Incidental Mutation 'R8798:Ly75'
ID 671346
Institutional Source Beutler Lab
Gene Symbol Ly75
Ensembl Gene ENSMUSG00000026980
Gene Name lymphocyte antigen 75
Synonyms DEC-205, CD205
MMRRC Submission 068724-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R8798 (G1)
Quality Score 225.009
Status Validated
Chromosome 2
Chromosomal Location 60292103-60383303 bp(-) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) A to G at 60323926 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Phenylalanine to Serine at position 1059 (F1059S)
Ref Sequence ENSEMBL: ENSMUSP00000028362 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000028362] [ENSMUST00000112533]
AlphaFold Q60767
Predicted Effect probably benign
Transcript: ENSMUST00000028362
AA Change: F1059S

PolyPhen 2 Score 0.317 (Sensitivity: 0.90; Specificity: 0.89)
SMART Domains Protein: ENSMUSP00000028362
Gene: ENSMUSG00000026980
AA Change: F1059S

DomainStartEndE-ValueType
signal peptide 1 27 N/A INTRINSIC
RICIN 33 146 2.63e-17 SMART
FN2 162 209 1.22e-23 SMART
CLECT 216 341 7.36e-32 SMART
CLECT 361 486 9.28e-29 SMART
CLECT 501 624 1.11e-17 SMART
CLECT 643 791 1.93e-26 SMART
CLECT 811 932 7.94e-2 SMART
CLECT 952 1091 5.81e-21 SMART
CLECT 1104 1222 1.04e-22 SMART
CLECT 1240 1382 3.48e-10 SMART
CLECT 1395 1513 9.59e-22 SMART
CLECT 1530 1661 7.79e-22 SMART
transmembrane domain 1670 1692 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000112533
AA Change: F1059S

PolyPhen 2 Score 0.061 (Sensitivity: 0.94; Specificity: 0.84)
SMART Domains Protein: ENSMUSP00000108152
Gene: ENSMUSG00000026980
AA Change: F1059S

DomainStartEndE-ValueType
signal peptide 1 27 N/A INTRINSIC
RICIN 33 146 2.63e-17 SMART
FN2 162 209 1.22e-23 SMART
CLECT 216 341 7.36e-32 SMART
CLECT 361 486 9.28e-29 SMART
CLECT 501 624 1.11e-17 SMART
CLECT 643 791 1.93e-26 SMART
CLECT 811 932 7.94e-2 SMART
CLECT 952 1091 5.81e-21 SMART
CLECT 1104 1222 1.04e-22 SMART
CLECT 1240 1382 3.48e-10 SMART
CLECT 1395 1513 9.59e-22 SMART
CLECT 1530 1661 7.79e-22 SMART
transmembrane domain 1670 1692 N/A INTRINSIC
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.8%
  • 20x: 99.4%
Validation Efficiency 100% (74/74)
MGI Phenotype PHENOTYPE: Mice homozygous for a knock-out allele display abnormalities in CD8-positive T cell morphology and cytotoxic T cell physiology. [provided by MGI curators]
Allele List at MGI

All alleles(7) : Targeted, knock-out(1) Targeted, other(1) Gene trapped(5)

Other mutations in this stock
Total: 76 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700011L22Rik G A 8: 79,210,751 (GRCm38) R176* probably null Het
2610044O15Rik8 G A 8: 129,219,298 (GRCm38) H349Y probably damaging Het
4921539E11Rik A C 4: 103,266,377 (GRCm38) probably benign Het
A430078G23Rik T A 8: 3,364,645 (GRCm38) Y8N probably benign Het
