Incidental Mutation 'R8791:Gpr179'
ID 670955
Institutional Source Beutler Lab
Gene Symbol Gpr179
Ensembl Gene ENSMUSG00000070337
Gene Name G protein-coupled receptor 179
Synonyms 5330439C02Rik
MMRRC Submission 068609-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.081) question?
Stock # R8791 (G1)
Quality Score 225.009
Status Validated
Chromosome 11
Chromosomal Location 97222935-97242903 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 97242739 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Leucine to Glutamine at position 35 (L35Q)
Ref Sequence ENSEMBL: ENSMUSP00000091474 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000093942]
AlphaFold E9PY61
Predicted Effect probably damaging
Transcript: ENSMUST00000093942
AA Change: L35Q

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000091474
Gene: ENSMUSG00000070337
AA Change: L35Q

DomainStartEndE-ValueType
signal peptide 1 27 N/A INTRINSIC
low complexity region 28 41 N/A INTRINSIC
EGF 281 357 1.91e1 SMART
Pfam:7tm_3 391 633 3.2e-40 PFAM
low complexity region 735 759 N/A INTRINSIC
low complexity region 868 880 N/A INTRINSIC
low complexity region 896 916 N/A INTRINSIC
low complexity region 959 988 N/A INTRINSIC
low complexity region 1107 1125 N/A INTRINSIC
internal_repeat_2 1156 1467 1.99e-12 PROSPERO
internal_repeat_1 1235 1674 2.85e-27 PROSPERO
internal_repeat_2 1569 1879 1.99e-12 PROSPERO
internal_repeat_1 1756 2284 2.85e-27 PROSPERO
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.7%
  • 20x: 99.1%
Validation Efficiency 100% (47/47)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the glutamate receptor subfamily of G protein-coupled receptors. The encoded protein has an EGF-like calcium binding domain and a seven transmembrane domain in the N-terminal region of the protein. Mutations in this gene are associated with congenital stationary night blindness type 1E. [provided by RefSeq, Apr 2012]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit absence of b wave without retinal abnormalities. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 47 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4931422A03Rik G T 2: 103,823,022 (GRCm39) T87K possibly damaging Het
Adar G A 3: 89,643,445 (GRCm39) R442Q probably benign Het
Agtr1b T A 3: 20,370,280 (GRCm39) S109C probably damaging Het
Akr1c6 T A 13: 4,499,373 (GRCm39) Y248N probably benign Het
Alpk2 A T 18: 65,438,597 (GRCm39) V932E probably benign Het
Apba3 T A 10: 81,105,104 (GRCm39) S126T probably benign Het
Brca2 T A 5: 150,466,061 (GRCm39) S1942T possibly damaging Het
Ccdc149 C T 5: 52,596,552 (GRCm39) C20Y probably damaging Het
Cd63 C A 10: 128,748,071 (GRCm39) N156K probably benign Het
Clvs1 A G 4: 9,429,807 (GRCm39) E270G probably damaging Het
Cplane1 A G 15: 8,216,744 (GRCm39) Y654C probably damaging Het
Dgki A T 6: 36,996,875 (GRCm39) D574E probably damaging Het
Esrrb A G 12: 86,517,056 (GRCm39) S63G probably damaging Het
Exoc1 C T 5: 76,683,412 (GRCm39) R46C probably damaging Het
Fcgr4 C A 1: 170,847,477 (GRCm39) A25D probably damaging Het
Fgf4 T C 7: 144,415,408 (GRCm39) V56A probably benign Het
Gfpt2 A G 11: 49,714,043 (GRCm39) I267V probably benign Het
Gm20939 A C 17: 95,184,648 (GRCm39) H432P probably damaging Het
Idh1 CA CAA 1: 65,204,347 (GRCm39) probably null Het
Ildr1 T C 16: 36,528,762 (GRCm39) I69T probably damaging Het
Lrfn1 A G 7: 28,159,344 (GRCm39) D421G probably benign Het
Mmp15 C T 8: 96,096,288 (GRCm39) Q360* probably null Het
Nfatc2 T C 2: 168,378,214 (GRCm39) K484E probably damaging Het
Nkpd1 G C 7: 19,258,095 (GRCm39) V625L probably benign Het
Nlrp4a C A 7: 26,143,561 (GRCm39) probably benign Het
