Mutagenetix > Incidental Mutation

Incidental Mutation 'R8790:Myo15a'

670884

Institutional Source

Beutler Lab

Gene Symbol

Myo15a

Ensembl Gene

ENSMUSG00000042678

Gene Name

myosin XVA

Synonyms

Myo15

MMRRC Submission

068634-MU

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

R8790 (G1)

Quality Score

225.009

Status

Validated

Chromosome

Chromosomal Location

60360165-60419195 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to C at 60367362 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Threonine to Proline at position 41 (T41P)

Ref Sequence

ENSEMBL: ENSMUSP00000071777 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000071880] [ENSMUST00000081823] [ENSMUST00000094135]

AlphaFold

no structure available at present

Predicted Effect

possibly damaging
Transcript: ENSMUST00000071880
AA Change: T41P

PolyPhen 2 Score 0.727 (Sensitivity: 0.86; Specificity: 0.92)

SMART Domains

Protein: ENSMUSP00000071777
Gene: ENSMUSG00000042678
AA Change: T41P

Domain	Start	End	E-Value	Type
low complexity region	4	24	N/A	INTRINSIC
low complexity region	87	100	N/A	INTRINSIC
low complexity region	107	120	N/A	INTRINSIC
low complexity region	269	292	N/A	INTRINSIC
low complexity region	295	306	N/A	INTRINSIC
low complexity region	311	325	N/A	INTRINSIC
low complexity region	349	384	N/A	INTRINSIC
low complexity region	425	435	N/A	INTRINSIC
low complexity region	487	498	N/A	INTRINSIC
low complexity region	502	509	N/A	INTRINSIC
low complexity region	653	681	N/A	INTRINSIC
low complexity region	692	705	N/A	INTRINSIC
low complexity region	737	747	N/A	INTRINSIC
low complexity region	758	775	N/A	INTRINSIC
low complexity region	781	792	N/A	INTRINSIC
low complexity region	796	809	N/A	INTRINSIC
low complexity region	825	849	N/A	INTRINSIC
low complexity region	883	897	N/A	INTRINSIC
low complexity region	1067	1082	N/A	INTRINSIC
low complexity region	1115	1130	N/A	INTRINSIC
MYSc	1200	1884	N/A	SMART
IQ	1885	1907	1.63e-1	SMART
IQ	1908	1930	1.77e-2	SMART
IQ	1931	1953	2.97e2	SMART
low complexity region	1955	1974	N/A	INTRINSIC
low complexity region	1992	2006	N/A	INTRINSIC
MyTH4	2049	2195	1.8e-42	SMART
low complexity region	2396	2405	N/A	INTRINSIC
low complexity region	2451	2461	N/A	INTRINSIC
Blast:MYSc	2665	2848	2e-14	BLAST
SH3	2851	2933	1.55e-4	SMART
low complexity region	2949	2962	N/A	INTRINSIC
MyTH4	3031	3185	5.59e-48	SMART
B41	3188	3400	6.94e-3	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000081823

SMART Domains

Protein: ENSMUSP00000080507
Gene: ENSMUSG00000042678

Domain	Start	End	E-Value	Type
MYSc	13	697	N/A	SMART
IQ	698	720	1.63e-1	SMART
IQ	721	743	1.77e-2	SMART
IQ	744	766	2.97e2	SMART
low complexity region	787	801	N/A	INTRINSIC
MyTH4	844	990	1.8e-42	SMART
low complexity region	1191	1200	N/A	INTRINSIC
low complexity region	1246	1256	N/A	INTRINSIC
Blast:MYSc	1460	1643	7e-15	BLAST
SH3	1646	1728	1.55e-4	SMART
low complexity region	1744	1757	N/A	INTRINSIC
MyTH4	1826	1980	5.59e-48	SMART
B41	1983	2195	6.94e-3	SMART

Predicted Effect

possibly damaging
Transcript: ENSMUST00000094135
AA Change: T41P

PolyPhen 2 Score 0.822 (Sensitivity: 0.84; Specificity: 0.93)