Abcc2 A G 19: 43,808,666 (GRCm38) N492S probably benign Het
Acox1 T C 11: 116,174,357 (GRCm38) Y624C probably damaging Het
Aff4 T C 11: 53,400,508 (GRCm38) probably benign Het
Ak9 T A 10: 41,382,851 (GRCm38) D781E Het
Arfgef3 T C 10: 18,647,051 (GRCm38) D409G probably damaging Het
Blnk A G 19: 40,962,351 (GRCm38) Y119H probably damaging Het
Brsk2 T C 7: 141,987,864 (GRCm38) L310P probably damaging Het
Cit T A 5: 115,969,043 (GRCm38) L1078Q probably damaging Het
Cpn1 A T 19: 43,986,236 (GRCm38) V18D possibly damaging Het
Csmd3 A T 15: 47,731,986 (GRCm38) Y1115N Het
Dnah9 A C 11: 65,905,231 (GRCm38) V3589G probably damaging Het
Dpp9 T C 17: 56,199,037 (GRCm38) Y454C probably damaging Het
Eif3i A G 4: 129,596,924 (GRCm38) V67A probably benign Het
Eif6 T C 2: 155,822,966 (GRCm38) N200S probably damaging Het
Fbxo10 T C 4: 45,051,605 (GRCm38) H502R possibly damaging Het
Fcer1a A G 1: 173,225,480 (GRCm38) Y50H probably benign Het
Filip1 G A 9: 79,820,090 (GRCm38) H416Y possibly damaging Het
Frmpd1 A T 4: 45,285,424 (GRCm38) N1415I possibly damaging Het
Gdpgp1 C T 7: 80,238,977 (GRCm38) P252L probably damaging Het
Gm340 C T 19: 41,585,259 (GRCm38) R818W probably damaging Het
Gsap T C 5: 21,271,250 (GRCm38) probably null Het
Hgs T C 11: 120,480,112 (GRCm38) V598A probably benign Het
Irf2 G T 8: 46,807,314 (GRCm38) V94L probably benign Het
Kalrn G T 16: 33,982,855 (GRCm38) H2675Q possibly damaging Het
Klhl33 C A 14: 50,893,108 (GRCm38) A50S possibly damaging Het
Klk1b11 T C 7: 43,995,948 (GRCm38) I15T probably benign Het
Lrrn3 A G 12: 41,453,175 (GRCm38) M381T possibly damaging Het
Ltbr A G 6: 125,307,295 (GRCm38) Y395H probably benign Het
Ltf A G 9: 111,023,760 (GRCm38) probably benign Het
Lypd6 T A 2: 50,188,762 (GRCm38) I90N possibly damaging Het
Map1a G A 2: 121,302,287 (GRCm38) V1195M probably benign Het
Mb21d1 G A 9: 78,443,066 (GRCm38) R5C probably benign Het
Mroh2b A T 15: 4,948,709 (GRCm38) I1320F probably damaging Het
Mug2 A G 6: 122,081,610 (GRCm38) T1324A probably damaging Het
Mylk G A 16: 34,899,402 (GRCm38) V562M possibly damaging Het
Myo15b G A 11: 115,863,406 (GRCm38) G911R Het
Neo1 A G 9: 58,913,166 (GRCm38) Y825H probably damaging Het
Nfat5 T G 8: 107,347,689 (GRCm38) V343G probably damaging Het
Nlrp2 A T 7: 5,327,888 (GRCm38) I503K possibly damaging Het
Olfr180 A T 16: 58,915,944 (GRCm38) D232E probably benign Het
Olfr270 C A 4: 52,970,790 (GRCm38) H56Q possibly damaging Het
Olfr924 G A 9: 38,848,917 (GRCm38) E268K probably benign Het
Olfr975 G A 9: 39,950,717 (GRCm38) T18I probably benign Het
Pdcl2 T C 5: 76,325,100 (GRCm38) D7G probably damaging Het
Phyh C T 2: 4,919,082 (GRCm38) R5C probably damaging Het
Prr11 A C 11: 87,106,055 (GRCm38) S28A unknown Het
Psmd13 T A 7: 140,897,750 (GRCm38) L190* probably null Het
Ptx4 A G 17: 25,124,742 (GRCm38) D322G probably damaging Het
