Incidental Mutation 'R8807:Cdcp3'
ID 672140
Institutional Source Beutler Lab
Gene Symbol Cdcp3
Ensembl Gene ENSMUSG00000006204
Gene Name CUB domain containing protein 3
Synonyms 5430419D17Rik
MMRRC Submission 068643-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R8807 (G1)
Quality Score 225.009
Status Validated
Chromosome 7
Chromosomal Location 130776131-130908180 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 130846507 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Phenylalanine at position 644 (I644F)
Ref Sequence ENSEMBL: ENSMUSP00000061529 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000050586] [ENSMUST00000124096] [ENSMUST00000208921]
AlphaFold no structure available at present
Predicted Effect probably damaging
Transcript: ENSMUST00000050586
AA Change: I644F

PolyPhen 2 Score 0.971 (Sensitivity: 0.77; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000061529
Gene: ENSMUSG00000006204
AA Change: I644F

DomainStartEndE-ValueType
signal peptide 1 23 N/A INTRINSIC
low complexity region 85 105 N/A INTRINSIC
SR 144 244 3.3e-57 SMART
CUB 272 378 1.2e-16 SMART
SR 428 528 3.9e-56 SMART
low complexity region 533 548 N/A INTRINSIC
CUB 556 667 5.1e-38 SMART
SR 680 780 1.5e-57 SMART
Pfam:CUB 795 840 3.1e-9 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000124096
SMART Domains Protein: ENSMUSP00000130971
Gene: ENSMUSG00000030849

DomainStartEndE-ValueType
Pfam:Pkinase 1 118 4.8e-19 PFAM
Pfam:Pkinase_Tyr 1 118 1.7e-50 PFAM
low complexity region 146 160 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000208921
AA Change: I760F

PolyPhen 2 Score 0.995 (Sensitivity: 0.68; Specificity: 0.97)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.7%
  • 20x: 99.1%
Validation Efficiency 99% (74/75)
Allele List at MGI
Other mutations in this stock
Total: 77 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
5730480H06Rik T C 5: 48,534,494 (GRCm39) I118T probably damaging Het
Abca8a A T 11: 109,974,252 (GRCm39) F227L probably benign Het
Abcc6 A T 7: 45,648,431 (GRCm39) I687N possibly damaging Het
Akain1 T C 17: 69,794,340 (GRCm39) *70Q probably null Het
Allc C T 12: 28,615,489 (GRCm39) G89S probably damaging Het
Aoc1l3 T C 6: 48,965,188 (GRCm39) F399L probably benign Het
Artn A T 4: 117,783,915 (GRCm39) S184T possibly damaging Het
B3galt9 A T 2: 34,728,818 (GRCm39) I206F probably damaging Het
Bcl2a1c A T 9: 114,159,248 (GRCm39) I9F probably damaging Het
Cacna2d1 T A 5: 16,472,452 (GRCm39) D286E probably damaging Het
Cdc25a G A 9: 109,708,303 (GRCm39) E98K probably benign Het
Cdr2l A T 11: 115,284,741 (GRCm39) Q359L probably damaging Het
Cmip C T 8: 118,138,094 (GRCm39) T103M probably benign Het
Dcaf1 A G 9: 106,742,268 (GRCm39) T1358A probably benign Het
Dedd2 C T 7: 24,910,705 (GRCm39) R157Q probably benign Het
Dhrs1 A G 14: 55,982,499 (GRCm39) V9A probably damaging Het
Dop1b T A 16: 93,558,973 (GRCm39) V573E probably benign Het
Eef2k A T 7: 120,490,930 (GRCm39) I517F possibly damaging Het
En1 T C 1: 120,531,090 (GRCm39) F110S possibly damaging Het
Evpl T A 11: 116,111,853 (GRCm39) I1946F probably damaging Het
Gaa A T 11: 119,168,393 (GRCm39) M502L probably benign Het
Gfer C T 17: 24,914,846 (GRCm39) A66T possibly damaging Het
Gm13271 A G 4: 88,673,213 (GRCm39) T37A probably benign Het
