Incidental Mutation 'R8790:Nin'
| ID |
670892 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Nin
|
| Ensembl Gene |
ENSMUSG00000021068 |
| Gene Name |
ninein |
| Synonyms |
3110068G20Rik |
| MMRRC Submission |
068634-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R8790 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
12 |
| Chromosomal Location |
70058209-70160491 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 70067793 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Arginine to Glycine
at position 1945
(R1945G)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000082422
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000021468]
[ENSMUST00000085314]
[ENSMUST00000095666]
[ENSMUST00000169074]
[ENSMUST00000220689]
[ENSMUST00000222237]
[ENSMUST00000223257]
|
| AlphaFold |
Q61043 |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000021468
AA Change: R1954G
PolyPhen 2
Score 0.934 (Sensitivity: 0.80; Specificity: 0.94)
|
| SMART Domains |
Protein: ENSMUSP00000021468
Gene: ENSMUSG00000021068
AA Change: R1954G
| Domain | Start | End | E-Value | Type |
|---|
|
internal_repeat_1
|
7 |
67 |
7.83e-8 |
PROSPERO |
|
low complexity region
|
97 |
108 |
N/A |
INTRINSIC |
|
low complexity region
|
115 |
132 |
N/A |
INTRINSIC |
|
internal_repeat_1
|
181 |
242 |
7.83e-8 |
PROSPERO |
|
low complexity region
|
276 |
289 |
N/A |
INTRINSIC |
|
low complexity region
|
336 |
353 |
N/A |
INTRINSIC |
|
coiled coil region
|
358 |
570 |
N/A |
INTRINSIC |
|
coiled coil region
|
625 |
802 |
N/A |
INTRINSIC |
|
coiled coil region
|
834 |
926 |
N/A |
INTRINSIC |
|
coiled coil region
|
957 |
1008 |
N/A |
INTRINSIC |
|
low complexity region
|
1035 |
1044 |
N/A |
INTRINSIC |
|
low complexity region
|
1047 |
1057 |
N/A |
INTRINSIC |
|
coiled coil region
|
1069 |
1094 |
N/A |
INTRINSIC |
|
coiled coil region
|
1178 |
1325 |
N/A |
INTRINSIC |
|
low complexity region
|
1374 |
1385 |
N/A |
INTRINSIC |
|
coiled coil region
|
1425 |
1806 |
N/A |
INTRINSIC |
|
coiled coil region
|
1980 |
2013 |
N/A |
INTRINSIC |
|
| Predicted Effect |
|
| SMART Domains |
Protein: ENSMUSP00000082422
Gene: ENSMUSG00000021068
AA Change: R1945G
| Domain | Start | End | E-Value | Type |
|---|
|
internal_repeat_1
|
7 |
67 |
4.15e-8 |
PROSPERO |
|
low complexity region
|
97 |
108 |
N/A |
INTRINSIC |
|
low complexity region
|
115 |
132 |
N/A |
INTRINSIC |
|
internal_repeat_1
|
181 |
242 |
4.15e-8 |
PROSPERO |
|
low complexity region
|
276 |
289 |
N/A |
INTRINSIC |
|
low complexity region
|
336 |
353 |
N/A |
INTRINSIC |
|
coiled coil region
|
358 |
570 |
N/A |
INTRINSIC |
|
coiled coil region
|
625 |
802 |
N/A |
INTRINSIC |
|
coiled coil region
|
834 |
926 |
N/A |
INTRINSIC |
|
coiled coil region
|
957 |
1008 |
N/A |
INTRINSIC |
|
low complexity region
|
1035 |
1044 |
N/A |
INTRINSIC |
|
low complexity region
|
1047 |
1057 |
N/A |
INTRINSIC |
|
coiled coil region
|
1069 |
1094 |
N/A |
INTRINSIC |
|
coiled coil region
|
1178 |
1325 |
N/A |
INTRINSIC |
|
low complexity region
|
1374 |
1385 |
N/A |
INTRINSIC |
|
coiled coil region
|
1425 |
1806 |