SMART Domains

Protein: ENSMUSP00000091686
Gene: ENSMUSG00000042678
AA Change: T41P

Domain	Start	End	E-Value	Type
low complexity region	4	24	N/A	INTRINSIC
low complexity region	87	100	N/A	INTRINSIC
low complexity region	107	120	N/A	INTRINSIC
low complexity region	269	292	N/A	INTRINSIC
low complexity region	295	306	N/A	INTRINSIC
low complexity region	311	325	N/A	INTRINSIC
low complexity region	349	384	N/A	INTRINSIC
low complexity region	425	435	N/A	INTRINSIC
low complexity region	487	498	N/A	INTRINSIC
low complexity region	502	509	N/A	INTRINSIC
low complexity region	653	681	N/A	INTRINSIC
low complexity region	692	705	N/A	INTRINSIC
low complexity region	737	747	N/A	INTRINSIC
low complexity region	758	775	N/A	INTRINSIC
low complexity region	781	792	N/A	INTRINSIC
low complexity region	796	809	N/A	INTRINSIC
low complexity region	825	849	N/A	INTRINSIC
low complexity region	883	897	N/A	INTRINSIC
low complexity region	1067	1082	N/A	INTRINSIC
low complexity region	1115	1130	N/A	INTRINSIC
MYSc	1200	1884	N/A	SMART
IQ	1885	1907	1.63e-1	SMART
IQ	1908	1930	1.77e-2	SMART
IQ	1931	1953	2.97e2	SMART
low complexity region	1974	1988	N/A	INTRINSIC
MyTH4	2031	2177	1.8e-42	SMART
low complexity region	2378	2387	N/A	INTRINSIC
low complexity region	2433	2443	N/A	INTRINSIC
Blast:MYSc	2647	2830	2e-14	BLAST
SH3	2833	2915	1.55e-4	SMART
low complexity region	2931	2944	N/A	INTRINSIC
MyTH4	3013	3167	5.59e-48	SMART
B41	3170	3382	6.94e-3	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000126522

SMART Domains

Protein: ENSMUSP00000120839
Gene: ENSMUSG00000042678

Domain	Start	End	E-Value	Type
MYSc	34	716	N/A	SMART
IQ	717	739	1.63e-1	SMART
IQ	740	762	1.77e-2	SMART
IQ	763	785	2.97e2	SMART
low complexity region	806	820	N/A	INTRINSIC
MyTH4	863	1009	1.8e-42	SMART
low complexity region	1210	1219	N/A	INTRINSIC
low complexity region	1265	1275	N/A	INTRINSIC
Blast:MYSc	1479	1662	5e-15	BLAST
SH3	1665	1747	1.55e-4	SMART
low complexity region	1763	1776	N/A	INTRINSIC

Coding Region Coverage

1x: 100.0%
3x: 100.0%
10x: 99.8%
20x: 99.3%

Validation Efficiency

100% (83/83)

