Incidental Mutation 'R8794:Nrcam'
| ID |
671134 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Nrcam
|
| Ensembl Gene |
ENSMUSG00000020598 |
| Gene Name |
neuronal cell adhesion molecule |
| Synonyms |
C130076O07Rik, C030017F07Rik, Bravo |
| MMRRC Submission |
068723-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R8794 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
12 |
| Chromosomal Location |
44375668-44648747 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
G to A
at 44624958 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Glycine to Aspartic acid
at position 1055
(G1055D)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000020939
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000020939]
[ENSMUST00000110748]
[ENSMUST00000220123]
|
| AlphaFold |
Q810U4 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000020939
AA Change: G1055D
PolyPhen 2
Score 0.008 (Sensitivity: 0.96; Specificity: 0.76)
|
| SMART Domains |
Protein: ENSMUSP00000020939
Gene: ENSMUSG00000020598
AA Change: G1055D
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
29 |
N/A |
INTRINSIC |
|
IGc2
|
53 |
124 |
5.37e-4 |
SMART |
|
IG
|
146 |
233 |
3.91e-6 |
SMART |
|
IGc2
|
277 |
341 |
1.73e-16 |
SMART |
|
IGc2
|
367 |
433 |
4.85e-11 |
SMART |
|
IGc2
|
461 |
526 |
4.92e-12 |
SMART |
|
IGc2
|
552 |
617 |
6.55e-8 |
SMART |
|
low complexity region
|
618 |
623 |
N/A |
INTRINSIC |
|
FN3
|
641 |
724 |
3.24e-10 |
SMART |
|
FN3
|
738 |
824 |
1.77e-2 |
SMART |
|
FN3
|
840 |
931 |
1.97e-9 |
SMART |
|
FN3
|
946 |
1031 |
3.73e-10 |
SMART |
|
transmembrane domain
|
1120 |
1142 |
N/A |
INTRINSIC |
|
Pfam:Bravo_FIGEY
|
1143 |
1232 |
2.9e-29 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000110748
|
| SMART Domains |
Protein: ENSMUSP00000106376
Gene: ENSMUSG00000020598
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
29 |
N/A |
INTRINSIC |
|
IGc2
|
53 |
124 |
5.37e-4 |
SMART |
|
IG
|
146 |
233 |
3.91e-6 |
SMART |
|
IGc2
|
277 |
341 |
1.73e-16 |
SMART |
|
IGc2
|
367 |
433 |
4.85e-11 |
SMART |
|
IGc2
|
461 |
526 |
4.92e-12 |
SMART |
|
IGc2
|
552 |
617 |
6.55e-8 |
SMART |
|
FN3
|
631 |
714 |
3.24e-10 |
SMART |
|
FN3
|
728 |
814 |
1.77e-2 |
SMART |
|
FN3
|
830 |
921 |
1.97e-9 |
SMART |
|
FN3
|
936 |
1021 |
3.73e-10 |
SMART |
|
transmembrane domain
|
1050 |
1072 |
N/A |
INTRINSIC |
|
Pfam:Bravo_FIGEY
|
1073 |
1164 |
9.3e-35 |
PFAM |
|
| Predicted Effect |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000220123
AA Change: G1061D
PolyPhen 2
Score 0.026 (Sensitivity: 0.95; Specificity: 0.81)
|
| Meta Mutation Damage Score |
0.0598 |
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 100.0%
- 10x: 99.9%
- 20x: 99.6%
|
| Validation Efficiency |
100% (86/86) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Cell adhesion molecules (CAMs) are members of the immunoglobulin superfamily. This gene encodes a neuronal cell adhesion molecule with multiple immunoglobulin-like C2-type domains and fibronectin type-III domains. This ankyrin-binding protein is involved in neuron-neuron adhesion and promotes directional signaling during axonal cone growth. This gene is also expressed in non-neural tissues and may play a general role in cell-cell communication via signaling from its intracellular domain to the actin cytoskeleton during directional cell migration. Allelic variants of this gene have been associated with autism and addiction vulnerability. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
