Mutagenetix > Incidental Mutation

Incidental Mutation 'R8759:Dock2'

671804

Institutional Source

Beutler Lab

Gene Symbol

Dock2

Ensembl Gene

ENSMUSG00000020143

Gene Name

dedicator of cyto-kinesis 2

Synonyms

CED-5, Hch, MBC

MMRRC Submission

068718-MU

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

R8759 (G1)

Quality Score

225.009

Status

Not validated

Chromosome

Chromosomal Location

34176815-34674719 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 34586067 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Aspartic acid to Glutamic Acid at position 538 (D538E)

Ref Sequence

ENSEMBL: ENSMUSP00000090884 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000093193] [ENSMUST00000101365] [ENSMUST00000143540]

AlphaFold

Q8C3J5

Predicted Effect

probably benign
Transcript: ENSMUST00000093193
AA Change: D538E

PolyPhen 2 Score 0.131 (Sensitivity: 0.93; Specificity: 0.86)

SMART Domains

Protein: ENSMUSP00000090884
Gene: ENSMUSG00000020143
AA Change: D538E

Domain	Start	End	E-Value	Type
SH3	11	68	1.22e-11	SMART
Pfam:DOCK_N	71	414	2e-113	PFAM
Pfam:DOCK-C2	419	616	1e-60	PFAM
Pfam:DHR-2	1114	1614	6.3e-96	PFAM
low complexity region	1691	1706	N/A	INTRINSIC
low complexity region	1793	1800	N/A	INTRINSIC

Predicted Effect

probably damaging
Transcript: ENSMUST00000101365
AA Change: D538E

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)

SMART Domains

Protein: ENSMUSP00000098916
Gene: ENSMUSG00000020143
AA Change: D538E

Domain	Start	End	E-Value	Type
SH3	11	68	1.22e-11	SMART
Pfam:DOCK_N	71	414	1.4e-113	PFAM
Pfam:DOCK-C2	419	616	5.5e-61	PFAM
low complexity region	1163	1171	N/A	INTRINSIC

Predicted Effect

probably damaging
Transcript: ENSMUST00000143540
AA Change: D538E

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)

SMART Domains

Protein: ENSMUSP00000116893
Gene: ENSMUSG00000020143
AA Change: D538E

Domain	Start	End	E-Value	Type
SH3	11	68	1.22e-11	SMART
Pfam:DOCK-C2	418	617	1.8e-55	PFAM