Nme9 T A 9: 99,350,301 (GRCm39) I178N probably damaging Het
Nrp2 C T 1: 62,788,356 (GRCm39) T352I probably damaging Het
Ntrk1 T C 3: 87,686,990 (GRCm39) I723V probably damaging Het
Or5p50 C T 7: 107,422,557 (GRCm39) V40M possibly damaging Het
Pias3 C A 3: 96,612,201 (GRCm39) Q553K probably benign Het
Pnp2 T G 14: 51,200,873 (GRCm39) H119Q probably benign Het
Rapgef6 T A 11: 54,459,295 (GRCm39) D156E probably benign Het
Rint1 T C 5: 24,005,594 (GRCm39) V92A probably damaging Het
Rnf148 A T 6: 23,654,993 (GRCm39) M1K probably null Het
Rnh1 C T 7: 140,742,346 (GRCm39) R404H probably benign Het
Slc4a8 T C 15: 100,705,134 (GRCm39) V832A possibly damaging Het
Snx31 A T 15: 36,537,678 (GRCm39) C167S probably benign Het
Spart A G 3: 55,029,100 (GRCm39) D297G probably benign Het
Spata13 C T 14: 60,929,275 (GRCm39) R278C probably damaging Het
Tmc1 T C 19: 20,767,209 (GRCm39) T716A probably benign Het
Tpi1 A G 6: 124,789,483 (GRCm39) V164A probably damaging Het
Trim17 A G 11: 58,862,002 (GRCm39) S345G probably benign Het
Vmn1r199 T A 13: 22,567,687 (GRCm39) L327Q probably damaging Het
Washc4 C T 10: 83,386,748 (GRCm39) T124I probably benign Het
Wdr76 C T 2: 121,357,484 (GRCm39) T180I probably benign Het
Zcchc8 T C 5: 123,845,362 (GRCm39) N333D probably benign Het
Zfp516 T C 18: 82,975,460 (GRCm39) S553P probably damaging Het
Other mutations in Gpr179
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01088:Gpr179 APN 11 97,228,627 (GRCm39) missense probably damaging 0.99
IGL01152:Gpr179 APN 11 97,228,237 (GRCm39) missense probably benign 0.08
IGL01402:Gpr179 APN 11 97,229,012 (GRCm39) nonsense probably null
IGL01404:Gpr179 APN 11 97,229,012 (GRCm39) nonsense probably null
IGL01773:Gpr179 APN 11 97,232,192 (GRCm39) missense probably benign 0.05
IGL02682:Gpr179 APN 11 97,242,691 (GRCm39) missense probably benign
IGL02728:Gpr179 APN 11 97,228,726 (GRCm39) missense probably damaging 0.99
IGL03243:Gpr179 APN 11 97,242,301 (GRCm39) missense probably benign 0.02
IGL03272:Gpr179 APN 11 97,227,419 (GRCm39) missense possibly damaging 0.89
IGL03347:Gpr179 APN 11 97,242,664 (GRCm39) missense probably damaging 1.00
IGL03355:Gpr179 APN 11 97,228,434 (GRCm39) missense possibly damaging 0.57
PIT4280001:Gpr179 UTSW 11 97,234,941 (GRCm39) missense probably damaging 1.00
PIT4366001:Gpr179 UTSW 11 97,227,677 (GRCm39) missense probably benign
R0042:Gpr179 UTSW 11 97,225,757 (GRCm39) missense probably benign 0.04
R0042:Gpr179 UTSW 11 97,225,757 (GRCm39) missense probably benign 0.04
R0080:Gpr179 UTSW 11 97,242,295 (GRCm39) missense probably benign 0.08
R0255:Gpr179 UTSW 11 97,226,892 (GRCm39) missense probably benign 0.24
R0412:Gpr179 UTSW 11 97,229,633 (GRCm39) missense probably damaging 1.00
R0481:Gpr179 UTSW 11 97,240,544 (GRCm39) missense probably damaging 1.00
R0612:Gpr179 UTSW 11 97,229,264 (GRCm39) missense possibly damaging 0.86
R0786:Gpr179 UTSW 11 97,234,100 (GRCm39) missense probably damaging 1.00
R1753:Gpr179 UTSW 11 97,237,404 (GRCm39) missense probably damaging 1.00
R1761:Gpr179 UTSW 11 97,225,932 (GRCm39) missense probably benign 0.00
R1796:Gpr179 UTSW 11 97,227,382 (GRCm39) missense possibly damaging 0.86
R1969:Gpr179 UTSW 11 97,228,784 (GRCm39) missense probably benign
R2240:Gpr179 UTSW 11 97,242,559 (GRCm39) missense probably damaging 1.00
R3855:Gpr179 UTSW 11 97,232,260 (GRCm39) missense probably damaging 1.00
R3913:Gpr179 UTSW 11 97,225,591 (GRCm39) missense probably benign 0.01
R4484:Gpr179 UTSW 11 97,226,537 (GRCm39) missense probably benign 0.28
R4806:Gpr179 UTSW 11 97,240,610 (GRCm39) missense possibly damaging 0.55
R4816:Gpr179 UTSW 11 97,230,074 (GRCm39) missense probably damaging 0.99