Grm3 C T 5: 9,561,499 (GRCm39) A784T probably damaging Het
H3c8 A G 13: 23,719,628 (GRCm39) K5E probably benign Het
Helz C G 11: 107,493,835 (GRCm39) S277C probably damaging Het
Henmt1 T G 3: 108,867,652 (GRCm39) *396G probably null Het
Hfe C T 13: 23,889,667 (GRCm39) V327I probably benign Het
Hoxd8 A T 2: 74,536,313 (GRCm39) Q141L probably damaging Het
Hspa12b T G 2: 130,987,103 (GRCm39) S675A probably benign Het
Ifi214 G A 1: 173,354,133 (GRCm39) T179I possibly damaging Het
Ighv5-9 T A 12: 113,625,404 (GRCm39) Y113F possibly damaging Het
Lca5l T A 16: 95,979,808 (GRCm39) R112S probably benign Het
Lmbrd1 C T 1: 24,770,843 (GRCm39) P257S probably benign Het
Loxhd1 C T 18: 77,444,468 (GRCm39) T608I possibly damaging Het
Lpl C A 8: 69,345,280 (GRCm39) L95I probably damaging Het
Lrp2bp A T 8: 46,473,732 (GRCm39) Q196L probably damaging Het
Ly6h A G 15: 75,438,056 (GRCm39) Y19H probably benign Het
Mfsd6 T C 1: 52,697,706 (GRCm39) probably benign Het
Mpo T C 11: 87,687,165 (GRCm39) I237T probably benign Het
Mrpl41 A G 2: 24,864,878 (GRCm39) W6R unknown Het
Muc16 T A 9: 18,567,353 (GRCm39) H1722L unknown Het
Mug1 A C 6: 121,851,434 (GRCm39) D777A probably benign Het
Myh1 A T 11: 67,111,354 (GRCm39) I1598F probably benign Het
Myo1f C T 17: 33,794,879 (GRCm39) R40C probably damaging Het
Myo6 G A 9: 80,207,949 (GRCm39) probably null Het
Nbeal2 G T 9: 110,458,707 (GRCm39) N2071K probably damaging Het
Nectin4 T A 1: 171,211,282 (GRCm39) C269S probably damaging Het
Nhlrc1 A T 13: 47,167,990 (GRCm39) L89Q probably damaging Het
Nup205 T C 6: 35,160,904 (GRCm39) F103S probably damaging Het
Obscn C A 11: 58,970,470 (GRCm39) V2379F probably damaging Het
Or5m8 A T 2: 85,823,172 (GRCm39) *337L probably null Het
Or5p62 A T 7: 107,771,852 (GRCm39) I33N possibly damaging Het
Plppr2 TCGCC TC 9: 21,855,727 (GRCm39) probably benign Het
Ptbp3 A G 4: 59,517,584 (GRCm39) V101A probably benign Het
Rps6kb2 C T 19: 4,213,229 (GRCm39) D6N probably damaging Het
Rsph1 T A 17: 31,484,828 (GRCm39) H154L probably damaging Het
Sdk1 G A 5: 142,071,382 (GRCm39) V1191M probably damaging Het
Selenos T A 7: 65,729,467 (GRCm39) D2E probably benign Het
Sema5a G A 15: 32,562,868 (GRCm39) G293D possibly damaging Het
Sgcg A G 14: 61,469,930 (GRCm39) S144P probably damaging Het
Sh3d19 T C 3: 85,992,659 (GRCm39) V229A probably benign Het
Sin3b C T 8: 73,476,708 (GRCm39) A714V probably benign Het
Slitrk6 T A 14: 110,988,123 (GRCm39) Q528L possibly damaging Het
Sprr2b CTGAGCCTTGTCCTCCTCCAAAGTGCCCTGAGCCTTGTCCTCCCCCAGTATGCTGTGAGCCTTGTCCTCCTCCAAAGTGCCCTGAGCCTTGTCCTCCCCCAGTATGCTGTGAGCCTTGTCCTCC CTGAGCCTTGTCCTCCTCCAAAGTGCCCTGAGCCTTGTCCTCCCCCAGTATGCTGTGAGCCTTGTCCTCC 3: 92,224,826 (GRCm39) probably benign Het
Stard9 T A 2: 120,535,932 (GRCm39) L4063H probably damaging Het
Stard9 A C 2: 120,535,943 (GRCm39) K4067Q probably damaging Het
Terb1 A G 8: 105,195,741 (GRCm39) probably null Het
Tex2 T A 11: 106,435,194 (GRCm39) H744L unknown Het
Tex2 T C 11: 106,458,414 (GRCm39) S339G unknown Het
Tmem135 G C 7: 88,797,186 (GRCm39) L357V probably benign Het
Trhr A T 15: 44,061,212 (GRCm39) N244I probably benign Het
Ttn G A 2: 76,582,409 (GRCm39) A22828V probably damaging Het
Uchl1 C T 5: 66,833,601 (GRCm39) probably benign Het
Uroc1 A T 6: 90,328,110 (GRCm39) I529F probably damaging Het