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes an unconventional myosin. This protein differs from other myosins in that it has a long N-terminal extension preceding the conserved motor domain. Studies in mice suggest that this protein is necessary for actin organization in the hair cells of the cochlea. Mutations in this gene have been associated with profound, congenital, neurosensory, nonsyndromal deafness. This gene is located within the Smith-Magenis syndrome region on chromosome 17. Read-through transcripts containing an upstream gene and this gene have been identified, but they are not thought to encode a fusion protein. Several alternatively spliced transcript variants have been described, but their full length sequences have not been determined. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mutations in this gene result in profound deafness and neurological behavior. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 83 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
2610008E11Rik	G	A	10: 78,928,285 (GRCm39)	P68S	possibly damaging	Het
Abcb5	T	A	12: 118,831,620 (GRCm39)	N1244I	possibly damaging	Het
Abcb9	A	G	5: 124,215,304 (GRCm39)	I479T	probably damaging	Het
Abi3bp	A	T	16: 56,495,437 (GRCm39)	I920F	probably damaging	Het
Adcy6	T	A	15: 98,496,881 (GRCm39)	T465S	probably damaging	Het
Ankrd12	A	T	17: 66,290,153 (GRCm39)	I1760N	possibly damaging	Het
Aoah	C	T	13: 21,035,840 (GRCm39)	R140C	probably benign	Het
Bmp7	T	A	2: 172,712,060 (GRCm39)	D388V	probably benign	Het
Bphl	C	T	13: 34,244,468 (GRCm39)	A195V	probably benign	Het
Cckar	A	G	5: 53,857,291 (GRCm39)	V373A	probably damaging	Het
Cd79b	T	G	11: 106,202,873 (GRCm39)	D243A	possibly damaging	Het
Cdc25a	T	A	9: 109,716,416 (GRCm39)		probably null	Het
Cfap57	T	A	4: 118,439,111 (GRCm39)	Q805L	possibly damaging	Het
Ckap2l	A	T	2: 129,111,172 (GRCm39)	M675K	possibly damaging	Het
Cluap1	T	A	16: 3,735,787 (GRCm39)		probably benign	Het
Cyp2b9	A	G	7: 25,898,167 (GRCm39)		probably benign	Het
D930020B18Rik	G	A	10: 121,503,568 (GRCm39)	G248S	possibly damaging	Het
Ddx1	A	T	12: 13,273,993 (GRCm39)	I570N	probably damaging	Het
Dmkn	G	A	7: 30,463,449 (GRCm39)	S34N	probably benign	Het
Dnaaf2	T	C	12: 69,244,068 (GRCm39)	D331G	probably damaging	Het
Dnah1	A	T	14: 31,018,232 (GRCm39)	Y1429N	possibly damaging	Het
Dnajc5b	T	A	3: 19,600,981 (GRCm39)	L26Q	probably damaging	Het
Epb41l1	T	G	2: 156,345,722 (GRCm39)	F242V	possibly damaging	Het
Esam	A	T	9: 37,442,927 (GRCm39)	I72F	probably benign	Het
Fam110a	C	T	2: 151,812,338 (GRCm39)	R144H	probably damaging	Het
Fam186a	T	C	15: 99,841,024 (GRCm39)	D1740G	possibly damaging	Het
Fam98a	A	G	17: 75,854,684 (GRCm39)	F42L	possibly damaging	Het
Fras1	C	T	5: 96,903,236 (GRCm39)	P3038S	probably damaging	Het
Gm32742	C	A	9: 51,059,140 (GRCm39)	G1035C	probably damaging	Het
Irf5	T	A	6: 29,535,026 (GRCm39)		probably benign	Het
Jam2	T	A	16: 84,606,259 (GRCm39)	I91K	possibly damaging	Het
Klhdc3	A	G	17: 46,991,626 (GRCm39)		probably benign	Het
Lgi1	C	T	19: 38,289,296 (GRCm39)	S215F	possibly damaging	Het
