCTGACCGCATGAG -3'
Posted On 2021-04-30