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.5%
20x: 98.2%

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene belongs to the CDM protein family. It is specifically expressed in hematopoietic cells and is predominantly expressed in peripheral blood leukocytes. The protein is involved in remodeling of the actin cytoskeleton required for lymphocyte migration in response to chemokine signaling. It activates members of the Rho family of GTPases, for example RAC1 and RAC2, by acting as a guanine nucleotide exchange factor (GEF) to exchange bound GDP for free GTP. [provided by RefSeq, Oct 2016]
PHENOTYPE: Homozygous mutants are defective in the migration of T and B lympohcytes in response to chemokines, and thus display immune defects such as lymphocytopenia, atrophy of lymphoid follicles and loss of marginal-zone B cells. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 54 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
2310022B05Rik	T	C	8: 125,365,916 (GRCm39)	T276A	probably benign	Het
6030468B19Rik	T	C	11: 117,697,112 (GRCm39)	V237A	probably benign	Het
Abca15	G	A	7: 120,006,631 (GRCm39)	V1632M	probably damaging	Het
Adamts18	G	A	8: 114,433,624 (GRCm39)	P1037S	probably damaging	Het
Apol7e	T	C	15: 77,602,065 (GRCm39)	V221A	probably benign	Het
Aqp4	T	G	18: 15,533,048 (GRCm39)	H15P	probably benign	Het
Atp6v0d2	T	A	4: 19,910,649 (GRCm39)	R80S	probably benign	Het
Cdh15	A	G	8: 123,587,628 (GRCm39)	D184G	probably damaging	Het
Cers3	G	A	7: 66,435,850 (GRCm39)	V270M	probably damaging	Het
Ces3a	A	G	8: 105,784,129 (GRCm39)	H443R	probably damaging	Het
Cntn1	T	G	15: 92,153,801 (GRCm39)	F485V	possibly damaging	Het
Cog6	A	G	3: 52,897,465 (GRCm39)	L536P	probably damaging	Het
Copa	A	G	1: 171,947,081 (GRCm39)	I1068M	probably benign	Het
Ddx50	T	C	10: 62,452,021 (GRCm39)	D734G	unknown	Het
Dgkz	T	C	2: 91,775,922 (GRCm39)	T114A	probably benign	Het
Drg1	T	C	11: 3,204,633 (GRCm39)	S198G	probably benign	Het
Epn3	C	A	11: 94,386,848 (GRCm39)	G174V	possibly damaging	Het
Ficd	G	T	5: 113,876,575 (GRCm39)	R250L	probably damaging	Het
Fmo2	A	G	1: 162,708,005 (GRCm39)	S377P	probably benign	Het
Gm17027	T	C	14: 41,981,251 (GRCm39)	I202V		Het
H6pd	C	T	4: 150,066,758 (GRCm39)	V551I	probably benign	Het
Ighg1	A	T	12: 113,292,657 (GRCm39)	L304*	probably null	Het
Itga8	T	C	2: 12,266,940 (GRCm39)	D165G	probably damaging	Het
Lipt2	GGCGCCCGCGCGCG	GGCG	7: 99,808,888 (GRCm39)		probably null	Het
Lrrc37a	A	G	11: 103,348,766 (GRCm39)	V2643A	unknown	Het
Lyz3	T	A	10: 117,070,340 (GRCm39)	I146F	probably damaging	Het
Mast2	A	T	4: 116,292,757 (GRCm39)	F71Y	possibly damaging	Het
Mkrn1	C	A	6: 39,376,344 (GRCm39)	E421*	probably null	Het
Myo3a	G	T	2: 22,448,319 (GRCm39)	K969N	possibly damaging	Het
Nr1d1	G	C	11: 98,660,073 (GRCm39)	R484G	probably damaging	Het
Nrg1	C	A	8: 32,308,103 (GRCm39)	A686S	probably damaging	Het
Or52e8	T	C	7: 104,624,325 (GRCm39)	N293S	probably damaging	Het
Plxna4	T	A	6: 32,169,276 (GRCm39)	D1307V	probably damaging	Het
Ppihl	A	T	5: 44,070,999 (GRCm39)	N119I	probably benign	Het
Ppp1r13l	G	T	7: 19,103,981 (GRCm39)	G154V	probably damaging	Het
Psmc5	A	G	11: 106,153,687 (GRCm39)	D382G	probably benign	Het
Ptch2	T	C	4: 116,967,630 (GRCm39)	L766P	probably damaging	Het
Rev1	A	C	1: 38,098,353 (GRCm39)	L730R	probably damaging	Het
Rin3	G	A	12: 102,339,861 (GRCm39)	V684I	probably damaging	Het
Secisbp2	G	A	13: 51,833,869 (GRCm39)	V670I	possibly damaging	Het
Sema6d	G	A	2: 124,497,134 (GRCm39)	C136Y	probably damaging	Het
Shprh	T	G	10: 11,032,908 (GRCm39)	V298G	possibly damaging	Het
Slc37a4	C	T	9: 44,313,632 (GRCm39)	T386I	probably benign	Het
Slc4a3	T	C	1: 75,531,282 (GRCm39)	I825T	probably damaging	Het
Spta1	C	T	1: 174,040,940 (GRCm39)	L1247F	probably damaging	Het
Tigar	A	T	6: 127,068,220 (GRCm39)	I66K	probably benign	Het
Tln2	T	C	9: 67,274,500 (GRCm39)	Y376C	probably damaging	Het
Tmem199	T	A	11: 78,398,633 (GRCm39)		probably benign	Het
Tnc	G	A	4: 63,924,501 (GRCm39)	R1066C	possibly damaging	Het
Ubqlnl	T	A	7: 103,799,206 (GRCm39)	H97L	probably damaging	Het
Vmn1r13	A	G	6: 57,187,524 (GRCm39)	T228A	probably damaging	Het
Xab2	T	C	8: 3,661,672 (GRCm39)	T594A	probably benign	Het
Zc3h18	A	G	8: 123,138,124 (GRCm39)	E687G	unknown	Het
Zfp831	A	G	2: 174,487,874 (GRCm39)	T850A	probably benign	Het