N/A |
INTRINSIC |
|
coiled coil region
|
1971 |
2045 |
N/A |
INTRINSIC |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000095666
AA Change: R1954G
PolyPhen 2
Score 0.934 (Sensitivity: 0.80; Specificity: 0.94)
|
| SMART Domains |
Protein: ENSMUSP00000093327
Gene: ENSMUSG00000021068
AA Change: R1954G
| Domain | Start | End | E-Value | Type |
|---|
|
internal_repeat_1
|
7 |
67 |
7.83e-8 |
PROSPERO |
|
low complexity region
|
97 |
108 |
N/A |
INTRINSIC |
|
low complexity region
|
115 |
132 |
N/A |
INTRINSIC |
|
internal_repeat_1
|
181 |
242 |
7.83e-8 |
PROSPERO |
|
low complexity region
|
276 |
289 |
N/A |
INTRINSIC |
|
low complexity region
|
336 |
353 |
N/A |
INTRINSIC |
|
coiled coil region
|
358 |
570 |
N/A |
INTRINSIC |
|
coiled coil region
|
625 |
802 |
N/A |
INTRINSIC |
|
coiled coil region
|
834 |
926 |
N/A |
INTRINSIC |
|
coiled coil region
|
957 |
1008 |
N/A |
INTRINSIC |
|
low complexity region
|
1035 |
1044 |
N/A |
INTRINSIC |
|
low complexity region
|
1047 |
1057 |
N/A |
INTRINSIC |
|
coiled coil region
|
1069 |
1094 |
N/A |
INTRINSIC |
|
coiled coil region
|
1178 |
1325 |
N/A |
INTRINSIC |
|
low complexity region
|
1374 |
1385 |
N/A |
INTRINSIC |
|
coiled coil region
|
1425 |
1806 |
N/A |
INTRINSIC |
|
coiled coil region
|
1980 |
2013 |
N/A |
INTRINSIC |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000169074
AA Change: R1954G
PolyPhen 2
Score 0.934 (Sensitivity: 0.80; Specificity: 0.94)
|
| SMART Domains |
Protein: ENSMUSP00000129648
Gene: ENSMUSG00000021068
AA Change: R1954G
| Domain | Start | End | E-Value | Type |
|---|
|
internal_repeat_1
|
7 |
67 |
7.83e-8 |
PROSPERO |
|
low complexity region
|
97 |
108 |
N/A |
INTRINSIC |
|
low complexity region
|
115 |
132 |
N/A |
INTRINSIC |
|
internal_repeat_1
|
181 |
242 |
7.83e-8 |
PROSPERO |
|
low complexity region
|
276 |
289 |
N/A |
INTRINSIC |
|
low complexity region
|
336 |
353 |
N/A |
INTRINSIC |
|
coiled coil region
|
358 |
570 |
N/A |
INTRINSIC |
|
coiled coil region
|
625 |
802 |
N/A |
INTRINSIC |
|
coiled coil region
|
834 |
926 |
N/A |
INTRINSIC |
|
coiled coil region
|
957 |
1008 |
N/A |
INTRINSIC |
|
low complexity region
|
1035 |
1044 |
N/A |
INTRINSIC |
|
low complexity region
|
1047 |
1057 |
N/A |
INTRINSIC |
|
coiled coil region
|
1069 |
1094 |
N/A |
INTRINSIC |
|
coiled coil region
|
1178 |
1325 |
N/A |
INTRINSIC |
|
low complexity region
|
1374 |
1385 |
N/A |
INTRINSIC |
|
coiled coil region
|
1425 |
1806 |
N/A |
INTRINSIC |
|
coiled coil region
|
1980 |
2013 |
N/A |
INTRINSIC |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000220689
AA Change: E1267G
PolyPhen 2
Score 0.893 (Sensitivity: 0.82; Specificity: 0.94)
|
| Predicted Effect |
|
| Predicted Effect |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000223257
AA Change: E1974G
PolyPhen 2
Score 0.321 (Sensitivity: 0.90; Specificity: 0.89)
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 100.0%
- 10x: 99.8%
- 20x: 99.3%
|
| Validation Efficiency |