PHENOTYPE: Homozygotes for targeted null mutations exhibit disorganization of lens fibers, cellular disintegration, and accumulation of cellular debris resulting in cataracts. Mutants show mild reductions in cerebellar lobe size. [provided by MGI curators]
|
| Allele List at MGI |
All alleles(9) : Targeted, knock-out(2) Targeted, other(4) Gene trapped(2) Chemically induced(1)
|
| Other mutations in this stock |
Total: 86 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 1700010I14Rik |
T |
A |
17: 9,226,939 (GRCm39) |
V498D |
unknown |
Het |
| Actn1 |
C |
T |
12: 80,245,754 (GRCm39) |
|
probably benign |
Het |
| Actrt2 |
T |
C |
4: 154,751,176 (GRCm39) |
E320G |
probably damaging |
Het |
| Adamts7 |
C |
T |
9: 90,076,239 (GRCm39) |
Q1265* |
probably null |
Het |
| Adra1a |
A |
G |
14: 66,875,064 (GRCm39) |
N13S |
probably benign |
Het |
| Alpk3 |
G |
T |
7: 80,707,403 (GRCm39) |
R9L |
unknown |
Het |
| Ankrd42 |
A |
G |
7: 92,263,674 (GRCm39) |
F225L |
probably benign |
Het |
| C3 |
T |
C |
17: 57,528,011 (GRCm39) |
E736G |
probably benign |
Het |
| Ccng1 |
A |
G |
11: 40,644,826 (GRCm39) |
S24P |
probably benign |
Het |
| Cdc42bpa |
A |
T |
1: 179,894,816 (GRCm39) |
N332I |
probably damaging |
Het |
| Cep131 |
G |
A |
11: 119,972,074 (GRCm39) |
P90S |
probably benign |
Het |
| Chd8 |
A |
G |
14: 52,441,904 (GRCm39) |
S2154P |
probably damaging |
Het |
| Cilp |
A |
G |
9: 65,186,535 (GRCm39) |
S877G |
probably benign |
Het |
| Clic6 |
T |
A |
16: 92,324,987 (GRCm39) |
S382T |
possibly damaging |
Het |
| Coq8a |
G |
T |
1: 180,006,773 (GRCm39) |
P85Q |
probably benign |
Het |
| Creb3l4 |
A |
G |
3: 90,145,225 (GRCm39) |
I309T |
probably benign |
Het |
| Cux2 |
T |
C |
5: 122,007,306 (GRCm39) |
E785G |
probably benign |
Het |
| Cyfip2 |
A |
G |
11: 46,144,800 (GRCm39) |
F685L |
possibly damaging |
Het |
| Epha6 |
T |
C |
16: 60,026,035 (GRCm39) |
D469G |
probably benign |
Het |
| Erc1 |
A |
T |
6: 119,607,616 (GRCm39) |
V962E |
probably damaging |
Het |
| Esrrb |
A |
T |
12: 86,517,038 (GRCm39) |
S57C |
probably damaging |
Het |
| Fam169a |
A |
G |
13: 97,250,628 (GRCm39) |
T320A |
possibly damaging |
Het |
| Farsb |
C |
T |
1: 78,401,678 (GRCm39) |
|
probably benign |
Het |
| Frem3 |
T |
C |
8: 81,338,907 (GRCm39) |
V400A |
probably damaging |
Het |
| Frem3 |
A |
T |
8: 81,342,851 (GRCm39) |
M1715L |
probably benign |
Het |
| Frmpd1 |
A |
G |
4: 45,279,632 (GRCm39) |
T786A |
probably benign |
Het |
| Gapvd1 |
A |
T |
2: 34,594,330 (GRCm39) |
S886T |
possibly damaging |
Het |
| Gba2 |
A |
G |
4: 43,568,077 (GRCm39) |
S737P |
probably damaging |
Het |
| Gm525 |
A |
G |
11: 88,979,479 (GRCm39) |
N85S |
probably damaging |
Het |
| Gnpda1 |
T |
A |
18: 38,465,091 (GRCm39) |
D175V |
probably benign |
Het |
| Heatr5b |
T |
C |
17: 79,123,015 (GRCm39) |
I655V |
probably benign |
Het |
| Hmcn1 |
G |
A |
1: 150,591,469 (GRCm39) |
T1910I |
probably benign |
Het |