Other mutations in Dock2

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00334:Dock2	APN	11	34,595,488 (GRCm39)	missense	probably damaging	1.00
IGL00469:Dock2	APN	11	34,179,603 (GRCm39)	splice site	probably benign
IGL01061:Dock2	APN	11	34,596,653 (GRCm39)	missense	probably damaging	1.00
IGL01319:Dock2	APN	11	34,589,617 (GRCm39)	missense	possibly damaging	0.61
IGL01451:Dock2	APN	11	34,260,390 (GRCm39)	missense	probably damaging	1.00
IGL01490:Dock2	APN	11	34,596,608 (GRCm39)	missense	probably damaging	0.97
IGL01601:Dock2	APN	11	34,189,528 (GRCm39)	critical splice donor site	probably null
IGL01800:Dock2	APN	11	34,647,100 (GRCm39)	missense	probably damaging	1.00
IGL01804:Dock2	APN	11	34,212,433 (GRCm39)	missense	probably benign	0.01
IGL01823:Dock2	APN	11	34,212,391 (GRCm39)	missense	probably damaging	1.00
IGL01829:Dock2	APN	11	34,596,668 (GRCm39)	missense	probably damaging	0.98
IGL01830:Dock2	APN	11	34,582,744 (GRCm39)	nonsense	probably null
IGL01835:Dock2	APN	11	34,260,435 (GRCm39)	missense	possibly damaging	0.51
IGL01845:Dock2	APN	11	34,599,692 (GRCm39)	missense	probably benign	0.02
IGL01953:Dock2	APN	11	34,623,183 (GRCm39)	missense	probably benign	0.28
IGL01989:Dock2	APN	11	34,218,053 (GRCm39)	missense	probably benign
IGL02081:Dock2	APN	11	34,204,355 (GRCm39)	missense	probably benign
IGL02105:Dock2	APN	11	34,605,352 (GRCm39)	missense	probably damaging	1.00
IGL02153:Dock2	APN	11	34,180,670 (GRCm39)	missense	probably benign	0.01
IGL02170:Dock2	APN	11	34,217,949 (GRCm39)	missense	probably damaging	1.00
IGL02344:Dock2	APN	11	34,622,337 (GRCm39)	missense	probably damaging	0.98
IGL02389:Dock2	APN	11	34,589,567 (GRCm39)	splice site	probably benign
IGL02409:Dock2	APN	11	34,451,204 (GRCm39)	missense	probably benign	0.00
IGL02472:Dock2	APN	11	34,199,801 (GRCm39)	missense	probably benign	0.00
IGL02625:Dock2	APN	11	34,451,168 (GRCm39)	critical splice donor site	probably null
IGL02929:Dock2	APN	11	34,218,048 (GRCm39)	missense	probably damaging	1.00
IGL02951:Dock2	APN	11	34,260,448 (GRCm39)	unclassified	probably benign
IGL02999:Dock2	APN	11	34,583,086 (GRCm39)	missense	probably damaging	0.99
IGL03165:Dock2	APN	11	34,578,360 (GRCm39)	missense	probably damaging	0.99
Arches	UTSW	11	34,580,587 (GRCm39)	missense	probably damaging	1.00
capitol_reef	UTSW	11	34,244,170 (GRCm39)	critical splice acceptor site	probably null
Croesus	UTSW	11	34,611,854 (GRCm39)	missense	probably damaging	1.00
denali	UTSW	11	34,179,472 (GRCm39)	critical splice donor site	probably null
dew	UTSW	11	34,198,636 (GRCm39)	nonsense	probably null
Dinghy	UTSW	11	34,212,460 (GRCm39)	missense	possibly damaging	0.70
Dry	UTSW	11	34,181,652 (GRCm39)	missense	possibly damaging	0.79
frazz	UTSW	11	34,198,572 (GRCm39)	critical splice donor site	probably benign
frizz	UTSW	11	34,208,184 (GRCm39)	splice site	probably benign
gildenstern	UTSW	11	34,623,166 (GRCm39)	critical splice donor site	probably null