100% (83/83) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes one of the proteins important for centrosomal function. This protein is important for positioning and anchoring the microtubules minus-ends in epithelial cells. Localization of this protein to the centrosome requires three leucine zippers in the central coiled-coil domain. Multiple alternatively spliced transcript variants that encode different isoforms have been reported. [provided by RefSeq, Jul 2008]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 84 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 2610008E11Rik |
G |
A |
10: 78,928,285 (GRCm39) |
P68S |
possibly damaging |
Het |
| Abcb5 |
T |
A |
12: 118,831,620 (GRCm39) |
N1244I |
possibly damaging |
Het |
| Abcb9 |
A |
G |
5: 124,215,304 (GRCm39) |
I479T |
probably damaging |
Het |
| Abi3bp |
A |
T |
16: 56,495,437 (GRCm39) |
I920F |
probably damaging |
Het |
| Adcy6 |
T |
A |
15: 98,496,881 (GRCm39) |
T465S |
probably damaging |
Het |
| Ankrd12 |
A |
T |
17: 66,290,153 (GRCm39) |
I1760N |
possibly damaging |
Het |
| Aoah |
C |
T |
13: 21,035,840 (GRCm39) |
R140C |
probably benign |
Het |
| Bmp7 |
T |
A |
2: 172,712,060 (GRCm39) |
D388V |
probably benign |
Het |
| Bphl |
C |
T |
13: 34,244,468 (GRCm39) |
A195V |
probably benign |
Het |
| Cckar |
A |
G |
5: 53,857,291 (GRCm39) |
V373A |
probably damaging |
Het |
| Cd79b |
T |
G |
11: 106,202,873 (GRCm39) |
D243A |
possibly damaging |
Het |
| Cdc25a |
T |
A |
9: 109,716,416 (GRCm39) |
|
probably null |
Het |
| Cfap57 |
T |
A |
4: 118,439,111 (GRCm39) |
Q805L |
possibly damaging |
Het |
| Ckap2l |
A |
T |
2: 129,111,172 (GRCm39) |
M675K |
possibly damaging |
Het |
| Cluap1 |
T |
A |
16: 3,735,787 (GRCm39) |
|
probably benign |
Het |
| Cyp2b9 |
A |
G |
7: 25,898,167 (GRCm39) |
|
probably benign |
Het |
| D930020B18Rik |
G |
A |
10: 121,503,568 (GRCm39) |
G248S |
possibly damaging |
Het |
| Ddx1 |
A |
T |
12: 13,273,993 (GRCm39) |
I570N |
probably damaging |
Het |
| Dmkn |
G |
A |
7: 30,463,449 (GRCm39) |
S34N |
probably benign |
Het |
| Dnaaf2 |
T |
C |
12: 69,244,068 (GRCm39) |
D331G |
probably damaging |
Het |
| Dnah1 |
A |
T |
14: 31,018,232 (GRCm39) |
Y1429N |
possibly damaging |
Het |
| Dnajc5b |
T |
A |
3: 19,600,981 (GRCm39) |
L26Q |
probably damaging |
Het |
| Epb41l1 |
T |
G |
2: 156,345,722 (GRCm39) |
F242V |
possibly damaging |
Het |
| Esam |
A |
T |
9: 37,442,927 (GRCm39) |
I72F |
probably benign |
Het |
| Fam110a |
C |
T |
2: 151,812,338 (GRCm39) |
R144H |
probably damaging |
Het |
| Fam186a |
T |
C |
15: 99,841,024 (GRCm39) |
D1740G |
possibly damaging |
Het |
| Fam98a |
A |
G |
17: 75,854,684 (GRCm39) |
F42L |
possibly damaging |
Het |
| Fras1 |
C |
T |
5: 96,903,236 (GRCm39) |
P3038S |
probably damaging |
Het |
| Gm32742 |
C |
A |
9: 51,059,140 (GRCm39) |
G1035C |
probably damaging |
Het |
| Irf5 |
T |
A |
6: 29,535,026 (GRCm39) |
|
probably benign |
Het |
| Jam2 |
T |
A |
16: 84,606,259 (GRCm39) |
I91K |
possibly damaging |
Het |
| Klhdc3 |
A |
G |
17: 46,991,626 (GRCm39) |
|
probably benign |
Het |
| Lgi1 |
C |
T |
19: 38,289,296 (GRCm39) |
S215F |
possibly damaging |
Het |
| Lrp1 |
G |
A |
10: 127,374,946 (GRCm39) |
T4504I |