| Idh1 |
CA |
CAA |
1: 65,204,347 (GRCm39) |
|
probably null |
Het |
| Ier2 |
A |
T |
8: 85,389,096 (GRCm39) |
D95E |
probably damaging |
Het |
| Ifi208 |
A |
G |
1: 173,523,370 (GRCm39) |
R547G |
possibly damaging |
Het |
| Itih3 |
T |
A |
14: 30,634,854 (GRCm39) |
S639C |
possibly damaging |
Het |
| Kif19b |
A |
G |
5: 140,461,785 (GRCm39) |
E529G |
probably damaging |
Het |
| Marchf7 |
G |
A |
2: 60,074,015 (GRCm39) |
|
probably null |
Het |
| Mep1b |
A |
C |
18: 21,224,325 (GRCm39) |
T373P |
probably damaging |
Het |
| Mlh3 |
G |
A |
12: 85,282,497 (GRCm39) |
P1379S |
probably damaging |
Het |
| Nav3 |
T |
A |
10: 109,605,032 (GRCm39) |
K1014* |
probably null |
Het |
| Nme1 |
A |
T |
11: 93,851,658 (GRCm39) |
F78I |
probably benign |
Het |
| Nos3 |
T |
A |
5: 24,576,745 (GRCm39) |
V458D |
probably damaging |
Het |
| Noxa1 |
A |
G |
2: 24,984,852 (GRCm39) |
F29L |
probably benign |
Het |
| Nutf2 |
A |
T |
8: 106,602,171 (GRCm39) |
|
probably benign |
Het |
| Oog3 |
A |
G |
4: 143,884,556 (GRCm39) |
I460T |
probably benign |
Het |
| Or4b1b |
A |
T |
2: 90,112,150 (GRCm39) |
Y256* |
probably null |
Het |
| Or4c113 |
T |
C |
2: 88,885,477 (GRCm39) |
M98V |
probably benign |
Het |
| Or5p78 |
A |
T |
7: 108,211,580 (GRCm39) |
D22V |
probably benign |
Het |
| Or7e175 |
A |
T |
9: 20,048,630 (GRCm39) |
M73L |
possibly damaging |
Het |
| Pde2a |
A |
T |
7: 101,155,136 (GRCm39) |
Y559F |
possibly damaging |
Het |
| Pde6d |
G |
A |
1: 86,475,209 (GRCm39) |
Q61* |
probably null |
Het |
| Pdpr |
A |
G |
8: 111,852,240 (GRCm39) |
T536A |
possibly damaging |
Het |
| Pias4 |
T |
A |
10: 80,999,846 (GRCm39) |
K69M |
probably damaging |
Het |
| Pigo |
A |
T |
4: 43,023,787 (GRCm39) |
D188E |
possibly damaging |
Het |
| Pik3r2 |
A |
G |
8: 71,224,007 (GRCm39) |
V270A |
probably benign |
Het |
| Plod2 |
T |
A |
9: 92,482,801 (GRCm39) |
W456R |
probably damaging |
Het |
| Pmpcb |
T |
C |
5: 21,961,832 (GRCm39) |
V450A |
probably benign |
Het |
| Poln |
G |
A |
5: 34,286,871 (GRCm39) |
T99I |
possibly damaging |
Het |
| Prg2 |
A |
G |
2: 84,812,404 (GRCm39) |
D38G |
possibly damaging |
Het |
| Psmd7 |
A |
C |
8: 108,310,831 (GRCm39) |
Y138D |
probably damaging |
Het |
| Ptprk |
T |
A |
10: 28,139,504 (GRCm39) |
Y76* |
probably null |
Het |
| Ranbp2 |
T |
A |
10: 58,328,414 (GRCm39) |
V2810E |
probably damaging |
Het |
| Rgma |
A |
T |
7: 73,067,648 (GRCm39) |
H411L |
probably damaging |
Het |
| Sapcd1 |
T |
C |
17: 35,246,814 (GRCm39) |
T25A |
probably damaging |
Het |
| Serpinb6e |
T |
C |
13: 34,024,977 (GRCm39) |
I105V |
possibly damaging |
Het |
| Serpinb9f |
A |
T |
13: 33,513,396 (GRCm39) |
T158S |
probably benign |
Het |
| Sirpb1b |
T |
A |
3: 15,613,843 (GRCm39) |
T80S |
probably benign |
Het |
| Skint6 |
A |
T |
4: 113,049,869 (GRCm39) |
S265R |
possibly damaging |
Het |
| Slc23a2 |
A |
T |
2: 131,902,629 (GRCm39) |
F524L |
probably benign |
Het |
| Slc2a13 |
C |
A |
15: 91,234,302 (GRCm39) |
G345C |
probably damaging |
Het |
| Sp110 |
A |
G |
1: 85,511,231 (GRCm39) |
|
probably null |
Het |
| Srcin1 |
A |
G |
11: 97,439,803 (GRCm39) |
V109A |
probably benign |
Het |
| Tfcp2l1 |
A |
G |
1: 118,560,118 (GRCm39) |
N70S |
probably damaging |