R4906:Gpr179 UTSW 11 97,237,487 (GRCm39) missense possibly damaging 0.87
R4945:Gpr179 UTSW 11 97,240,544 (GRCm39) missense probably damaging 1.00
R5191:Gpr179 UTSW 11 97,228,975 (GRCm39) missense possibly damaging 0.76
R5273:Gpr179 UTSW 11 97,238,256 (GRCm39) missense probably damaging 1.00
R5317:Gpr179 UTSW 11 97,228,671 (GRCm39) missense probably damaging 1.00
R5459:Gpr179 UTSW 11 97,227,483 (GRCm39) missense probably benign 0.00
R5507:Gpr179 UTSW 11 97,229,156 (GRCm39) missense probably damaging 1.00
R5523:Gpr179 UTSW 11 97,227,608 (GRCm39) missense probably benign 0.37
R5536:Gpr179 UTSW 11 97,234,641 (GRCm39) missense probably damaging 1.00
R5591:Gpr179 UTSW 11 97,236,581 (GRCm39) missense probably benign 0.17
R5679:Gpr179 UTSW 11 97,227,571 (GRCm39) missense probably benign 0.20
R5738:Gpr179 UTSW 11 97,242,232 (GRCm39) missense probably damaging 1.00
R5829:Gpr179 UTSW 11 97,226,524 (GRCm39) missense probably benign 0.11
R5836:Gpr179 UTSW 11 97,229,882 (GRCm39) missense probably benign 0.03
R6007:Gpr179 UTSW 11 97,226,628 (GRCm39) nonsense probably null
R6047:Gpr179 UTSW 11 97,229,242 (GRCm39) missense probably damaging 1.00
R6339:Gpr179 UTSW 11 97,235,002 (GRCm39) missense probably damaging 1.00
R6383:Gpr179 UTSW 11 97,227,973 (GRCm39) missense possibly damaging 0.88
R6674:Gpr179 UTSW 11 97,238,231 (GRCm39) critical splice donor site probably null
R6712:Gpr179 UTSW 11 97,226,993 (GRCm39) missense possibly damaging 0.94
R6835:Gpr179 UTSW 11 97,238,293 (GRCm39) missense probably damaging 1.00
R6980:Gpr179 UTSW 11 97,225,684 (GRCm39) missense probably benign 0.38
R7044:Gpr179 UTSW 11 97,240,616 (GRCm39) missense probably benign 0.19
R7121:Gpr179 UTSW 11 97,225,556 (GRCm39) missense probably benign 0.00
R7307:Gpr179 UTSW 11 97,229,672 (GRCm39) missense probably benign 0.36
R7406:Gpr179 UTSW 11 97,242,420 (GRCm39) missense probably damaging 0.99
R7467:Gpr179 UTSW 11 97,226,115 (GRCm39) missense probably benign 0.02
R7477:Gpr179 UTSW 11 97,226,665 (GRCm39) missense possibly damaging 0.87
R7725:Gpr179 UTSW 11 97,242,118 (GRCm39) missense probably damaging 1.00
R8028:Gpr179 UTSW 11 97,228,627 (GRCm39) missense probably damaging 0.99
R8165:Gpr179 UTSW 11 97,242,364 (GRCm39) missense probably benign 0.12
R8262:Gpr179 UTSW 11 97,226,983 (GRCm39) missense probably benign 0.00
R8674:Gpr179 UTSW 11 97,225,873 (GRCm39) missense probably benign 0.00
R8695:Gpr179 UTSW 11 97,227,124 (GRCm39) missense possibly damaging 0.59
R8731:Gpr179 UTSW 11 97,234,555 (GRCm39) missense probably damaging 1.00
R8889:Gpr179 UTSW 11 97,226,590 (GRCm39) missense possibly damaging 0.95
R8892:Gpr179 UTSW 11 97,226,590 (GRCm39) missense possibly damaging 0.95
R8898:Gpr179 UTSW 11 97,242,329 (GRCm39) nonsense probably null
R8940:Gpr179 UTSW 11 97,228,675 (GRCm39) missense probably damaging 1.00
R9266:Gpr179 UTSW 11 97,227,766 (GRCm39) missense probably benign
R9332:Gpr179 UTSW 11 97,229,551 (GRCm39) missense probably damaging 1.00
R9440:Gpr179 UTSW 11 97,229,315 (GRCm39) missense probably benign 0.11
R9557:Gpr179 UTSW 11 97,235,029 (GRCm39) missense probably damaging 0.97
R9594:Gpr179 UTSW 11 97,225,727 (GRCm39) missense probably benign 0.13
R9723:Gpr179 UTSW 11 97,225,546 (GRCm39) missense possibly damaging 0.93
X0065:Gpr179 UTSW 11 97,238,264 (GRCm39) missense probably benign 0.08
Z1176:Gpr179 UTSW 11 97,227,474 (GRCm39) missense probably benign 0.05
Z1177:Gpr179 UTSW 11 97,242,065 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TGAGAAAGTTGGCAGCCTG -3'
(R):5'- TCAGACTGTATGCCAGCCTC -3'

Sequencing Primer
(F):5'- CGCTGCTCTCTGTAGGACTG -3'
(R):5'- GTATGCCAGCCTCTGCCTG -3'
Posted On 2021-04-30