probably damaging |
Het |
| Mafa |
T |
A |
15: 75,619,224 (GRCm39) |
H183L |
probably benign |
Het |
| Map2 |
T |
C |
1: 66,477,997 (GRCm39) |
V1773A |
probably damaging |
Het |
| Mesp1 |
G |
A |
7: 79,442,825 (GRCm39) |
R151* |
probably null |
Het |
| Mphosph9 |
T |
C |
5: 124,453,736 (GRCm39) |
D192G |
probably damaging |
Het |
| Mthfr |
C |
A |
4: 148,139,991 (GRCm39) |
D678E |
probably benign |
Het |
| Myo15a |
A |
C |
11: 60,367,362 (GRCm39) |
T41P |
possibly damaging |
Het |
| Myo15a |
G |
T |
11: 60,378,047 (GRCm39) |
R185L |
|
Het |
| Myom2 |
T |
G |
8: 15,169,242 (GRCm39) |
L1136W |
probably damaging |
Het |
| Naa30 |
A |
G |
14: 49,418,208 (GRCm39) |
D316G |
probably benign |
Het |
| Ngef |
T |
C |
1: 87,405,319 (GRCm39) |
Q697R |
probably benign |
Het |
| Obox8 |
A |
T |
7: 14,066,908 (GRCm39) |
Y45* |
probably null |
Het |
| Ocln |
C |
T |
13: 100,642,727 (GRCm39) |
V452I |
probably benign |
Het |
| Oog3 |
T |
A |
4: 143,885,710 (GRCm39) |
D296V |
possibly damaging |
Het |
| Or5a1 |
T |
C |
19: 12,097,906 (GRCm39) |
N57D |
probably damaging |
Het |
| Or5h19 |
T |
C |
16: 58,856,580 (GRCm39) |
I173M |
possibly damaging |
Het |
| Or8g4 |
T |
A |
9: 39,662,204 (GRCm39) |
I174K |
probably damaging |
Het |
| Or8k35 |
T |
C |
2: 86,424,278 (GRCm39) |
K298R |
possibly damaging |
Het |
| Papln |
T |
C |
12: 83,823,918 (GRCm39) |
V499A |
probably benign |
Het |
| Paxip1 |
G |
T |
5: 27,977,078 (GRCm39) |
P328Q |
unknown |
Het |
| Pcnx2 |
T |
C |
8: 126,604,306 (GRCm39) |
H650R |
probably benign |
Het |
| Pcnx3 |
A |
T |
19: 5,735,206 (GRCm39) |
V540E |
possibly damaging |
Het |
| Pnpla5 |
C |
T |
15: 84,002,819 (GRCm39) |
G255R |
probably damaging |
Het |
| Ppdpf |
G |
T |
2: 180,829,646 (GRCm39) |
E34* |
probably null |
Het |
| Pum3 |
T |
C |
19: 27,394,199 (GRCm39) |
Y357C |
probably damaging |
Het |
| R3hdm2 |
T |
G |
10: 127,293,521 (GRCm39) |
S142A |
probably damaging |
Het |
| Rasa3 |
A |
T |
8: 13,727,391 (GRCm39) |
|
probably null |
Het |
| Rcor2 |
T |
A |
19: 7,246,340 (GRCm39) |
M5K |
possibly damaging |
Het |
| Rere |
A |
G |
4: 150,593,332 (GRCm39) |
T309A |
unknown |
Het |
| Ryr1 |
A |
T |
7: 28,776,297 (GRCm39) |
I2250N |
probably damaging |
Het |
| Sema6c |
T |
C |
3: 95,075,341 (GRCm39) |
V130A |
probably benign |
Het |
| Slc26a9 |
T |
A |
1: 131,683,155 (GRCm39) |
S200T |
probably damaging |
Het |
| Slc38a10 |
A |
G |
11: 120,023,519 (GRCm39) |
L299P |
possibly damaging |
Het |
| Smim10l1 |
G |
T |
6: 133,084,848 (GRCm39) |
V72L |
unknown |
Het |
| Sptbn2 |
C |
A |
19: 4,782,052 (GRCm39) |
F430L |
probably damaging |
Het |
| Svep1 |
T |
A |
4: 58,118,145 (GRCm39) |
Y859F |
possibly damaging |
Het |
| Svil |
C |
A |
18: 5,056,098 (GRCm39) |
Q324K |
possibly damaging |
Het |
| Tgfb1i1 |
A |
T |
7: 127,852,049 (GRCm39) |
D377V |
probably damaging |
Het |
| Tmed10 |
C |
A |
12: 85,390,254 (GRCm39) |
W203L |
probably damaging |
Het |
| Tmem51 |
T |
A |
4: 141,765,056 (GRCm39) |
M1L |
possibly damaging |
Het |
| Tmprss11e |
A |
G |
5: 86,855,259 (GRCm39) |
V382A |
probably benign |
Het |
| Tnfrsf13b |