Lrp1	G	A	10: 127,374,946 (GRCm39)	T4504I	probably damaging	Het
Mafa	T	A	15: 75,619,224 (GRCm39)	H183L	probably benign	Het
Map2	T	C	1: 66,477,997 (GRCm39)	V1773A	probably damaging	Het
Mesp1	G	A	7: 79,442,825 (GRCm39)	R151*	probably null	Het
Mphosph9	T	C	5: 124,453,736 (GRCm39)	D192G	probably damaging	Het
Mthfr	C	A	4: 148,139,991 (GRCm39)	D678E	probably benign	Het
Myom2	T	G	8: 15,169,242 (GRCm39)	L1136W	probably damaging	Het
Naa30	A	G	14: 49,418,208 (GRCm39)	D316G	probably benign	Het
Ngef	T	C	1: 87,405,319 (GRCm39)	Q697R	probably benign	Het
Nin	T	C	12: 70,067,793 (GRCm39)	R1945G		Het
Obox8	A	T	7: 14,066,908 (GRCm39)	Y45*	probably null	Het
Ocln	C	T	13: 100,642,727 (GRCm39)	V452I	probably benign	Het
Oog3	T	A	4: 143,885,710 (GRCm39)	D296V	possibly damaging	Het
Or5a1	T	C	19: 12,097,906 (GRCm39)	N57D	probably damaging	Het
Or5h19	T	C	16: 58,856,580 (GRCm39)	I173M	possibly damaging	Het
Or8g4	T	A	9: 39,662,204 (GRCm39)	I174K	probably damaging	Het
Or8k35	T	C	2: 86,424,278 (GRCm39)	K298R	possibly damaging	Het
Papln	T	C	12: 83,823,918 (GRCm39)	V499A	probably benign	Het
Paxip1	G	T	5: 27,977,078 (GRCm39)	P328Q	unknown	Het
Pcnx2	T	C	8: 126,604,306 (GRCm39)	H650R	probably benign	Het
Pcnx3	A	T	19: 5,735,206 (GRCm39)	V540E	possibly damaging	Het
Pnpla5	C	T	15: 84,002,819 (GRCm39)	G255R	probably damaging	Het
Ppdpf	G	T	2: 180,829,646 (GRCm39)	E34*	probably null	Het
Pum3	T	C	19: 27,394,199 (GRCm39)	Y357C	probably damaging	Het
R3hdm2	T	G	10: 127,293,521 (GRCm39)	S142A	probably damaging	Het
Rasa3	A	T	8: 13,727,391 (GRCm39)		probably null	Het
Rcor2	T	A	19: 7,246,340 (GRCm39)	M5K	possibly damaging	Het
Rere	A	G	4: 150,593,332 (GRCm39)	T309A	unknown	Het
Ryr1	A	T	7: 28,776,297 (GRCm39)	I2250N	probably damaging	Het
Sema6c	T	C	3: 95,075,341 (GRCm39)	V130A	probably benign	Het
Slc26a9	T	A	1: 131,683,155 (GRCm39)	S200T	probably damaging	Het
Slc38a10	A	G	11: 120,023,519 (GRCm39)	L299P	possibly damaging	Het
Smim10l1	G	T	6: 133,084,848 (GRCm39)	V72L	unknown	Het
Sptbn2	C	A	19: 4,782,052 (GRCm39)	F430L	probably damaging	Het
Svep1	T	A	4: 58,118,145 (GRCm39)	Y859F	possibly damaging	Het
Svil	C	A	18: 5,056,098 (GRCm39)	Q324K	possibly damaging	Het
Tgfb1i1	A	T	7: 127,852,049 (GRCm39)	D377V	probably damaging	Het
Tmed10	C	A	12: 85,390,254 (GRCm39)	W203L	probably damaging	Het
Tmem51	T	A	4: 141,765,056 (GRCm39)	M1L	possibly damaging	Het
Tmprss11e	A	G	5: 86,855,259 (GRCm39)	V382A	probably benign	Het
Tnfrsf13b	G	T	11: 61,038,350 (GRCm39)	R211L	possibly damaging	Het
Tns3	A	G	11: 8,468,273 (GRCm39)	V317A	probably damaging	Het
Top3a	G	A	11: 60,631,363 (GRCm39)	P1000S	possibly damaging	Het
Traj32	A	T	14: 54,423,587 (GRCm39)	I10F		Het
Trav8-1	T	A	14: 53,707,677 (GRCm39)	C106S	probably damaging	Het
Trbv2	A	G	6: 41,024,655 (GRCm39)	I24V	probably benign	Het
Ubap2	A	G	4: 41,209,351 (GRCm39)		probably null	Het
Vmn2r97	T	A	17: 19,160,472 (GRCm39)	C536S	probably damaging	Het
Zfp879	G	T	11: 50,723,429 (GRCm39)	C542*	probably null	Het
Znfx1	C	T	2: 166,892,500 (GRCm39)		probably benign	Het