godsgrace	UTSW	11	34,586,280 (GRCm39)	missense	probably damaging	1.00
Harborside	UTSW	11	34,212,445 (GRCm39)	missense	probably benign
Landing	UTSW	11	34,605,328 (GRCm39)	missense	possibly damaging	0.83
latest	UTSW	11	34,647,049 (GRCm39)	missense	probably damaging	1.00
Launch	UTSW	11	34,206,562 (GRCm39)	missense	probably damaging	1.00
liaoning	UTSW	11	34,599,620 (GRCm39)	missense	probably damaging	1.00
lucre	UTSW	11	34,595,436 (GRCm39)	frame shift	probably null
midas	UTSW	11	34,244,323 (GRCm39)	missense	probably damaging	0.99
muelle	UTSW	11	34,578,365 (GRCm39)	missense	probably damaging	1.00
narrowest	UTSW	11	34,232,652 (GRCm39)	missense	probably damaging	0.98
pier	UTSW	11	34,580,593 (GRCm39)	missense	probably damaging	1.00
Plank	UTSW	11	34,674,622 (GRCm39)	missense	possibly damaging	0.51
resplendent	UTSW	11	34,618,287 (GRCm39)	nonsense	probably null
riches	UTSW	11	34,579,279 (GRCm39)	critical splice donor site	probably null
skiff	UTSW	11	34,212,388 (GRCm39)	missense	probably null	0.80
Slip	UTSW	11	34,244,286 (GRCm39)	missense	probably benign	0.25
toothskin	UTSW	11	34,414,922 (GRCm39)	missense	probably damaging	1.00
Touch	UTSW	11	34,223,750 (GRCm39)	missense	possibly damaging	0.95
wassup	UTSW	11	34,453,413 (GRCm39)	missense	probably damaging	1.00
Wharf	UTSW	11	34,623,198 (GRCm39)	missense	possibly damaging	0.81
BB009:Dock2	UTSW	11	34,217,998 (GRCm39)	missense	probably benign	0.00
BB019:Dock2	UTSW	11	34,217,998 (GRCm39)	missense	probably benign	0.00
IGL03052:Dock2	UTSW	11	34,182,853 (GRCm39)	missense	probably benign	0.01
PIT4377001:Dock2	UTSW	11	34,611,835 (GRCm39)	missense	probably benign	0.02
R0006:Dock2	UTSW	11	34,262,453 (GRCm39)	unclassified	probably benign
R0012:Dock2	UTSW	11	34,674,622 (GRCm39)	missense	possibly damaging	0.51
R0063:Dock2	UTSW	11	34,647,111 (GRCm39)	critical splice acceptor site	probably null
R0063:Dock2	UTSW	11	34,647,111 (GRCm39)	critical splice acceptor site	probably null
R0116:Dock2	UTSW	11	34,579,392 (GRCm39)	intron	probably benign
R0149:Dock2	UTSW	11	34,388,327 (GRCm39)	missense	probably damaging	1.00
R0361:Dock2	UTSW	11	34,388,327 (GRCm39)	missense	probably damaging	1.00
R0462:Dock2	UTSW	11	34,218,052 (GRCm39)	missense	possibly damaging	0.74
R0471:Dock2	UTSW	11	34,579,380 (GRCm39)	missense	probably benign	0.30
R0538:Dock2	UTSW	11	34,595,545 (GRCm39)	splice site	probably benign
R0543:Dock2	UTSW	11	34,244,325 (GRCm39)	missense	probably damaging	1.00
R0660:Dock2	UTSW	11	34,198,621 (GRCm39)	missense	probably damaging	1.00
R0676:Dock2	UTSW	11	34,586,063 (GRCm39)	missense	probably damaging	0.99
R0722:Dock2	UTSW	11	34,414,970 (GRCm39)	splice site	probably benign
R0801:Dock2	UTSW	11	34,599,620 (GRCm39)	missense	probably damaging	1.00
R1110:Dock2	UTSW	11	34,206,535 (GRCm39)	missense	possibly damaging	0.78
R1171:Dock2	UTSW	11	34,586,068 (GRCm39)	missense	probably damaging	1.00