G |
T |
11: 61,038,350 (GRCm39) |
R211L |
possibly damaging |
Het |
| Tns3 |
A |
G |
11: 8,468,273 (GRCm39) |
V317A |
probably damaging |
Het |
| Top3a |
G |
A |
11: 60,631,363 (GRCm39) |
P1000S |
possibly damaging |
Het |
| Traj32 |
A |
T |
14: 54,423,587 (GRCm39) |
I10F |
|
Het |
| Trav8-1 |
T |
A |
14: 53,707,677 (GRCm39) |
C106S |
probably damaging |
Het |
| Trbv2 |
A |
G |
6: 41,024,655 (GRCm39) |
I24V |
probably benign |
Het |
| Ubap2 |
A |
G |
4: 41,209,351 (GRCm39) |
|
probably null |
Het |
| Vmn2r97 |
T |
A |
17: 19,160,472 (GRCm39) |
C536S |
probably damaging |
Het |
| Zfp879 |
G |
T |
11: 50,723,429 (GRCm39) |
C542* |
probably null |
Het |
| Znfx1 |
C |
T |
2: 166,892,500 (GRCm39) |
|
probably benign |
Het |
|
| Other mutations in Nin |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00472:Nin
|
APN |
12 |
70,076,862 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL00677:Nin
|
APN |
12 |
70,073,634 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00823:Nin
|
APN |
12 |
70,061,567 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL01103:Nin
|
APN |
12 |
70,103,532 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01113:Nin
|
APN |
12 |
70,078,553 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01420:Nin
|
APN |
12 |
70,092,188 (GRCm39) |
missense |
probably benign |
0.08 |
|
IGL01556:Nin
|
APN |
12 |
70,089,962 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL01663:Nin
|
APN |
12 |
70,090,439 (GRCm39) |
missense |
possibly damaging |
0.72 |
|
IGL02002:Nin
|
APN |
12 |
70,109,473 (GRCm39) |
nonsense |
probably null |
|
|
IGL02030:Nin
|
APN |
12 |
70,092,042 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02202:Nin
|
APN |
12 |
70,102,210 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02207:Nin
|
APN |
12 |
70,103,431 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02257:Nin
|
APN |
12 |
70,149,465 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
IGL02394:Nin
|
APN |
12 |
70,090,805 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02531:Nin
|
APN |
12 |
70,067,706 (GRCm39) |
missense |
probably benign |
0.02 |
|
IGL03028:Nin
|
APN |
12 |
70,082,044 (GRCm39) |
missense |
probably benign |
0.13 |
|
IGL03155:Nin
|
APN |
12 |
70,078,544 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03197:Nin
|
APN |
12 |
70,073,584 (GRCm39) |
missense |
probably benign |
0.03 |
|
IGL02835:Nin
|
UTSW |
12 |
70,103,512 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0131:Nin
|
UTSW |
12 |
70,097,915 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0131:Nin
|
UTSW |
12 |
70,097,915 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0132:Nin
|
UTSW |
12 |
70,097,915 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0211:Nin
|
UTSW |
12 |
70,061,649 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0211:Nin
|
UTSW |
12 |
70,061,649 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0734:Nin
|
UTSW |
12 |
70,076,887 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0947:Nin
|
UTSW |
12 |
70,107,960 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1085:Nin