Other mutations in Myo15a

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00845:Myo15a	APN	11	60,368,605 (GRCm39)	missense	probably damaging	1.00
IGL01011:Myo15a	APN	11	60,367,818 (GRCm39)	missense	probably benign	0.33
IGL01100:Myo15a	APN	11	60,401,984 (GRCm39)	missense	probably damaging	1.00
IGL01357:Myo15a	APN	11	60,393,115 (GRCm39)	splice site	probably benign
IGL01634:Myo15a	APN	11	60,386,298 (GRCm39)	missense	probably damaging	1.00
IGL01763:Myo15a	APN	11	60,412,564 (GRCm39)	missense	probably benign	0.07
IGL01901:Myo15a	APN	11	60,418,260 (GRCm39)	utr 3 prime	probably benign
IGL01931:Myo15a	APN	11	60,386,964 (GRCm39)	missense	probably damaging	1.00
IGL02006:Myo15a	APN	11	60,401,954 (GRCm39)	missense	probably damaging	1.00
IGL02041:Myo15a	APN	11	60,397,689 (GRCm39)	missense	probably damaging	0.99
IGL02094:Myo15a	APN	11	60,401,473 (GRCm39)	unclassified	probably benign
IGL02122:Myo15a	APN	11	60,374,292 (GRCm39)	missense	probably benign	0.23
IGL02153:Myo15a	APN	11	60,389,223 (GRCm39)	missense	probably damaging	1.00
IGL02328:Myo15a	APN	11	60,417,433 (GRCm39)	missense	probably benign	0.13
IGL02330:Myo15a	APN	11	60,367,987 (GRCm39)	missense	possibly damaging	0.94
IGL02431:Myo15a	APN	11	60,401,465 (GRCm39)	missense	possibly damaging	0.73
IGL02639:Myo15a	APN	11	60,369,447 (GRCm39)	missense	probably benign
IGL02659:Myo15a	APN	11	60,382,609 (GRCm39)	splice site	probably benign
IGL02800:Myo15a	APN	11	60,393,195 (GRCm39)	missense	probably damaging	1.00
IGL02812:Myo15a	APN	11	60,368,005 (GRCm39)	missense	probably benign	0.15
IGL02863:Myo15a	APN	11	60,368,953 (GRCm39)	missense	probably damaging	1.00
IGL02873:Myo15a	APN	11	60,374,308 (GRCm39)	missense	probably damaging	1.00
IGL02990:Myo15a	APN	11	60,370,266 (GRCm39)	missense	probably benign	0.02
IGL03011:Myo15a	APN	11	60,400,357 (GRCm39)	splice site	probably benign
IGL03243:Myo15a	APN	11	60,387,344 (GRCm39)	missense	probably damaging	1.00
IGL03297:Myo15a	APN	11	60,369,967 (GRCm39)	missense	probably damaging	1.00
novichok	UTSW	11	60,372,566 (GRCm39)	critical splice donor site	probably null
parker	UTSW	11	60,411,740 (GRCm39)	critical splice donor site	probably null
Typhoon	UTSW	11	60,378,251 (GRCm39)	critical splice donor site	probably null
PIT4131001:Myo15a	UTSW	11	60,386,280 (GRCm39)	missense	probably damaging	1.00
PIT4131001:Myo15a	UTSW	11	60,373,953 (GRCm39)	missense	probably damaging	1.00
R0133:Myo15a	UTSW	11	60,368,676 (GRCm39)	missense	possibly damaging	0.94
R0265:Myo15a	UTSW	11	60,405,723 (GRCm39)	critical splice acceptor site	probably null
R0389:Myo15a	UTSW	11	60,369,364 (GRCm39)	missense	probably benign
R0416:Myo15a	UTSW	11	60,402,000 (GRCm39)	missense	probably damaging	1.00
R0449:Myo15a	UTSW	11	60,400,422 (GRCm39)	missense	possibly damaging	0.92
R0477:Myo15a	UTSW	11	60,411,740 (GRCm39)	critical splice donor site	probably null
R0543:Myo15a	UTSW	11	60,369,877 (GRCm39)	missense	probably benign
R0546:Myo15a	UTSW	11	60,397,139 (GRCm39)	missense	probably damaging	1.00
R0555:Myo15a	UTSW	11	60,412,464 (GRCm39)	missense	probably damaging	1.00
R0639:Myo15a	UTSW	11	60,370,162 (GRCm39)	missense	probably benign	0.12