Rnf40 T C 7: 127,589,782 (GRCm38) L109P probably damaging Het
Rrp1 T C 10: 78,409,190 (GRCm38) T102A probably damaging Het
Sema4a T G 3: 88,436,697 (GRCm38) D749A possibly damaging Het
Serpina3f A T 12: 104,217,443 (GRCm38) D188V probably benign Het
Smarca5 C A 8: 80,716,508 (GRCm38) A570S probably damaging Het
Spocd1 G C 4: 129,930,204 (GRCm38) probably null Het
Stard9 G A 2: 120,704,731 (GRCm38) G3823D probably benign Het
Suco A G 1: 161,820,435 (GRCm38) L1094S probably damaging Het
Tcf7 T C 11: 52,260,594 (GRCm38) D79G probably damaging Het
Tdrd12 A G 7: 35,529,180 (GRCm38) M39T probably damaging Het
Thnsl1 A G 2: 21,212,398 (GRCm38) N321S probably benign Het
Tmem132c T A 5: 127,360,153 (GRCm38) Y235* probably null Het
Tnfaip6 T C 2: 52,043,812 (GRCm38) F60L probably benign Het
Tnpo3 T C 6: 29,572,621 (GRCm38) I411V probably benign Het
Trio A C 15: 27,851,837 (GRCm38) V856G possibly damaging Het
Trpc2 C G 7: 102,084,560 (GRCm38) R239G probably benign Het
Ttn C T 2: 76,826,132 (GRCm38) V12502I unknown Het
Usf3 A G 16: 44,220,173 (GRCm38) D1672G probably damaging Het
Usp24 A G 4: 106,379,239 (GRCm38) N1011S probably benign Het
Vac14 A G 8: 110,719,887 (GRCm38) E756G probably benign Het
Vmn2r41 A G 7: 8,161,523 (GRCm38) L10P probably damaging Het
Xrcc5 T C 1: 72,314,178 (GRCm38) M115T probably damaging Het
Zfp827 G A 8: 79,189,834 (GRCm38) probably benign Het
Zmym1 A T 4: 127,049,871 (GRCm38) N241K possibly damaging Het
Other mutations in Ly75
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00561:Ly75 APN 2 60,376,077 (GRCm38) missense probably damaging 1.00
IGL01072:Ly75 APN 2 60,354,496 (GRCm38) missense probably damaging 1.00
IGL01409:Ly75 APN 2 60,321,692 (GRCm38) splice site probably null
IGL01432:Ly75 APN 2 60,376,007 (GRCm38) missense probably damaging 1.00
IGL01626:Ly75 APN 2 60,301,015 (GRCm38) missense probably benign 0.13
IGL01690:Ly75 APN 2 60,338,311 (GRCm38) missense probably damaging 1.00
IGL01862:Ly75 APN 2 60,299,172 (GRCm38) missense probably damaging 1.00
IGL01982:Ly75 APN 2 60,311,764 (GRCm38) missense probably damaging 1.00
IGL02075:Ly75 APN 2 60,352,356 (GRCm38) missense probably damaging 0.99
IGL02338:Ly75 APN 2 60,354,452 (GRCm38) missense probably benign 0.04
IGL02364:Ly75 APN 2 60,358,507 (GRCm38) missense probably damaging 1.00
IGL02456:Ly75 APN 2 60,293,781 (GRCm38) missense probably benign 0.09
IGL02474:Ly75 APN 2 60,383,182 (GRCm38) missense probably null 1.00
IGL02608:Ly75 APN 2 60,321,900 (GRCm38) missense probably benign 0.41
IGL02986:Ly75 APN 2 60,308,191 (GRCm38) missense probably damaging 1.00
IGL03015:Ly75 APN 2 60,376,160 (GRCm38) missense probably damaging 1.00
IGL03049:Ly75 APN 2 60,352,070 (GRCm38) missense probably damaging 0.99
euphues UTSW 2 60,299,045 (GRCm38) critical splice donor site probably null