R1387:Dock2	UTSW	11	34,223,309 (GRCm39)	splice site	probably benign
R1445:Dock2	UTSW	11	34,189,705 (GRCm39)	missense	probably benign
R1494:Dock2	UTSW	11	34,232,761 (GRCm39)	nonsense	probably null
R1589:Dock2	UTSW	11	34,597,288 (GRCm39)	missense	probably damaging	0.99
R1597:Dock2	UTSW	11	34,595,474 (GRCm39)	missense	probably benign	0.00
R1629:Dock2	UTSW	11	34,212,480 (GRCm39)	splice site	probably null
R1749:Dock2	UTSW	11	34,182,767 (GRCm39)	critical splice donor site	probably null
R1888:Dock2	UTSW	11	34,598,169 (GRCm39)	missense	probably damaging	1.00
R1888:Dock2	UTSW	11	34,598,169 (GRCm39)	missense	probably damaging	1.00
R1899:Dock2	UTSW	11	34,244,286 (GRCm39)	missense	probably benign	0.25
R1924:Dock2	UTSW	11	34,414,934 (GRCm39)	missense	possibly damaging	0.69
R2031:Dock2	UTSW	11	34,618,297 (GRCm39)	splice site	probably benign
R2045:Dock2	UTSW	11	34,244,106 (GRCm39)	splice site	probably null
R2098:Dock2	UTSW	11	34,609,832 (GRCm39)	missense	probably damaging	0.99
R2098:Dock2	UTSW	11	34,216,279 (GRCm39)	missense	probably benign	0.16
R2129:Dock2	UTSW	11	34,618,242 (GRCm39)	missense	probably damaging	1.00
R2147:Dock2	UTSW	11	34,179,472 (GRCm39)	critical splice donor site	probably null
R2149:Dock2	UTSW	11	34,179,472 (GRCm39)	critical splice donor site	probably null
R2150:Dock2	UTSW	11	34,179,472 (GRCm39)	critical splice donor site	probably null
R2176:Dock2	UTSW	11	34,586,044 (GRCm39)	missense	probably benign	0.00
R2230:Dock2	UTSW	11	34,244,323 (GRCm39)	missense	probably damaging	0.99
R2508:Dock2	UTSW	11	34,262,485 (GRCm39)	missense	probably benign	0.04
R2875:Dock2	UTSW	11	34,609,712 (GRCm39)	missense	probably damaging	1.00
R2885:Dock2	UTSW	11	34,580,593 (GRCm39)	missense	probably damaging	1.00
R2910:Dock2	UTSW	11	34,182,910 (GRCm39)	splice site	probably benign
R3081:Dock2	UTSW	11	34,181,610 (GRCm39)	missense	probably benign
R3418:Dock2	UTSW	11	34,580,587 (GRCm39)	missense	probably damaging	1.00
R3552:Dock2	UTSW	11	34,611,787 (GRCm39)	missense	probably benign	0.22
R3731:Dock2	UTSW	11	34,599,722 (GRCm39)	missense	probably damaging	1.00
R3846:Dock2	UTSW	11	34,623,198 (GRCm39)	missense	possibly damaging	0.81
R4135:Dock2	UTSW	11	34,605,328 (GRCm39)	missense	possibly damaging	0.83
R4598:Dock2	UTSW	11	34,189,536 (GRCm39)	missense	probably damaging	1.00
R4599:Dock2	UTSW	11	34,189,536 (GRCm39)	missense	probably damaging	1.00
R4715:Dock2	UTSW	11	34,244,118 (GRCm39)	missense	probably damaging	1.00
R4722:Dock2	UTSW	11	34,586,298 (GRCm39)	missense	probably damaging	1.00
R4742:Dock2	UTSW	11	34,244,170 (GRCm39)	critical splice acceptor site	probably null
R4830:Dock2	UTSW	11	34,223,767 (GRCm39)	splice site	probably null
R4884:Dock2	UTSW	11	34,216,248 (GRCm39)	missense	probably damaging	1.00
R4990:Dock2	UTSW	11	34,586,078 (GRCm39)	missense	probably damaging	1.00
R5334:Dock2	UTSW	11	34,178,643 (GRCm39)	missense	probably benign	0.00