R0723:Myo15a	UTSW	11	60,369,803 (GRCm39)	missense	possibly damaging	0.94
R0837:Myo15a	UTSW	11	60,378,077 (GRCm39)	missense	probably damaging	0.98
R0865:Myo15a	UTSW	11	60,382,514 (GRCm39)	missense	probably damaging	1.00
R0899:Myo15a	UTSW	11	60,368,011 (GRCm39)	missense	possibly damaging	0.87
R1022:Myo15a	UTSW	11	60,370,442 (GRCm39)	missense	probably benign	0.00
R1024:Myo15a	UTSW	11	60,370,442 (GRCm39)	missense	probably benign	0.00
R1035:Myo15a	UTSW	11	60,401,384 (GRCm39)	unclassified	probably benign
R1109:Myo15a	UTSW	11	60,383,892 (GRCm39)	missense	probably damaging	1.00
R1170:Myo15a	UTSW	11	60,370,233 (GRCm39)	missense	probably benign	0.04
R1241:Myo15a	UTSW	11	60,390,256 (GRCm39)	missense	possibly damaging	0.58
R1392:Myo15a	UTSW	11	60,368,800 (GRCm39)	missense	possibly damaging	0.95
R1392:Myo15a	UTSW	11	60,368,800 (GRCm39)	missense	possibly damaging	0.95
R1434:Myo15a	UTSW	11	60,395,157 (GRCm39)	missense	probably benign	0.00
R1450:Myo15a	UTSW	11	60,386,308 (GRCm39)	missense	probably damaging	1.00
R1456:Myo15a	UTSW	11	60,399,028 (GRCm39)	missense	probably damaging	1.00
R1468:Myo15a	UTSW	11	60,396,832 (GRCm39)	missense	probably damaging	1.00
R1468:Myo15a	UTSW	11	60,396,832 (GRCm39)	missense	probably damaging	1.00
R1548:Myo15a	UTSW	11	60,379,064 (GRCm39)	missense	probably damaging	1.00
R1551:Myo15a	UTSW	11	60,383,791 (GRCm39)	missense	possibly damaging	0.70
R1571:Myo15a	UTSW	11	60,409,290 (GRCm39)	missense	probably damaging	1.00
R1662:Myo15a	UTSW	11	60,392,527 (GRCm39)	missense	probably damaging	1.00
R1777:Myo15a	UTSW	11	60,405,762 (GRCm39)	missense	probably benign
R1778:Myo15a	UTSW	11	60,369,238 (GRCm39)	missense	possibly damaging	0.57
R1847:Myo15a	UTSW	11	60,390,321 (GRCm39)	nonsense	probably null
R1875:Myo15a	UTSW	11	60,398,354 (GRCm39)	missense	probably damaging	0.99
R1944:Myo15a	UTSW	11	60,392,909 (GRCm39)	missense	probably damaging	0.99
R1945:Myo15a	UTSW	11	60,392,909 (GRCm39)	missense	probably damaging	0.99
R2013:Myo15a	UTSW	11	60,385,057 (GRCm39)	missense	probably damaging	1.00
R2107:Myo15a	UTSW	11	60,382,636 (GRCm39)	missense	probably damaging	1.00
R2108:Myo15a	UTSW	11	60,382,636 (GRCm39)	missense	probably damaging	1.00
R2112:Myo15a	UTSW	11	60,384,994 (GRCm39)	missense	probably damaging	0.99
R2147:Myo15a	UTSW	11	60,401,055 (GRCm39)	missense	possibly damaging	0.66
R2196:Myo15a	UTSW	11	60,400,847 (GRCm39)	nonsense	probably null
R2207:Myo15a	UTSW	11	60,396,860 (GRCm39)	missense	probably benign	0.01
R2245:Myo15a	UTSW	11	60,399,925 (GRCm39)	missense	probably damaging	1.00
R2367:Myo15a	UTSW	11	60,408,064 (GRCm39)	missense	probably damaging	0.99
R2374:Myo15a	UTSW	11	60,369,669 (GRCm39)	missense	possibly damaging	0.88
R2438:Myo15a	UTSW	11	60,373,878 (GRCm39)	missense	probably damaging	1.00
R3154:Myo15a	UTSW	11	60,370,186 (GRCm39)	splice site	probably null
R3423:Myo15a	UTSW	11	60,401,126 (GRCm39)	critical splice donor site	probably null
R3551:Myo15a	UTSW	11	60,400,489 (GRCm39)	missense	possibly damaging	0.93
R3552:Myo15a	UTSW	11	60,400,489 (GRCm39)	missense	possibly damaging	0.93
R3612:Myo15a	UTSW	11	60,368,505 (GRCm39)	missense	probably damaging	1.00