|
UTSW |
12 |
70,067,736 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R1367:Nin
|
UTSW |
12 |
70,090,703 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1452:Nin
|
UTSW |
12 |
70,064,424 (GRCm39) |
nonsense |
probably null |
|
|
R1477:Nin
|
UTSW |
12 |
70,090,958 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R1518:Nin
|
UTSW |
12 |
70,061,547 (GRCm39) |
missense |
probably benign |
0.27 |
|
R1566:Nin
|
UTSW |
12 |
70,101,253 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1572:Nin
|
UTSW |
12 |
70,085,524 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1583:Nin
|
UTSW |
12 |
70,078,512 (GRCm39) |
missense |
probably benign |
|
|
R1584:Nin
|
UTSW |
12 |
70,089,443 (GRCm39) |
missense |
probably benign |
0.03 |
|
R1699:Nin
|
UTSW |
12 |
70,092,337 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R1699:Nin
|
UTSW |
12 |
70,077,712 (GRCm39) |
missense |
probably benign |
0.40 |
|
R1765:Nin
|
UTSW |
12 |
70,089,665 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1794:Nin
|
UTSW |
12 |
70,090,569 (GRCm39) |
nonsense |
probably null |
|
|
R1952:Nin
|
UTSW |
12 |
70,077,700 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2004:Nin
|
UTSW |
12 |
70,072,251 (GRCm39) |
missense |
probably benign |
0.01 |
|
R2025:Nin
|
UTSW |
12 |
70,076,782 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2060:Nin
|
UTSW |
12 |
70,089,192 (GRCm39) |
missense |
possibly damaging |
0.64 |
|
R2213:Nin
|
UTSW |
12 |
70,092,128 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2224:Nin
|
UTSW |
12 |
70,108,004 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2247:Nin
|
UTSW |
12 |
70,101,319 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2972:Nin
|
UTSW |
12 |
70,109,487 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3776:Nin
|
UTSW |
12 |
70,085,456 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R3881:Nin
|
UTSW |
12 |
70,089,315 (GRCm39) |
missense |
probably benign |
0.00 |
|
R3930:Nin
|
UTSW |
12 |
70,125,016 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3959:Nin
|
UTSW |
12 |
70,097,526 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4229:Nin
|
UTSW |
12 |
70,097,984 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4359:Nin
|
UTSW |
12 |
70,061,712 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4423:Nin
|
UTSW |
12 |
70,089,752 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4461:Nin
|
UTSW |
12 |
70,089,359 (GRCm39) |
missense |
probably benign |
0.37 |
|
R4639:Nin
|
UTSW |
12 |
70,085,375 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R4791:Nin
|
UTSW |
12 |
70,090,581 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R4839:Nin
|
UTSW |
12 |
70,137,325 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R4912:Nin
|
UTSW |
12 |
70,090,837 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5712:Nin
|
UTSW |
12 |
70,089,543 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5726:Nin
|
UTSW |
12 |
70,124,953 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5804:Nin
|
UTSW |
12 |
70,092,375 (GRCm39) |
missense |