four_score UTSW 2 60,311,771 (GRCm38) missense possibly damaging 0.75
lyly UTSW 2 60,327,873 (GRCm38) missense possibly damaging 0.49
Witty UTSW 2 60,354,500 (GRCm38) missense probably damaging 1.00
D605:Ly75 UTSW 2 60,352,352 (GRCm38) critical splice donor site probably null
R0046:Ly75 UTSW 2 60,339,457 (GRCm38) intron probably benign
R0055:Ly75 UTSW 2 60,321,918 (GRCm38) missense probably benign 0.01
R0055:Ly75 UTSW 2 60,321,918 (GRCm38) missense probably benign 0.01
R0071:Ly75 UTSW 2 60,321,819 (GRCm38) missense probably benign 0.01
R0071:Ly75 UTSW 2 60,321,819 (GRCm38) missense probably benign 0.01
R0285:Ly75 UTSW 2 60,318,319 (GRCm38) missense probably damaging 1.00
R0387:Ly75 UTSW 2 60,306,404 (GRCm38) missense probably benign 0.20
R0492:Ly75 UTSW 2 60,308,276 (GRCm38) missense probably damaging 1.00
R0688:Ly75 UTSW 2 60,316,221 (GRCm38) missense probably benign 0.41
R1367:Ly75 UTSW 2 60,293,758 (GRCm38) splice site probably null
R1463:Ly75 UTSW 2 60,368,757 (GRCm38) critical splice donor site probably null
R1581:Ly75 UTSW 2 60,327,893 (GRCm38) missense probably damaging 1.00
R1663:Ly75 UTSW 2 60,314,234 (GRCm38) missense probably damaging 1.00
R1818:Ly75 UTSW 2 60,311,777 (GRCm38) missense probably damaging 1.00
R1881:Ly75 UTSW 2 60,349,940 (GRCm38) missense probably benign 0.00
R2244:Ly75 UTSW 2 60,349,913 (GRCm38) missense probably benign 0.01
R2905:Ly75 UTSW 2 60,334,554 (GRCm38) missense probably benign 0.00
R3967:Ly75 UTSW 2 60,327,873 (GRCm38) missense possibly damaging 0.49
R3968:Ly75 UTSW 2 60,327,873 (GRCm38) missense possibly damaging 0.49
R4039:Ly75 UTSW 2 60,352,995 (GRCm38) missense probably damaging 1.00
R4406:Ly75 UTSW 2 60,354,550 (GRCm38) missense probably damaging 1.00
R4526:Ly75 UTSW 2 60,330,773 (GRCm38) missense probably benign 0.09
R4647:Ly75 UTSW 2 60,308,278 (GRCm38) missense probably damaging 1.00
R4795:Ly75 UTSW 2 60,349,940 (GRCm38) missense probably benign 0.00
R4796:Ly75 UTSW 2 60,349,940 (GRCm38) missense probably benign 0.00
R4962:Ly75 UTSW 2 60,352,125 (GRCm38) missense probably damaging 1.00
R4979:Ly75 UTSW 2 60,375,894 (GRCm38) missense probably damaging 1.00
R5072:Ly75 UTSW 2 60,375,963 (GRCm38) missense probably damaging 1.00
R5288:Ly75 UTSW 2 60,303,641 (GRCm38) missense probably damaging 1.00
R5373:Ly75 UTSW 2 60,311,771 (GRCm38) missense possibly damaging 0.75
R5374:Ly75 UTSW 2 60,311,771 (GRCm38) missense possibly damaging 0.75
R5384:Ly75 UTSW 2 60,334,487 (GRCm38) nonsense probably null
R5385:Ly75 UTSW 2 60,303,641 (GRCm38) missense probably damaging 1.00
R5395:Ly75 UTSW 2 60,365,111 (GRCm38) missense probably benign 0.41
R5531:Ly75 UTSW 2 60,365,145 (GRCm38) missense probably damaging 0.98
R5662:Ly75 UTSW 2 60,352,381 (GRCm38) missense probably damaging 1.00
R5667:Ly75 UTSW 2 60,308,311 (GRCm38) missense probably damaging 1.00