R3620:Myo15a	UTSW	11	60,369,468 (GRCm39)	missense	possibly damaging	0.63
R3713:Myo15a	UTSW	11	60,370,057 (GRCm39)	missense	possibly damaging	0.55
R3714:Myo15a	UTSW	11	60,370,057 (GRCm39)	missense	possibly damaging	0.55
R3715:Myo15a	UTSW	11	60,370,057 (GRCm39)	missense	possibly damaging	0.55
R3783:Myo15a	UTSW	11	60,368,398 (GRCm39)	missense	probably damaging	0.97
R3784:Myo15a	UTSW	11	60,368,398 (GRCm39)	missense	probably damaging	0.97
R3785:Myo15a	UTSW	11	60,368,398 (GRCm39)	missense	probably damaging	0.97
R3786:Myo15a	UTSW	11	60,368,398 (GRCm39)	missense	probably damaging	0.97
R3787:Myo15a	UTSW	11	60,368,398 (GRCm39)	missense	probably damaging	0.97
R3894:Myo15a	UTSW	11	60,395,145 (GRCm39)	missense	probably benign	0.00
R3962:Myo15a	UTSW	11	60,370,654 (GRCm39)	missense	probably benign	0.00
R4082:Myo15a	UTSW	11	60,378,022 (GRCm39)	missense	possibly damaging	0.92
R4555:Myo15a	UTSW	11	60,387,763 (GRCm39)	missense	probably damaging	1.00
R4641:Myo15a	UTSW	11	60,393,867 (GRCm39)	missense	probably damaging	1.00
R4665:Myo15a	UTSW	11	60,395,705 (GRCm39)	critical splice acceptor site	probably null
R4713:Myo15a	UTSW	11	60,370,756 (GRCm39)	missense	probably benign	0.21
R4820:Myo15a	UTSW	11	60,367,741 (GRCm39)	missense	probably damaging	0.98
R5013:Myo15a	UTSW	11	60,382,493 (GRCm39)	missense	probably damaging	1.00
R5051:Myo15a	UTSW	11	60,378,251 (GRCm39)	critical splice donor site	probably null
R5187:Myo15a	UTSW	11	60,394,440 (GRCm39)	missense	probably damaging	1.00
R5230:Myo15a	UTSW	11	60,393,674 (GRCm39)	missense	possibly damaging	0.68
R5277:Myo15a	UTSW	11	60,367,940 (GRCm39)	nonsense	probably null
R5345:Myo15a	UTSW	11	60,388,364 (GRCm39)	missense	probably damaging	0.99
R5349:Myo15a	UTSW	11	60,384,409 (GRCm39)	missense	probably damaging	1.00
R5356:Myo15a	UTSW	11	60,389,192 (GRCm39)	missense	probably damaging	1.00
R5445:Myo15a	UTSW	11	60,411,603 (GRCm39)	nonsense	probably null
R5477:Myo15a	UTSW	11	60,368,503 (GRCm39)	missense	probably damaging	1.00
R5629:Myo15a	UTSW	11	60,370,578 (GRCm39)	missense	probably benign
R5728:Myo15a	UTSW	11	60,379,722 (GRCm39)	missense	probably damaging	1.00
R5818:Myo15a	UTSW	11	60,388,777 (GRCm39)	missense	probably benign	0.06
R5952:Myo15a	UTSW	11	60,370,246 (GRCm39)	missense	possibly damaging	0.50
R6338:Myo15a	UTSW	11	60,368,959 (GRCm39)	missense	probably damaging	0.99
R6467:Myo15a	UTSW	11	60,417,487 (GRCm39)	critical splice donor site	probably null
R6488:Myo15a	UTSW	11	60,369,313 (GRCm39)	missense	possibly damaging	0.86
R6521:Myo15a	UTSW	11	60,393,195 (GRCm39)	missense	probably damaging	1.00
R6645:Myo15a	UTSW	11	60,368,118 (GRCm39)	missense	probably benign	0.00
R6702:Myo15a	UTSW	11	60,383,818 (GRCm39)	missense	probably benign	0.16
R6703:Myo15a	UTSW	11	60,383,818 (GRCm39)	missense	probably benign	0.16
R6821:Myo15a	UTSW	11	60,415,301 (GRCm39)	missense	probably damaging	1.00
R6882:Myo15a	UTSW	11	60,414,832 (GRCm39)	missense	probably damaging	1.00
R6908:Myo15a	UTSW	11	60,396,832 (GRCm39)	missense	probably damaging	1.00
R6932:Myo15a	UTSW	11	60,390,320 (GRCm39)	missense	probably damaging	1.00