Vps13c G T 9: 67,766,122 (GRCm39) V80F probably damaging Het
Wnt1 T A 15: 98,690,645 (GRCm39) C325S probably damaging Het
Other mutations in Cdcp3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00226:Cdcp3 APN 7 130,839,823 (GRCm39) splice site probably null
IGL00848:Cdcp3 APN 7 130,848,453 (GRCm39) missense probably damaging 1.00
IGL00966:Cdcp3 APN 7 130,844,836 (GRCm39) nonsense probably null
IGL01286:Cdcp3 APN 7 130,848,432 (GRCm39) missense probably damaging 1.00
IGL01303:Cdcp3 APN 7 130,796,060 (GRCm39) missense possibly damaging 0.53
IGL01585:Cdcp3 APN 7 130,846,487 (GRCm39) missense probably damaging 0.97
IGL01665:Cdcp3 APN 7 130,848,386 (GRCm39) nonsense probably null
IGL01953:Cdcp3 APN 7 130,826,709 (GRCm39) missense probably benign 0.04
IGL02427:Cdcp3 APN 7 130,846,517 (GRCm39) missense probably damaging 0.99
IGL02508:Cdcp3 APN 7 130,824,559 (GRCm39) missense probably damaging 1.00
IGL02678:Cdcp3 APN 7 130,830,646 (GRCm39) missense probably damaging 1.00
IGL03092:Cdcp3 APN 7 130,803,527 (GRCm39) critical splice donor site probably null
IGL03122:Cdcp3 APN 7 130,798,243 (GRCm39) missense possibly damaging 0.68
IGL03343:Cdcp3 APN 7 130,848,420 (GRCm39) missense probably damaging 1.00
R0011:Cdcp3 UTSW 7 130,831,722 (GRCm39) missense probably damaging 0.99
R0011:Cdcp3 UTSW 7 130,831,722 (GRCm39) missense probably damaging 0.99
R0234:Cdcp3 UTSW 7 130,796,032 (GRCm39) splice site probably null
R0234:Cdcp3 UTSW 7 130,796,032 (GRCm39) splice site probably null
R0268:Cdcp3 UTSW 7 130,839,905 (GRCm39) missense probably damaging 1.00
R0383:Cdcp3 UTSW 7 130,841,268 (GRCm39) missense probably benign 0.05
R0973:Cdcp3 UTSW 7 130,839,911 (GRCm39) missense probably damaging 1.00
R0973:Cdcp3 UTSW 7 130,839,911 (GRCm39) missense probably damaging 1.00
R0974:Cdcp3 UTSW 7 130,839,911 (GRCm39) missense probably damaging 1.00
R1572:Cdcp3 UTSW 7 130,846,560 (GRCm39) nonsense probably null
R1911:Cdcp3 UTSW 7 130,839,818 (GRCm39) missense probably damaging 1.00
R2032:Cdcp3 UTSW 7 130,844,781 (GRCm39) missense probably damaging 1.00
R2097:Cdcp3 UTSW 7 130,783,693 (GRCm39) nonsense probably null
R2221:Cdcp3 UTSW 7 130,849,186 (GRCm39) critical splice acceptor site probably null
R2223:Cdcp3 UTSW 7 130,849,186 (GRCm39) critical splice acceptor site probably null
R2254:Cdcp3 UTSW 7 130,824,634 (GRCm39) missense probably damaging 1.00
R2913:Cdcp3 UTSW 7 130,783,753 (GRCm39) missense possibly damaging 0.90
R2991:Cdcp3 UTSW 7 130,848,429 (GRCm39) missense probably damaging 1.00
R3439:Cdcp3 UTSW 7 130,790,508 (GRCm39) critical splice donor site probably null
R4418:Cdcp3 UTSW 7 130,849,194 (GRCm39) missense possibly damaging 0.86
R4916:Cdcp3 UTSW 7 130,776,206 (GRCm39) splice site probably null
R5488:Cdcp3 UTSW 7 130,848,324 (GRCm39) missense probably damaging 1.00
R5594:Cdcp3 UTSW 7 130,841,252 (GRCm39) missense probably benign 0.12
R5897:Cdcp3 UTSW 7 130,798,280 (GRCm39) splice site probably null
R5898:Cdcp3 UTSW 7 130,843,696 (GRCm39) splice site probably null
R5940:Cdcp3 UTSW 7 130,839,992 (GRCm39) missense probably damaging 1.00
R6170:Cdcp3 UTSW 7 130,776,216 (GRCm39) splice site probably null
R6187:Cdcp3 UTSW 7 130,872,328 (GRCm39) intron probably benign
R6321:Cdcp3 UTSW 7 130,858,735 (GRCm39) critical splice donor site probably null