R5668:Ly75 UTSW 2 60,354,500 (GRCm38) missense probably damaging 1.00
R5671:Ly75 UTSW 2 60,308,311 (GRCm38) missense probably damaging 1.00
R5677:Ly75 UTSW 2 60,299,082 (GRCm38) missense probably benign 0.00
R5764:Ly75 UTSW 2 60,318,439 (GRCm38) missense probably benign
R5896:Ly75 UTSW 2 60,383,146 (GRCm38) missense probably benign
R6025:Ly75 UTSW 2 60,375,962 (GRCm38) missense probably damaging 1.00
R6113:Ly75 UTSW 2 60,368,873 (GRCm38) missense probably benign 0.04
R6448:Ly75 UTSW 2 60,299,045 (GRCm38) critical splice donor site probably null
R6601:Ly75 UTSW 2 60,318,376 (GRCm38) missense probably benign 0.11
R6745:Ly75 UTSW 2 60,308,179 (GRCm38) missense probably damaging 1.00
R6955:Ly75 UTSW 2 60,327,873 (GRCm38) missense possibly damaging 0.49
R6960:Ly75 UTSW 2 60,306,405 (GRCm38) missense probably benign
R7100:Ly75 UTSW 2 60,306,434 (GRCm38) missense probably benign
R7110:Ly75 UTSW 2 60,376,184 (GRCm38) missense probably benign 0.31
R7203:Ly75 UTSW 2 60,323,852 (GRCm38) nonsense probably null
R7291:Ly75 UTSW 2 60,329,993 (GRCm38) missense probably damaging 0.98
R7308:Ly75 UTSW 2 60,334,515 (GRCm38) missense probably benign 0.04
R7447:Ly75 UTSW 2 60,334,474 (GRCm38) nonsense probably null
R7512:Ly75 UTSW 2 60,334,563 (GRCm38) missense probably damaging 1.00
R7595:Ly75 UTSW 2 60,293,827 (GRCm38) missense probably benign 0.01
R7976:Ly75 UTSW 2 60,365,088 (GRCm38) missense probably damaging 1.00
R8005:Ly75 UTSW 2 60,332,934 (GRCm38) missense probably damaging 1.00
R8171:Ly75 UTSW 2 60,314,228 (GRCm38) missense possibly damaging 0.51
R8392:Ly75 UTSW 2 60,349,940 (GRCm38) missense probably benign 0.00
R8705:Ly75 UTSW 2 60,318,385 (GRCm38) missense probably damaging 0.98
R8714:Ly75 UTSW 2 60,334,485 (GRCm38) missense probably damaging 1.00
R8799:Ly75 UTSW 2 60,348,441 (GRCm38) missense probably damaging 1.00
R8834:Ly75 UTSW 2 60,331,089 (GRCm38) missense probably benign
R8990:Ly75 UTSW 2 60,358,559 (GRCm38) missense probably benign 0.10
R9015:Ly75 UTSW 2 60,316,098 (GRCm38) missense probably benign
R9547:Ly75 UTSW 2 60,330,725 (GRCm38) critical splice donor site probably null
R9628:Ly75 UTSW 2 60,327,941 (GRCm38) missense probably damaging 1.00
R9659:Ly75 UTSW 2 60,338,321 (GRCm38) missense probably damaging 1.00
R9660:Ly75 UTSW 2 60,323,840 (GRCm38) missense probably damaging 1.00
R9747:Ly75 UTSW 2 60,306,328 (GRCm38) critical splice donor site probably null
X0025:Ly75 UTSW 2 60,354,475 (GRCm38) missense probably damaging 1.00
Z1177:Ly75 UTSW 2 60,352,133 (GRCm38) missense possibly damaging 0.65
Z1177:Ly75 UTSW 2 60,350,004 (GRCm38) nonsense probably null
Predicted Primers PCR Primer
(F):5'- TGGCCAGTGCTCATCTTCCT -3'
(R):5'- AGTTAACTGCCATTTTCTAGGTCTCA -3'

Sequencing Primer
(F):5'- AGCTTACTTCAAATTTGGCTCG -3'
(R):5'- AGGTCTCAAATGTCCGTCATG -3'
Posted On 2021-04-30