Het |
| Tmem30c |
T |
A |
16: 57,090,553 (GRCm39) |
H218L |
probably benign |
Het |
| Tmprss11d |
G |
A |
5: 86,486,680 (GRCm39) |
T70I |
probably damaging |
Het |
| Tnpo2 |
A |
T |
8: 85,765,114 (GRCm39) |
Q32L |
probably benign |
Het |
| Trav16n |
A |
C |
14: 53,588,867 (GRCm39) |
T48P |
probably damaging |
Het |
| Ufc1 |
A |
G |
1: 171,117,095 (GRCm39) |
Y110H |
probably damaging |
Het |
| Wars2 |
A |
G |
3: 99,123,888 (GRCm39) |
K250E |
probably damaging |
Het |
| Wdfy4 |
G |
T |
14: 32,869,049 (GRCm39) |
N326K |
probably benign |
Het |
| Xirp2 |
A |
T |
2: 67,341,557 (GRCm39) |
E1266V |
probably damaging |
Het |
| Zfp423 |
A |
C |
8: 88,507,857 (GRCm39) |
L829R |
probably damaging |
Het |
| Zfp735 |
A |
G |
11: 73,603,029 (GRCm39) |
K658E |
possibly damaging |
Het |
| Zscan12 |
T |
A |
13: 21,547,847 (GRCm39) |
C10S |
possibly damaging |
Het |
| Zswim3 |
T |
A |
2: 164,662,687 (GRCm39) |
M389K |
probably damaging |
Het |
|
| Other mutations in Nrcam |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01399:Nrcam
|
APN |
12 |
44,622,667 (GRCm39) |
missense |
probably benign |
0.27 |
|
IGL01657:Nrcam
|
APN |
12 |
44,606,583 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02434:Nrcam
|
APN |
12 |
44,637,026 (GRCm39) |
splice site |
probably benign |
|
|
IGL02455:Nrcam
|
APN |
12 |
44,617,313 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02712:Nrcam
|
APN |
12 |
44,620,610 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02834:Nrcam
|
APN |
12 |
44,587,858 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL03022:Nrcam
|
APN |
12 |
44,645,225 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03174:Nrcam
|
APN |
12 |
44,622,789 (GRCm39) |
splice site |
probably benign |
|
|
IGL03389:Nrcam
|
APN |
12 |
44,596,689 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL03397:Nrcam
|
APN |
12 |
44,606,540 (GRCm39) |
missense |
probably damaging |
1.00 |
|
I2288:Nrcam
|
UTSW |
12 |
44,611,098 (GRCm39) |
missense |
probably benign |
0.06 |
|
I2289:Nrcam
|
UTSW |
12 |
44,611,098 (GRCm39) |
missense |
probably benign |
0.06 |
|
R0063:Nrcam
|
UTSW |
12 |
44,596,811 (GRCm39) |
missense |
possibly damaging |
0.49 |
|
R0063:Nrcam
|
UTSW |
12 |
44,596,811 (GRCm39) |
missense |
possibly damaging |
0.49 |
|
R0195:Nrcam
|
UTSW |
12 |
44,631,628 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0463:Nrcam
|
UTSW |
12 |
44,598,124 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0590:Nrcam
|
UTSW |
12 |
44,610,815 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0674:Nrcam
|
UTSW |
12 |
44,611,105 (GRCm39) |
missense |
probably benign |
0.17 |
|
R0930:Nrcam
|
UTSW |
12 |
44,596,667 (GRCm39) |
missense |
probably benign |
|
|
R1241:Nrcam
|
UTSW |
12 |
44,636,947 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1279:Nrcam
|
UTSW |
12 |
44,591,660 (GRCm39) |
splice site |
probably null |
|
|
R1523:Nrcam
|
UTSW |
12 |
44,619,032 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1572:Nrcam
|
UTSW |
12 |
44,584,147 (GRCm39) |
splice site |
probably benign |
|
|
R1629:Nrcam
|
UTSW |
12 |
44,610,769 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1651:Nrcam
|
UTSW |
12 |