possibly damaging |
0.58 |
|
R5874:Nin
|
UTSW |
12 |
70,077,692 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R5992:Nin
|
UTSW |
12 |
70,092,298 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R6077:Nin
|
UTSW |
12 |
70,066,006 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6184:Nin
|
UTSW |
12 |
70,090,511 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6307:Nin
|
UTSW |
12 |
70,061,631 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R6315:Nin
|
UTSW |
12 |
70,092,389 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6326:Nin
|
UTSW |
12 |
70,091,955 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R6492:Nin
|
UTSW |
12 |
70,101,308 (GRCm39) |
missense |
probably benign |
0.22 |
|
R6562:Nin
|
UTSW |
12 |
70,102,728 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6578:Nin
|
UTSW |
12 |
70,107,968 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6613:Nin
|
UTSW |
12 |
70,077,728 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7112:Nin
|
UTSW |
12 |
70,149,573 (GRCm39) |
missense |
|
|
|
R7170:Nin
|
UTSW |
12 |
70,091,013 (GRCm39) |
missense |
|
|
|
R7324:Nin
|
UTSW |
12 |
70,090,508 (GRCm39) |
missense |
|
|
|
R7338:Nin
|
UTSW |
12 |
70,090,838 (GRCm39) |
missense |
|
|
|
R7372:Nin
|
UTSW |
12 |
70,102,803 (GRCm39) |
missense |
|
|
|
R7431:Nin
|
UTSW |
12 |
70,124,997 (GRCm39) |
missense |
|
|
|
R7577:Nin
|
UTSW |
12 |
70,109,480 (GRCm39) |
missense |
|
|
|
R7655:Nin
|
UTSW |
12 |
70,089,542 (GRCm39) |
missense |
|
|
|
R7656:Nin
|
UTSW |
12 |
70,089,542 (GRCm39) |
missense |
|
|
|
R7683:Nin
|
UTSW |
12 |
70,124,956 (GRCm39) |
missense |
|
|
|
R7769:Nin
|
UTSW |
12 |
70,090,004 (GRCm39) |
missense |
|
|
|
R7981:Nin
|
UTSW |
12 |
70,089,591 (GRCm39) |
missense |
|
|
|
R8138:Nin
|
UTSW |
12 |
70,089,672 (GRCm39) |
missense |
|
|
|
R8141:Nin
|
UTSW |
12 |
70,076,795 (GRCm39) |
missense |
|
|
|
R8754:Nin
|
UTSW |
12 |
70,077,787 (GRCm39) |
intron |
probably benign |
|
|
R8899:Nin
|
UTSW |
12 |
70,077,710 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8974:Nin
|
UTSW |
12 |
70,124,932 (GRCm39) |
missense |
|
|
|
R9085:Nin
|
UTSW |
12 |
70,076,786 (GRCm39) |
nonsense |
probably null |
|
|
R9143:Nin
|
UTSW |
12 |
70,137,349 (GRCm39) |
missense |
|
|
|
R9380:Nin
|
UTSW |
12 |
70,074,805 (GRCm39) |
missense |
|
|
|
R9496:Nin
|
UTSW |
12 |
70,102,762 (GRCm39) |
missense |
|
|
|
R9638:Nin
|
UTSW |
12 |
70,067,618 (GRCm39) |
missense |
|
|
|
R9709:Nin
|
UTSW |
12 |
70,149,468 (GRCm39) |
missense |
|
|
|
R9745:Nin
|
UTSW |
12 |
70,089,899 (GRCm39) |
missense |
|
|
|
R9792:Nin
|
UTSW |
12 |
70,094,009 (GRCm39) |
missense |
|
|
|
Z1176:Nin
|
UTSW |
12 |
70,095,938 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
Z1177:Nin
|
UTSW |
12 |
70,101,200 (GRCm39) |
missense |
|
|
|
Z1177:Nin
|
UTSW |
12 |
70,090,869 (GRCm39) |
missense |
|
|
|
| Predicted Primers |
PCR Primer
(F):5'- CGGGAGAAGAACACTCTGTAC -3'
(R):5'- GAGTTATCTCCAGGGAGCAAC -3'
Sequencing Primer
(F):5'- AAGAACACTCTGTACCTGTGGTG -3'
(R):5'- GAGCAACAAAAGGGTTCTTCC -3'
|
| Posted On |
2021-04-30 |
Incidental Mutation