Incidental Mutation 'R8795:Prl2c1'
ID 671218
Institutional Source Beutler Lab
Gene Symbol Prl2c1
Ensembl Gene ENSMUSG00000062551
Gene Name Prolactin family 2, subfamily c, member 1
Synonyms
MMRRC Submission 068636-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.064) question?
Stock # R8795 (G1)
Quality Score 216.009
Status Not validated
Chromosome 13
Chromosomal Location 28033325-28041771 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to C at 28033389 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamine to Proline at position 2 (Q2P)
Ref Sequence ENSEMBL: ENSMUSP00000105964 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000054932] [ENSMUST00000110335]
AlphaFold Q5SVL9
Predicted Effect possibly damaging
Transcript: ENSMUST00000054932
AA Change: Q2P

PolyPhen 2 Score 0.820 (Sensitivity: 0.84; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000053446
Gene: ENSMUSG00000062551
AA Change: Q2P

DomainStartEndE-ValueType
Pfam:Hormone_1 16 226 1.8e-73 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000110335
AA Change: Q2P

PolyPhen 2 Score 0.863 (Sensitivity: 0.83; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000105964
Gene: ENSMUSG00000062551
AA Change: Q2P

DomainStartEndE-ValueType
Pfam:Hormone_1 16 228 1.9e-77 PFAM
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.7%
  • 20x: 99.0%
Validation Efficiency 97% (72/74)
Allele List at MGI
Other mutations in this stock
Total: 73 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aars2 A T 17: 45,818,598 (GRCm39) M128L probably damaging Het
Abcc12 A G 8: 87,258,213 (GRCm39) S768P possibly damaging Het
Adamts8 A T 9: 30,854,484 (GRCm39) M118L probably benign Het
Adgrl4 A G 3: 151,216,416 (GRCm39) N533S probably benign Het
Agk T G 6: 40,363,854 (GRCm39) I278R possibly damaging Het
Atr T A 9: 95,749,584 (GRCm39) W466R probably damaging Het
Cacna1h C T 17: 25,612,538 (GRCm39) V387I probably damaging Het
Cand2 T G 6: 115,763,889 (GRCm39) D270E probably benign Het
Ccdc107 C T 4: 43,495,514 (GRCm39) T139M probably damaging Het
Cenpl A G 1: 160,910,584 (GRCm39) E177G probably benign Het
Clint1 C A 11: 45,775,178 (GRCm39) Q56K probably damaging Het
Col9a1 A G 1: 24,233,812 (GRCm39) R249G unknown Het
Cpne5 C T 17: 29,423,662 (GRCm39) probably benign Het
Ddx27 A G 2: 166,859,730 (GRCm39) D54G probably benign Het
Dync2h1 C T 9: 7,137,087 (GRCm39) E1468K probably benign Het
E130308A19Rik A T 4: 59,737,676 (GRCm39) N429I possibly damaging Het
Endov G T 11: 119,390,380 (GRCm39) G86C possibly damaging Het
Ercc5 A T 1: 44,203,089 (GRCm39) Y242F possibly damaging Het
Gabrr1 T A 4: 33,161,756 (GRCm39) V360E probably damaging Het
Gcn1 T C 5: 115,752,454 (GRCm39) I2153T probably benign Het
Gje1 T C 10: 14,593,870 (GRCm39) N8S probably benign Het
Greb1l A G 18: 10,553,739 (GRCm39) H1580R probably damaging Het
Grin1 C G 2: 25,187,468 (GRCm39) S614T probably damaging Het
Hmcn2 A G 2: 31,315,393 (GRCm39) N3714S probably benign Het
Idh1 CA CAA 1: 65,204,347 (GRCm39) probably null Het
Ifitm2 A T 7: 140,535,661 (GRCm39) H56Q probably damaging Het
Ifrd1 G A 12: 40,263,076 (GRCm39) T218I possibly damaging Het
Igkv1-99 G T 6: 68,519,370 (GRCm39) G109V Het
Impg2 A G 16: 56,080,611 (GRCm39) E805G probably benign Het
Itgb6 T A 2: 60,483,629 (GRCm39) N260Y probably damaging Het
Maneal G T 4: 124,750,483 (GRCm39) Y424* probably null Het
Map4k2 T G 19: 6,401,640 (GRCm39) C677W probably damaging Het
Med6 T C 12: 81,638,034 (GRCm39) H59R probably benign Het