R5570:Dock2	UTSW	11	34,618,233 (GRCm39)	missense	probably damaging	1.00
R5602:Dock2	UTSW	11	34,204,391 (GRCm39)	missense	probably benign	0.16
R5681:Dock2	UTSW	11	34,199,836 (GRCm39)	missense	probably benign	0.06
R5809:Dock2	UTSW	11	34,212,445 (GRCm39)	missense	probably benign
R5860:Dock2	UTSW	11	34,206,562 (GRCm39)	missense	probably damaging	1.00
R6111:Dock2	UTSW	11	34,599,614 (GRCm39)	missense	probably damaging	0.99
R6155:Dock2	UTSW	11	34,244,123 (GRCm39)	missense	probably benign	0.06
R6156:Dock2	UTSW	11	34,197,789 (GRCm39)	missense	possibly damaging	0.51
R6173:Dock2	UTSW	11	34,212,388 (GRCm39)	missense	probably null	0.80
R6182:Dock2	UTSW	11	34,179,476 (GRCm39)	missense	probably damaging	0.97
R6188:Dock2	UTSW	11	34,453,396 (GRCm39)	missense	probably damaging	0.98
R6191:Dock2	UTSW	11	34,181,652 (GRCm39)	missense	possibly damaging	0.79
R6283:Dock2	UTSW	11	34,598,152 (GRCm39)	missense	probably damaging	0.99
R6395:Dock2	UTSW	11	34,182,874 (GRCm39)	missense	probably damaging	1.00
R6465:Dock2	UTSW	11	34,453,413 (GRCm39)	missense	probably damaging	1.00
R6500:Dock2	UTSW	11	34,312,822 (GRCm39)	missense	possibly damaging	0.76
R6561:Dock2	UTSW	11	34,578,365 (GRCm39)	missense	probably damaging	1.00
R6745:Dock2	UTSW	11	34,596,670 (GRCm39)	missense	probably damaging	1.00
R6745:Dock2	UTSW	11	34,596,669 (GRCm39)	missense	probably damaging	1.00
R6880:Dock2	UTSW	11	34,579,279 (GRCm39)	critical splice donor site	probably null
R6913:Dock2	UTSW	11	34,647,049 (GRCm39)	missense	probably damaging	1.00
R6997:Dock2	UTSW	11	34,414,922 (GRCm39)	missense	probably damaging	1.00
R7057:Dock2	UTSW	11	34,586,044 (GRCm39)	missense	probably benign	0.00
R7057:Dock2	UTSW	11	34,177,684 (GRCm39)	missense	probably benign	0.10
R7134:Dock2	UTSW	11	34,260,363 (GRCm39)	missense	probably benign	0.03
R7188:Dock2	UTSW	11	34,189,675 (GRCm39)	missense	possibly damaging	0.87
R7239:Dock2	UTSW	11	34,181,677 (GRCm39)	missense	probably benign	0.00
R7247:Dock2	UTSW	11	34,605,340 (GRCm39)	nonsense	probably null
R7250:Dock2	UTSW	11	34,586,120 (GRCm39)	missense	probably damaging	1.00
R7250:Dock2	UTSW	11	34,586,032 (GRCm39)	missense	probably benign	0.01
R7271:Dock2	UTSW	11	34,223,750 (GRCm39)	missense	possibly damaging	0.95
R7284:Dock2	UTSW	11	34,180,672 (GRCm39)	missense	probably benign	0.01
R7397:Dock2	UTSW	11	34,609,816 (GRCm39)	missense	probably benign	0.00
R7464:Dock2	UTSW	11	34,586,105 (GRCm39)	missense	probably damaging	0.99
R7512:Dock2	UTSW	11	34,262,542 (GRCm39)	missense	possibly damaging	0.95
R7556:Dock2	UTSW	11	34,611,778 (GRCm39)	missense	probably benign	0.43
R7663:Dock2	UTSW	11	34,611,854 (GRCm39)	missense	probably damaging	1.00
R7779:Dock2	UTSW	11	34,605,282 (GRCm39)	missense	probably benign	0.38
R7797:Dock2	UTSW	11	34,232,652 (GRCm39)	missense	probably damaging	0.98
R7855:Dock2	UTSW	11	34,223,698 (GRCm39)	missense	probably damaging	1.00