44,623,462 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R1729:Nrcam
|
UTSW |
12 |
44,620,633 (GRCm39) |
missense |
probably benign |
|
|
R1739:Nrcam
|
UTSW |
12 |
44,618,458 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1803:Nrcam
|
UTSW |
12 |
44,618,991 (GRCm39) |
missense |
probably benign |
|
|
R1884:Nrcam
|
UTSW |
12 |
44,591,538 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1974:Nrcam
|
UTSW |
12 |
44,610,776 (GRCm39) |
missense |
probably benign |
0.05 |
|
R1992:Nrcam
|
UTSW |
12 |
44,587,753 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2102:Nrcam
|
UTSW |
12 |
44,623,471 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2106:Nrcam
|
UTSW |
12 |
44,617,073 (GRCm39) |
missense |
probably benign |
0.12 |
|
R3854:Nrcam
|
UTSW |
12 |
44,622,667 (GRCm39) |
missense |
probably benign |
0.27 |
|
R4005:Nrcam
|
UTSW |
12 |
44,579,429 (GRCm39) |
missense |
probably benign |
|
|
R4088:Nrcam
|
UTSW |
12 |
44,618,985 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R4115:Nrcam
|
UTSW |
12 |
44,613,109 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R4428:Nrcam
|
UTSW |
12 |
44,623,558 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R4458:Nrcam
|
UTSW |
12 |
44,606,513 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4580:Nrcam
|
UTSW |
12 |
44,609,323 (GRCm39) |
critical splice donor site |
probably null |
|
|
R4601:Nrcam
|
UTSW |
12 |
44,637,839 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4688:Nrcam
|
UTSW |
12 |
44,594,020 (GRCm39) |
missense |
probably benign |
|
|
R4825:Nrcam
|
UTSW |
12 |
44,622,769 (GRCm39) |
nonsense |
probably null |
|
|
R4838:Nrcam
|
UTSW |
12 |
44,620,802 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4950:Nrcam
|
UTSW |
12 |
44,645,273 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4960:Nrcam
|
UTSW |
12 |
44,613,082 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5081:Nrcam
|
UTSW |
12 |
44,617,136 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5297:Nrcam
|
UTSW |
12 |
44,591,567 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5504:Nrcam
|
UTSW |
12 |
44,610,915 (GRCm39) |
critical splice donor site |
probably null |
|
|
R5593:Nrcam
|
UTSW |
12 |
44,606,483 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5654:Nrcam
|
UTSW |
12 |
44,610,841 (GRCm39) |
missense |
probably benign |
|
|
R5691:Nrcam
|
UTSW |
12 |
44,611,039 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5890:Nrcam
|
UTSW |
12 |
44,623,554 (GRCm39) |
missense |
probably benign |
|
|
R5937:Nrcam
|
UTSW |
12 |
44,619,074 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5980:Nrcam
|
UTSW |
12 |
44,618,416 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6132:Nrcam
|
UTSW |
12 |
44,617,007 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6213:Nrcam
|
UTSW |
12 |
44,609,215 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R6334:Nrcam
|
UTSW |
12 |
44,619,083 (GRCm39) |
missense |
probably benign |
|
|
R6617:Nrcam
|
UTSW |
12 |
44,587,746 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6666:Nrcam
|
UTSW |
12 |
44,618,338 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7191:Nrcam
|
UTSW |
12 |
44,619,027 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7284:Nrcam