R6958:Myo15a	UTSW	11	60,394,451 (GRCm39)	missense	probably benign	0.07
R7041:Myo15a	UTSW	11	60,396,832 (GRCm39)	missense	probably damaging	1.00
R7149:Myo15a	UTSW	11	60,400,836 (GRCm39)	missense	possibly damaging	0.56
R7163:Myo15a	UTSW	11	60,389,195 (GRCm39)	missense
R7229:Myo15a	UTSW	11	60,387,321 (GRCm39)	missense	probably benign	0.08
R7347:Myo15a	UTSW	11	60,368,787 (GRCm39)	missense	probably benign
R7368:Myo15a	UTSW	11	60,381,741 (GRCm39)	splice site	probably null
R7392:Myo15a	UTSW	11	60,396,802 (GRCm39)	missense
R7414:Myo15a	UTSW	11	60,374,309 (GRCm39)	missense
R7461:Myo15a	UTSW	11	60,395,978 (GRCm39)	missense
R7609:Myo15a	UTSW	11	60,379,637 (GRCm39)	missense
R7613:Myo15a	UTSW	11	60,395,978 (GRCm39)	missense
R7734:Myo15a	UTSW	11	60,401,108 (GRCm39)	missense	probably benign
R7748:Myo15a	UTSW	11	60,395,727 (GRCm39)	missense
R7767:Myo15a	UTSW	11	60,392,922 (GRCm39)	missense
R7769:Myo15a	UTSW	11	60,399,975 (GRCm39)	missense
R7894:Myo15a	UTSW	11	60,381,963 (GRCm39)	missense
R7919:Myo15a	UTSW	11	60,417,356 (GRCm39)	missense	probably damaging	1.00
R8100:Myo15a	UTSW	11	60,408,016 (GRCm39)	missense	probably damaging	1.00
R8124:Myo15a	UTSW	11	60,398,279 (GRCm39)	missense
R8129:Myo15a	UTSW	11	60,399,026 (GRCm39)	missense
R8428:Myo15a	UTSW	11	60,387,241 (GRCm39)	missense	probably damaging	1.00
R8706:Myo15a	UTSW	11	60,370,443 (GRCm39)	missense	probably benign
R8735:Myo15a	UTSW	11	60,401,679 (GRCm39)	critical splice acceptor site	probably null
R8739:Myo15a	UTSW	11	60,368,088 (GRCm39)	missense	probably benign	0.06
R8790:Myo15a	UTSW	11	60,378,047 (GRCm39)	missense
R8822:Myo15a	UTSW	11	60,367,740 (GRCm39)	missense	probably damaging	0.99
R8907:Myo15a	UTSW	11	60,417,434 (GRCm39)	missense
R8931:Myo15a	UTSW	11	60,368,020 (GRCm39)	missense	probably benign
R9061:Myo15a	UTSW	11	60,393,692 (GRCm39)	missense
R9124:Myo15a	UTSW	11	60,369,952 (GRCm39)	missense	probably benign	0.37
R9297:Myo15a	UTSW	11	60,385,899 (GRCm39)	missense	probably null
R9347:Myo15a	UTSW	11	60,374,555 (GRCm39)	missense
R9417:Myo15a	UTSW	11	60,378,243 (GRCm39)	missense
R9456:Myo15a	UTSW	11	60,392,668 (GRCm39)	missense
R9460:Myo15a	UTSW	11	60,372,566 (GRCm39)	critical splice donor site	probably null
R9615:Myo15a	UTSW	11	60,374,320 (GRCm39)	missense
R9630:Myo15a	UTSW	11	60,407,988 (GRCm39)	missense	probably damaging	1.00
R9746:Myo15a	UTSW	11	60,378,234 (GRCm39)	nonsense	probably null
X0021:Myo15a	UTSW	11	60,373,185 (GRCm39)	nonsense	probably null
X0066:Myo15a	UTSW	11	60,369,046 (GRCm39)	missense	probably damaging	1.00
X0067:Myo15a	UTSW	11	60,369,444 (GRCm39)	missense	possibly damaging	0.88
Z1176:Myo15a	UTSW	11	60,389,229 (GRCm39)	missense
Z1176:Myo15a	UTSW	11	60,379,084 (GRCm39)	missense
Z1176:Myo15a	UTSW	11	60,415,267 (GRCm39)	missense	probably damaging	1.00
Z1177:Myo15a	UTSW	11	60,386,301 (GRCm39)	missense
Z1177:Myo15a	UTSW	11	60,379,663 (GRCm39)	missense
Z1177:Myo15a	UTSW	11	60,368,349 (GRCm39)	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- ACTGTAGGTTCAGCTACAAGC -3'
(R):5'- TGAACGAGGGCTTCTTTCCC -3'

Sequencing Primer
(F):5'- GTCTCCAAGCAGTGTCTCCAAG -3'
(R):5'- GGGCTTCTTTCCCTTCATCG -3'

Posted On

2021-04-30