R7922:Dock2	UTSW	11	34,598,154 (GRCm39)	missense	probably benign	0.29
R7932:Dock2	UTSW	11	34,217,998 (GRCm39)	missense	probably benign	0.00
R8013:Dock2	UTSW	11	34,596,677 (GRCm39)	missense	probably damaging	0.96
R8192:Dock2	UTSW	11	34,623,166 (GRCm39)	critical splice donor site	probably null
R8244:Dock2	UTSW	11	34,586,280 (GRCm39)	missense	probably damaging	1.00
R8307:Dock2	UTSW	11	34,260,362 (GRCm39)	missense	possibly damaging	0.95
R8418:Dock2	UTSW	11	34,609,795 (GRCm39)	missense	probably benign	0.01
R8460:Dock2	UTSW	11	34,180,825 (GRCm39)	critical splice acceptor site	probably null
R8495:Dock2	UTSW	11	34,181,622 (GRCm39)	missense	probably benign	0.14
R8556:Dock2	UTSW	11	34,212,457 (GRCm39)	missense	possibly damaging	0.84
R8690:Dock2	UTSW	11	34,618,287 (GRCm39)	nonsense	probably null
R8743:Dock2	UTSW	11	34,223,252 (GRCm39)	nonsense	probably null
R8757:Dock2	UTSW	11	34,586,067 (GRCm39)	missense	probably benign	0.13
R8793:Dock2	UTSW	11	34,451,215 (GRCm39)	missense	probably benign	0.00
R8882:Dock2	UTSW	11	34,595,436 (GRCm39)	frame shift	probably null
R8885:Dock2	UTSW	11	34,260,396 (GRCm39)	missense	probably benign	0.01
R8943:Dock2	UTSW	11	34,599,646 (GRCm39)	missense	possibly damaging	0.63
R9171:Dock2	UTSW	11	34,589,670 (GRCm39)	missense	probably benign	0.12
R9182:Dock2	UTSW	11	34,260,398 (GRCm39)	missense	possibly damaging	0.51
R9203:Dock2	UTSW	11	34,622,366 (GRCm39)	missense	possibly damaging	0.92
R9310:Dock2	UTSW	11	34,244,139 (GRCm39)	missense	possibly damaging	0.71
R9388:Dock2	UTSW	11	34,212,460 (GRCm39)	missense	possibly damaging	0.70
R9490:Dock2	UTSW	11	34,589,582 (GRCm39)	missense	possibly damaging	0.90
R9568:Dock2	UTSW	11	34,599,638 (GRCm39)	missense	possibly damaging	0.83
R9593:Dock2	UTSW	11	34,178,607 (GRCm39)	missense	probably benign	0.34
R9694:Dock2	UTSW	11	34,218,054 (GRCm39)	missense	probably benign
R9697:Dock2	UTSW	11	34,204,417 (GRCm39)	missense	probably benign
R9753:Dock2	UTSW	11	34,223,673 (GRCm39)	missense	possibly damaging	0.68
R9783:Dock2	UTSW	11	34,208,128 (GRCm39)	missense	possibly damaging	0.83
X0017:Dock2	UTSW	11	34,216,271 (GRCm39)	missense	probably benign	0.08
X0018:Dock2	UTSW	11	34,182,833 (GRCm39)	missense	possibly damaging	0.65
X0058:Dock2	UTSW	11	34,206,564 (GRCm39)	missense	probably damaging	1.00
X0066:Dock2	UTSW	11	34,260,357 (GRCm39)	missense	possibly damaging	0.95
Z1088:Dock2	UTSW	11	34,583,209 (GRCm39)	missense	probably damaging	1.00
Z1088:Dock2	UTSW	11	34,388,300 (GRCm39)	missense	probably benign	0.14
Z1088:Dock2	UTSW	11	34,586,039 (GRCm39)	nonsense	probably null
Z1176:Dock2	UTSW	11	34,609,751 (GRCm39)	missense	probably benign	0.04
Z1177:Dock2	UTSW	11	34,262,553 (GRCm39)	missense	possibly damaging	0.68

Predicted Primers

PCR Primer
(F):5'- AAGCAACTGTCTCATCACTTCC -3'
(R):5'- TGCCCGCTGTACCATTAAAG -3'

Sequencing Primer
(F):5'- TCATAAGGATTCCCTGAGGGCTC -3'
(R):5'- CCCGCTGTACCATTAAAGAGAGG -3'

Posted On

2021-04-30