R6409:Cdcp3 UTSW 7 130,863,800 (GRCm39) intron probably benign
R6432:Cdcp3 UTSW 7 130,846,601 (GRCm39) critical splice donor site probably null
R6481:Cdcp3 UTSW 7 130,858,530 (GRCm39) missense probably benign 0.05
R6750:Cdcp3 UTSW 7 130,889,974 (GRCm39) intron probably benign
R6783:Cdcp3 UTSW 7 130,828,493 (GRCm39) missense probably damaging 0.99
R6836:Cdcp3 UTSW 7 130,798,233 (GRCm39) missense possibly damaging 0.84
R6925:Cdcp3 UTSW 7 130,824,436 (GRCm39) missense possibly damaging 0.92
R6995:Cdcp3 UTSW 7 130,824,400 (GRCm39) missense probably damaging 1.00
R7199:Cdcp3 UTSW 7 130,837,641 (GRCm39) nonsense probably null
R7205:Cdcp3 UTSW 7 130,879,352 (GRCm39) critical splice donor site probably null
R7340:Cdcp3 UTSW 7 130,879,344 (GRCm39) missense unknown
R7354:Cdcp3 UTSW 7 130,873,762 (GRCm39) missense unknown
R7354:Cdcp3 UTSW 7 130,858,458 (GRCm39) missense possibly damaging 0.84
R7434:Cdcp3 UTSW 7 130,881,212 (GRCm39) missense unknown
R7485:Cdcp3 UTSW 7 130,830,562 (GRCm39) missense probably damaging 0.99
R7513:Cdcp3 UTSW 7 130,873,800 (GRCm39) missense unknown
R7562:Cdcp3 UTSW 7 130,904,426 (GRCm39) missense unknown
R7623:Cdcp3 UTSW 7 130,879,295 (GRCm39) splice site probably null
R7782:Cdcp3 UTSW 7 130,904,466 (GRCm39) splice site probably null
R7879:Cdcp3 UTSW 7 130,844,871 (GRCm39) missense probably damaging 0.98
R7935:Cdcp3 UTSW 7 130,852,205 (GRCm39) missense probably damaging 0.96
R7949:Cdcp3 UTSW 7 130,895,324 (GRCm39) splice site probably null
R7964:Cdcp3 UTSW 7 130,899,963 (GRCm39) missense unknown
R7980:Cdcp3 UTSW 7 130,836,506 (GRCm39) missense probably damaging 0.98
R8145:Cdcp3 UTSW 7 130,898,045 (GRCm39) missense unknown
R8673:Cdcp3 UTSW 7 130,844,846 (GRCm39) missense probably damaging 0.99
R8684:Cdcp3 UTSW 7 130,837,688 (GRCm39) nonsense probably null
R8721:Cdcp3 UTSW 7 130,879,335 (GRCm39) missense unknown
R8725:Cdcp3 UTSW 7 130,875,485 (GRCm39) missense unknown
R8727:Cdcp3 UTSW 7 130,875,485 (GRCm39) missense unknown
R8742:Cdcp3 UTSW 7 130,783,741 (GRCm39) missense unknown
R8822:Cdcp3 UTSW 7 130,843,706 (GRCm39) critical splice acceptor site probably null
R8861:Cdcp3 UTSW 7 130,861,690 (GRCm39) nonsense probably null
R8897:Cdcp3 UTSW 7 130,867,566 (GRCm39) missense unknown
R8900:Cdcp3 UTSW 7 130,904,197 (GRCm39) intron probably benign
R9214:Cdcp3 UTSW 7 130,824,481 (GRCm39) missense possibly damaging 0.89
R9218:Cdcp3 UTSW 7 130,863,728 (GRCm39) missense unknown
R9311:Cdcp3 UTSW 7 130,859,490 (GRCm39) missense unknown
R9323:Cdcp3 UTSW 7 130,828,401 (GRCm39) missense probably damaging 0.96
R9384:Cdcp3 UTSW 7 130,904,404 (GRCm39) missense unknown
R9387:Cdcp3 UTSW 7 130,863,620 (GRCm39) missense unknown
R9417:Cdcp3 UTSW 7 130,852,218 (GRCm39) missense possibly damaging 0.60
R9502:Cdcp3 UTSW 7 130,836,815 (GRCm39) missense possibly damaging 0.61
R9603:Cdcp3 UTSW 7 130,830,643 (GRCm39) missense probably damaging 0.98
R9642:Cdcp3 UTSW 7 130,848,257 (GRCm39) missense probably benign 0.01
Z1088:Cdcp3 UTSW 7 130,848,362 (GRCm39) missense probably damaging 1.00
Z1177:Cdcp3 UTSW 7 130,867,595 (GRCm39) missense unknown
Predicted Primers PCR Primer
(F):5'- ACTGAAGATGTTGCTACTGTGTC -3'
(R):5'- GTGATACTACCACCTCTAGCAG -3'

Sequencing Primer
(F):5'- GAAGATGTTGCTACTGTGTCATTAAC -3'
(R):5'- CCTCTAGCAGGTAAGGTGTG -3'
Posted On 2021-04-30