Mms22l T A 4: 24,536,245 (GRCm39) D571E probably benign Het
Mroh8 A G 2: 157,067,493 (GRCm39) F622S probably damaging Het
Mrpl44 A T 1: 79,753,974 (GRCm39) Q42L probably damaging Het
Myh8 G T 11: 67,174,203 (GRCm39) probably benign Het
Ndufb2 T C 6: 39,569,586 (GRCm39) V13A probably benign Het
Nf1 T A 11: 79,316,442 (GRCm39) L499Q probably damaging Het
Opa1 T C 16: 29,448,450 (GRCm39) C874R probably damaging Het
Or1i2 T C 10: 78,447,698 (GRCm39) Y259C probably damaging Het
Or4c99 T G 2: 88,329,855 (GRCm39) V142G probably damaging Het
Or4k37 T A 2: 111,158,881 (GRCm39) L39* probably null Het
Or6c6 T C 10: 129,187,194 (GRCm39) I254T probably damaging Het
Pld3 T A 7: 27,235,286 (GRCm39) D314V possibly damaging Het
Pou6f1 A C 15: 100,485,686 (GRCm39) C114W possibly damaging Het
Pzp C A 6: 128,471,701 (GRCm39) K908N probably damaging Het
Rab6b G A 9: 103,039,825 (GRCm39) G125D probably damaging Het
Rhbdd2 C T 5: 135,663,985 (GRCm39) T69I probably benign Het
Samd9l A T 6: 3,374,221 (GRCm39) Y1013* probably null Het
Slc13a4 T A 6: 35,260,230 (GRCm39) T217S probably benign Het
Slc66a3 A G 12: 17,043,481 (GRCm39) W150R probably damaging Het
Smarcad1 T C 6: 65,049,033 (GRCm39) L253S probably benign Het
Snrpa C A 7: 26,891,034 (GRCm39) V146L possibly damaging Het
Spata31f1e A G 4: 42,792,992 (GRCm39) V380A probably benign Het
Srrt A T 5: 137,298,238 (GRCm39) D311E probably benign Het
Stk32b A T 5: 37,806,483 (GRCm39) F20L probably damaging Het
Sult2a7 T C 7: 14,224,014 (GRCm39) T136A probably benign Het
Sv2a G A 3: 96,094,396 (GRCm39) V244I probably benign Het
Tesk1 T A 4: 43,446,070 (GRCm39) probably null Het
Tmem260 A G 14: 48,689,370 (GRCm39) H63R probably damaging Het
Ugt1a6b A G 1: 88,034,794 (GRCm39) E44G probably benign Het
Unc79 A T 12: 103,074,513 (GRCm39) I1363F probably damaging Het
Usp15 T A 10: 122,988,953 (GRCm39) N255Y probably benign Het
Usp35 A G 7: 96,961,167 (GRCm39) V753A possibly damaging Het
Usp35 T C 7: 96,961,270 (GRCm39) N719D probably benign Het
Vmn2r104 T A 17: 20,262,988 (GRCm39) I158L probably benign Het
Vmn2r69 A T 7: 85,064,883 (GRCm39) M1K probably null Het
Zan C T 5: 137,396,522 (GRCm39) E4345K unknown Het
Zc3h7a A T 16: 10,965,147 (GRCm39) M662K possibly damaging Het
Zfp512 G A 5: 31,634,134 (GRCm39) V438M probably damaging Het
Zfy1 T C Y: 738,945 (GRCm39) D87G unknown Het
Zmym4 A T 4: 126,799,819 (GRCm39) V653E probably benign Het
Other mutations in Prl2c1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02630:Prl2c1 APN 13 28,041,480 (GRCm39) splice site probably benign
IGL02648:Prl2c1 APN 13 28,041,542 (GRCm39) missense probably benign 0.44
IGL02823:Prl2c1 APN 13 28,040,416 (GRCm39) splice site probably benign
IGL03024:Prl2c1 APN 13 28,040,524 (GRCm39) missense probably benign 0.22
IGL03229:Prl2c1 APN 13 28,040,612 (GRCm39) splice site probably benign
R4739:Prl2c1 UTSW 13 28,041,661 (GRCm39) missense probably damaging 1.00
R4978:Prl2c1 UTSW 13 28,041,553 (GRCm39) missense probably benign 0.00
R6860:Prl2c1 UTSW 13 28,035,724 (GRCm39) missense probably benign 0.31
R7719:Prl2c1 UTSW 13 28,035,780 (GRCm39) missense probably damaging 1.00
R7984:Prl2c1 UTSW 13 28,039,310 (GRCm39) critical splice donor site probably null
R8795:Prl2c1 UTSW 13 28,033,390 (GRCm39) missense probably benign 0.02
Predicted Primers PCR Primer
(F):5'- TCCTCAACTTGGATTCCAGAC -3'
(R):5'- CACTGGTCTAAGAGTTAGTAGTCAC -3'

Sequencing Primer
(F):5'- CAACTTGGATTCCAGACATTGC -3'
(R):5'- GAGTTAGTAGTCACTGTCTAGAGAG -3'
Posted On 2021-04-30