Incidental Mutation 'R8791:Snx31'
ID 670962
Institutional Source Beutler Lab
Gene Symbol Snx31
Ensembl Gene ENSMUSG00000013611
Gene Name sorting nexin 31
Synonyms 4631426E05Rik
MMRRC Submission 068609-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R8791 (G1)
Quality Score 225.009
Status Validated
Chromosome 15
Chromosomal Location 36504208-36555718 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 36537678 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Cysteine to Serine at position 167 (C167S)
Ref Sequence ENSEMBL: ENSMUSP00000124063 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000013755] [ENSMUST00000161202]
AlphaFold Q6P8Y7
Predicted Effect probably benign
Transcript: ENSMUST00000013755
AA Change: C167S

PolyPhen 2 Score 0.017 (Sensitivity: 0.95; Specificity: 0.80)
SMART Domains Protein: ENSMUSP00000013755
Gene: ENSMUSG00000013611
AA Change: C167S

DomainStartEndE-ValueType
PX 1 105 5.44e-9 SMART
PDB:4GXB|A 112 382 1e-64 PDB
Blast:B41 115 324 1e-49 BLAST
Predicted Effect probably benign
Transcript: ENSMUST00000161202
AA Change: C167S

PolyPhen 2 Score 0.010 (Sensitivity: 0.96; Specificity: 0.77)
SMART Domains Protein: ENSMUSP00000124063
Gene: ENSMUSG00000013611
AA Change: C167S