|
UTSW |
12 |
44,610,817 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7326:Nrcam
|
UTSW |
12 |
44,610,809 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R7388:Nrcam
|
UTSW |
12 |
44,645,272 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7650:Nrcam
|
UTSW |
12 |
44,594,105 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7734:Nrcam
|
UTSW |
12 |
44,584,034 (GRCm39) |
missense |
possibly damaging |
0.49 |
|
R7757:Nrcam
|
UTSW |
12 |
44,596,681 (GRCm39) |
nonsense |
probably null |
|
|
R7840:Nrcam
|
UTSW |
12 |
44,587,858 (GRCm39) |
critical splice donor site |
probably null |
|
|
R7917:Nrcam
|
UTSW |
12 |
44,620,546 (GRCm39) |
splice site |
probably null |
|
|
R7935:Nrcam
|
UTSW |
12 |
44,631,644 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R7955:Nrcam
|
UTSW |
12 |
44,631,737 (GRCm39) |
missense |
probably benign |
0.26 |
|
R8117:Nrcam
|
UTSW |
12 |
44,618,371 (GRCm39) |
missense |
probably benign |
0.04 |
|
R8117:Nrcam
|
UTSW |
12 |
44,645,365 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8153:Nrcam
|
UTSW |
12 |
44,631,755 (GRCm39) |
missense |
probably benign |
|
|
R8189:Nrcam
|
UTSW |
12 |
44,617,291 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R8215:Nrcam
|
UTSW |
12 |
44,610,896 (GRCm39) |
missense |
probably benign |
0.02 |
|
R8719:Nrcam
|
UTSW |
12 |
44,586,325 (GRCm39) |
missense |
probably benign |
|
|
R8738:Nrcam
|
UTSW |
12 |
44,619,075 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R8831:Nrcam
|
UTSW |
12 |
44,591,680 (GRCm39) |
critical splice donor site |
probably null |
|
|
R8858:Nrcam
|
UTSW |
12 |
44,644,554 (GRCm39) |
splice site |
probably benign |
|
|
R8885:Nrcam
|
UTSW |
12 |
44,610,908 (GRCm39) |
missense |
probably benign |
0.10 |
|
R8912:Nrcam
|
UTSW |
12 |
44,645,366 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9178:Nrcam
|
UTSW |
12 |
44,615,329 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
R9243:Nrcam
|
UTSW |
12 |
44,620,607 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9257:Nrcam
|
UTSW |
12 |
44,610,837 (GRCm39) |
missense |
probably benign |
0.27 |
|
R9266:Nrcam
|
UTSW |
12 |
44,636,917 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9606:Nrcam
|
UTSW |
12 |
44,609,240 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R9623:Nrcam
|
UTSW |
12 |
44,636,931 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9681:Nrcam
|
UTSW |
12 |
44,598,133 (GRCm39) |
missense |
probably null |
1.00 |
|
R9747:Nrcam
|
UTSW |
12 |
44,645,192 (GRCm39) |
missense |
probably damaging |
1.00 |
|
U24488:Nrcam
|
UTSW |
12 |
44,584,042 (GRCm39) |
missense |
probably damaging |
1.00 |
|
X0057:Nrcam
|
UTSW |
12 |
44,598,199 (GRCm39) |
missense |
probably benign |
|
|
X0066:Nrcam
|
UTSW |
12 |
44,596,812 (GRCm39) |
missense |
probably benign |
0.00 |
|
Z1176:Nrcam
|
UTSW |
12 |
44,618,353 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1177:Nrcam
|
UTSW |
12 |
44,620,799 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- TCCCTGTGCCTGATGAAATAGG -3'
(R):5'- ACGATTAGGATTTGCACCAGG -3'
Sequencing Primer
(F):5'- AATAGGCTTTATTCATCCTGCATGC -3'
(R):5'- TGGGAGAATTAAACATGTGACTTTC -3'
|
| Posted On |
2021-04-30 |
Incidental Mutation