DomainStartEndE-ValueType
PX 1 105 5.44e-9 SMART
PDB:4GXB|A 112 382 1e-64 PDB
Blast:B41 115 324 1e-49 BLAST
Meta Mutation Damage Score 0.0846 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.7%
  • 20x: 99.1%
Validation Efficiency 100% (47/47)
Allele List at MGI
Other mutations in this stock
Total: 47 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4931422A03Rik G T 2: 103,823,022 (GRCm39) T87K possibly damaging Het
Adar G A 3: 89,643,445 (GRCm39) R442Q probably benign Het
Agtr1b T A 3: 20,370,280 (GRCm39) S109C probably damaging Het
Akr1c6 T A 13: 4,499,373 (GRCm39) Y248N probably benign Het
Alpk2 A T 18: 65,438,597 (GRCm39) V932E probably benign Het
Apba3 T A 10: 81,105,104 (GRCm39) S126T probably benign Het
Brca2 T A 5: 150,466,061 (GRCm39) S1942T possibly damaging Het
Ccdc149 C T 5: 52,596,552 (GRCm39) C20Y probably damaging Het
Cd63 C A 10: 128,748,071 (GRCm39) N156K probably benign Het
Clvs1 A G 4: 9,429,807 (GRCm39) E270G probably damaging Het
Cplane1 A G 15: 8,216,744 (GRCm39) Y654C probably damaging Het
Dgki A T 6: 36,996,875 (GRCm39) D574E probably damaging Het
Esrrb A G 12: 86,517,056 (GRCm39) S63G probably damaging Het
Exoc1 C T 5: 76,683,412 (GRCm39) R46C probably damaging Het
Fcgr4 C A 1: 170,847,477 (GRCm39) A25D probably damaging Het
Fgf4 T C 7: 144,415,408 (GRCm39) V56A probably benign Het
Gfpt2 A G 11: 49,714,043 (GRCm39) I267V probably benign Het
Gm20939 A C 17: 95,184,648 (GRCm39) H432P probably damaging Het
Gpr179 A T 11: 97,242,739 (GRCm39) L35Q probably damaging Het
Idh1 CA CAA 1: 65,204,347 (GRCm39) probably null Het
Ildr1 T C 16: 36,528,762 (GRCm39) I69T probably damaging Het
Lrfn1 A G 7: 28,159,344 (GRCm39) D421G probably benign Het
Mmp15 C T 8: 96,096,288 (GRCm39) Q360* probably null Het
Nfatc2 T C 2: 168,378,214 (GRCm39) K484E probably damaging Het
Nkpd1 G C 7: 19,258,095 (GRCm39) V625L probably benign Het
Nlrp4a C A 7: 26,143,561 (GRCm39) probably benign Het
Nme9 T A 9: 99,350,301 (GRCm39) I178N probably damaging Het
Nrp2 C T 1: 62,788,356 (GRCm39) T352I probably damaging Het
Ntrk1 T C 3: 87,686,990 (GRCm39) I723V probably damaging Het
Or5p50 C T 7: 107,422,557 (GRCm39) V40M possibly damaging Het
Pias3 C A 3: 96,612,201 (GRCm39) Q553K probably benign Het
Pnp2 T G 14: 51,200,873 (GRCm39) H119Q probably benign Het
Rapgef6 T A 11: 54,459,295 (GRCm39) D156E probably benign Het
Rint1 T C 5: 24,005,594 (GRCm39) V92A probably damaging Het
Rnf148 A T 6: 23,654,993 (GRCm39) M1K probably null Het
Rnh1 C T 7: 140,742,346 (GRCm39) R404H probably benign Het
Slc4a8 T C 15: 100,705,134 (GRCm39) V832A possibly damaging Het
Spart A G 3: 55,029,100 (GRCm39) D297G probably benign Het
Spata13 C T 14: 60,929,275 (GRCm39) R278C probably damaging Het
Tmc1 T C 19: 20,767,209 (GRCm39) T716A probably benign Het
Tpi1 A G 6: 124,789,483 (GRCm39) V164A probably damaging Het
Trim17 A G 11: 58,862,002 (GRCm39) S345G probably benign Het
Vmn1r199 T A 13: 22,567,687 (GRCm39) L327Q probably damaging Het
Washc4 C T 10: 83,386,748 (GRCm39) T124I probably benign Het
Wdr76 C T 2: 121,357,484 (GRCm39) T180I probably benign Het
Zcchc8 T C 5: 123,845,362 (GRCm39) N333D probably benign Het
Zfp516 T C 18: 82,975,460 (GRCm39) S553P probably damaging Het
Other mutations in Snx31
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00094:Snx31 APN 15 36,545,761 (GRCm39) critical splice acceptor site probably null
IGL01627:Snx31 APN 15 36,517,818 (GRCm39) missense probably damaging 1.00
IGL02514:Snx31 APN 15 36,525,728 (GRCm39) missense probably damaging 1.00
IGL03069:Snx31 APN 15 36,525,749 (GRCm39) nonsense probably null
IGL03182:Snx31 APN 15 36,525,833 (GRCm39) missense probably benign 0.00
R0755:Snx31 UTSW 15 36,534,576 (GRCm39) missense probably damaging 0.99
R1005:Snx31 UTSW 15 36,517,837 (GRCm39) splice site probably benign
R1463:Snx31 UTSW 15 36,539,444 (GRCm39) missense probably null 1.00
R1513:Snx31 UTSW 15 36,545,745 (GRCm39) missense probably damaging 0.99
R2030:Snx31 UTSW 15 36,525,848 (GRCm39) missense probably benign 0.31
R3404:Snx31 UTSW 15 36,525,799 (GRCm39) missense probably benign 0.00
R3720:Snx31 UTSW 15 36,523,704 (GRCm39) critical splice acceptor site probably null
R4152:Snx31 UTSW 15 36,525,785 (GRCm39) missense probably benign
R4474:Snx31 UTSW 15 36,546,256 (GRCm39) intron probably benign
R4729:Snx31 UTSW 15 36,523,698 (GRCm39) missense possibly damaging 0.92
R4998:Snx31 UTSW 15 36,539,513 (GRCm39) missense probably damaging 0.96
R5010:Snx31 UTSW 15 36,555,469 (GRCm39) missense probably damaging 1.00
R5375:Snx31 UTSW 15 36,525,730 (GRCm39) missense probably damaging 0.99
R5893:Snx31 UTSW 15 36,523,601 (GRCm39) missense probably damaging 0.98
R5970:Snx31 UTSW 15 36,523,634 (GRCm39) nonsense probably null
R6211:Snx31 UTSW 15 36,547,030 (GRCm39) missense probably damaging 0.98
R7198:Snx31 UTSW 15 36,555,455 (GRCm39) missense probably benign 0.04
R7293:Snx31 UTSW 15 36,523,596 (GRCm39) missense probably damaging 0.97
R7329:Snx31 UTSW 15 36,555,621 (GRCm39) missense probably benign 0.00
R7741:Snx31 UTSW 15 36,523,587 (GRCm39) critical splice donor site probably null
R8057:Snx31 UTSW 15 36,523,606 (GRCm39) missense probably damaging 0.98
R8806:Snx31 UTSW 15 36,537,698 (GRCm39) missense probably damaging 1.00
R9349:Snx31 UTSW 15 36,555,430 (GRCm39) missense probably damaging 1.00
R9655:Snx31 UTSW 15 36,534,582 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- GAGCAATGACAGTCTTTTATTCTCC -3'
(R):5'- GTCTACTGGCCTGCAAAAGC -3'

Sequencing Primer
(F):5'- TGCTCATTTAAGACAGGGCC -3'
(R):5'- TGGCCTGCAAAAGCATTCG -3'
Posted On 2021-04-30